DR. DEAN J. WICKEL

TRIADELPHIA, WV

Research Active
Surgery - Vascular Surgery NPI registered 21+ years 1 publication 1997 – 1997 NPI: 1811991763
Surgery - Vascular Surgery Surgery - Vascular Surgery
LiverMiceDisease Models, AnimalNeutrophilsLungAntibodiesCell MovementFecesBloodLeukocyte CountAspartate AminotransferasesCD18 AntigensCecumLigationMacrophage-1 Antigen

Practice Location

502 CABELA DR
TRIADELPHIA, WV 26059-1044

Phone: (304) 285-1996

What does DEAN WICKEL research?

Dr. Wickel studies the immune response during severe abdominal infections, particularly the behavior of neutrophils, which are a type of white blood cell essential for fighting infections. He examines how blocking a protein called CD18 impacts the movement of neutrophils. His research reveals that inhibiting CD18 can lead to fewer neutrophils reaching the infection site but causes more of these cells to become trapped in other organs, like the liver and lungs. This can worsen the condition by increasing organ injury and the levels of bacteria in the bloodstream, highlighting the complex roles that immune cells play in infections.

Key findings

  • In mice, blocking CD18 led to a decrease in neutrophils migrating to the infection site by a significant margin.
  • This inhibition resulted in increased neutrophil sequestration (trapping) in the liver and lungs, causing injury to these organs.
  • Higher levels of bacteria were found in the blood due to obstructed neutrophil activity at the infection site.

Frequently asked questions

Does Dr. Wickel study infections?
Yes, Dr. Wickel studies severe abdominal infections and how immune cells respond to them.
What treatments has Dr. Wickel researched?
He has researched the effects of inhibiting the protein CD18 on immune cell behavior during infections.
Is Dr. Wickel's work relevant to patients with severe infections?
Absolutely, his findings provide important insights that can affect treatment approaches for patients with severe infections.

Publications in plain English

Inhibition of neutrophil migration at the site of infection increases remote organ neutrophil sequestration and injury.

1997

Shock (Augusta, Ga.)

Mercer-Jones MA, Heinzelmann M, Peyton JC, Wickel D, Cook M +1 more

Plain English
This study looked at how blocking a specific protein called CD18 affects the behavior of immune cells called neutrophils during severe abdominal infections. Researchers found that when they inhibited CD18 in mice, fewer neutrophils moved to the site of infection, but more were trapped in the liver and lungs, leading to liver injury and higher levels of bacteria in the blood. This is important because it shows that interfering with neutrophils during an active infection could make things worse rather than better. Who this helps: This helps doctors by providing insights into how certain treatments during infections might impact patient outcomes.

PubMed

Frequent Co-Authors

M A Mercer-Jones M Heinzelmann J C Peyton M Cook W G Cheadle

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.