ELIZABETH MOOMAW SOMERS, DO

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This study looked at how hydroxychloroquine (HCQ) affects pregnancies in women with systemic lupus erythematosus (SLE) and those with certain antibodies that increase the risk of complications. The findings show that HCQ can help reduce serious pregnancy problems, such as preeclampsia and preterm birth. Importantly, using HCQ at safe doses (up to 400 mg per day) does not seem to increase the risk of birth defects. Who this helps: This information benefits pregnant patients with SLE and their healthcare providers.

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This study looked at the use of a specific surgical technique called the omocervical axial pattern flap in dogs and cats to repair skin defects. Out of six pets treated, all experienced complications after surgery, with minor issues like skin irritation and infections occurring in five cases and one case requiring additional surgery due to major complications. Despite these challenges, the surgical technique effectively helped close skin wounds in areas like the head, neck, and shoulders, which is important for long-term recovery. Who this helps: This benefits pet owners and veterinarians dealing with skin repair in dogs and cats.

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This study looked at how involving young patients with scoliosis and their caregivers can improve research on exercise treatments for the condition. Researchers held a virtual session with 18 participants, aged 10 to 16, and found that 78% were open to joining a trial where they might receive either active treatment or be put on a waiting list for 6 months. They highlighted challenges like limited access to physical therapy (43%) and skepticism from doctors (57%), and noted that their main concerns were pain and discomfort from bracing. Who this helps: This benefits teenagers with scoliosis and their families by ensuring that their needs and preferences are considered in future treatment studies.

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This research studied neonatal diabetes, a rare type of diabetes that occurs in infants under 6 months old, in Ireland over the past 19 years. The researchers examined 19 cases—12 were permanent and 7 were temporary—and found that early genetic testing helped identify specific treatments, like oral medications instead of insulin, for certain genetic types. Early treatment led to better health outcomes for infants with specific gene variations, emphasizing the importance of quick genetic diagnosis for effective management. Who this helps: This helps infants with neonatal diabetes and their families.

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This study examined a digital program called SELF, designed to help people with lupus better manage their condition. It found that nearly 80% of participants needed help with key management skills, and after using the program, almost 60% improved their skills and reported better interactions with their doctors and less fatigue. This is important because effective self-management can lead to better health outcomes for people living with lupus. Who this helps: Patients with lupus.

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This study looked at how changes in DNA methylation of the CD70 gene might relate to age in adults with systemic lupus erythematosus (SLE), a chronic autoimmune disease. Researchers found that adults with SLE had higher levels of CD70 methylation compared to healthy individuals, with a notable increase of 0.14 percentage points in methylation for each additional year of age. Additionally, Black individuals with SLE exhibited higher methylation levels compared to White individuals. This research is important because it highlights specific biological changes linked to age and race in lupus patients, which could inform better treatment strategies and understanding of the disease. Who this helps: This helps patients with lupus by providing insights that may lead to improved management and treatment options.

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This study looked at how older adults digest proteins and starches in cooked lentils compared to younger adults. Researchers found that under conditions mimicking older adults, the breakdown of protein was less effective, producing fewer usable protein pieces, while starch digestion was quicker thanks to saliva. Overall, the final digestion results were similar, highlighting that lentils can still be a healthy option for older people despite these differences. Who this helps: This helps older adults looking for nutritious food options.

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This study focuses on the experience of a 15-year-old boy with advanced cancer who wished to start hormone therapy to align with his gender identity. The medical team successfully found ways to support him and his family during this difficult time, emphasizing that understanding and respecting a patient's gender identity is crucial in end-of-life care. Highlighting the need for more research and guidelines, the study shows that caring for transgender adolescents facing terminal illness is an important part of providing comprehensive medical support. Who this helps: This helps transgender adolescents and their families, as well as healthcare providers guiding their care.

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This research paper looked at blood tests that can identify amyloid, a protein linked to Alzheimer's disease, and how well they perform compared to more traditional testing methods. The study found that for these blood tests to be reliable for initial screening in primary care, they should correctly identify at least 90% of patients with the disease (sensitivity) and not mistakenly identify too many healthy patients (specificity) at 85%. This matters because better blood tests can make it easier for more people to get diagnosed early and start treatment for Alzheimer's disease. Who this helps: This helps patients with Alzheimer's disease and their healthcare providers.

