GRACE S. LEE-RIDDLE, MD

PHILADELPHIA, PA

Research Active
Surgery NPI registered 14+ years 14 publications 2020 – 2026 NPI: 1457612731

Practice Location

1101 CHESTNUT ST
PHILADELPHIA, PA 19107-3612

Phone: (215) 955-6000

What does GRACE LEE-RIDDLE research?

Grace S Lee-Riddle studies multiple facets of organ transplantation, particularly liver and kidney transplants. She investigates how new preservation techniques, like hypothermic oxygenated machine perfusion, can enhance organ function and reduce complications after surgery. Additionally, her research looks at the experiences of patients, including their use of online resources like Reddit to seek information and support. Lee-Riddle also examines the implications of insurance coverage on transplant outcomes and has explored the perceptions of patients and caregivers regarding medication adherence technologies designed to help individuals remember to take their medicines.

Key findings

  • Livers preserved with hypothermic oxygenated machine perfusion had only 11.1% early complications compared to 16.4% for traditionally stored livers.
  • The survival rate after liver transplantation for uninsured patients was 93.3% at one year and 79.6% at three years, comparable to those with insurance.
  • Using machine perfusion for donor livers resulted in a 20% reduction in complications for patients receiving 'marginal' livers.
  • Among 151 women who became living liver donors, the rates of live births were similar before (69%) and after donation (72%), despite some complications.
  • 25% of surveyed liver transplant centers frequently offered second opinions after patient denials, indicating variable access to care.

Frequently asked questions

Does Dr. Lee-Riddle study liver transplants?
Yes, Dr. Lee-Riddle's research focuses significantly on liver transplants, exploring techniques to improve outcomes and patient experiences.
What kind of treatments does Dr. Lee-Riddle research?
She researches innovative preservation techniques for donated organs and the effectiveness of state assistance programs for uninsured transplant patients.
Is Dr. Lee-Riddle's work relevant to kidney transplant patients?
Absolutely, her findings on kidney transplant outcomes, especially from older donors, contribute valuable insights for kidney transplant patients.
How does Dr. Lee-Riddle ensure patients adhere to their medication?
Her research examines patient and caregiver preferences for medication adherence technologies, showing that simple methods like text reminders are preferred.
What impact does insurance have on transplant outcomes according to Dr. Lee-Riddle's findings?
Her research shows that uninsured patients can achieve similar health outcomes to insured patients after liver transplantation, highlighting the value of state assistance programs.

Publications in plain English

Consulting r/Transplant: Assessment of Reddit Use and Sentiment in Solid Organ Transplantation.

2026

Transplantation direct

Herzog A, Goyal D, Paterno F, Amin A, Guarrera JV +2 more

Plain English
This study looked at how people in the transplant community use Reddit to share their experiences and information about solid organ transplants, like kidney and liver surgeries. Researchers analyzed 1,000 posts and found that most were positive, with 66.5% coming from transplant recipients and discussing life after surgery. These findings highlight that Reddit is a valuable resource for support and information exchange, which could inform improvements in healthcare for transplant patients.

PubMed

Ethical considerations of conditional directed living donation-A North American perspective.

2025

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Lee-Riddle GS, Thiessen C, Parent B, Goldberg A, Jones JL +1 more

PubMed

Acceptable outcomes of liver transplantation in uninsured patients under the coverage of a state assistance program.

2025

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Paterno F, Lee-Riddle GS, Olivo R, Amin AN, Koneru B +3 more

Plain English
This study examined outcomes from 60 uninsured liver transplant patients whose procedures were covered by a state charity care program, comparing them to insured patients transplanted at the same center over 18 years. Survival rates at one and three years were statistically identical across uninsured, privately insured, and government-insured groups, with no differences in graft survival, hospital stay length, or readmission rates. The results demonstrate that with adequate financial support, uninsured patients can achieve transplant outcomes equal to insured patients.

PubMed

Transplant recipient, care partner, and clinician perceptions of medication adherence monitoring technology: A mixed methods study.

2024

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Lee-Riddle GS, Schmidt HJ, Reese PP, Nelson MN, Neergaard R +2 more

Plain English
Researchers studied the opinions of kidney and liver transplant patients, their caregivers, and doctors regarding tools designed to help people remember to take their medications. They found that most people preferred simple methods like text message reminders instead of more complex options like video checks, which many found invasive and inconvenient. This research highlights the importance of using straightforward technology to support medication adherence, which is crucial for the success of organ transplants.

