Dr. Duvivier studies a wide range of health issues, particularly emphasizing how genetic and non-genetic mechanisms affect treatment responses in lung cancer. His research on drug-resistant tuberculosis aims to enhance patient adherence to treatment through structured counseling. Additionally, he focuses on the mental health of migrants, specifically how tailored interventions can prevent relapses in patients with paranoid schizophrenia. His work also spans maternal health, particularly supporting women living with HIV in South Africa, and effective pain management strategies for chronic pain sufferers.
Key findings
In lung cancer, combining treatments can help reduce permanent KRAS inhibitor resistance in cells that initially adapt temporarily due to non-genetic changes.
In a case study, an Ethiopian patient with paranoid schizophrenia became self-sufficient and free from hospital relapses after six weeks of tailored support.
In South Africa, 85.9% of patients remained on antiretroviral treatment six months after starting, with 95.4% achieving viral load suppression through improved counseling methods.
In a trial of BAM therapy for multiple myeloma, 74% of patients had a positive response, and 16% achieved complete remission.
Using zoledronic acid, patients with MGUS experienced an average increase of 15% in bone density, significantly reducing their risk of fractures.
Frequently asked questions
Does Dr. Duvivier study lung cancer?
Yes, Dr. Duvivier researches factors that lead to treatment resistance in lung cancer, specifically focusing on KRAS inhibitors.
What treatments has Dr. Duvivier researched for drug-resistant tuberculosis?
He has developed a counseling toolkit aimed at improving patient adherence to treatment for drug-resistant tuberculosis in South Africa.
Is Dr. Duvivier's work relevant to migraine patients?
While his main focus is not on migraines, he does study chronic pain management, which may provide insights for treating various types of pain.
What support does Dr. Duvivier provide for patients with severe mental illnesses?
He focuses on tailored interventions, such as support systems for migrants with paranoid schizophrenia, helping them manage their condition and treatment effectively.
How does Dr. Duvivier's research help mothers living with HIV?
Dr. Duvivier examines how support clubs can enhance knowledge and health behaviors among mothers living with HIV, benefiting both them and their infants.
Publications in plain English
A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.
2023
Biomolecules
Kulkarni P, Mohanty A, Ramisetty S, Duvivier H, Khan A +7 more
Plain English This study looked at how lung cancer cells can become resistant to KRAS inhibitors, not just through genetic mutations but also through non-genetic changes. Researchers found that these cells initially adapt in a temporary way, but over time, they can develop permanent resistance due to genetic mutations. They also discovered that combining treatments might help prevent or reduce this resistance.
Who this helps: This benefits lung cancer patients and doctors seeking more effective treatment options.
Tailored intervention to prevent relapses and hospitalization in a migrant suffering from paranoid schizophrenia.
2021
Oxford medical case reports
Duvivier H, Lashmi K
Plain English This study focused on helping an Ethiopian man with paranoid schizophrenia who had multiple relapses after being hospitalized. With support from outreach teams and a treatment buddy, he learned to stick to his medication and attend all his appointments. Over a period of six weeks, he became self-sufficient, managing his own treatment without any relapses that required hospitalization.
Who this helps: This benefits patients with severe mental illnesses, especially those who are migrants and may face healthcare barriers.
Knowledge transmission, peer support, behaviour change and satisfaction in post Natal clubs in Khayelitsha, South Africa: a qualitative study.
2020
Reproductive health
Duvivier H, Decroo T, Nelson A, Cassidy T, Mbakaz Z +4 more
Plain English The study examined how Post Natal Clubs (PNCs) support women living with HIV and their infants in Khayelitsha, South Africa, focusing on knowledge sharing, peer support, behavior changes, and overall satisfaction with care. It found that 17 participating women reported gaining important knowledge about HIV and child health, developing strong connections with peers, and changing their behaviors to improve their health and that of their babies. Overall, participants were very satisfied with the PNC experience, although there are concerns about ensuring enough staff for continued support.
Who this helps: This helps mothers living with HIV and their infants by providing them with vital support and information.
Indian Health Service pharmacists engaged in opioid safety initiatives and expanding access to naloxone.
2017
Journal of the American Pharmacists Association : JAPhA
Duvivier H, Gustafson S, Greutman M, Jangchup T, Harden AK +2 more
Plain English This study focused on how pharmacists in the Indian Health Service are tackling the opioid crisis by promoting safe prescribing practices, improving access to medication-assisted treatment (MAT), and distributing naloxone, a drug that can reverse opioid overdoses. They trained 350 law enforcement officers across six districts and implemented community programs to enhance the availability of naloxone. As a result, their efforts have led to better patient care and reduced the risks of opioid dependency and overdose deaths among American Indian and Alaska Native populations.
Who this helps: This benefits patients struggling with opioid use disorders, their families, and first responders in tribal communities.
Outcomes from the implementation of a counselling model supporting rapid antiretroviral treatment initiation in a primary healthcare clinic in Khayelitsha, South Africa.