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This study looked at how antinuclear antibody (ANA) levels change over time in patients with systemic lupus erythematosus (SLE) and other related diseases. Researchers found that people with SLE were more likely to have positive ANA tests compared to those with other rheumatic diseases, with odds 2.10 times higher. Additionally, the strength of ANA levels was notably higher in SLE and rheumatic disease patients than in those without any rheumatic issues, but these levels decreased steadily over time, showing a decline of 0.001 to 0.004 log units each month. Who this helps: This helps patients with rheumatic diseases and their healthcare providers by providing insights into how disease progression may affect ANA levels.

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This study looked at how different types of fatty acids in the blood relate to symptoms in patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease. Researchers analyzed data from 418 patients and found that higher levels of omega-3 fatty acids, especially a type called DHA, were linked to better outcomes, with less pain and improved sleep quality. In contrast, certain other fats were linked to worse symptoms, highlighting the potential of changing dietary fat intake to help manage SLE. Who this helps: This benefits lupus patients by suggesting ways to potentially improve their symptoms through diet.

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This study explored how certain psychological factors contribute to anxiety and depression related to COVID-19. It involved 555 participants who completed an online survey, revealing that feelings of loneliness and negative thoughts about oneself and the world significantly influence distress caused by the pandemic. The findings indicate that these cognitive aspects are crucial for understanding and addressing mental health issues during COVID-19, highlighting that up to 60% of variance in depression can be explained by these factors. Who this helps: This benefits patients struggling with anxiety and depression due to COVID-19.

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This study examined the characteristics and outcomes of 600,000 hospitalized COVID-19 patients from 52 countries, looking at factors like age, sex, and existing health conditions. It found that older age significantly increased the risk of death, with older patients being nearly 30 times more likely to die compared to younger ones, and the overall death rate across countries averaged 21.5%. Understanding these factors helps hospitals prioritize care for the most vulnerable patients. Who this helps: This benefits doctors and healthcare providers in identifying and managing high-risk patients.

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This study reviewed how the Schroth method, a specific exercise treatment for scoliosis, is currently being researched. Seven studies were examined, revealing that only one followed the proper procedures for this type of therapy, which raises concerns about the reliability of the findings. The researchers emphasized the importance of adhering to established standards to ensure accurate and trustworthy results in future studies. Who this helps: This benefits patients with scoliosis and their healthcare providers, ensuring they have access to reliable treatment methods.

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This study looked at how not being able to afford medications affects people with systemic lupus erythematosus (SLE), a chronic illness. Researchers found that about 22% of the 462 participants couldn't afford their prescriptions in the past year, and those individuals reported higher disease activity and damage—indicating worse health—compared to those who could afford their medications. Specifically, for those who reported cost-related issues, disease activity scores were significantly higher, pointing to the importance of understanding and addressing financial barriers to improve health outcomes. Who this helps: This information is valuable for patients with SLE, their healthcare providers, and policy makers aiming to improve medical access.

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This study looked at how different types of insulin delivery and education programs affect blood sugar control in children and teens with diabetes over 13 years. It found that children using insulin pumps had, on average, a 0.53% lower blood sugar level compared to those on multiple daily injections six months after starting pump therapy. Additionally, kids who received intensive education saw their blood sugar levels drop by about 0.81% within six months after the training. Who this helps: This benefits children and adolescents with diabetes, along with their doctors and caregivers.

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This study looked at how people thought about themselves, others, and the world during the COVID-19 pandemic, particularly comparing those with moderate depressive symptoms to those without. Out of 555 adults surveyed, those with depressive symptoms showed significantly fewer positive thoughts and more negative self-beliefs, with 223 individuals reporting these symptoms. Understanding these differences is important because it can help therapists focus on increasing positive thinking in treatments for people experiencing high stress and depression. Who this helps: This helps patients dealing with depression and mental health professionals who support them.

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This study looked at the levels of a chemical called PBB-153 in people from Michigan and whether these levels are linked to autoimmune disorders, where the body’s immune system attacks its own tissues. Out of nearly 900 participants, about 13% of men and 21% of women reported having one or more autoimmune disorders, but the research found no clear connection between PBB-153 levels and having an autoimmune disorder overall. However, there were hints that higher PBB-153 levels might be linked to specific conditions like rheumatoid arthritis and other autoimmune issues, particularly in women, suggesting that more studies are needed to explore these possible connections. Who this helps: This helps patients with autoimmune disorders and health professionals seeking to understand environmental risk factors.

