DR. CARL AUGUSTINE MINNING JR., MD

ZANESVILLE, OH

Research Active
Ophthalmology NPI registered 21+ years 2 publications 2013 – 2014 NPI: 1316940513
Ophthalmology
DNA MethylationImaging, Three-DimensionalGene Expression Regulation, NeoplasticBreast NeoplasmsGene Expression ProfilingNeoplasm StagingGenomicsEpigenesis, GeneticPromoter Regions, GeneticCpG IslandsEpigenomicsCerebral AngiographyAneurysm, RupturedCarcinogenesisHallucinations

Practice Location

2935 MAPLE AVE
ZANESVILLE, OH 43701-1487

Phone: (740) 454-1216

What does CARL MINNING research?

Dr. Minning studies breast cancer, specifically investigating how alterations in DNA molecules influence the behavior of this disease. He employs techniques like integrative genomics (the study of genetic information) and epigenomics (how genes are turned on and off) to examine breast tumors. His research reveals critical insights about the genetic factors that contribute to the growth and spread of cancer, which can lead to more effective therapies for patients suffering from this condition.

Key findings

  • In a study of 76 breast tumors, 1,389 DNA sites were found to be more methylated and 22 sites less methylated in cancerous tissue compared to normal tissue.
  • The research identified 51 genes with low expression linked to high methylation, indicating that their inactivity may contribute to cancer progression.
  • Additionally, 13 genes were found with high expression that were also associated with high methylation, highlighting complex relationships in gene activity.

Frequently asked questions

Does Dr. Minning study breast cancer?
Yes, Dr. Minning specializes in researching breast cancer and its underlying genetic mechanisms.
What findings have come from Dr. Minning's research?
His research highlighted significant genetic changes in breast cancer, revealing over 1,400 DNA sites with altered methylation.
How can Dr. Minning's work help patients?
His findings may lead to targeted therapies that specifically address the genetic markers associated with breast cancer, potentially improving treatment outcomes.

Publications in plain English

Exploring breast carcinogenesis through integrative genomics and epigenomics analyses.

2014

International journal of oncology

Minning C, Mokhtar NM, Abdullah N, Muhammad R, Emran NA +3 more

Plain English
This study looked at how changes in DNA methylation (a chemical modification) in breast cancer tissues relate to gene activity. Researchers analyzed 76 breast tumors and found that 1,389 sites were more methylated and 22 sites were less methylated in cancer compared to normal tissue. They identified 51 genes with low expression linked to high methylation and 13 genes with high expression also associated with high methylation, highlighting important pathways involved in breast cancer development. Who this helps: Patients with breast cancer may benefit from targeted therapies based on these findings.

PubMed

Charles Bonnet syndrome and Terson's syndrome from subarachnoid hemorrhage: good news from bad news.

2013

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Cebulla CM, Minning C, Pratt C, Lubow M

PubMed

Frequent Co-Authors

Norfilza Mohd Mokhtar Norlia Abdullah Rohaizak Muhammad Nor Aina Emran Siti Aishah M D Ali Roslan Harun Rahman Jamal Colleen M Cebulla Cedric Pratt Martin Lubow

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.