PubMed

Liver Transplant Begins With the Donor: A Blueprint to Improve Local Recovery.

2024

Transplantation

Lee-Riddle GS, Lunsford KE

PubMed

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial.

2024

Hepatology (Baltimore, Md.)

Panayotova GG, Lunsford KE, Quillin RC, Rana A, Agopian VG +13 more

Plain English
Livers stored on ice before transplant suffer ischemia damage that worsens outcomes. This randomized trial tested a portable device that keeps the liver oxygenated and perfused during transport, compared to standard cold storage. The results support that hypothermic oxygenated machine perfusion reduces injury and could become a new standard for liver preservation in the U.S.

PubMed

Using organ perfusion to optimize donor livers.

2023

Current opinion in organ transplantation

Lee-Riddle GS, Panayotova GG, Guarrera JV

Plain English
Researchers studied how using machines to pump fluids through donor livers can improve their condition before transplantation. They found that using this technique, called machine perfusion, led to better liver function and fewer complications in patients receiving "marginal" livers, which are often considered riskier—showing about a 20% reduction in problems. This is important because it can help more patients receive healthy transplants, addressing the critical shortage of available donor organs.

PubMed

CAQ Corner: Evaluation and management of the living donor recipient.

2023

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Lee-Riddle GS, Samstein B

PubMed

National survey of second opinions for hospitalized patients in need of liver transplantation.

2023

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Kaplan A, Lee-Riddle GS, Nobel Y, Dove L, Shenoy A +4 more

Plain English
A national survey of 60 U.S. liver transplant programs examined how often and under what circumstances centers refer declined patients for a second opinion at another center. While all centers receive second-opinion referrals, only 25% frequently facilitate them for their own declined patients, and practices vary widely with no standardized process. Standardizing second-opinion pathways could improve equity for patients denied transplant listing.

PubMed

Low-dose aspirin, rejection, and thrombosis: Is it the Wonder Drug® of liver transplantation?

2022

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Lee-Riddle GS, Rocca JP

PubMed

Deceased donor liver transplantation in patients on direct oral anticoagulants at the time of transplant surgery: A case series.

2022

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Salerno DM, Lee-Riddle GS, Brar S, Samstein B, Brown RS +1 more

PubMed

Surgical Boot Camps Increases Confidence for Residents Transitioning to Senior Responsibilities.

2021

Journal of surgical education

Lee-Riddle GS, Sigmon DF, Newton AD, Kelz RR, Dumon KR +1 more

Plain English
Surgical boot camps were studied to see if they boost the confidence of second-year surgical residents. After a 2-hour training session, 31 residents reported significantly higher confidence in crucial skills, such as managing emergency situations and performing procedures, with some improvements showing as high as a 99.9% increase in confidence. This is important because building confidence in these skills helps ensure that new residents can effectively handle their increased responsibilities in surgeries and emergency situations.

PubMed

Pregnancy Outcomes After Living Liver Donation: A Multi-Institutional Study.

2021

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Sonnenberg EM, Lee-Riddle GS, Walls DO, Caicedo JC, Jackson WE +9 more

Plain English
This study looked at the pregnancy outcomes of women who donated a part of their liver, focusing on whether their pregnancies changed after donation. Out of 276 women surveyed, 151 responded, reporting a total of 313 pregnancies, with live birth rates of about 69% before donation and 72% after. While some women experienced more abnormal liver tests and higher cesarean delivery rates after donating, overall pregnancy health was not significantly affected, indicating that living liver donation should not discourage women from having children.

PubMed

Kidney transplant outcomes from donation after circulatory death donors of advanced age.

2020

Clinical transplantation

Walls DO, Lee-Riddle GS, Bover Manderski M, Sawinski DL, Abt PL

Plain English
This study looked at kidney transplants from older donors who died after their heart stopped beating, comparing them to those from donors who died from brain death. It found that kidneys from older donors (age 50-64) gave similar or better survival rates compared to the latter, although they had higher rates of initial complications. This is important because it shows that we can potentially use kidneys from older donors to increase the number of available organs for transplant.

PubMed

Frequent Co-Authors

James V Guarrera Keri E Lunsford Flavio Paterno Benjamin Samstein Arpit Amin Guergana G Panayotova Juan P Rocca Robert S Brown David O Walls Peter L Abt

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.