JOHN PIERRUS HANSON JR., M.D.

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This study looked at how popular music and movies can trigger personal memories in people. Researchers found that music is better at evoking strong memories than movies, particularly songs from a specific time in people's lives known as the "reminiscence bump." They discovered that music had a greater impact on memory recall across all ages, helping to create a helpful resource for researchers in the field. Who this helps: This helps researchers and therapists working with patients who use music or movies to recall memories.

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This study looked at the effectiveness and safety of a treatment called suprachoroidal triamcinolone acetonide for patients suffering from noninfectious cystoid macular edema, which can occur for various reasons like diabetes or eye surgery. After one month, 59% of patients saw their condition completely resolve, and visual acuity improved from 20/80 to 20/60, meaning they could see better. Only a small number (about 12%) experienced increased eye pressure, but there were no serious side effects like infection or cataracts. Who this helps: This research benefits patients with noninfectious cystoid macular edema, particularly those with diabetes or who have had eye surgery.

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This study looked at how a new training program could help rehabilitation professionals use the best evidence-based practices when treating children with cerebral palsy. The program included online training and support over 15 weeks, leading to improvements in professionals' confidence and attitudes toward these practices, with confidence levels rising by about 49%. While there were no major changes in the overall use of evidence-based activities, the program was still seen as useful and practical, though challenges within organizations need to be addressed for it to last. Who this helps: This helps rehabilitation professionals working with children with cerebral palsy.

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This study focused on acute rheumatic fever (ARF) in remote areas of Far North Queensland, Australia. Researchers looked at 67 patients diagnosed with ARF from January 2020 to December 2024 and found that 64% did not seek medical help before their diagnosis, while only 21% showed signs of a possible Strep A infection. This is important because it highlights the need for better ways to identify and treat Strep A infections to prevent ARF, especially in First Nations communities where most of the patients are from. Who this helps: This research benefits patients, particularly those in remote Indigenous communities.

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This study looked at how effective the Native CHOICES program is in preventing fetal alcohol exposure in American Indian communities and found that it reduces the risk by 18-20% in the six months after participation. This translates to a decrease in fetal alcohol spectrum disorders (FASDs) by about 6.84-7.6%. The program not only helps avoid significant health issues but also saves money, estimated at $308,295 to $376,951 in economic benefits during the same period, making it a smart investment for these communities. Who this helps: This benefits American Indian communities and health care providers working to reduce alcohol exposure during pregnancy.

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This study explored a new ultrasound imaging method called multifrequency ultrasound (MFUS) to better understand liver conditions in mice. Researchers found that MFUS could reliably measure liver tissue characteristics, showing that mice with a special diet that causes liver fat buildup had different ultrasound signals, specifically an increased attenuation coefficient and a decreased scatterer size measurement compared to normal mice. These findings indicate that MFUS could be a valuable tool for diagnosing and monitoring liver diseases. Who this helps: This helps patients with liver diseases, doctors diagnosing liver conditions, and researchers studying metabolic liver disorders.

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This study focused on a training program where students from different health professions worked together to create care plans for stroke patients. After participating in 12 sessions over two academic years, 91% of the 736 students reported being satisfied with the experience and showed a stronger appreciation for working in teams. This is important because learning to collaborate effectively boosts the quality of patient care and can lead to better outcomes. Who this helps: This helps students training to become healthcare professionals and ultimately benefits their future patients by improving teamwork in care.

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This study looked at how well diagnostic radiographers (the professionals who operate imaging machines) feel prepared to handle allergic reactions caused by special dyes used in CT scans. Out of 90 radiographers surveyed, 70% felt they needed more training to confidently manage these reactions, even though a large majority had received educational training on the subject. This matters because better preparedness can lead to safer CT procedures for patients who are at risk of allergic reactions. Who this helps: This helps patients undergoing CT scans, especially those with a history of allergies.

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This study looked at the outcomes of a procedure called percutaneous biliary drainage and stenting in patients with a type of bile duct blockage caused by cancer. Researchers found that this procedure significantly lowered bilirubin levels, which is important for liver function, and patients had a median survival of about 82 days after the procedure. However, those with liver cirrhosis or multiple liver lesions had poorer survival rates, highlighting the need for careful evaluation before proceeding with this treatment. Who this helps: This helps patients with malignant bile duct obstructions and their doctors by providing insights for better treatment decisions.