2015
Southern African journal of HIV medicine
Wilkinson L, Duvivier H, Patten G, Solomon S, Mdani L +3 more
Plain English This study looked at how changing the way patients receive counselling before starting antiretroviral treatment (ART) for HIV can help more people get the treatment they need. In a clinic in South Africa, they found that only 3.6% of patients didn’t return to start ART, while 85.9% were still on treatment six months later. Most impressively, 95.4% of those who continued with treatment achieved viral load suppression, which is essential for keeping the virus under control.
Who this helps: This approach benefits patients by making it easier for them to start and stay on HIV treatment.
A Multidisciplinary Chronic Pain Management Clinic in an Indian Health Service Facility.
2015
Federal practitioner : for the health care professionals of the VA, DoD, and PHS
Duvivier H, Houck M, Ressler E, Shafiq Z, Sams L
Plain English Researchers examined the benefits of a pain clinic managed by pharmacists in an Indian Health Service facility. They found that patients had better outcomes and were more likely to follow their medication plans, which resulted in higher satisfaction levels and less pressure on primary care and emergency room doctors. This is important because it shows an effective way to support people with chronic pain while reducing the burden on healthcare providers.
Who this helps: This mainly helps patients with chronic pain and their healthcare providers.
Patient support interventions to improve adherence to drug-resistant tuberculosis treatment: A counselling toolkit.
2015
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Mohr E, Hughes J, Snyman L, Beko B, Harmans X +4 more
Plain English This study focused on improving the treatment of drug-resistant tuberculosis (DR-TB) in South Africa by introducing a counselling toolkit designed to help patients stick to their treatment. The toolkit provides structured guidance to educate patients and their families about the disease and offers strategies to support them throughout the long treatment process. It is important because effective support can significantly reduce the number of patients who stop their treatment prematurely.
Who this helps: This benefits patients with drug-resistant tuberculosis and their families.
A phase I study of samarium lexidronam/bortezomib combination therapy for the treatment of relapsed or refractory multiple myeloma.
2009
Clinical cancer research : an official journal of the American Association for Cancer Research
Berenson JR, Yellin O, Patel R, Duvivier H, Nassir Y +3 more
Plain English This study looked at how safe and effective a new treatment combining samarium lexidronam and bortezomib is for patients with a type of blood cancer called multiple myeloma who haven't responded to other treatments. Out of 24 patients, about 21% had a positive response to the therapy, including 12.5% who saw their cancer go away completely. The treatment was generally well tolerated, with significant side effects mostly related to blood cells.
Who this helps: This benefits patients with relapsed or refractory multiple myeloma who need new treatment options.
Bortezomib, ascorbic acid and melphalan (BAM) therapy for patients with newly diagnosed multiple myeloma: an effective and well-tolerated frontline regimen.
2009
European journal of haematology
Berenson JR, Yellin O, Woytowitz D, Flam MS, Cartmell A +7 more
Plain English This study looked at a treatment called BAM (bortezomib, ascorbic acid, and melphalan) for people who were newly diagnosed with multiple myeloma, a type of blood cancer. Out of 35 patients, 74% showed a positive response to the treatment, with 16% achieving complete remission and 94% enjoying some level of disease control for an average of 19 months. This matters because BAM offers an effective treatment option without the need for steroids or certain other drugs, which can have unpleasant side effects.
Who this helps: This helps patients with newly diagnosed multiple myeloma.
Zoledronic acid markedly improves bone mineral density for patients with monoclonal gammopathy of undetermined significance and bone loss.
2008
Clinical cancer research : an official journal of the American Association for Cancer Research
Berenson JR, Yellin O, Boccia RV, Flam M, Wong SF +6 more
Plain English This study looked at how effective zoledronic acid is in improving bone strength for patients with a condition called monoclonal gammopathy of undetermined significance (MGUS) who are experiencing bone loss. Researchers treated 54 patients with three doses of the medication over a year and found that their bone density in the spine increased by an average of 15%, with no new fractures or serious side effects reported. This is important because it shows that zoledronic acid can help patients with MGUS strengthen their bones and reduce the risk of fractures.
Who this helps: This helps patients with MGUS who are at risk of bone loss and fractures.
Development of an enzyme-linked immunosorbent assay for specific equine neutrophil myeloperoxidase measurement in blood.
2005
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Franck T, Grulke S, Deby-Dupont G, Deby C, Duvivier H +2 more
Plain English This study developed a new test to measure a specific enzyme called myeloperoxidase (MPO) in horses' blood, which helps assess inflammation. Researchers found that healthy horses had an average MPO level of about 182 ng/ml, while horses with intestinal blockages had much higher levels, ranging from 478 to 2,748 ng/ml. This test is important because it can help veterinarians quickly identify inflammation in horses, leading to better treatment decisions.
Who this helps: This helps veterinarians and horse owners.
Votion D, Vandenput S, Duvivier H, Art T, Lekeux P
Plain English Researchers studied lung images from five healthy horses to understand how air inhalation and blood flow are distributed in their lungs. They developed a new method to analyze these images and found that the distribution of inhalation and blood flow matched well, indicating healthy lung function. This is important because it establishes a baseline for comparing the lung health of other horses.
Who this helps: This helps veterinarians assess lung health in horses.