JON J. JANSEN, MD

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This study looked at how involved patients feel in the digital consultation process between their general practitioners (GPs) and specialists. Researchers found that patients usually see this process as a first step in their care and feel they aren't actively involved, with about half of the patients indicating they had little say in starting the consultation. The study highlights the importance of trust in the GP-patient relationship and how factors like the urgency of the health issue and patient preferences can significantly influence their involvement. Who this helps: This research benefits patients seeking more active roles in their healthcare and helps doctors understand how to better engage patients in digital consultations.

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The study looked at how well the Natura 2000 network of protected areas in the European Union is doing in preserving plant diversity. Researchers analyzed information from over 1.2 million vegetation plots and found that nearly 90% of native plant species were present in these protected areas, but this varied significantly by region—ranging from 0% in Lithuania’s Boreal region to 98% in Croatia's Alpine region. This matters because it shows that while the Natura 2000 network helps protect many plants, some areas are lacking representation, and future expansions should focus on these gaps to ensure better conservation of plant biodiversity. Who this helps: This benefits conservationists and policy makers working to protect plant species in Europe.

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This research focused on creating a new 3D synthetic model that closely mimics the environment of the kidney to study diseases better than traditional flat cell models. The researchers developed a special gel system that allows kidney cells to grow in a more realistic way and showed this model could effectively simulate kidney damage by adding a substance that causes fibrosis. This work is important because it provides a more accurate tool for understanding kidney diseases and testing potential treatments. Who this helps: This benefits researchers studying kidney diseases and doctors looking for better treatment options for their patients.

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The study looked at how general practitioners (GPs) help patients with limited health literacy clarify their values and preferences when making health decisions. It found that GPs view this process as important but often challenging and noted that patients sometimes take a passive role, which can lead GPs to guide decisions more than engage with patients. GPs expressed a need for better training and tools to support them in this process, emphasizing the ongoing relationships they have with patients make them well-suited to facilitate meaningful discussions. Who this helps: This helps patients with limited health literacy and their doctors.

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This study explores the use of very heavy ions, specifically neon ions, in targeted cancer treatment to improve patient outcomes. Researchers believe these ions can effectively treat hard-to-kill tumors while causing less damage to nearby healthy tissue, using new techniques that minimize toxicity. They emphasize that neon ions could be a promising option, especially for patients with tumors that resist conventional treatments. Who this helps: This benefits cancer patients, especially those with difficult-to-treat tumors.

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This study looked at how certain features observed in kidney tissue samples can help predict how well patients with primary nephrotic syndrome (PNS) will respond to treatment. Researchers analyzed samples from 106 patients and found that in those with idiopathic nephrotic syndrome (iNS), about 60% achieved complete remission after treatment, and important indicators like podocyte density and fibrosis levels could predict this outcome. For patients with membranous nephropathy (MN), 54% reached complete remission, with similar predictors like glomerular density being significant. Who this helps: This research benefits patients with primary nephrotic syndrome and their doctors by providing better tools to anticipate treatment outcomes.

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This study looked at how losing special kidney cells called podocytes in urine relates to how well patients with primary nephrotic syndrome (PNS) respond to treatment. Among 59 patients with PNS, those with a certain type of kidney problem (minimal change disease or focal segmental glomerulosclerosis) had a 24% rate of partial remission and a 59% rate of complete remission after 12.9 months. Meanwhile, patients with another type (membranous nephropathy) saw a 64% partial remission rate but only a 19% complete remission rate after about 15.5 months. The findings show that measuring podocytes in urine could help doctors predict treatment outcomes in these patients. Who this helps: This study benefits patients with primary nephrotic syndrome and their doctors.

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This study looked at how HIV-1 affects dendritic cells, which are crucial for immune responses. Researchers found that dendritic cells with active HIV-1 were under stress and less effective at presenting antigens, while cells with latent HIV-1 showed overall decreased immune activity but no active virus production. This matters because understanding these differences helps researchers find ways to improve HIV treatment and enable the immune system to better fight the virus. Who this helps: This helps patients living with HIV.

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This study looked at how to better analyze the effects of cancer treatments for stage III/IV melanoma patients who have had surgery, focusing on the possibility of some patients being cured. Researchers proposed a new method called mixture cure models (MCM) to compare treatment outcomes, which showed that some patients could achieve long-lasting survival. They found that using this method allows for a clearer understanding of how different treatments may benefit certain patients in the long run. Who this helps: This benefits cancer patients and their doctors by providing better insights into treatment options and long-term outcomes.

