DR. GARY DEAVER BOSTON, M.D.

PHOENIX, AZ

Research Active
Orthopaedic Surgery NPI registered 21+ years 2 publications 1986 – 2024 NPI: 1063414241
Orthopaedic Surgery
Electric StimulationChromatography, High Pressure LiquidMuscle ContractionMuscle, SmoothAdenosineIn Vitro TechniquesAdenine NucleotidesNADIleumGuinea PigsAdenosine DeaminaseAdenosine Deaminase InhibitorsAdenosine MonophosphateCoformycinPentostatin

Practice Location

4212 N 16TH ST
PHOENIX, AZ 85016-5319

Phone: (602) 263-1200

What does GARY BOSTON research?

Dr. Boston focuses on CADASIL, a hereditary condition caused by mutations in a specific gene that can lead to serious complications like strokes and cognitive decline. His research involved identifying the most common mutations associated with this disorder, which helps in understanding how the disease progresses and how symptoms vary among individuals. By studying how different mutations affect patients, Dr. Boston aims to provide insights that can guide doctors in predicting disease outcomes and customizing patient treatment plans.

Key findings

  • Identified six common NOTCH3 mutations linked to CADASIL, with the p.R133C mutation being the most prevalent.
  • Found that the p.R141C mutation is associated with more severe symptoms in patients.
  • Determined that carriers of the p.R544C mutation typically show symptoms approximately 10 years later than those with more severe mutations.

Frequently asked questions

Does Dr. Boston study CADASIL?
Yes, Dr. Boston's research specifically focuses on CADASIL and the genetic mutations associated with it.
What treatments has Dr. Boston researched for CADASIL?
While his work primarily focuses on identifying genetic mutations, understanding these mutations helps in tailoring treatments and managing symptoms for CADASIL patients.
Is Dr. Boston's work relevant to patients with cognitive decline?
Yes, his research on CADASIL is relevant as the condition can lead to significant cognitive decline, and identifying mutations can help in managing patient care.

Publications in plain English

Most common NOTCH3 mutations causing CADASIL or CADASIL-like cerebral small vessel disease: A systematic review.

2024

Cerebral circulation - cognition and behavior

Boston G, Jobson D, Mizuno T, Ihara M, Kalaria RN

Plain English
This study looked at common genetic mutations linked to a brain disorder called CADASIL, which affects blood flow in the brain. The researchers found that six mutations are most often associated with the condition, with the p.R133C mutation being the most frequent. Notably, the p.R141C mutation leads to more severe symptoms, while those with the p.R544C mutation develop symptoms later, around 10 years later on average. Understanding these patterns helps doctors better predict disease progression and tailor treatments for affected patients. Who this helps: This helps patients and their doctors in managing CADASIL symptoms more effectively.

PubMed

Purine metabolism by guinea-pig ileum.

1986

Advances in experimental medicine and biology

Webster DR, Boston G, Paton DM

PubMed

Frequent Co-Authors

Dan Jobson Toshiki Mizuno Masafumi Ihara Raj N Kalaria D R Webster D M Paton

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.