DR. JACQUELINE MEIER COFFMAN, DO

BIRMINGHAM, MI

Research Active
Pediatrics NPI registered 4+ years 2 publications 1980 – 2024 NPI: 1215679170
Pediatrics Medical Resident/Fellow
Caenorhabditis elegansCaenorhabditis elegans ProteinsTranscription FactorsHistonesLipid Metabolism

Practice Location

2055 E 14 MILE RD
BIRMINGHAM, MI 48009-7256

Phone: (248) 645-1740

What does JACQUELINE COFFMAN research?

J G Coffman studies how early life experiences, particularly mild stress exposure during development, can significantly alter how cells manage fat for energy. By investigating the mechanisms involved, especially the role of a stress-response protein called HSF-1, he has uncovered that these metabolic changes can protect against toxic amyloid protein buildup, which is often seen in neurodegenerative diseases. This research not only highlights the importance of early life conditions on future health outcomes but also opens potential avenues for developing preventive strategies against age-related cognitive decline.

Key findings

  • Young worms exposed to mild stress showed a protective effect against amyloid toxicity, which is linked to neurodegenerative diseases like Alzheimer's.
  • The metabolic shift caused by this early life stress led to more efficient fatburning, preventing harmful protein buildup as they aged.
  • The protection conferred by these changes persisted into the worms' old age, demonstrating the long-lasting impact of early developmental experiences.

Frequently asked questions

Does Dr. Coffman study Alzheimer's disease?
Yes, his research focuses on the mechanisms that can protect against toxic amyloid proteins, which are closely associated with Alzheimer's.
What impact does early life stress have according to Dr. Coffman's research?
His research indicates that mild stress during early development can lead to metabolic changes that provide long-term protection against neurodegenerative effects.
Is Dr. Coffman's work relevant for understanding aging?
Yes, his findings are significant for understanding how early life experiences can influence the aging process and susceptibility to age-related diseases.

Publications in plain English

Early life changes in histone landscape protect against age-associated amyloid toxicities through HSF-1-dependent regulation of lipid metabolism.

2024

Nature aging

Oleson BJ, Bhattrai J, Zalubas SL, Kravchenko TR, Ji Y +7 more

Plain English
Researchers found that exposing worms to mild stress early in life reprograms how their cells manage fats and energy, which protects them from harmful protein clumps that accumulate with age. This protection works through a protein called HSF-1 that gets activated during development and permanently changes how the worms' cells burn fat for energy. The discovery shows that surviving stress in youth creates a metabolic shield against brain diseases like Alzheimer's that involve toxic protein buildup.

PubMed

Survey on body image, weight, and diet of college students.

1980

Journal of the American Dietetic Association

Miller TM, Coffman JG, Linke RA

Plain English
The study looked at body image, weight, and diet among college students visiting a university health service. It found that while 55% of men had an accurate view of their body size, 63% of women thought they weighed more than they actually did. Many students were trying to change their eating habits, especially 60% of those unhappy with their body image, and nearly half of the women wanted to weigh less than what is considered healthy. Who this helps: This helps college students by providing insight into the importance of body image awareness and healthy eating habits.

PubMed

Frequent Co-Authors

Bryndon J Oleson Janakraj Bhattrai Sarah L Zalubas Tessa R Kravchenko Yuanyuan Ji Emily L Jiang Christine C Lu Ciara R Madden Julia G Coffman Daphne Bazopoulou

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.