Overall survival with relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): a phase 3 randomised controlled trial.
2026Lancet (London, England)
Lorusso D, Gladieff L, O'Malley DM, Kim JW, Garbaos G +36 more
Plain English
This study looked at the effects of adding a drug called relacorilant to the chemotherapy nab-paclitaxel in patients with platinum-resistant ovarian cancer. Researchers found that patients who received both treatments had a 46% overall survival rate at 18 months, compared to just 27% for those who received nab-paclitaxel alone, with an average overall survival increase of 4.1 months (16 months vs. 11.9 months). These results are important because they show that the combination treatment could become a new standard option for patients struggling with this form of cancer.
Who this helps: Patients with platinum-resistant ovarian cancer.