Hot Spot and Whole-Tumor Enumeration of CD8Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer.
2018Clinical breast cancer
McIntire PJ, Irshaid L, Liu Y, Chen Z, Menken F +3 more
Plain English
This study examined the presence of a type of immune cell, called CD8 tumor-infiltrating lymphocytes (TILs), in triple-negative breast cancer to see how it might help predict patient outcomes. Researchers found that counting these immune cells in small "hot spots" within the tumor is just as useful for predicting survival as counting them throughout the entire tumor. For example, a specific size of hot spot showed a significant link to overall survival, indicating its potential to help doctors gauge how well a patient might do after treatment.
Who this helps: This helps patients with triple-negative breast cancer and their doctors in making more informed treatment decisions.