Real-Life Long-Term Weight Trends After Switching to INSTI-Based Therapy in People Living with HIV: A 12-Year Retrospective Cohort Study.
2025The new microbiologica
Ceccarelli G, Branda F, Bortolani L, Albanese M, De Angelis I +12 more
Plain English
This study looked at how switching from older HIV medications (protease inhibitors) to newer ones (integrase strand transfer inhibitors, or INSTIs) affected weight in people living with HIV over 12 years. Researchers followed 89 individuals and found that those who switched to INSTIs gained more weight, with an average body weight increase of about 6.9 kg (15.2 lbs) compared to those who stayed on the older medications. These findings are important because they demonstrate that while INSTIs are generally safe and effective, there is a need to monitor weight changes in patients taking these treatments.
Who this helps: This helps patients living with HIV by providing insights into the effects of their medication on weight.