CATHERINE E. MEIKLE, M.D.

OAKLAND, ME

Research Active
Orthopaedic Surgery NPI registered 21+ years 2 publications 2001 – 2025 NPI: 1851394449
Orthopaedic Surgery
SwineSARS-CoV-2COVID-19Disease Models, AnimalCD8-Positive T-LymphocytesLymph NodesMacaca mulattaImmunohistochemistrySingle-Cell AnalysisCOVID-19 VaccinesSwine DiseasesLeukocytes, MononuclearDermatitisNephrotic SyndromePasteurella multocida

Practice Location

107 FIRST PARK DRIVE
OAKLAND, ME 04963

Phone: (207) 873-8100

What does CATHERINE MEIKLE research?

Dr. Meikle studies how infants' immune systems react to vaccines and viral challenges, specifically looking at SARS-CoV-2, the virus that causes COVID-19. In her most recent work, she compared the immune responses of vaccinated versus unvaccinated infant rhesus macaques when exposed to the virus. The goal is to better understand the effectiveness of vaccinations in young children, which can help inform vaccine development and health guidelines for infants.

Key findings

  • Vaccinated infant rhesus macaques showed lower levels of activated T cells, indicating a milder immune response to SARS-CoV-2.
  • Infant macaques that received the vaccine had significantly lower viral loads, suggesting they experienced less severe illness when exposed to the virus.
  • The research highlighted that vaccination correlates with milder symptoms in infected infants, which is critical for future vaccine strategies.

Frequently asked questions

Does Dr. Meikle study COVID-19 vaccines in infants?
Yes, Dr. Meikle's research specifically investigates how infants' immune systems respond to COVID-19 vaccinations.
What immune conditions does Dr. Meikle research?
Her work primarily focuses on immune responses related to viral infections, particularly in the context of vaccination against SARS-CoV-2.
Is Dr. Meikle's work relevant to parents of infants?
Yes, her research provides important insights for parents regarding the effectiveness and safety of COVID-19 vaccines for young children.
What were the outcomes of Dr. Meikle's recent study?
The study found that vaccinated infant macaques experienced milder illness and had lower levels of the virus compared to those who did not receive the vaccine.

Publications in plain English

Comparative single-cell immune responses in peripheral blood and lymph node of immunized SARS-CoV-2 challenged infant rhesus macaques.

2025

Frontiers in immunology

Anronikov S, Meikle C, Milligan EC, Chen H, Mukherjee N +8 more

Plain English
This study looked at how vaccinated and unvaccinated infant rhesus macaques respond to the SARS-CoV-2 virus after being vaccinated. The researchers found that the vaccinated macaques had lower levels of certain immune cells and less severe illness when exposed to the virus. Specifically, they found fewer activated T cells and lower viral loads in vaccinated macaques, which correlated with milder symptoms. Who this helps: This information is valuable for vaccine developers, doctors, and parents of infants.

PubMed

Porcine dermatitis and nephropathy syndrome.

2001

The Veterinary record

Thomson J, Henderson L, Meikle C, MacIntyre N

PubMed

Frequent Co-Authors

Sasha Anronikov Emma C Milligan Han Chen Nilanjan Mukherjee Zach Bjornson Brice Gaudillière Sizun Jiang Sallie R Permar Koen K A Van Rompay Garry P Nolan

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.