DR. DANIEL ROBERT VIG, MD

RALEIGH, NC

Research Active
Surgery NPI registered 21+ years 2 publications 2018 – 2018 NPI: 1194729020
Surgery
MiceCell ProliferationSignal TransductionBiomechanical PhenomenaMesenchymal Stem CellsPhosphorylationSubstrate SpecificityCell NucleusCell AdhesionBody Patterning3T3 CellsCell ShapeCell SizeCellsMyosin Light Chains

Practice Location

2800 BLUE RIDGE RD
RALEIGH, NC 27607-6477

Phone: (919) 782-8210

What does DANIEL VIG research?

Dr. Vig studies the interactions between cells and their physical environment, particularly how the stiffness of surfaces and the organization of cells affect their size and development. He investigates how mechanical factors influence cell volume and the formation of blood vessel structures during early human growth. His research reveals that the way cells sense and respond to their surroundings has significant implications for creating effective treatments for conditions like cancer and improving methods for tissue regeneration.

Key findings

  • As surface stiffness increases, cell volume also increases, highlighting the role of a protein called YAP/TAZ in cell growth.
  • Higher cell density enhances the organization of blood vessel-like structures, indicating that spatial arrangement is crucial for vascular development.
  • These findings suggest potential advances in tissue engineering by manipulating mechanical properties to optimize cell behavior.

Frequently asked questions

Does Dr. Vig study cancer?
Yes, he studies how cell growth and behavior relate to cancer development.
What treatments has Dr. Vig researched?
He has researched methods related to tissue engineering and the regeneration of blood vessels.
Is Dr. Vig's work relevant to patients needing tissue repair?
Absolutely, his studies aim to improve treatments for patients requiring tissue regeneration.
How does stiffness affect cell behavior according to Dr. Vig's research?
His research shows that stiffer surfaces lead to larger cell sizes, which is important for understanding cell growth.
How does cell arrangement influence blood vessel development?
His findings indicate that closer cell proximity leads to better organization into vascular structures, which is key for effective tissue engineering.

Publications in plain English

Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate.

2018

Proceedings of the National Academy of Sciences of the United States of America

Smith Q, Rochman N, Carmo AM, Vig D, Chan XY +2 more

Plain English
This study looked at how the physical arrangement and tension of cells affect their development into blood vessels during early human growth. The researchers found that just changing how close the cells are to each other can predict their development into vascular cells, showing that higher cell density leads to better organization of blood vessel-like structures. This discovery is important because it helps us understand how to create more effective blood vessel tissues, which could benefit tissue engineering and medical treatments. Who this helps: This helps patients needing tissue regeneration and doctors involved in stem cell treatments.

PubMed

Cell tension and mechanical regulation of cell volume.

2018

Molecular biology of the cell

Perez Gonzalez N, Tao J, Rochman ND, Vig D, Chiu E +2 more

Plain English
This study looked at how the stiffness of the surface that cells stick to affects their size. Researchers found that as the surface becomes stiffer, the cells grow larger; specifically, when the stiffness increases, so does the cell volume, which is linked to a protein called YAP/TAZ that helps control cell growth. Understanding this process is important because it reveals how cells sense their environment and adjust their size accordingly, which could have implications for tissue engineering and cancer research. Who this helps: This helps researchers and doctors working on cancer and tissue repair.

PubMed

Frequent Co-Authors

Nicolas Perez Gonzalez Jiaxiang Tao Nash D Rochman Evelyn Chiu Denis Wirtz Sean X Sun Quinton Smith Nash Rochman Ana Maria Carmo Xin Yi Chan

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.