Practice Location

14601 HOPE CENTER LOOP
FORT MYERS, FL 33912-4707

Phone: (239) 334-7000

What does FLETCHER REYNOLDS research?

Dr. Reynolds studies the effects of community-based interventions, like arts therapies, on psychological well-being for patients recovering from strokes and other health issues. For instance, his research on the 'HeART of Stroke' program shows how art can promote healing and boost self-confidence among stroke survivors. He also looks into how cognitive abilities impact children's early mathematics skills and how experiences of patients with progressive cerebellar ataxia affect their views on physiotherapy. Moreover, he examines the role of identity and social connections in recovery from mental health conditions, considering the implications of cultural factors in treatment adherence and well-being.

Key findings

  • In the 'HeART of Stroke' program, 83% of participants completed at least six sessions, indicating a strong engagement with arts therapy for psychological recovery.
  • In the study on cognitive skills and early arithmetic, visuospatial working memory was identified as the strongest predictor of success in simple addition tasks for children from vastly different cultural backgrounds.
  • Among patients with progressive cerebellar ataxia, the emphasis on building trusting relationships with physiotherapists led to improved mental and emotional outcomes.
  • Seven out of fourteen patients in a vegetative state later emerged with varied behaviors, which could help caregivers and doctors identify those likely to recover.
  • In a study of patients post-stroke in Kuwait, higher self-efficacy correlated with greater life satisfaction, highlighting the importance of confidence in recovery.

Frequently asked questions

Does Dr. Reynolds study recovery after a stroke?
Yes, he researches interventions like the HeART of Stroke program to improve psychological well-being in stroke survivors.
What other conditions does Dr. Reynolds focus on?
He also studies cognitive skills in children, progressive cerebellar ataxia, mental health recovery, and the impact of cultural beliefs on patients' experiences.
Is Dr. Reynolds's work relevant for caregivers of people with dementia?
Yes, he has investigated programs that support family caregivers of dementia patients, helping them manage their responsibilities.
How does art therapy help patients?
His research shows that art therapy can improve mental health, boost self-confidence, and provide a sense of accomplishment for various patient groups.
What does Dr. Reynolds's research say about mental health and work?
He found that meaningful work and daily activities are crucial for people recovering from serious mental health conditions, enhancing their sense of identity.

Publications in plain English

Developing paediatric chief investigators within the NHS: the Clinical Trials Scholars programme.

2023

Archives of disease in childhood. Education and practice edition

Kirk J, Reynolds F, Adey E, Boazman M, Brookes M +1 more

PubMed

HeART of Stroke: randomised controlled, parallel-arm, feasibility study of a community-based arts and health intervention plus usual care compared with usual care to increase psychological well-being in people following a stroke.

2019

BMJ open

Ellis-Hill C, Thomas S, Gracey F, Lamont-Robinson C, Cant R +10 more

Plain English
This study looked at the "HeART of Stroke" program, a community arts therapy designed to improve psychological well-being for people recovering from a stroke. Researchers found that while only 14% of potential participants signed up, they successfully enrolled 56 people—29 in the arts program and 27 in a control group—showing that the program was generally well-received and 83% of those who attended completed at least six sessions. These results matter because they indicate that such arts interventions could be beneficial and that a larger study could be done to test the program's effectiveness. Who this helps: Stroke survivors who seek to improve their mental health and well-being.

PubMed

Can behavioural observations made during the SMART assessment detect the potential for later emergence from vegetative state?

2018

Neuropsychological rehabilitation

da Conceição Teixeira L, Gill-Thwaites H, Reynolds F, Duport S

Plain English
This study looked at whether certain behaviors observed during a specific assessment can help predict if patients in a vegetative state (VS) will later recover. Researchers analyzed 14 patients and found that seven of them eventually emerged from VS, showing more varied behaviors than the other seven who did not recover. This research is important because identifying patients likely to recover can improve their treatment and care management. Who this helps: This helps patients in a vegetative state and their families.

PubMed

The meanings of physiotherapy and exercise for people living with progressive cerebellar ataxia: an interpretative phenomenological analysis.