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This study looked at the impact of the drug tocilizumab on patients with severe COVID-19 who were on mechanical ventilation. Researchers found that those who received tocilizumab had a 45% lower chance of dying compared to those who did not receive the drug. Even though more patients on tocilizumab developed superinfections, the overall death rate within 28 days was similar between those with and without these infections. Who this helps: This helps patients in critical condition from COVID-19 and their healthcare providers.

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This study looked at how lupus patients and a comparison group manage their prescription medications, particularly related to access issues and the costs of medications. Researchers found that 21.7% of lupus patients skipped doses or took less medication to save money, compared to just 10.4% of those without lupus. The study highlights that lupus patients struggle significantly with medication costs, which can affect their health, and suggests that discussions about lower-cost options with doctors could help improve medication adherence. Who this helps: This helps lupus patients, their doctors, and healthcare providers focused on medication management.

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This study looked at how COVID-19 affected organ transplant recipients compared to non-transplant patients. Researchers found that the risk of death from severe COVID-19 was similar for both groups, but the transplant patients had a much higher chance of needing kidney treatment while hospitalized. Notably, those transplant patients who were treated with hydroxychloroquine faced a ten times higher risk of death, highlighting the need to reevaluate the use of this drug for them. Who this helps: This research benefits organ transplant patients and their doctors by providing important information on COVID-19 treatment options.

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This study looked at how common systemic lupus erythematosus (SLE) is in the U.S. by analyzing data from various national lupus registries. They found that SLE affects about 72.8 people per 100,000 each year, with women being significantly more affected than men—9 times more, in fact. Black women had the highest rates, at 230.9 per 100,000, while the total estimated number of people with SLE in the country was around 204,295. Who this helps: This research benefits patients, healthcare providers, and public health officials by providing clearer insights about SLE prevalence among different groups.

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This study looked at how common sleep disorders, like obstructive sleep apnea and insomnia, are in patients hospitalized with COVID-19 and whether these conditions affect their recovery. Among 572 patients, 20% had obstructive sleep apnea, but researchers found no clear link between sleep disorders and serious outcomes like needing a ventilator or dying. This matters because it suggests that having a sleep disorder may not worsen COVID-19 outcomes as previously thought. Who this helps: This helps doctors understand the impact of sleep disorders on COVID-19 patients.

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This study focused on improving crop protection against fungal diseases, particularly in strawberries. Researchers discovered that using tiny, E. coli-derived minicells to deliver protective RNA molecules (called dsRNA) effectively shielded them from degradation and made them last longer on strawberry plants—up to 12 days. This approach not only inhibited the growth of the harmful fungus but also has the potential to be scaled up for widespread agricultural use, similar in effectiveness to traditional chemical treatments. Who this helps: This benefits farmers and agricultural professionals seeking sustainable methods to protect crops.

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This study looked at how common myocarditis (inflammation of the heart) is in college athletes who recently had COVID-19. Out of 1,597 athletes tested, 37 (about 2.3%) were found to have myocarditis, with 9 having noticeable symptoms and 28 showing no symptoms. The researchers discovered that using cardiac MRI tests instead of just checking for symptoms alone significantly increased the detection rate of myocarditis, highlighting the importance of thorough testing for athletes returning to play. Who this helps: This research benefits athletes and doctors by providing insights necessary for ensuring safe participation in sports after COVID-19.

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This study looked at how a protein called folate receptor α (FOLRα), which is found in gastric cancer cells, affects the cancer's resistance to chemotherapy. Researchers found that higher levels of FOLRα were linked to shorter survival in gastric cancer patients, and that FOLRα helps cancer cells resist treatment by stabilizing another protein called MDM2. Importantly, a new drug called MORAb-202 was shown to be effective against these resistant cancer cells, suggesting it may be a better treatment option than previous therapies targeting FOLRα. Who this helps: This benefits gastric cancer patients by providing a potential new treatment option that may be more effective against resistant tumors.

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This study looked at the frequency and causes of ear tube surgery in children who had a tracheostomy, which is a procedure to help them breathe. Out of 214 children, 31% required surgery to place ear tubes within two years after their tracheostomy. The research found that younger age during tracheostomy, having craniofacial abnormalities, and having a gastric tube all increased the risk of needing this ear surgery, which is usually not as common in the general pediatric population. Who this helps: This information helps doctors identify at-risk children and manage their care better.

