DR. CHARLES DINERSTEIN, MD

LEBANON, PA

Research Active
Surgery - Vascular Surgery NPI registered 21+ years 2 publications 1989 – 1990 NPI: 1255336715
Diabetes Mellitus, Type 2RNA, MessengerAngioplasty, BalloonSkinCardiac CatheterizationNucleic Acid HybridizationFemoral ArteryCollagenVascular DiseasesFibronectinsDiabetic AngiopathiesCapillariesBasement MembraneLaminin

Practice Location

4TH & WALNUT STREETS
LEBANON, PA 17042-6123

Phone: (717) 270-3751

What does CHARLES DINERSTEIN research?

Dr. Dinerstein studies how certain proteins in blood vessel structures behave in people with type II diabetes, specifically looking at skin samples to learn more about complications related to blood vessels. His research has shown that diabetic patients have lower levels of important proteins that help maintain blood vessel health. He also investigates the risks and complications associated with heart procedures, comparing different methods to ensure patient safety and effective treatment.

Key findings

  • In diabetic patients, the levels of mRNA for type IV collagen, fibronectin, and laminin were significantly reduced, suggesting that blood vessel thickening is due to inadequate breakdown of these proteins rather than increased production.
  • In a comparison of complications between two heart procedures, only 0.9% of 644 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) developed vascular complications, compared to 1.2% of 2,904 patients who had traditional cardiac catheterization.
  • These findings emphasize the importance of understanding protein levels in diabetes for developing better treatment options and managing risks during heart procedures.

Frequently asked questions

Does Dr. Dinerstein study diabetes?
Yes, he studies how diabetes affects blood vessel health, particularly through the examination of protein levels.
What heart procedures has Dr. Dinerstein researched?
He has researched percutaneous transluminal coronary angioplasty and traditional cardiac catheterization, focusing on their complications.
Is Dr. Dinerstein's work relevant to diabetic patients?
Yes, his research seeks to improve understanding and treatment of complications related to blood vessels in diabetic patients.

Publications in plain English

Changes in steady-state levels of mRNAs coding for type IV collagen, laminin and fibronectin following capillary basement membrane thickening in human adult onset diabetes.

1990

Connective tissue research

Kolbe M, Kaufman JL, Friedman J, Dinerstein C, Mackenzie JW +1 more

Plain English
This study looked at skin samples from people with type II diabetes and compared them to samples from non-diabetics to understand how certain proteins related to blood vessel structure behave in diabetic patients. Researchers found that while some mRNA levels stayed the same, there were significantly lower amounts of mRNA for type IV collagen, fibronectin, and another protein in the skin of diabetic patients. This matters because it suggests that the thickening of blood vessel linings in diabetes is due to a lack of breakdown of these structures rather than an increase in their production. Who this helps: This helps patients with diabetes by providing insights that could lead to better treatments for complications related to blood vessels.

PubMed

Peripheral vascular complications from percutaneous transluminal coronary angioplasty: a comparison with transfemoral cardiac catheterization.

1989

The American journal of the medical sciences

Kaufman J, Moglia R, Lacy C, Dinerstein C, Moreyra A

Plain English
This study looked at complications related to two heart procedures: percutaneous transluminal coronary angioplasty (PTCA) and traditional cardiac catheterization. Among 644 patients who had PTCA, 6 (0.9%) developed complications related to blood vessels, compared to 35 out of 2,904 (1.2%) patients who had cardiac catheterization. The findings show that both procedures carry similar risks of these complications, highlighting the need for careful management to avoid severe injuries or bleeding. Who this helps: This information benefits doctors and healthcare providers in managing patient care during these procedures.

PubMed

Frequent Co-Authors

M Kolbe J L Kaufman J Friedman J W Mackenzie C D Boyd J Kaufman R Moglia C Lacy A Moreyra

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.