2018

Disability and rehabilitation

Cassidy E, Naylor S, Reynolds F

Plain English
This study explored how people with progressive cerebellar ataxia view physiotherapy and exercise. Twelve participants shared that they value building trusting relationships with their physiotherapists more than just improving their physical symptoms. They also found that exercises they chose for themselves brought important mental and emotional benefits that were often missing from exercises prescribed by their therapists. Understanding these perspectives can help healthcare providers offer more effective and meaningful support tailored to patients’ needs. Who this helps: This benefits patients with progressive cerebellar ataxia and their physiotherapists.

PubMed

Culture-Independent Prerequisites for Early Arithmetic.

2018

Psychological science

Reeve RA, Reynolds F, Paul J, Butterworth BL

Plain English
This study examined how certain cognitive skills relate to early math ability in children from two very different backgrounds: indigenous children in remote northern Australia who have limited counting practices and nonindigenous children from a city. The researchers found that both groups showed similar results, with visuospatial working memory being the strongest predictor of how well the children performed simple addition tasks. This matters because it indicates that the cognitive skills needed for math learning are universal, not solely influenced by cultural practices. Who this helps: This research helps educators and policymakers in designing effective learning strategies for all children, regardless of their cultural background.

PubMed

'Without Occupation You Don't Exist': Occupational Engagement and Mental Illness.

2015

Journal of occupational science

Blank AA, Harries P, Reynolds F

Plain English
This study looked at how important work and daily activities are for people dealing with serious mental health issues. Researchers interviewed ten participants over 18 months and found that most wanted to work, seeing it as a key part of their recovery and identity. They emphasized that engaging in meaningful activities helps them feel connected to others and boosts their sense of self. Who this helps: This benefits patients struggling with mental health conditions.

PubMed

'': A qualitative study of a creative arts leisure programme for family caregivers of people with dementia.

2015

Health psychology open

Pienaar L, Reynolds F

Plain English
This study examined a 5-week creative arts program for family caregivers of people with dementia. Those who participated felt that the program provided freedom, support, and a sense of accomplishment, while also helping them cope better with their caregiving responsibilities. Some caregivers wished the program had lasted longer. Who this helps: This benefits family caregivers of individuals with dementia.

PubMed

'HeART of Stroke (HoS)', a community-based Arts for Health group intervention to support self-confidence and psychological well-being following a stroke: protocol for a randomised controlled feasibility study.

2015

BMJ open

Ellis-Hill C, Gracey F, Thomas S, Lamont-Robinson C, Thomas PW +7 more

Plain English
This study looked at the potential benefits of a community art program called "HeART of Stroke" for people recovering from a stroke. With 64 stroke survivors participating, the program involved 10 group sessions aimed at improving their self-confidence and emotional well-being. The study is important because it could reveal how arts activities can help many stroke survivors feel better after their incidents. Who this helps: Stroke survivors who need support in rebuilding their confidence and mental health.

PubMed

Religious faith and psychosocial adaptation among stroke patients in Kuwait: a mixed method study.

2014

Journal of religion and health

Omu O, Al-Obaidi S, Reynolds F

Plain English
This study looked at how religious faith affects stroke recovery among female patients in Kuwait. Researchers found that, while there was no clear link between faith and patients' overall satisfaction or confidence in recovery, healthcare professionals noted that religious beliefs play a significant role in how patients adapt after a stroke. It's important to recognize these beliefs in rehabilitation programs to better support patients. Who this helps: This helps stroke patients and their healthcare providers in Kuwait.

PubMed

Experiences of obesity among Saudi Arabian women contemplating bariatric surgery: an interpretative phenomenological analysis.

2014

Journal of health psychology

Alqout O, Reynolds F

Plain English
This study looked at seven Saudi women who were thinking about weight loss surgery and how their experiences with obesity shaped that decision. The women felt limited by cultural norms that affected their activities and faced stigma related to their weight, which made them see surgery as a way to improve their health and regain their social roles. They often felt unable to manage their weight on their own and were influenced by family members who had surgery, making this a socially acceptable choice for them. Who this helps: This research benefits women struggling with obesity, their families, and health professionals working with them.

PubMed

'It's like having a day of freedom, a day off from being ill': exploring the experiences of people living with mental health problems who attend a community-based arts project, using interpretative phenomenological analysis.

