D L Kewalramani's research spans two main areas: the responsible integration of artificial intelligence into surgery and medical education, and clinical care of patients with rare neurological and metabolic disorders in children. On the AI side, the work focuses on how to evaluate, implement, and ethically deploy AI tools in training environments and real-world surgical care. The clinical work documents rare pediatric cases involving immune-mediated brain disease, inborn errors of metabolism, and genetic conditions, often from resource-limited settings.
Publications
Artificial intelligence literacy and infectious diseases competency: Essential considerations for future revisions of the surgical critical care curriculum.
A scoping review of artificial intelligence in acute care surgery: promise, pitfalls, and a path forward.
2026
International journal of surgery (London, England)
Kewalramani D, Chattopadhyay K, Benton J, Hua J, Cheruvu S +17 more
Plain English This review examined 49 studies covering 341 AI models built for acute care surgery, the high-stakes field of emergency operations. Most AI focused narrowly on predicting surgical risk before operations and was tested only on the data it was trained on, with almost none independently validated or approved for real use. The gap between what these tools promise and their actual readiness for clinical practice remains wide.
Position statement from the society of University surgeons, surgical education committee: Artificial intelligence in surgical training for medical students, residents, and fellows.
2026
Surgery
Kewalramani D, Jawa RS, Martin CA, Gosain A, Wan D +7 more
Plain English A surgical educators' committee laid out a framework for responsibly bringing AI into the training of medical students, residents, and fellows in surgery. The guidelines cover both narrow AI tools like computer vision and generative AI like large language models, and give practical advice to accrediting bodies, institutions, and individual surgeons. The core message is that AI should enhance—not replace—the mentorship relationship that defines surgical training.
Innovation in Surgical Education and Increasing the Surgical Workforce.
2025
The Surgical clinics of North America
Kewalramani D, Narayan M
Plain English With a global shortage of surgeons threatening healthcare in low-resource settings, this article argues for modernizing how surgeons are trained. Technology like virtual reality simulation, telementoring, and AI-assisted learning can expand access and compress training timelines. Pairing these tools with policy reforms like national surgical plans and task-sharing could help close the workforce gap faster.
Chronic granulomatous herpes simplex encephalitis in a child with digeorge syndrome- expanding the spectrum of herpes-associated neurological disease.
2025
BMC infectious diseases
Kewalramani DA, Kanagavel Y, Krishnaswamy V, Ravichandran L, Cruz LD +3 more
Plain English A 10-month-old girl with DiGeorge syndrome (a genetic immune deficiency) had an initial seizure episode that was treated, but then developed progressive brain disease over the next decade. Brain biopsy ultimately confirmed chronic herpes simplex virus encephalitis, a rare presentation that had been missed because spinal fluid tests kept coming back negative. Long-term antiviral therapy led to meaningful improvement, highlighting the need to consider chronic viral brain infection in children with immune deficiencies and atypical neurological decline.
Kewalramani D, Roman DS, Lagos SA, Rammsy F, Villagran I +7 more
Plain English Researchers tested whether better instructor feedback leads to better skill acquisition, using an AI tool called Teach1 to rate the quality of feedback given to medical students learning a bedside procedure. Higher-quality feedback was directly tied to greater skill improvement, with every 10% increase in feedback quality corresponding to a measurable score gain. This shows that AI can objectively evaluate teaching quality and help standardize surgical education at scale.
Gaps and Opportunities in Antimicrobial Stewardship and Surgical Site Infection Surveillance Across India.
2025
Surgical infections
Tumati A, Singh HK, Kewalramani D, Joshi M, Barie PS +2 more
Plain English This survey of five major Indian hospitals found that programs to track and prevent surgical site infections—which are common but largely preventable—varied widely and had significant gaps in oversight, education, and data infrastructure. Drug-resistant bacteria rates were high across all sites, with one hospital reporting that nearly 58% of certain infections involved resistant organisms. The findings underscore an urgent need for standardized stewardship programs across India.
Building health systems capable of leveraging AI: applying Paul Farmer's 5S framework for equitable global health.
2025
BMC global and public health
McCoy LG, Bihorac A, Celi LA, Elmore M, Kewalramani D +7 more
Plain English This essay argues that deploying AI in healthcare settings that lack adequate staffing, equipment, and infrastructure is not only ineffective but potentially harmful. Using Paul Farmer's framework for what health systems actually need to function, the authors warn that AI investment in under-resourced contexts risks diverting limited funds from more foundational needs. Concrete questions are proposed to help policymakers assess whether a health system is ready for AI before committing resources.
Impact of the Good Samaritan Law on bystander intervention willingness and perceived legal risks in India.
2025
The journal of trauma and acute care surgery
Kewalramani D, Choron RL, Whitley D, Teichman A, Raina K +8 more
Plain English After India passed a Good Samaritan Law in 2016 protecting bystanders who help road accident victims from legal and financial liability, this study compared survey data from before and after the law. Willingness to help jumped by 65% and fear of legal consequences dropped by 81%. The law worked, but awareness remained much higher in smaller cities than in major metros, pointing to a need for targeted public education campaigns.
A case of carbonic anhydrase type VA deficiency presenting as West syndrome in an infant with a novel mutation in the CA-VA gene.
2022
Epilepsy & behavior reports
Mani Urmila N, Kewalramani D, Balakrishnan U, Manokaran RK
Plain English A 10-month-old boy had a metabolic crisis at birth and later developed infantile spasms; genetic testing revealed a mutation causing carbonic anhydrase VA deficiency, a rare enzyme disorder affecting ammonia processing. What was unusual was the combination of epilepsy with this condition, which had not been reported before. The case expands the known range of neurological problems this rare disease can cause and adds to the small worldwide count of documented patients.
Favorable response to classic ketogenic diet in a child with anti-GAD 65 antibody mediated super refractory status epilepticus.
2022
Epilepsy & behavior reports
Sivathanu D, Kewalramani D, Kumar Manokaran R
Plain English A 7-year-old boy with a specific type of autoimmune brain inflammation kept having severe, uncontrollable seizures despite multiple medications and immune therapies. Switching to a ketogenic diet stopped the seizures within two days. The case suggests this dietary approach may be an effective add-on treatment for children with autoimmune-driven epilepsy when standard therapies fail.
Plain English Three patients developed serious spinal cord injury after chiropractic manipulation of the neck, with all three losing the ability to move their arms and legs within 24 hours of the procedure. Two had fractures found on imaging; one required surgery and only one of the three recovered meaningful function. The report warns that neck manipulation can cause severe and potentially irreversible neurological damage.