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This study looked at the importance of allied healthcare professionals (AHPs), like physical therapists and nutritionists, for patients with chronic obstructive pulmonary disease (COPD). It found that even with the best medication, patients still face significant physical and mental challenges, so AHPs can help improve their overall care and quality of life. Currently, AHPs are not used as much as they should be, and increasing their involvement is crucial for better COPD management. Who this helps: This helps COPD patients and their healthcare teams.

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This study looked at how much carbon dioxide and methane are found at different depths in 522 lakes, ponds, and reservoirs around the world. Researchers collected over 2,500 measurements from various locations, revealing important patterns in how these gases are produced and stored in lake waters. Understanding these depth-specific gas concentrations is crucial because it can enhance predictions about how lakes contribute to global greenhouse gas emissions as climate change affects these water bodies. Who this helps: This benefits scientists studying climate change and environmental policy makers.

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This study looked at how a modified form of acetyllysine, called ketolysine (KeK), can be used to better understand protein acetylation in cells. The researchers found that KeK stays stable in cells, allowing them to study its effects on the important protein p53 without it being quickly removed like regular acetyllysine. This is significant because it provides a new way to understand how acetylation affects protein functions, which is vital for cancer research since p53 is a tumor suppressor. Who this helps: This helps researchers studying cancer and protein functions.

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This study looked at how a national program called OncoPRO helped 12 health systems implement a system for remotely monitoring cancer patients' symptoms using electronic surveys. Researchers found 29 challenges that arose during this process, like getting doctors on board, and they developed 37 strategies to overcome these challenges. This matters because it provides a detailed guide on building successful programs that improve patient care by using technology to track symptoms. Who this helps: This helps cancer patients and healthcare providers by improving how symptoms are monitored and managed.

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This study looked at a new type of radiation treatment called FLASH-RT to see how it affects mice with medulloblastoma, a type of brain cancer. The researchers found that FLASH-RT not only completely eliminated tumors in all treated mice (100%) but also helped more of them maintain their cognitive abilities afterwards—38% of FLASH-treated mice did better than only 7% of those who received conventional radiation. This is important because it shows that FLASH-RT can effectively fight cancer while reducing harmful side effects on brain function. Who this helps: Patients with medulloblastoma and their doctors.

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This study looked at how electronic symptom monitoring during cancer treatment helps patients and whether these benefits differ based on age, sex, race, and education level. They found that patients using this monitoring reported better symptom control and physical function after three months, with improvements of 2.37 points and 1.54 points respectively compared to those receiving standard care. Notably, younger, female, Black, and less educated patients experienced the most significant benefits, suggesting that this digital method can improve care for groups that often face more challenges. Who this helps: This helps cancer patients, especially those from diverse backgrounds or with lower educational levels.

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This study focused on how fibrosis, a buildup of scar tissue in the kidneys, leads to worsening kidney function in chronic kidney disease (CKD). Researchers found that special cells called myofibroblasts contribute significantly to this process by promoting inflammation and creating a harmful environment for the kidney. They also highlighted how new technologies can help identify potential treatments to prevent this damaging cycle, improving the chances of developing effective antifibrotic drugs. Who this helps: This helps patients with chronic kidney disease and their doctors.

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This study compared two different ways of improving how hospitals test for and refer patients with Lynch syndrome (a condition that increases cancer risk). Researchers looked at nearly 3,321 colorectal cancer patients across seven hospitals in Australia. They found that the plan based on medical theories slightly helped improve testing rates but didn’t show clear benefits overall, while it did significantly reduce the number of patients not receiving genetic referrals (with a 50% reduction for those with high-risk tumor test results). Who this helps: This research benefits doctors and healthcare systems working to implement effective cancer care strategies.

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This study created new guidelines to help doctors and healthcare professionals safely reduce or stop unnecessary medicines for older patients, who are often at risk for problems when taking many drugs at once. The guidelines provide 185 recommendations and 70 good practices on when and how to deprescribe, as well as how to monitor patients after adjustments are made. This is important because it helps ensure that treatments align with what each patient actually needs over time, reducing the risk of side effects and improving their health outcomes. Who this helps: These guidelines benefit older patients who often take multiple medications, as well as their healthcare providers.