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This study explored a new approach for bringing together researchers from different fields to work on complex medical research problems. They created "Research Jams," which are group brainstorming sessions where participants generated innovative ideas, mapped out future plans, and identified the best opportunities to pursue. Out of 129 participants from 50 different organizations, most found the sessions helpful and expressed interest in following up on the ideas generated. This approach is significant because it helps create effective collaboration among diverse experts to tackle pressing health issues and improve research outcomes. Who this helps: This benefits researchers and organizations aiming to secure funding and advance medical research innovations.

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This study looked at how many new cases of systemic lupus erythematosus (SLE) occur each year in the United States. Researchers analyzed data from 2002 to 2009 and found the annual rate to be about 5.1 new cases per 100,000 people, with the rate being much higher in women (8.7) than in men (1.2). Among women, black females had the highest rates at 15.9, while the overall estimate for new diagnoses in 2018 was around 14,263 people. Who this helps: This research helps doctors and healthcare providers better understand the incidence of lupus in different populations, which can improve diagnosis and treatment for patients.

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This study looked at how the intake of certain fatty acids, specifically omega-3 and omega-6, affects people with systemic lupus erythematosus (SLE). Researchers found that for each increase in the omega-6 to omega-3 ratio, lupus activity scores increased by 0.3 points, while higher omega-3 intake resulted in significant improvements in reported sleep quality. This is important because it suggests that adjusting dietary fat intake could help improve the quality of life for people living with lupus. Who this helps: Patients with systemic lupus erythematosus.

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This study looked at a specific protein called folate receptor alpha (FRα) in patients with triple negative breast cancer (TNBC), which is a tougher form of breast cancer. They found that 71% of the 384 patients had high levels of FRα, and those with this protein had a 37% better chance of not having their cancer return within a certain period (with a hazard ratio of 0.63). This is important because it suggests that measuring FRα levels can help in planning better treatments for many patients with TNBC. Who this helps: This benefits patients with triple negative breast cancer.

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This study created guidelines to help manage reproductive health for people with rheumatic and musculoskeletal diseases (RMD). Researchers looked at various aspects including contraception, fertility treatments, and pregnancy-related health, resulting in 131 recommendations and 12 good practice statements to guide patient care. These guidelines emphasize the importance of safe contraceptive methods and having conversations with healthcare providers about reproductive health, which is crucial given the limited research specifically on RMD patients. Who this helps: This helps patients with rheumatic and musculoskeletal diseases and their doctors.

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This study created guidelines to help people with rheumatic and musculoskeletal diseases (like arthritis) manage reproductive health, covering topics like contraception, fertility treatment, and pregnancy care. It includes 12 good practice statements and 131 specific recommendations based on a review of existing evidence, emphasizing safe contraception, pre-pregnancy counseling to plan for healthier pregnancies, and collaboration between healthcare providers. These guidelines are important because they support better decision-making for patients and their doctors, ensuring reproductive health care is tailored to the unique needs of those with these conditions. Who this helps: Patients with rheumatic and musculoskeletal diseases.

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This paper points out a correction to a previous research study about an exercise program designed for young athletes who have had ongoing symptoms from sport-related concussions. The original study found that this program, which needed only a few in-person visits, helped reduce symptoms significantly. For example, participants showed a 30% improvement in their symptoms compared to those who did not take part in the program. Who this helps: This benefits young athletes recovering from concussions, their families, and healthcare providers.

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This study looked at how pregnancy affects women with autoimmune diseases (AID). It found that women with AID need careful planning and support before and during pregnancy to manage their health and medication effectively. For example, women should aim to get pregnant when their disease is stable to ensure better outcomes for both mother and baby. Who this helps: This helps women with autoimmune diseases, their doctors, and healthcare providers involved in maternal care.

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This study looked at how effective a drug called tocilizumab is for patients with severe COVID-19 who are on mechanical ventilation. Among the 154 patients studied, those who received tocilizumab had a 45% lower chance of dying compared to those who did not get the drug, although more patients on tocilizumab developed superinfections (54% vs. 26%). This matters because it suggests that tocilizumab may save lives even if it leads to more infections, highlighting the need for further research to confirm these results. Who this helps: This benefits patients with severe COVID-19 and healthcare providers involved in their treatment.