2014

Journal of health psychology

Lawson J, Reynolds F, Bryant W, Wilson L

Plain English
This study looked at how a two-year community arts project impacted eight people with long-term mental health issues. The participants reported feeling more confident, free from their illness labels, and connected to others, with many saying their newfound creative skills helped them better manage their mental health. However, there was concern about the project ending and what that would mean for their progress. Who this helps: This benefits individuals with mental health challenges looking for community support and personal growth.

PubMed

"It gave me something big in my life to wonder and think about which took over the space … and not MS": managing well-being in multiple sclerosis through art-making.

2014

Disability and rehabilitation

Hunt L, Nikopoulou-Smyrni P, Reynolds F

Plain English
This study looked at how creating art helps people with Multiple Sclerosis (MS) manage their well-being. Researchers interviewed five adults with MS and found that making art provided them a way to enjoy life more, connect with others, and escape worries about their illness. Participants reported feeling more confident and fulfilled through their art, which helped them maintain their sense of identity despite the challenges of living with MS. Who this helps: This helps people living with Multiple Sclerosis and their caregivers.

PubMed

Religious faith and self-efficacy among stroke patients in Kuwait: health professionals' views.

2014

Disability and rehabilitation

Omu O, Reynolds F

Plain English
This study looked at how Muslim beliefs affect the confidence of stroke patients in Kuwait during their recovery. Health professionals found that when patients felt a partnership with God, it boosted their confidence and motivation for rehabilitation, while beliefs that considered the stroke as punishment decreased their confidence. This is important because it shows that being aware of and respecting a patient's religious beliefs can significantly impact their recovery and self-esteem. Who this helps: This helps patients and health professionals working with stroke patients in Kuwait.

PubMed

Keeping in the Reynolds zone.

2014

International journal of obstetric anesthesia

Reynolds F

PubMed

Does direct admission from an emergency department with on-site neurosurgical services facilitate time critical surgical intervention following a traumatic brain injury in children?

2013

British journal of neurosurgery

Fayeye O, Ushewokunze S, Stickley J, Reynolds F, Solanki G +3 more

Plain English
This study looked at how quickly children with traumatic brain injuries receive emergency surgery when they are admitted to hospitals with on-site neurosurgery compared to those who are transferred from other hospitals. The researchers found that 77% of the surgeries were performed within 4 hours for those admitted directly to a hospital with on-site neurosurgery, compared to only 17% for those who were transferred (p = 0.001232). This is important because faster surgery can lead to better outcomes for children with severe brain injuries. Who this helps: This helps children with traumatic brain injuries and their families.

PubMed

The meaning and experience of work in the context of severe and enduring mental health problems: an interpretative phenomenological analysis.

2013

Work (Reading, Mass.)

Blank A, Harries P, Reynolds F

Plain English
This study explored how work affects the lives of a person with severe mental health issues who was thinking about returning to the workforce. Through three interviews over 18 months, the researcher identified key themes around beliefs about work, the experience of working while managing a mental health problem, and future planning. The findings show that work can hold various meanings and significantly impact the quality of life for individuals with mental health challenges. Who this helps: This helps patients with mental health problems looking to return to work, as well as their healthcare providers.

PubMed

Working beyond 65: a qualitative study of perceived hazards and discomforts at work.

2013

Work (Reading, Mass.)

Reynolds F, Farrow A, Blank A

Plain English
This study looked at the experiences of 30 people aged 66 to 91 who continue to work, focusing on the challenges they face and how they cope with them. Participants reported feeling tired as the biggest discomfort and mentioned other issues like physical demands and dealing with difficult clients, but none had experienced recent accidents. The study highlights how older workers manage their work by adapting their roles and using strategies like staying fit and communicating openly with coworkers, showing that age alone does not increase risk at work. Who this helps: This helps older workers and employers understand and support the needs of senior employees.

PubMed

Aortic arch thrombosis mimicking interrupted aortic arch.

