IZIK YITZHAKI, M.D.

TOTOWA, NJ

Research Active
Anesthesiology NPI registered 21+ years 1 publication 2014 – 2014 NPI: 1902809957
Anesthesiology
MutationTranscription FactorsGene Expression Regulation, NeoplasticBreast NeoplasmsCell LineProto-Oncogene Proteins c-bcl-2Cell Transformation, NeoplasticADAM ProteinsEye ProteinsGATA3 Transcription FactorMammary Glands, HumanThrombospondins

Practice Location

525 UNION BLVD
TOTOWA, NJ 07512-2442

Phone: (973) 928-5360

What does IZIK YITZHAKI research?

Dr. Yitzhaki studies breast cancer, specifically looking at how the GATA3 protein functions in this disease. In healthy cells, GATA3 helps keep breast cells normal and functioning properly. However, in certain types of breast cancer (like luminal breast cancer), mutations can cause GATA3 to change its role from protecting against cancer to actually helping it grow. By understanding these changes, Dr. Yitzhaki and his team aim to help doctors provide better treatment options tailored to patients' specific conditions.

Key findings

  • In luminal breast cancers, mutations in GATA3 alter its role, impacting tumor growth and progression significantly.
  • Three specific genes controlled by GATA3 were found to be disrupted, which is crucial for predicting disease behavior.
  • Understanding GATA3's dual role can enhance treatment personalization for patients diagnosed with breast cancer.

Frequently asked questions

Does Dr. Yitzhaki study breast cancer?
Yes, Dr. Yitzhaki specializes in breast cancer, focusing particularly on the GATA3 protein and its mutations.
What treatments has Dr. Yitzhaki researched for breast cancer?
His research aims to help tailor treatments by understanding how GATA3 mutations influence cancer growth, which can inform treatment decisions.
Is Dr. Yitzhaki's work relevant to patients with luminal breast cancer?
Yes, his findings are directly relevant to patients with luminal breast cancer, as they can influence treatment strategies.
What is GATA3 and why is it important?
GATA3 is a protein involved in the normal development of breast cells, and understanding its role in cancer helps doctors in predicting and treating breast cancer.

Publications in plain English

Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer.

2014

Breast cancer research : BCR

Cohen H, Ben-Hamo R, Gidoni M, Yitzhaki I, Kozol R +2 more

Plain English
This study looked at the role of GATA3, a protein involved in breast cell development, in breast cancer. Researchers found that in luminal breast cancers, GATA3 can switch from helping to prevent tumors to actually promoting their growth due to mutations and changes in its functions. Specifically, three key genes were disrupted, which can affect how the cancer progresses. Understanding these changes is important because they can influence how doctors predict the disease's course and decide on treatments. Who this helps: This helps patients with luminal breast cancer and their doctors in choosing more effective treatments.

PubMed

Frequent Co-Authors

Helit Cohen Rotem Ben-Hamo Moriah Gidoni Renana Kozol Alona Zilberberg Sol Efroni

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.