Sarah L Zalubas

1 publication 2024 – 2024
Caenorhabditis elegansCaenorhabditis elegans ProteinsTranscription FactorsHistonesLipid Metabolism

Research Overview

Sarah L Zalubas studies how early life stress can protect organisms from age-related diseases, particularly focusing on amyloid toxicity in aging. Her research demonstrates that mild stress in youth triggers long-lasting changes in how cells regulate fat metabolism through a protein called HSF-1, which builds resilience against protein damage later in life. Her work suggests that early adversity may have evolved as a protective mechanism that prepares the body for aging-related challenges.

Publications

Early life changes in histone landscape protect against age-associated amyloid toxicities through HSF-1-dependent regulation of lipid metabolism.

2024

Nature aging

Oleson BJ, Bhattrai J, Zalubas SL, Kravchenko TR, Ji Y +7 more

Plain English
Researchers exposed young worms to mild stress early in life and found that this experience protected them from a toxic protein called amyloid that normally damages cells as they age. The protection worked by activating a protein called HSF-1, which rewired how the worms' bodies process fats and energy, making them more resistant to the amyloid damage later on. This shows that challenging experiences early in life can reprogram our bodies at a fundamental level to protect us from age-related diseases.

View on PubMed

Frequent Co-Authors

Bryndon J Oleson Janakraj Bhattrai Tessa R Kravchenko Yuanyuan Ji Emily L Jiang Christine C Lu Ciara R Madden Julia G Coffman Daphne Bazopoulou Jace W Jones

Publication data sourced from PubMed . Plain-English summaries generated by AI. Not medical advice.