2013

Case reports in critical care

Neal R, Mattishent K, Reynolds F

Plain English
This study focused on a 32-week-old male fetus who showed signs of having a blocked aorta, which was initially thought to be a different serious condition known as interrupted aortic arch. After further tests, doctors discovered a large blood clot in the aorta instead. The baby had successful surgery to remove the clot and repair the aorta, and doctors are now monitoring him for any related blood conditions since there was no family history of clotting issues. Who this helps: This helps doctors understand and treat similar cases in premature infants better.

PubMed

Life satisfaction and self-efficacy in patients affected by a first stroke living in Kuwait: a two-phase study.

2013

Physiotherapy theory and practice

Omu O, Reynolds F

Plain English
This study looked at how satisfied female stroke patients in Kuwait felt about their lives and their confidence in recovering from the stroke. Researchers found that women with higher confidence in managing their health and adapting socially after a stroke reported greater life satisfaction. Health professionals highlighted key strategies to boost patients' confidence, such as motivating them, providing education about stroke, and setting clear goals for rehabilitation. Who this helps: This benefits stroke patients and the doctors and therapists who support their recovery.

PubMed

Incentives and barriers to research participation and brain donation among African Americans.

2013

American journal of Alzheimer's disease and other dementias

Schnieders T, Danner DD, McGuire C, Reynolds F, Abner E

Plain English
This study looked at how to effectively recruit older African Americans for research on aging and brain donation. Out of 91 participants aged 65 and older, 71% decided to join the study, and about half agreed to donate their brains after death. The findings highlight that many participants were motivated by the potential benefits for themselves and their families, showing that building trust and providing education can significantly improve participation rates. Who this helps: This helps African American seniors and their families, as well as researchers who need diverse participants for studies.

PubMed

MRSA screening on a paediatric intensive care unit.

2012

Archives of disease in childhood

Gray J, Patel M, Turner H, Reynolds F

Plain English
This study looked at two methods for testing children in the intensive care unit for a harmful bacteria called MRSA. Out of 1,336 swabs tested, only 20 (1.6%) were found to have MRSA using the standard method. The newer PCR test was better at detecting positive cases but had a lower accuracy rate for correctly identifying those who didn't have the infection. Since starting the screening, no patients developed new MRSA infections, which is a significant improvement compared to the previous years where 16 cases occurred. Who this helps: This helps patients in the intensive care unit by reducing the risk of MRSA infections.

PubMed

Health professionals' perceptions of cultural influences on stroke experiences and rehabilitation in Kuwait.

2012

Disability and rehabilitation

Omu O, Reynolds F

Plain English
This study looked at how health professionals in Kuwait view the impact of culture on stroke patients' experiences and their rehabilitation. The researchers interviewed 12 health professionals and found that cultural factors such as religious beliefs, family involvement, negative attitudes towards stroke, and social stigma significantly affect the recovery process. These insights highlight the importance of providing care that respects Kuwaiti cultural values to improve outcomes for stroke patients. Who this helps: Patients recovering from strokes and their families in Kuwait.

PubMed

Health and safety of the older worker.

2012

Occupational medicine (Oxford, England)

Farrow A, Reynolds F

Plain English
This research looked at the health and safety risks for workers over 60 in the UK, especially since more people in this age group are staying in the workforce longer. The study found that while older workers had fewer accidents, when they did have accidents, they were often more serious or even fatal. Specifically, age-related issues like hearing loss can increase safety risks. Understanding these factors is crucial for creating safer work environments for older employees. Who this helps: This helps older workers and the employers who support them.

PubMed

Stability and change in markers of core numerical competencies.

2012

Journal of experimental psychology. General

Reeve R, Reynolds F, Humberstone J, Butterworth B

Plain English
This study looked at how children's abilities to count dots and compare numbers change as they grow older. Researchers tested 159 children over six years and found that while most kids stayed in the same group in terms of their number skills (69% remained in the same subgroup), their specific abilities changed as they aged. The findings are important because they show that a child's number skills can predict future math abilities, helping to identify early where additional support may be needed. Who this helps: This helps teachers and parents identify children who might struggle with math early on.

PubMed

Calculating the need for intensive care beds.

