DR. BRUCE ROBERT HOLLADAY, MD

EDGEWOOD, KY

Research Active
Orthopaedic Surgery NPI registered 21+ years 11 publications 2004 – 2024 NPI: 1548262793
AlgorithmsCertificationImage Processing, Computer-AssistedTask Performance and AnalysisAge FactorsAllied Health PersonnelRadiation, IonizingRadiometryChromosome AberrationsLaboratoriesMedical Laboratory Personnelalpha 1-Antitrypsin DeficiencyMedical Laboratory SciencePhlebotomyBiological Assay

Practice Location

560 S LOOP RD
EDGEWOOD, KY 41017-3405

Phone: (859) 301-2663

What does BRUCE HOLLADAY research?

Dr. Holladay studies how to effectively measure and assess exposure to radiation, particularly through methods like the dicentric chromosome assay, which evaluates damage to DNA caused by radiation. His research is crucial for ensuring accurate health assessments for patients exposed to radiation. Additionally, he investigates the genetic condition alpha-1 antitrypsin deficiency (AATD), specifically its links to asthma and liver disease. His work helps in understanding how AATD can lead to respiratory problems and severe liver conditions, providing vital information for healthcare providers and patients.

Key findings

  • In a 2024 study, Dr. Holladay found that while most labs accurately estimated radiation doses from blood samples exposed to 4 Gy, two labs struggled with lower doses of 1.5 Gy.
  • His 2006 research showed that 44.6% of participants with AATD reported having asthma, particularly those with the PiZZ mutation, indicating a link between asthma and chronic obstructive pulmonary disease (COPD).
  • In a 2005 study, he found that out of 165 adults with AATD, 25 had advanced liver disease, highlighting the increased risk factors such as male gender and higher body weight.

Frequently asked questions

Does Dr. Holladay study alpha-1 antitrypsin deficiency?
Yes, he researches alpha-1 antitrypsin deficiency (AATD), particularly its effects on asthma and liver health.
What techniques does Dr. Holladay use to measure radiation exposure?
He uses the dicentric chromosome assay to analyze DNA damage from radiation, improving assessment methods across laboratories.
Is Dr. Holladay's work relevant for patients exposed to radiation?
Yes, his research is crucial for ensuring accurate assessments of health risks associated with radiation exposure.
What are the health risks associated with alpha-1 antitrypsin deficiency?
Patients with AATD are at a higher risk for developing asthma and advanced liver diseases.
How does Dr. Holladay's research help healthcare providers?
His studies provide valuable data for diagnosing and managing conditions like AATD and assure the reliability of radiation exposure assessments.

Publications in plain English

LBDNet interlaboratory comparison for the dicentric chromosome assay by digitized image analysis applying weighted robust statistical methods.

2024

International journal of radiation biology

González Mesa JE, Alem Glison D, Chaves-Campos FA, Ortíz Morales F, Valle Bourrouet L +23 more

Plain English
This study looked at how well different labs in the Latin-American Biodosimetry Network could analyze images of cells for signs of radiation exposure. They found that most labs provided accurate dose estimates for blood samples exposed to 4 Gy of radiation, but some had trouble with lower doses, especially at 1.5 Gy, where two labs were inaccurate. Using advanced methods to adjust for the varying skill levels of the labs helped improve accuracy. Who this helps: This benefits researchers and doctors who need reliable data on radiation exposure.

PubMed

Assessment methods for inter-laboratory comparisons of the dicentric assay.

2023

International journal of radiation biology

González Mesa JE, Holladay B, Higueras M, Di Giorgio M, Barquinero JF

Plain English
This study looked at how different methods (algorithms) can be used to assess the performance of labs comparing their results on dicentric chromosome analysis, which helps measure radiation exposure. Researchers found that the Q/Hampel algorithm was the most effective for determining the average radiation dose when many samples had the same results, while Algorithm B performed better when fewer identical values were present. These findings are important because they help ensure that radiation exposure assessments across different laboratories are accurate, leading to better health monitoring for individuals exposed to radiation. Who this helps: Patients who have been exposed to radiation and need accurate health assessments.

PubMed

The fluctuation-dissipation measurement instrument at the Linac Coherent Light Source.

2022

The Review of scientific instruments

Assefa TA, Seaberg MH, Reid AH, Shen L, Esposito V +18 more

Plain English
This study focused on creating new tools to study tiny changes in materials using advanced x-ray technology. Researchers built a new instrument that successfully measured fluctuations in quantum materials, showing improved precision in their measurements. Specifically, the new method provided access to higher momentum resolution, which helps in understanding the properties of these materials better. Who this helps: This benefits scientists researching advanced quantum materials.

PubMed

Nanoscale magnetization inhomogeneity within single phase nanopillars.

2019

Physical review materials

Farmer TO, Guo EJ, Desautels RD, DeBeer-Schmitt L, Chen A +7 more

Plain English
The researchers studied tiny magnetic pillars made of CoFeO material within a BaTiO structure to understand how their magnetic properties change depending on their structure. They found that these pillars exhibit different magnetic behaviors in their core and outer layers, and this is important for creating new technologies like low-power memory and sensors. Specifically, they noticed that variations in magnetization occur at a very small scale, which could lead to more efficient device designs. Who this helps: This benefits engineers and scientists working on advanced memory and sensing technologies.

