Does Dr. Mackel study HIV?

Dr. Mackel's research focuses on simian immunodeficiency virus (SIV), which is similar to HIV and helps inform treatments for HIV in humans.

What treatments has Dr. Mackel researched?

He has researched antiretroviral therapy (ART) and its effects on SIV in sooty mangabeys.

Is Dr. Mackel's work relevant to HIV patients?

Yes, his findings can help improve understanding and treatment approaches for HIV in human patients.

JERRY L. MACKEL, M.D.

FORT WAYNE, IN

Research Active

Orthopaedic Surgery NPI registered 21+ years 2 publications 1992 – 2016 NPI: 1629071600

Orthopaedic Surgery

CD8-Positive T-Lymphocytes Canada Viral Load Nurse Practitioners Anti-Retroviral Agents CD4 Lymphocyte Count Family Practice Intestinal Mucosa Interprofessional Relations Blood Cercocebus atys Lentivirus Infections Primate Diseases Simian Immunodeficiency Virus

Practice Location

7601 W JEFFERSON BLVD
FORT WAYNE, IN 46804-4133

Phone: (260) 436-8686

What does JERRY MACKEL research?

Dr. Mackel studies the impact of antiretroviral therapy (ART) on animals infected with a virus that closely resembles HIV. His research specifically looks at sooty mangabeys, a type of monkey, to see how their bodies respond to treatment. By examining how the therapy reduces virus levels and improves immune system responses, his work aims to uncover the underlying processes of AIDS pathogenesis and improve treatment strategies for humans suffering from HIV.

Key findings

In a study with 12 sooty mangabeys, antiretroviral therapy significantly reduced virus levels in most animals treated for 2 to 12 months.
The therapy led to observable improvements in immune responses among the mangabeys.
After stopping ART, the virus levels quickly returned, indicating persistence of the virus even during treatment.

Frequently asked questions

Does Dr. Mackel study HIV?: Dr. Mackel's research focuses on simian immunodeficiency virus (SIV), which is similar to HIV and helps inform treatments for HIV in humans.
What treatments has Dr. Mackel researched?: He has researched antiretroviral therapy (ART) and its effects on SIV in sooty mangabeys.
Is Dr. Mackel's work relevant to HIV patients?: Yes, his findings can help improve understanding and treatment approaches for HIV in human patients.

Publications in plain English

Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis.

2016

Journal of virology

Calascibetta F, Micci L, Carnathan D, Lawson B, Vanderford TH +9 more

Plain English
Researchers studied how antiretroviral therapy (ART) affects sooty mangabeys infected with the simian immunodeficiency virus (SIV), a virus similar to HIV in humans. They treated 12 mangabeys with ART for 2 to 12 months. The results showed that ART significantly reduced the virus levels in most animals and led to improvements in immune responses, but the virus quickly came back once treatment stopped, indicating that the virus can persist even at low levels. Who this helps: This helps researchers and doctors understand virus behavior in SIV infections, which may inform treatments for HIV in humans.

PubMed

Nurse practitioners and family medicine.

1992

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Mackel J, Moores D, Hartog R

PubMed

Frequent Co-Authors

Francesca Calascibetta Luca Micci Diane Carnathan Benton Lawson Thomas H Vanderford Steven E Bosinger Kirk Easley Ann Chahroudi Brandon F Keele Samuel Long

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.