Changes in steady-state levels of mRNAs coding for type IV collagen, laminin and fibronectin following capillary basement membrane thickening in human adult onset diabetes.
1990Connective tissue research
Kolbe M, Kaufman JL, Friedman J, Dinerstein C, Mackenzie JW +1 more
Plain English
This study looked at skin samples from people with type II diabetes and compared them to samples from non-diabetics to understand how certain proteins related to blood vessel structure behave in diabetic patients. Researchers found that while some mRNA levels stayed the same, there were significantly lower amounts of mRNA for type IV collagen, fibronectin, and another protein in the skin of diabetic patients. This matters because it suggests that the thickening of blood vessel linings in diabetes is due to a lack of breakdown of these structures rather than an increase in their production.
Who this helps: This helps patients with diabetes by providing insights that could lead to better treatments for complications related to blood vessels.