2012

Archives of disease in childhood

Pearson GA, Reynolds F, Stickley J

Plain English
The study investigated how many beds are needed in a pediatric intensive care unit, examining the number of patient admissions and those turned away due to lack of space. It found that while the traditional method recommended 27 beds to meet demand, a more advanced method called the Monte Carlo approach revealed that 34 beds would be necessary for 95% of the year, with specific needs rising to 30 beds in summer and 38 in winter. This shows that the current capacity is not enough to handle patient needs, indicating a significant gap in healthcare resources. Who this helps: This benefits patients in need of intensive care and healthcare providers managing admissions.

PubMed

Using interpretative phenomenological analysis to inform physiotherapy practice: an introduction with reference to the lived experience of cerebellar ataxia.

2011

Physiotherapy theory and practice

Cassidy E, Reynolds F, Naylor S, De Souza L

Plain English
This study looks at how researchers can better understand the experiences of people with health conditions, specifically through a method called interpretative phenomenological analysis (IPA). It emphasizes that using IPA can give detailed insights into how people cope with issues like cerebellar ataxia, which can help improve physiotherapy practices. By focusing on personal experiences, this research provides important information that can reshape current understanding and improve care. Who this helps: This helps patients with conditions like cerebellar ataxia and their physiotherapists.

PubMed

Labour analgesia and the baby: good news is no news.

2011

International journal of obstetric anesthesia

Reynolds F

Plain English
This study looked at different pain relief methods for women during labor and how these methods affect newborns. It found that using neuraxial analgesia (like epidurals) leads to better health outcomes for babies compared to pethidine, a common systemic pain relief option, which can harm newborns by lowering their oxygen levels and overall condition. Additionally, neuraxial analgesia results in improved Apgar scores, which assess a baby's health right after birth, indicating that this method is safer for infants. Who this helps: This helps mothers and their babies during childbirth.

PubMed

A functional proteomic method for biomarker discovery.

2011

PloS one

Reynolds F, Panneer N, Tutino CM, Wu M, Skrabal WR +2 more

Plain English
This research focused on developing a new method to discover proteins that could serve as biomarkers for diseases, particularly pancreatic cancer. The study successfully identified 15 specific peptides related to pancreatic cancer and found three new protein partners that may play a role in the disease. This is important because understanding these proteins can help improve diagnosis and treatment for patients. Who this helps: Patients with pancreatic cancer.

PubMed

Techniques for molecular imaging probe design.

2011

Molecular imaging

Reynolds F, Kelly KA

Plain English
This study looked at how to create better tools for molecular imaging, which helps doctors see specific disease-related molecules in patients. Researchers found that while many disease targets have been identified, the development of imaging probes hasn't kept up, highlighting a need for collaborative work across several scientific fields. Improving these imaging tools is crucial because they can enhance diagnosis and treatment options for patients. Who this helps: This benefits patients by providing more accurate diagnoses and tailored treatments.

PubMed

Young women's accounts of intimate partner violence during adolescence and subsequent recovery processes: an interpretative phenomenological analysis.

2011

Psychology and psychotherapy

Reynolds F, Shepherd C

Plain English
This study looked at the experiences of three young women who faced intimate partner violence (IPV) during their teenage years. They found that these women felt confused and powerless, which made them vulnerable to long-term abusive relationships. While recovering, they focused on rebuilding their identities by reconnecting with friends and family, which helped them regain control over their lives. Who this helps: This helps young women who have experienced IPV and those who support them, like counselors and healthcare providers.

PubMed

The effects of maternal labour analgesia on the fetus.

2010

Best practice & research. Clinical obstetrics & gynaecology

Reynolds F

Plain English
This study looked at how different pain relief methods during labor affect unborn babies. It found that using epidurals (a type of nerve block) leads to better outcomes for newborns compared to opioids like pethidine, with fewer issues like low Apgar scores and better acid-base balance in the baby. This is important because it suggests that epidurals are a safer option for mothers and their babies during childbirth. Who this helps: This helps pregnant women and their newborns.

PubMed

General anesthesia is unacceptable for elective cesarean section.

2010

International journal of obstetric anesthesia

Reynolds F

PubMed

Uterine rupture and epidural analgesia: a spurious risk factor?

2010

BJOG : an international journal of obstetrics and gynaecology

Reynolds F, O'Sullivan G

PubMed

Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety.

