DR. JIM ALAN GOSEWEHR, M.D.

TIGARD, OR

Research Active
Obstetrics & Gynecology - Gynecologic Oncology NPI registered 21+ years 1 publication 1994 – 1994 NPI: 1629071592
Obstetrics & Gynecology - Gynecologic Oncology
Gene ExpressionOvarian NeoplasmsImmunohistochemistryMolecular Sequence DataAllelesBase SequenceCarcinomaEpitheliumRetinoblastoma ProteinChromosomes, Human, Pair 13CystadenomaGene DeletionGenes, RetinoblastomaHeterozygote

Practice Location

12123 SW 69TH AVE
TIGARD, OR 97223-8514

Phone: (971) 708-7600

What does JIM GOSEWEHR research?

Dr. Gosewehr studies ovarian epithelial tumors, particularly the genetic features that differentiate more aggressive forms of cancer from those that are less aggressive. He investigates specific alterations on chromosome 13 and their implications for tumor behavior. His work helps clarify why some ovarian tumors are more dangerous and how they might respond differently to treatments compared to other tumor types.

Key findings

  • In a study of 77 cases, approximately 50% of high-grade carcinomas exhibited a loss of genetic variation on chromosome 13.
  • High-grade ovarian tumors showed normal expression of the retinoblastoma gene, indicating it may not be involved in the aggressive behavior of these tumors.
  • No loss of genetic variation on chromosome 13 was observed in less aggressive tumor types.

Frequently asked questions

Does Dr. Gosewehr study ovarian cancer?
Yes, Dr. Gosewehr specifically researches ovarian epithelial tumors, focusing on genetic changes associated with aggressive forms of this cancer.
What have Dr. Gosewehr's studies revealed about tumor genetics?
His research has shown that about 50% of aggressive high-grade ovarian tumors have a specific genetic alteration on chromosome 13, while less aggressive tumors do not.
How does Dr. Gosewehr's work help patients?
By understanding the genetic changes in aggressive tumors, his work aids doctors in determining more effective treatment strategies for patients with high-grade ovarian cancer.

Publications in plain English

Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.

1994

Cancer research

Kim TM, Benedict WF, Xu HJ, Hu SX, Gosewehr J +5 more

Plain English
This study looked at 77 cases of ovarian tumors, specifically focusing on changes on chromosome 13. Researchers found that about 50% of high-grade carcinomas showed a loss of genetic variation on this chromosome, while other types of tumors did not show this issue at all. Importantly, these high-grade tumors maintained normal expression of the retinoblastoma gene, which means that this gene is likely not involved in the genetic changes observed in these aggressive tumors. Who this helps: This information benefits doctors treating patients with high-grade ovarian cancer by improving understanding of tumor behavior.

PubMed

Frequent Co-Authors

T M Kim W F Benedict H J Xu S X Hu M Velicescu E Yin J Zheng G D'Ablaing L Dubeau

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.