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This study looked at how race, income levels, and location affect access to epilepsy surgery in Minnesota. Out of over 6,500 epilepsy patients, only 132 had surgery, with Black patients being less likely to undergo the procedure and those from poorer areas being more likely to have surgery. The findings show that race and geography impact who gets epilepsy surgery, highlighting the need for targeted efforts to improve access for underrepresented groups. Who this helps: This helps patients with epilepsy, particularly those from minority and disadvantaged communities.

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This study looked at different solutions to see how well they can clean out bioceramic sealers used in root canals without damaging the surrounding tooth structure. The researchers found that a special solvent called Endo Sealer Solvent (ESS) and another solution called EDTA were better at dissolving the bioceramic than others tested, but all solutions allowed the root canals to be reopened completely within the same amount of time. This is important because it shows that dentists can choose effective cleaning solutions without worrying about affecting their patients' teeth. Who this helps: This benefits dentists and patients undergoing root canal treatments.

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This study looked at cerebrotendinous xanthomatosis (CTX), a genetic disorder that affects how the body processes certain fats and cholesterol. Researchers analyzed the blood of a patient with CTX before and after six months of treatment with chenodeoxycholic acid (CDCA) and found significant changes in various metabolites: levels of bile acids improved, while sterol precursors normalized. These findings show that CTX affects many metabolic pathways, not just bile acids, and highlight the effectiveness of CDCA in managing the condition. Who this helps: This research benefits patients with CTX and their doctors by providing better diagnostic tools and treatment insights.

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This study focused on Riboglow probes, which are molecules used to detect RNA by shining bright light when they bind to RNA. The researchers found that a specific type of link connecting the two parts of the probe, called glycine linkers, made the probes glow much brighter than others. They discovered that using more glycine in the linker led to even stronger fluorescence, which is important for identifying multiple RNA types at once, especially in live cells. Who this helps: This helps researchers and doctors who need to monitor and study RNA in living cells.

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This study focused on developing a new version of an online program called ENVISAGE that supports families and service providers working with children who have developmental disabilities. Researchers teamed up with parents and service providers to adapt the program, and they found that 12 participants—including 7 service providers and 5 parents—felt that this integrated version was valuable and relevant. The study highlighted the need for ongoing improvements and showed that participants wanted more time for discussions and better use of online resources to enhance learning. Who this helps: This findings benefit parents of children with neurodevelopmental disabilities and the service providers who support them.

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This research paper looks at how immigrant communities in Western countries face higher risks for sexually transmitted infections (STIs) and HIV due to barriers like racism and a lack of culturally relevant healthcare. The goal is to find effective sexual health programs that meet the specific needs of these communities. By collecting and analyzing information from various studies, the researchers aim to highlight successful interventions that could help improve sexual health outcomes for these groups. Who this helps: This benefits patients in racialised immigrant communities and the healthcare providers supporting them.

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This study looked at 290 people in Australia who survived a severe infection called melioidosis between 2016 and 2024 to see how many died early after leaving the hospital. The researchers found that 21% of these survivors died within about eight months, usually due to existing health issues; only 9% of these deaths were considered preventable. This is important because it highlights that while many early deaths cannot be avoided, addressing ongoing health problems during and after treatment for melioidosis can improve long-term health outcomes. Who this helps: This helps patients recovering from melioidosis and their doctors by emphasizing the need for continued healthcare support.

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This study looked at the effectiveness and safety of a treatment called accelerated corneal crosslinking (CXL) for patients with progressive keratoconus, done by specially trained nurses. Over two years, the treatment improved vision for patients, shown by a notable reduction in vision impairment scores (from 0.30 to 0.20) and a decrease in corneal bulging (Kmax) measurements (from 59.1 D to 58.1 D). Importantly, there were very few side effects, with only 3% of patients experiencing temporary issues, and no serious complications were reported. Who this helps: This benefits patients with keratoconus by providing effective treatment options and potentially preserving their vision.

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This study examined livestock feeds sold in Addis Ababa to check for contamination by a harmful toxin called aflatoxin B and to identify the types of fungi present in these feeds. The researchers found that a high percentage of samples were contaminated: 92% of poultry feed, 72% of dairy feed, and significant amounts of various oilseed cakes exceeded safety levels for aflatoxin. These findings are important because they highlight risks to animal health and food safety, emphasizing a need for better practices and regulations in feed management. Who this helps: This helps livestock farmers, feed vendors, and ultimately consumers of animal products.