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This study looked at how dairy veterinarians communicate with farmers during health visits in Flanders, Belgium. Researchers found that while veterinarians frequently asked about the farm's history and provided follow-up advice, they often neglected to set agendas and understand farmers' specific needs. Notably, younger veterinarians and those who had received communication training were better at connecting with farmers and following up on their needs. Who this helps: This research benefits farmers and dairy veterinarians by improving their communication and collaboration.

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This research looked at how different countries recommend managing medication for patients taking multiple drugs (polypharmacy) in primary care. It found that out of eight guidelines from different countries, the best approach was to conduct a medication review by a doctor or pharmacist, with active participation from the patient. However, only three of the guidelines were of high quality, indicating a need for better clarity on how to implement these recommendations effectively. Who this helps: This helps patients and healthcare providers improve medication safety and effectiveness in managing multiple prescriptions.

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This study looked at ways to reduce the hidden HIV-1 virus still present in the body after treatment. Researchers found that using a combination of a special drug (SMACm) with certain immune system activators (TLR8 and RLR) significantly reduced the amount of HIV-1 in blood samples from people living with HIV. Specifically, using SMACm alongside TLR8 reduced the HIV-1 reservoir in 25% of samples, showing promise for more effective treatments. Who this helps: This benefits patients with HIV by offering new strategies for clearing the virus from their bodies.

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This study looked at how patients in palliative care and their families make decisions about reducing the number of medications they take. Researchers talked to 25 patients and their family members, finding that it's important for patients to understand their medication needs and to be actively involved in the decision-making process about stopping certain drugs. This is crucial because it can reduce the burden of medication for patients, helping them feel more in control and possibly improving their quality of life. Who this helps: This helps patients in palliative care and their families.

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This study examined a 73-year-old woman who developed tetanus, a serious infection, after a minor leg injury. She experienced trismus, which is a condition that causes difficulty opening the mouth due to muscle spasms. It's important for healthcare providers to ensure patients are vaccinated against tetanus, especially after injuries, to prevent such life-threatening infections. Who this helps: This helps patients, particularly older adults who may be at greater risk for tetanus.

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This study looked at how electronic patient-reported outcomes (ePROs) can improve cancer care in community practices. Interviews with 98 clinic staff and 67 patients showed that ePROs help enhance communication between patients and their care teams, increase awareness of symptoms, and support better self-management of health. The findings also highlighted the need for better integration of ePROs into existing clinic workflows and recommended training for staff and clinicians to improve future implementations. Who this helps: This benefits patients receiving cancer treatment and their healthcare providers.

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This study looked at the effects of two types of brain radiation therapy—traditional and ultra-fast, known as FLASH—on mice's brains and thinking skills. The researchers found that mice treated with traditional radiation showed a decline in brain function, while those treated with FLASH radiation performed as well as untreated mice. They also observed changes in brain structure only in the traditional radiation group, suggesting that FLASH radiation might be safer for brain health. Who this helps: This benefits patients undergoing radiation therapy for brain tumors.

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The study examined how offering patients the option to report their health symptoms over the phone (IVR) compared to reporting online affected their care and outcomes in cancer treatment. Out of 593 patients, 36% chose the phone option, which included more older patients and those from disadvantaged backgrounds. It found that while phone users reported more concerning symptoms, they received similar overall health benefits as those using the web, highlighting the importance of providing multiple reporting options to better serve all patients. Who this helps: This helps cancer patients, particularly older adults and those from disadvantaged backgrounds.

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This study looked at critically ill patients being moved between hospitals in the Euregio Meuse-Rhine region, involving both Dutch and German hospitals. It found that in the Netherlands, 89% of patients were transported by mobile intensive care units and mainly accompanied by intensivists, while in Germany, only 48% were taken by intensive care ambulances, often with various specialists. There were adverse events reported in 5% of the cases, highlighting significant differences in how these patients are transported, which is important for making improvements in patient care during transport. Who this helps: This helps patients in critical care who need safe and effective transportation between hospitals.

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This study looked at how dissolved oxygen levels in ice-covered lakes have changed over time as ice cover has declined due to global warming. Researchers analyzed data from nearly 20,000 lakes between 1960 and 2022 and found that smaller lakes (less than 10 hectares) saw a significant drop in oxygen levels, decreasing by 0.14 mg per liter each decade. In contrast, larger lakes (10 hectares or more) experienced an increase in oxygen levels, rising by 0.11 mg per liter each decade. This matters because low oxygen levels can threaten fish survival and overall lake health, especially in smaller lakes where conditions are worsening due to climate change. Who this helps: This study benefits lake managers and environmental scientists working to protect aquatic ecosystems.