PubMed

Nanosecond X-Ray Photon Correlation Spectroscopy on Magnetic Skyrmions.

2017

Physical review letters

Seaberg MH, Holladay B, Lee JCT, Sikorski M, Reid AH +15 more

Plain English
This study focused on a new x-ray technique to observe tiny changes in magnetic materials called magnetic skyrmions, which are important for advanced technologies. Researchers found that the timing of these changes varies in different magnetic patterns: the skyrmion phase had different fluctuation timings compared to areas near it. Understanding these fluctuations is crucial as it opens up new possibilities for research in materials science. Who this helps: This benefits researchers and engineers working on next-generation magnetic materials and devices.

PubMed

Exploring professional-related outcome differences between phlebotomy technicians, medical laboratory technicians, and medical technologists.

2008

Journal of allied health

Blau G, Portwood J, Chapman S, Doyle K, Holladay B +1 more

Plain English
This study looked at how phlebotomy technicians, medical laboratory technicians, and medical technologists perform in areas like professional development and quality assurance. It found that while phlebotomy technicians did not have significant differences in professional development or employer reimbursement compared to the others, they scored lower on quality assurance monitoring, which fits with what is expected for their role. This is important because improving professional development can help attract and keep health workers, especially as the demand for healthcare services grows. Who this helps: This helps health professionals, employers, and healthcare organizations.

PubMed

Task scales performed and testing for scale differences among phlebotomy technicians, medical laboratory technicians, and medical technologists.

2007

Journal of allied health

Blau G, Chapman S, Doyle K, Freeman V, Holladay B

Plain English
This study looked at the different tasks performed by three types of lab workers: phlebotomy technicians, medical laboratory technicians, and medical technologists. Researchers examined the work of 1,152 professionals and identified 38 specific tasks they perform, finding distinct differences in task performance between the groups. This is important because it helps ensure that certification tests reflect the actual skills needed for each job, maintaining high standards in the medical field. Who this helps: This helps patients and healthcare providers by ensuring that lab workers are properly trained for their specific roles.

PubMed

Further testing the impact of shift schedule on task scale variables for medical laboratory professionals.

2007

Journal of allied health

Blau G, Fertig J, Lopez A, Aaronson W, Holladay B

Plain English
This study looked at how different work schedules affect the jobs of medical laboratory professionals. It found that those working fixed day shifts felt their tasks were more varied and engaging compared to those on evening, night, or rotating shifts, which can lead to job boredom. This is important because keeping lab professionals motivated and satisfied can improve the quality of care they provide. Who this helps: This benefits medical laboratory professionals and healthcare organizations.

PubMed

Asthma and allergy in alpha-1 antitrypsin deficiency.

2006

Respiratory medicine

Eden E, Strange C, Holladay B, Xie L

Plain English
This study looked at how common asthma and allergies are in people with alpha-1 antitrypsin deficiency (AATD). Out of 2,418 participants, 757 responded, and 44.6% reported having asthma. It found that those with a specific AATD mutation called PiZZ were more likely to have asthma along with chronic obstructive pulmonary disease (COPD), indicating that asthma is often linked to COPD in these patients. Who this helps: This research benefits patients with AATD, particularly those experiencing asthma and respiratory issues.

PubMed

Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency.

2005

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Bowlus CL, Willner I, Zern MA, Reuben A, Chen P +4 more

Plain English
This research studied adults with a genetic condition called alpha-1-antitrypsin deficiency (AAT) that can lead to severe liver disease. Out of 165 participants with liver issues, 15 children and 25 adults had advanced liver disease, indicating a need for liver transplants. Key findings include that being male and having a higher body weight increase the risk of severe liver disease, while factors like alcohol use and viral hepatitis did not have a significant impact. Who this helps: This information benefits patients with AAT deficiency, healthcare providers, and researchers focusing on liver diseases.

PubMed

Genetic testing for alpha1-antitrypsin deficiency.

2004

Genetics in medicine : official journal of the American College of Medical Genetics

Strange C, Dickson R, Carter C, Carpenter MJ, Holladay B +2 more

Plain English
This study looked at home genetic testing for a condition called alpha1-antitrypsin deficiency (AATD), where nearly 1,000 adults took a simple blood test at home. The results showed that most participants found value in getting a diagnosis and helping their family, with 78% of smokers saying they would likely quit smoking if diagnosed. More than 60% of people planned to share their results with family and doctors, but less than 30% were willing to share with insurance companies, highlighting the need for better support for those getting tested. Who this helps: This helps patients and their families understand their genetic risks and make informed health choices.

PubMed

Frequent Co-Authors

Gary Blau Charlie Strange Jorge Ernesto González Mesa Marina Di Giorgio M H Seaberg A H Reid G L Dakovski R Streubel S A Montoya S Moeller

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.