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This study examined how different types of trace metal supplements affect milk production and health in cows with mastitis, a painful infection of the udder. They tested two supplement forms on 36 cows undergoing repeated intramammary challenges over six weeks. Cows receiving the methionine-based supplements had slightly better milk lactose levels, while those treated with sulfate had lower antioxidant levels in their blood, indicating that the type of trace metal given may help better maintain cow health during the infection. Who this helps: This benefits dairy farmers and veterinarians by improving cow health and milk quality.

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Researchers developed a new vaccine to protect pigs from African swine fever (ASF), a deadly virus that can kill nearly all infected pigs within a week. They created a special protein and delivered it using tiny particles to improve immune responses, and found that the vaccine triggered strong reactions from the immune system in pigs after two doses. These results are significant because they indicate that this new vaccine could help prevent ASF outbreaks, which would be harmful to pig farmers and the pork industry. Who this helps: This helps pig farmers and the pork industry by potentially preventing ASF outbreaks.

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This study looked at the effects of two different treatment combinations that include dolutegravir for people with HIV who were changing their medication. Over nearly two years, people taking dolutegravir with other medications gained more weight compared to those on a different treatment. Specifically, 826 participants showed that the dolutegravir groups had significant increases in weight and body mass index, along with changes in cholesterol levels, but no major changes in blood pressure. Who this helps: This research benefits patients with HIV who are considering their treatment options and clinicians deciding on therapy plans.

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This study looked at a case where a man experienced severe facial pain that was initially thought to be from a tooth issue but was later found to be caused by shingles (herpes zoster). The patient, who was 54 years old, received antiviral treatment that helped with the immediate pain, but he later developed lasting nerve pain and other complications. Recognizing shingles early in patients with dental pain is vital to provide the right treatment and avoid further problems. Who this helps: This helps patients with dental pain and potentially shingles, as well as doctors diagnosing these conditions.

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This study looked at the challenges and supportive factors that affect how family-focused programs for early childhood development are put into practice outside of research settings. Researchers reviewed 31 articles, finding a total of 204 barriers and 183 facilitators to implementing these programs. They discovered that individual characteristics of program users often create the biggest hurdles, while the characteristics of the programs themselves can help promote their success. Understanding these factors is crucial for improving the rollout of these vital programs, which support children with disabilities or developmental differences. Who this helps: This benefits families with young children, particularly those dealing with disabilities or developmental challenges.

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Scientists analyzed the gravitational wave signal GW250114 — the strongest ever detected — to test whether the black hole produced by the merger behaves exactly as Einstein's general relativity predicts. The analysis confirmed at least two distinct oscillation modes in the signal and measured their frequencies to within a few percent of theoretical predictions, providing the most stringent single-event test of general relativity to date. These results validate both the theory and the Kerr description of black holes with unprecedented precision.

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The study focused on how to help women in academic medicine balance their jobs with caregiving responsibilities. Researchers created a support group called DOM Moms & Caregivers at Washington University, which hosted events for 36 women to discuss their experiences and needs. Feedback showed that these women wanted more opportunities to connect and share stories with others in similar situations, highlighting the importance of community support in preventing burnout and promoting professional growth. Who this helps: This helps women in academic medicine who are caregivers, including those raising children or caring for aging family members.

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This study looked at how a specific protein complex called OPENER is necessary for building ribosomes in plants, specifically in the plant model Arabidopsis thaliana. The researchers found that when parts of this complex were missing, the plants faced problems reproducing and struggled to properly assemble ribosomes, leading to about 100% reproductive failure in the affected samples. This discovery shows that the OPENER complex is crucial for healthy ribosome production, which is essential for plant growth and function. Who this helps: This helps plant scientists and agricultural researchers aiming to improve crop yields.

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This study focused on measuring the activity of specific enzymes that break down harmful environmental pollutants containing fluorine and chlorine. Researchers developed a new continuous testing method that allows them to monitor the activity of these enzymes in real time, finding that the Delftia enzyme works better with most pollutants compared to another enzyme tested. This is important because it can help identify ways to reduce dangerous chemicals like PFAS from the environment. Who this helps: Patients and communities affected by environmental pollution.

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This study looked at a rare condition called eosinophilic mesenteric vasculitis (EMV), which can be confused with more common inflammatory bowel diseases (IBD) like Crohn's Disease. The researchers detailed the case of a 15-year-old girl who first seemed to have Crohn’s Disease but, after not improving with regular treatments, was correctly diagnosed with EMV. This is important because recognizing EMV is critical for providing the right treatment and avoiding unnecessary surgeries. Who this helps: This helps patients with rare forms of intestinal diseases and their doctors in making accurate diagnoses.