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Researchers developed a new test called the HIVRRA to measure how potential HIV treatments can reduce the hidden HIV-1 virus in the blood of people living with HIV. This test is faster, easier, and more sensitive than traditional methods, using total blood cells instead of just one type, which streamlines the process and requires fewer resources. The findings are crucial because they help identify effective therapies for eliminating or controlling the HIV reservoir, ultimately moving us closer to a cure. Who this helps: This benefits patients living with HIV and researchers developing treatment strategies.

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This study looked at how to evaluate the safety and benefits of psychedelic drugs for medical use in Europe. Researchers found that there are significant gaps in knowledge about how to conduct clinical trials for these substances. They emphasized the importance of designing trials that align with patient needs and carefully considering the overall treatment approach, which includes psychological support, to gather reliable evidence about the drugs’ effectiveness and safety. Who this helps: This benefits patients seeking new treatment options, as well as doctors who need clear guidelines for prescribing psychedelics.

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This study focused on how WellSpan Health, a nonprofit healthcare system serving parts of Pennsylvania and Maryland, is working to improve health care and reduce health inequalities in its communities. They found that by gathering community input and developing targeted health improvement projects, they created a comprehensive 30-year plan aimed at enhancing life expectancy and quality of life for residents in the region. The efforts are especially important because the region has significant differences in health status and outcomes among its population. Who this helps: This benefits patients living in areas with health disparities, as well as healthcare providers looking to improve community health outcomes.

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This study looked at how to improve conversations about treatment options and risks for people with limited health literacy. Researchers ran focus groups with health experts, doctors, and patients, finding that everyone agreed it's crucial to adjust communication to fit each patient's needs and use visual tools to explain treatment choices. Most patients preferred face-to-face discussions and liked information presented gradually, but some found complex comparisons confusing. Who this helps: This helps patients with limited health literacy and their doctors.

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This study looked at how well a group of 58 fully vaccinated adults in Berlin can fight off different variants of the SARS-CoV-2 virus over a year, from September 2023 to September 2024. They found that while exposure to new variants helps to improve overall immunity, the strength of this immunity against the newest variants, KP.3.1.1 and XEC, was still low, meaning that many people might not have enough protection. This matters because it shows the need to monitor immunity levels closely to decide if new vaccines are necessary as the virus continues to change. Who this helps: This helps public health officials and vaccine developers understand how to adjust vaccination strategies for the community.

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This study looked at the surgical outcomes of a specific eye surgery for patients with a condition called idiopathic epiretinal membrane (ERM). Out of 996 eyes treated, vision improved on average from 20/40 to 20/25 after about 15 months, although about 6.5% of patients experienced a worsening of vision after the surgery. The research also found that about 23% of patients developed swelling in the eye called macular edema after surgery, especially those with more severe disease (44% in the worst stage), which shows the importance of monitoring and managing this condition post-surgery. Who this helps: This benefits patients with idiopathic ERM and their doctors, providing insights into expected surgery outcomes and complications.

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This study looked at a group of fungi called Nannizzia, which can cause tough skin, hair, and nail infections. Researchers tested two different tools to identify these fungi and how well eight antifungal medications worked against them. They found that one method identified the fungi accurately 62% of the time, while the other method had a slightly better accuracy of 67%. Additionally, the antifungal terbinafine was the most effective, requiring very little concentration to work. Who this helps: This helps patients suffering from stubborn fungal infections and doctors trying to treat them effectively.

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This study looked at workplace harassment and bad behavior in veterinary clinics in the Netherlands by surveying 632 staff members, including nurses, technicians, and veterinarians. They found that 69.6% of respondents experienced some type of harassment in 2023, with aggression being the most common at 59.7%. Younger workers and support staff reported higher rates of aggression and bullying, indicating a pressing need for improvement in the work environment. Who this helps: This research benefits veterinary clinic staff and management by highlighting the need for safer workplaces.

