DEAN A. CIONE, M.D., F.A.C.S

PLANO, TX

Research Active
Surgery NPI registered 21+ years 1 publication 1992 – 1992 NPI: 1346246808
Surgery
Disease Models, AnimalImmunoglobulin GLungAntigensGuinea PigsAlveolitis, Extrinsic AllergicPeriplanetaAntibody SpecificityGranuloma

Practice Location

6124 W PARKER RD
PLANO, TX 75093-8125

Phone: (972) 608-3356

What does DEAN CIONE research?

Dr. Cione studies how exposure to cockroach proteins affects lung health, particularly in individuals who may be allergic or suffer from asthma. He uses guinea pigs in his research to model how these proteins can lead to lung inflammation and changes in lung tissue. This research is crucial for understanding conditions like hypersensitivity pneumonitis, which can occur when the immune system overreacts to allergens.

Key findings

  • Guinea pigs exposed to cockroach proteins developed lung inflammation over 12 weeks, demonstrating significant airway tissue changes.
  • Specific antibodies related to the cockroach allergens were identified in the guinea pigs, indicating a strong immune response.
  • Histological analysis revealed cellular infiltrates and granulomas in the lung tissue of affected animals, highlighting the structural impact of the allergens.

Frequently asked questions

Does Dr. Cione study allergies related to cockroaches?
Yes, he specifically studies how cockroach proteins can cause lung inflammation and affect people with allergies.
What conditions are related to Dr. Cione's research?
His work is relevant to patients suffering from asthma and allergies, particularly those triggered by cockroach exposure.
What are granulomas and why are they significant?
Granulomas are organized clusters of immune cells that form in response to inflammation. Their presence indicates a strong immune reaction to allergens, like those from cockroaches.

Publications in plain English

Interstitial pneumonitis induced in guinea-pigs by the antigens of Periplaneta americana.

1992

Journal of investigational allergology & clinical immunology

Alonso A, Albónico JF, Belloti M, Mouchián K, Pionetti CH +1 more

Plain English
In this study, researchers exposed guinea pigs to a protein from cockroaches to see how it affected their lungs. Over 12 weeks, the guinea pigs developed signs of lung inflammation, including specific antibodies and changes in lung tissue, such as cellular infiltrates and granulomas. This is significant because it helps to understand how exposure to cockroach allergens can lead to lung diseases like hypersensitivity pneumonitis. Who this helps: This helps patients with allergies or asthma triggered by cockroaches.

PubMed

Frequent Co-Authors

A Alonso J F Albónico M Belloti K Mouchián C H Pionetti

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.