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This study focused on a rare genetic disorder called Cerebrotendinous Xanthomatosis (CTX), which can result in symptoms similar to Parkinson's disease. Researchers reviewed cases of 72 people with CTX and found that parkinsonism typically starts around age 42 and is linked to nerve cell damage in the brain's dopamine-producing areas. About 88% of patients showed brain abnormalities typical of CTX, and most responded well to dopamine medication. Who this helps: This research benefits patients with CTX and their doctors by improving diagnosis and treatment options for those experiencing parkinsonism symptoms.

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This study focused on enhancing the ability of gravitational wave observatories to detect low-frequency signals, which can provide valuable information about black holes and neutron star collisions. The researchers successfully used a method called Deep Loop Shaping, reducing control noise by more than 30 times, and even up to 100 times in specific ranges, leading to much clearer readings. This improvement allows scientists to study more cosmic events and gather better data faster, which is important for understanding the universe and for early warnings of cosmic events. Who this helps: This benefits scientists and researchers studying black holes and neutron stars.

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This study looked at how differences in brain structure relate to impulsivity in young people. Researchers analyzed data from over 9,000 participants and found that impulsivity is linked to variations in brain areas involved in decision-making and emotional regulation. Specifically, they found that changes in brain thickness and volume in certain regions are associated with impulsive behavior, and that some of these relationships differ between boys and girls. Who this helps: This research benefits young patients at risk for impulsivity-related issues by improving understanding of their brain development.

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This study looked at how listening to meditation, nature sounds, or music affects patients' feelings during intravitreal injections, which are eye treatments. Out of 121 patients, those who heard meditation, nature sounds, or music felt about 33% less anxious after these brief interventions before their injection. However, there was no significant difference in their pain levels or overall satisfaction compared to patients who did not receive any intervention. Who this helps: This benefits patients undergoing eye treatments, as it explores ways to make their experience less stressful.

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This study examined a specific kind of involuntary chewing movement that occurs in patients who have had a cardiac arrest and are comatose. Researchers found that in 12 patients, these movements, called postanoxic oral automatism (PAOA), usually lasted 4-5 seconds and were linked to brain activity. Despite these movements not improving patients' conditions—since all patients died within a median of 5 days—understanding them helps healthcare providers recognize severe brain dysfunction after cardiac arrest. Who this helps: This benefits doctors and emergency medical staff caring for cardiac arrest patients.

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This study looked at the use of a medication called suprachoroidal triamcinolone acetonide (SCS-TA) to treat eye inflammation in children, specifically conditions like uveitic macular edema and retinal vasculitis. In a group of eight children, 70% of the eyes showed stable or improved vision after the injection, with an average improvement of one line on the vision chart. The treatment also had a good safety record, with only one eye experiencing significant pressure increase and one developing a cataract. Who this helps: This research benefits pediatric patients suffering from eye inflammation and their doctors by providing a new treatment option.

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This study looked at patients in tropical Australia who had blood infections caused by three bacteria: Burkholderia pseudomallei, Staphylococcus aureus, and Escherichia coli. The researchers found that 10.7% of those with B. pseudomallei bacteraemia died within 30 days, while the death rates were 10.3% for S. aureus and just 5.3% for E. coli. This matters because it shows that infections from B. pseudomallei are more deadly than those from the other bacteria, underscoring the need for better treatment strategies in areas where these infections occur. Who this helps: This information benefits doctors and healthcare providers treating patients with these infections.

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This study focused on how a specific antibiotic, ceftazidime, can effectively treat melioidosis in patients who are on long-term dialysis. Researchers found that administering ceftazidime three times a week after dialysis resulted in successful treatment for nearly all patients, with 92% surviving the intensive phase of therapy. Importantly, this approach led to adequate drug levels in the blood, resulting in all patients being clinically cured, with no serious side effects observed. Who this helps: This benefits patients with melioidosis who are undergoing chronic intermittent dialysis.

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This study looked at two specific brain wave patterns (14 and 6 Hz positive spikes) in children with a type of epilepsy called Self-limited Epilepsy with Centrotemporal Spikes. Researchers found that 80.8% of the children with epilepsy exhibited these brain wave patterns, while none of the control group did. This is important because it suggests that these spikes may be linked to developmental issues in the brain rather than being harmless, which could change how doctors understand and treat this type of epilepsy. Who this helps: This helps patients with epilepsy and their doctors.