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This study looked at how different groups involved in healthcare view digital interdisciplinary consultation (DIDC), which helps general practitioners get specialist advice online and can reduce unnecessary hospital visits. Researchers interviewed 46 people, including doctors, patients, and health insurance representatives, and found that while most stakeholders were positive about DIDC, they emphasized the need for easy-to-use digital tools and good communication among everyone involved. The benefits of DIDC, such as saving time for doctors and providing quick care for patients without extra costs, were seen as potentially significant. Who this helps: Everyone involved in healthcare, especially patients and their doctors.

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The study looked at how aging affects immune cells, specifically monocytes, in healthy older adults compared to younger individuals. Researchers found that while most elderly individuals had similar immune responses to young adults, a subgroup of elderly individuals, labelled "immune-unfit," produced more lactate and displayed a higher level of immune activity. This subgroup showed a heightened risk of cardiovascular problems due to their altered immune function, with higher levels of certain harmful substances in their blood. Who this helps: This research benefits elderly individuals who may be at greater risk of age-related health issues by identifying those with weaker immune systems.

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This study focused on developing a tool called PHLOWER, which helps researchers better understand how different types of cells develop from a single cell. Using a new method, PHLOWER was able to successfully predict complex cell development paths and identify key proteins involved in these processes, particularly in kidney cells. This is important because it provides insights into how cells differentiate, which can improve research on diseases and therapies related to organ function. Who this helps: This helps scientists and researchers studying cell development and potential treatments for kidney diseases.

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This study looked at a specific kidney issue called idiopathic nephrotic syndrome (INS) and how certain proteins are absorbed by kidney cells. Researchers found that kidney cells made from stem cells (called organoids) had a strong ability to express proteins involved in this absorption process, which is not seen in traditional cell cultures. They highlighted that when there’s an excess of proteins, more kidney cells produced a crucial protein for absorption, but this reverted once the overload was removed. This matters because it shows how organoids can effectively model kidney functions and potentially help in understanding and treating conditions like INS better. Who this helps: This helps patients with kidney diseases, especially those with nephrotic syndrome.

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This study looked at rare tumors in the middle ear called middle ear neuroendocrine tumors (MeNETs) in three patients who had serious cases. Over a period of 6 to 16 years after their diagnosis, all three patients developed serious complications, with two ultimately dying from the disease. The findings emphasize the importance of careful monitoring and follow-ups for these patients, as their condition can worsen over time without clear warning signs. Who this helps: This helps doctors and patients by highlighting the need for ongoing observation in those diagnosed with MeNETs.

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This study looked at how well combat medics trained in a new educational program performed compared to those who were already emergency medical technicians (EMTs). Out of 137 students, both groups scored similarly in theoretical and practical tests, indicating that even those without prior EMT experience did just as well in high-pressure scenarios. This is important as it shows that the new training program is effective regardless of previous medical experience. Who this helps: This benefits future combat medics and military trainers by demonstrating that effective education can level the playing field for all candidates.

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This study examined why Dutch general practitioners (GPs) often order unnecessary tests for vitamin D and B12. Researchers found that factors influencing testing included education, availability of patient information, and feedback on testing habits. They discovered that using clear guidelines and providing better materials could help reduce unnecessary tests. Who this helps: This information benefits patients by reducing unnecessary testing and associated costs.

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This study looked at how general practitioners (GPs) in the Netherlands communicate diagnostic test results to patients who can now access these results online. Researchers interviewed 18 GPs and found that while online access can make healthcare more efficient, it can also lead to misunderstandings when patients misinterpret test results. GPs emphasized the importance of clear communication to avoid confusion and suggested improving the clarity of health information shared online. Who this helps: This helps patients by ensuring they better understand their test results and receive clearer guidance from their doctors.

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This study looked at how fucoxanthin, a natural compound found in some seaweeds, affects brain health in middle-aged rats. The researchers found that after giving the rats fucoxanthin for four weeks, it reduced signs of oxidative stress and altered more than 5,600 genes related to brain aging. This research matters because it highlights a potential dietary approach to help protect the brain from age-related damage and may lead to strategies for preventing neurodegenerative diseases. Who this helps: This benefits patients and individuals concerned about brain health as they age.

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This study looked at how preschool children, aged 3 to 5, perform on digital tests using tablets that include stories and animations. Researchers tested these story-based assessments on 60 South African children and found that this fun, gamified approach can effectively measure young children’s development. The findings emphasize the need for new strategies and tools for assessing early childhood development in our increasingly digital world. Who this helps: This benefits preschool teachers and child development specialists.