Dr. Bhagwath studies various aspects of cancer, particularly esophageal cancer and acute promyelocytic leukemia (APL). She has explored how itraconazole, a medication typically used to treat fungal infections, can slow the growth of esophageal cancer by interrupting cancer-promoting proteins. Additionally, she investigates diagnostic methods for APL, discovering rare genetic variations that can aid in more accurate diagnoses. Her work aims to enhance patient care by addressing both treatment options and diagnosis accuracy in oncology.
Key findings
Itraconazole slowed the growth of esophageal cancer cells and tumors in mice, and reduced HER2 and AKT protein levels in patients, indicating its potential as a treatment.
In her APL research, she identified a rare gene variation missed by standard tests, enhancing diagnostic accuracy.
Her study on diagnostic errors found that approximately 33% of lung and colorectal cancer diagnoses were incorrect due to a lack of situational awareness.
Following her recommendations, timely colonoscopy follow-ups for positive fecal occult blood tests increased from 31.7% to 60.5%, and procedure wait times decreased from 190 days to 96.5 days.
Frequently asked questions
Does Dr. Bhagwath study esophageal cancer?
Yes, Dr. Bhagwath studies esophageal cancer and has researched the effects of itraconazole as a potential treatment.
What treatments has Dr. Bhagwath researched for leukemia?
She has investigated specific genetic changes in acute promyelocytic leukemia (APL) to improve diagnostic accuracy.
Is Dr. Bhagwath's work relevant to patients who receive positive stool tests for colon cancer?
Yes, her research helps ensure patients get timely follow-up care after positive fecal occult blood test results.
How does Dr. Bhagwath's research improve cancer diagnosis?
Her work focuses on identifying rare genetic variations that can lead to more accurate diagnoses and reduce diagnostic errors.
What improvements has Dr. Bhagwath implemented in cancer screening?
Through quality improvement strategies, she significantly increased timely colonoscopy follow-ups after positive tests, which enhances early detection.
Publications in plain English
Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer By Suppressing the HER2/AKT Signaling Pathway.
2021
Molecular cancer therapeutics
Zhang W, Bhagwath AS, Ramzan Z, Williams TA, Subramaniyan I +19 more
Plain English This study looked at how itraconazole, a drug usually used for fungal infections, affects esophageal cancer. Researchers found that itraconazole slowed the growth of cancer cells and tumors in mice and reduced levels of certain proteins linked to cancer growth, specifically HER2 and AKT. In a small group of patients, itraconazole also lowered the expression of these proteins in tumors, showing its potential as a cancer treatment.
Who this helps: This helps patients with esophageal cancer by offering a new possible treatment option.
Exploring situational awareness in diagnostic errors in primary care.
2012
BMJ quality & safety
Singh H, Giardina TD, Petersen LA, Smith MW, Paul LW +3 more
Plain English This study examined how incorrect diagnoses in primary care often happen and how situational awareness—understanding what’s happening in their environment—plays a role in these errors. Out of 254 patient cases studied, errors occurred in about 33% of lung cancer and colorectal cancer diagnoses. The findings highlight that a lack of situational awareness in doctors may lead to missed opportunities for timely diagnosis, showing that better understanding this framework can improve patient care.
Who this helps: This research benefits doctors and healthcare providers by offering insights to reduce diagnostic errors.
Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation.
2012
Cancer genetics
Koshy J, Qian YW, Bhagwath G, Willis M, Kelley TW +1 more
Plain English This study looked at a specific type of leukemia called acute promyelocytic leukemia (APL), which is usually marked by a specific gene change. Researchers found a rare variation of this gene change that regular tests missed, but a special test called reverse transcriptase-polymerase chain reaction (RT-PCR) detected it instead. They also found a significant increase in a part of another gene, which helps explain why the regular tests were misleading.
Who this helps: This research helps doctors accurately diagnose APL in patients, ensuring they get the right treatment.
Using a multifaceted approach to improve the follow-up of positive fecal occult blood test results.
2009
The American journal of gastroenterology
Singh H, Kadiyala H, Bhagwath G, Shethia A, El-Serag H +3 more
Plain English This study looked at how to improve the follow-up care for patients who received positive results from a fecal occult blood test (FOBT), which is used to screen for colon cancer. After implementing several quality improvement strategies, timely colonoscopy referrals and procedures significantly increased from 31.7% to 60.5%, and the time it took to get these procedures reduced from 190 days to 96.5 days. This is important because better follow-up can lead to earlier detection and treatment of colon cancer, ultimately improving patient outcomes.
Who this helps: This benefits patients who receive positive FOBT results, ensuring they get timely and appropriate follow-up care.
Hardeep Singh Laura A Petersen Wei Zhang Ankur S Bhagwath Zeeshan Ramzan Taylor A Williams Indhumathy Subramaniyan Vindhya Edpuganti Raja Reddy Kallem Kerry B Dunbar
Physician data sourced from the
NPPES NPI Registry
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Publication data from
PubMed
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Plain-English summaries generated by AI.
Not medical advice.