2010

ALTEX

Westmoreland C, Carmichael P, Dent M, Fentem J, MacKay C +3 more

Plain English
Unilever is working on a research program to ensure consumer safety without using animal testing. They started this project in 2004 and have focused on developing new methods to assess risks related to skin allergies, cancer, and general toxicity. Their efforts involve creating new biological and computer models to better understand safety without relying on animal data, with ongoing collaboration with other scientific institutions to enhance these approaches. Who this helps: Patients and consumers who benefit from safer products without animal testing.

PubMed

Ultrasound venous access simulation: the Italian job.

2009

Emergency medicine journal : EMJ

Rose A, Reynolds F

PubMed

Novel manikin for chest re-opening simulation training.

2009

Intensive care medicine

Lo TY, Morrison R, Atkins K, Reynolds F

PubMed

Life-saving or ineffective? An observational study of the use of cricoid pressure and maternal outcome in an African setting.

2009

International journal of obstetric anesthesia

Fenton PM, Reynolds F

Plain English
This study looked at the effectiveness of cricoid pressure, a technique used during anesthesia for cesarean sections, in preventing vomiting or death among women in Malawi from 1998 to 2000. Out of nearly 5,000 cases, cricoid pressure was used 61% of the time, but it did not show a clear benefit: there were 139 instances of vomiting or regurgitation, and 77 deaths, with many tied to pre-existing health issues rather than the cricoid pressure itself. This finding is important because it suggests that focusing on better preoperative care, like ensuring the stomach is empty, may be a more effective way to prevent serious complications. Who this helps: This helps doctors and healthcare providers in obstetric care.

PubMed

Effective performance of a new post-operative cardiac resuscitation simulation training scheme in the Paediatric Intensive Care Unit.

2009

Intensive care medicine

Lo TY, Morrison R, Atkins K, Reynolds F

Plain English
This study looked at a new training program for medical teams that helps them practice saving the lives of children who have just had heart surgery. Researchers found that the average time it took for team leaders to order needed procedures, like reopening the chest, was 4 minutes, and inexperienced leaders were slower than experts. This training is important because it shows that even basic simulation exercises can improve critical skills in stressful situations without needing expensive equipment. Who this helps: This helps doctors and medical teams performing heart surgery on kids.

PubMed

Capacity building for global action in mother and child health.

2009

Journal of tropical pediatrics

Ebrahim GJ, Heller RF, Reynolds F

PubMed

Quality of cardio-pulmonary resuscitation (CPR) during paediatric resuscitation training: time to stop the blind leading the blind.

2009

Resuscitation

Arshid M, Lo TY, Reynolds F

Plain English
This study examined the quality of CPR during pediatric resuscitation training and discovered that it was poor. Specifically, CPR was improperly performed in 18 out of 20 sessions, with chest compressions often too shallow and interrupted unnecessarily. This is important because high-quality CPR is vital for saving children's lives during emergencies. Who this helps: This benefits children in medical emergencies and the healthcare providers who respond to them.

PubMed

To use intraosseous access or not to use intraosseous access: determinants of trainees' decision in paediatric emergencies.

2009

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

Lo TY, Reynolds F

Plain English
This study looked at how the training and real-life experiences of pediatric trainees affect their decisions when needing to access veins during emergencies. Out of 98 surveyed trainees, only 52% chose intraosseous (IO) access for a critical situation in infants, despite recommendations to use it. Those trainees with more than six years of experience were almost six times more likely to have real-life experience with IO insertion, and having that experience made them ten times more likely to choose IO access in emergencies. This is important because better training and hands-on experience can lead to more effective care in life-threatening situations for young patients. Who this helps: This helps pediatricians and their young patients in emergency situations.

PubMed

Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.

2009

Circulation

Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E +7 more

Plain English
This study looked at how a special imaging technique can detect inflammation in atherosclerotic plaques in rabbits, specifically targeting an enzyme called myeloperoxidase that indicates active inflammation. Researchers found that areas with high levels of this enzyme showed more than double the increase in imaging contrast compared to normal tissue, which helps identify problematic plaques. This is important because it could lead to better ways to identify unstable plaques before they cause serious health issues like heart attacks. Who this helps: This helps doctors and patients by improving how we detect dangerous heart conditions before they become critical.