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Researchers studied a rare disorder called cerebrotendinous xanthomatosis (CTX) to understand its clinical symptoms better. They found that out of 83 families with CTX, 79 showed similar signs of the disorder, challenging the belief that the disease varies greatly among patients. Specifically, patients with certain gene mutations had more severe symptoms, and recognizing common symptoms can help with earlier diagnosis and treatment of this manageable condition. Who this helps: This benefits doctors and patients by improving diagnosis and treatment strategies for CTX.

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This study looked at how elementary school teachers use food rewards in the classroom, particularly candy, and how this relates to their beliefs about nutrition. About 56% of teachers reported using candy as a reward at least sometimes. The findings show that teachers are more likely to use food rewards when they think there are obstacles to stopping, highlighting that addressing these challenges could help reduce the use of unhealthy food rewards in schools. Who this helps: This benefits students by promoting healthier school environments.

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This study looked at a treatment called faricimab for patients suffering from a stubborn type of eye swelling known as cystoid macular edema (CME), which didn't respond to other therapies for eight years. In one case involving an 83-year-old man, after just three injections of faricimab, the swelling decreased significantly from 748 micrometers to 339 micrometers, and his vision improved from 20/50 to 20/40. This matters because it shows that faricimab can be effective when other treatments fail, potentially offering hope for patients with chronic eye conditions. Who this helps: This helps patients with persistent eye swelling, particularly those who have not responded to standard treatments.

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This study looked at patients with leptospirosis, a tropical disease, to see how lung problems affected their recovery. Out of 109 patients, 57% had lung involvement, which made their condition more serious and required longer treatment. For example, those with lung issues received antibiotics later, and 66% of them needed to be admitted to intensive care compared to 32% without lung involvement. It’s important because it shows that even healthy young adults can have severe lung complications, but with prompt and appropriate care, they can recover well. Who this helps: Patients with leptospirosis and their doctors.

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This research paper presents the "Concise Guide to Pharmacology 2025/26," which gives an overview of the key properties of around 1,900 drug targets and nearly 7,000 interactions involving 4,400 ligands, all aimed at improving our understanding of how different drugs work in the body. It acts as a reliable reference as it consolidates essential information in a user-friendly format and offers expert recommendations for pharmacological tools to help identify specific drug targets. This is important because it provides a solid foundation for researchers and healthcare professionals to develop and use drugs effectively and accurately. Who this helps: This benefits researchers, doctors, and healthcare professionals involved in drug development and treatment.

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This study looked at the characteristics of patients who develop severe leptospirosis, a serious infection, by reviewing research published before March 2025. Researchers found that older age and issues like low blood pressure, breathing problems, reduced urine output, jaundice, and altered mental state can signal a more severe form of the disease. Lab tests showing abnormal blood counts and kidney or liver function were also linked to severe cases. Understanding these indicators can help doctors quickly identify high-risk patients and provide better care, especially in areas with fewer resources. Who this helps: This helps doctors and healthcare providers working with patients at risk for severe leptospirosis.

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This research focused on creating a way to measure "love of neighbor," which is important for community wellbeing and has been discussed in many cultures and religions. The researchers found two main types of neighbor love: unitive love, which refers to connection and belonging, and contributory love, which involves helping and support, with both having distinct features compared to general compassionate love. These findings create a solid basis for future research on how neighbor love is experienced across different groups and its impact on communities. Who this helps: This benefits researchers, community leaders, and organizations focused on social wellbeing.

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This study examined the food habits of different predatory fish in western Lake Superior to understand how they compete for food. The researchers found that the three fish types, siscowet lake trout, walleye, and introduced salmon, occupy different dietary positions, but walleye and lean lake trout overlap in their food sources. Specifically, the study showed that siscowet lake trout were at the top of the food chain, while walleye and lean lake trout shared similar diets, relying on both invertebrates and fish. Who this helps: This research benefits fishery managers and conservationists working to balance native and introduced fish populations.

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The gravitational wave event GW250114 was detected with exceptional signal strength, making it the loudest gravitational wave observed so far. Analysis of the post-merger signal confirmed it matches the predicted vibrations of a Kerr black hole, and Hawking's area law — which says black hole surface area cannot decrease — was verified to high confidence. The event provides an unusually precise single-observation test of general relativity.