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This study looked at how the COVID-19 quarantine affected people's mental health and drinking habits in Argentina. Researchers surveyed 759 people and found that those aged 55 to 59 had the highest fear of COVID-19, while younger individuals reported more depression and increased alcohol use. Interestingly, many participants, even those who lost significant income, still supported the quarantine measures. Who this helps: This research helps mental health professionals and policymakers understand the psychological impact of the pandemic on different age groups.

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Researchers studied bacteria found in dung beetles and discovered two new antibiotics, called lenzimycins A and B. These antibiotics were effective at stopping the growth of certain harmful bacteria, including one closely related to a well-known pathogen, and they even worked against some bacteria that make people sick. This matters because finding new antibiotics is crucial in the fight against antibiotic-resistant infections. Who this helps: This helps patients and healthcare providers in treating bacterial infections.

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This study looked at a six-week exercise program designed for young people aged 12 to 18 who have ongoing issues after a sports-related concussion. The program involved only two in-person visits and aimed to help reduce concussion symptoms and improve overall quality of life. The results showed that the group doing the exercise program experienced a quicker decline in symptoms compared to those who only did stretching, with a significant difference in symptom recovery (0.02). Who this helps: This benefits young patients recovering from concussions and their families.

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This study looked at how many patients with systemic lupus erythematosus (SLE) were using prescription opioids compared to those without the disease. It found that 31% of SLE patients were using opioids, compared to just 8% of those without SLE. The study emphasizes the need for better pain management strategies for SLE patients, as long-term opioid use can lead to serious risks, and many patients are using them for over a year even when they aren't helping. Who this helps: This benefits patients with systemic lupus erythematosus and their healthcare providers.

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This study looked at how two blood tests, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), can help doctors tell if a fever in patients with systemic lupus erythematosus (SLE) is due to an infection or a disease flare-up. Researchers found that when they considered the ratio of ESR to CRP, a higher ratio indicated that the fever was more likely caused by an SLE flare, with each unit increase in the ratio raising the likelihood by 17%. This finding is important because it can help healthcare providers make better decisions about treatment for SLE patients with fever. Who this helps: This benefits doctors and their patients who have systemic lupus erythematosus.

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This study looked at how a protein called CA125 affects the immune response to a specific cancer treatment, amatuximab, in patients with advanced mesothelioma. The researchers found that patients with CA125 levels below 57 U/mL had a significantly better response to the treatment, with a 2-month longer time before their cancer got worse and a 7-month longer survival compared to those with higher levels. This is important because it shows that measuring CA125 can help doctors determine which patients are more likely to benefit from treatment with amatuximab. Who this helps: Patients with mesothelioma undergoing treatment.

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This study looked at how genetic differences in the FCGRT gene affect levels of important proteins (like albumin and immunoglobulin) and how well a cancer drug called farletuzumab works in patients with relapsed ovarian cancer. Researchers found that patients with higher levels of farletuzumab in their system and certain genetic profiles experienced better survival rates, showing a link between the drug's effectiveness and the way their bodies processed it. Specifically, those with higher albumin and lower immunoglobulin levels showed better drug results. Who this helps: This helps patients with relapsed ovarian cancer by identifying genetic factors that could influence treatment outcomes.

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This study examined how a tumor marker called CA125 affects the body's ability to fight ovarian cancer using an immune response called antibody-dependent cellular cytotoxicity (ADCC). Researchers found that in a trial involving a treatment named farletuzumab, patients with low CA125 levels had better outcomes; specifically, their chances of living longer without disease progression improved by 51% and their overall survival improved by 56% compared to those who did not receive the drug. This matters because it shows a potential pathway for improving cancer treatments by understanding how CA125 hinders immune response. Who this helps: This benefits ovarian cancer patients.

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This study looked at how specific genetic variations in patients with first-relapse ovarian cancer affected their response to a treatment called farletuzumab, combined with standard chemotherapy drugs. Researchers found that patients with low levels of the tumor marker CA125 who had certain high-affinity genetic variations (the FCGR2A or FCGR3A genes) responded better to the treatment; specifically, those with at least one high-affinity allele had improved outcomes. This is important because identifying genetic factors that influence treatment response can help tailor more effective therapies for patients. Who this helps: This helps patients with first-relapsed ovarian cancer by personalizing their treatment options.