PubMed

Swine-origin influenza virus H1N1, seasonal influenza virus, and critical illness in children.

2009

Lancet (London, England)

Lister P, Reynolds F, Parslow R, Chan A, Cooper M +3 more

PubMed

Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.

2009

Circulation. Cardiovascular imaging

Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL +5 more

Plain English
This study explored a new MRI technique that can differentiate between dying (apoptotic) and dead (necrotic) heart cells in mice shortly after heart injury. Researchers found that the new MRI method highlighted many heart cells that were dying but may still be alive, with about 79% of these cells not showing signs of necrosis. This is important because it indicates the potential to save heart tissue that is on the verge of dying during a heart attack. Who this helps: This helps doctors who treat heart attack patients by identifying potentially salvageable heart tissue.

PubMed

Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

2009

Circulation. Cardiovascular imaging

Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E +7 more

Plain English
This study focused on a new imaging technology that can detect dying heart cells in a specific type of heart failure using mice. Researchers found that the technology could identify low levels of heart cell death with a significant difference in imaging results (7.6 milliseconds vs. 16.8 milliseconds) between treated and control groups. This advancement is important because it can lead to better diagnosis and more targeted treatments for heart failure. Who this helps: This benefits patients with heart failure and their doctors.

PubMed

Non-animal approaches for consumer safety risk assessments: Unilever's scientific research programme.

2009

Alternatives to laboratory animals : ATLA

Carmichael P, Davies M, Dent M, Fentem J, Fletcher S +7 more

Plain English
Unilever studied non-animal methods to assess consumer safety, particularly for skin allergy, cancer, and general toxicity. Their research shows that these methods are viable alternatives to traditional testing, which has led to a better understanding of biological and chemical processes. This is important because it allows for safer consumer products without harming animals. Who this helps: This helps consumers, companies, and regulatory bodies by ensuring safer products.

PubMed

Quantitative Measurement of Protease-Activity with Correction of Probe Delivery and Tissue Absorption Effects.

2009

Sensors and actuators. B, Chemical

Salthouse CD, Reynolds F, Tam JM, Josephson L, Mahmood U

Plain English
This study looked at measuring how active proteases are in tissues, which are important enzymes linked to diseases like heart disease and cancer. Researchers developed a new technique using special probes that can adjust for factors influencing their readings, like how well the probes get to their target and how tissue absorbs light. Their method improved accuracy, leading to more reliable measurements. Who this helps: This helps researchers and doctors better understand disease processes and assess treatment effectiveness.

PubMed

Assuring consumer safety without animal testing: a feasibility case study for skin sensitisation.

2008

Alternatives to laboratory animals : ATLA

Maxwell G, Aleksic M, Aptula A, Carmichael P, Fentem J +8 more

Plain English
This research focused on finding safer ways to test cosmetic ingredients for skin allergies without using animals. The team explored new technologies and methods to create models that predict skin sensitization in humans, aiming to ensure consumer safety while adhering to upcoming animal testing bans in the European Union. Their work shows that it's possible to assess the risk of skin sensitization effectively using non-animal testing methods. Who this helps: This benefits consumers and patients with skin sensitivities by promoting safer cosmetic products.

PubMed

Mask masks, spinal anaesthesia and meningitis.

2008

Anaesthesia

Reynolds F

PubMed

How do adults with cystic fibrosis cope following a diagnosis of diabetes?

2008

Journal of advanced nursing

Collins S, Reynolds F

Plain English
This study looked at how adults with cystic fibrosis cope when they are also diagnosed with diabetes, another serious health condition. Researchers interviewed 22 adults and found that the emotional challenges of the diabetes diagnosis were significant, but the skills they developed managing cystic fibrosis helped them deal with diabetes. The study highlights the need for better support and education from healthcare professionals about managing both conditions, especially regarding diet. Who this helps: This helps patients with cystic fibrosis and diabetes, as well as their healthcare providers.

PubMed

Frequent Co-Authors

Onutobor Omu Carl Westmoreland Paul Carmichael Julia Fentem Gavin Maxwell Camilla Pease Lee Josephson Ralph Weissleder Caroline Ellis-Hill Sarah Thomas

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.