DR. KAREN ANN TISINAI, M.D.

TERRE HAUTE, IN

Research Active
Surgery NPI registered 21+ years 1 publication 1990 – 1990 NPI: 1396749966
Surgery
Graft SurvivalRatsKidneyRats, Inbred StrainsFetusalpha-GlucosidasesNeovascularization, PathologicIleumJejunumOmentum

Practice Location

1429 N 6TH ST
TERRE HAUTE, IN 47807-1037

Phone: (812) 242-3110

What does KAREN TISINAI research?

Dr. Tisinai studies the growth and development of fetal small intestine transplants, which are small pieces of intestine taken from a fetus and used to help patients who need intestinal grafts. Specifically, she investigates how these grafts perform when implanted in different locations in the body, such as the abdomen or around the kidneys. By looking at factors like blood vessel formation and enzyme activity, Dr. Tisinai's work aims to enhance the effectiveness of intestinal transplants, which can be crucial for patients with severe intestinal problems.

Key findings

  • 34 out of 40 grafts placed in the omentum were viable, compared to 27 out of 35 in the renal capsule.
  • Grafts in the omentum showed significantly better enzyme activity, with maltase levels at 33.4, significantly higher than the control pups' 8.3 (P < .005).
  • Overall growth and vascular development were better in the omentum, indicating it as a more favorable site for fetal intestinal grafts.

Frequently asked questions

Does Dr. Tisinai study intestinal transplants?
Yes, she focuses on the growth and viability of fetal intestinal grafts in transplantation.
What are the benefits of her research?
Her findings can help improve the success rates and effectiveness of intestinal grafts for patients in need.
Which conditions does Dr. Tisinai's work relate to?
Her research is particularly relevant for patients with severe intestinal disorders who may require grafts.
What locations did she study for graft implantation?
Dr. Tisinai compared outcomes of grafts implanted in the omentum and renal capsule.
Are her findings clinically significant?
Yes, her research demonstrates important differences in graft viability and function based on implantation site.

Publications in plain English

Comparison of growth, neovascularization, and enzymatic function of fetal intestinal grafts in the omentum and renal capsule.

1990

Journal of pediatric surgery

Tisinai K, Shedd F, Harris R, Unthank J, Grosfeld J +2 more

Plain English
This study examined how well fetal small intestine segments grew and developed new blood vessels when transplanted into two different areas in rats: the omentum (a layer of tissue in the abdomen) and the renal capsule (the area around the kidneys). The researchers found that 34 out of 40 grafts in the omentum were viable, while 27 out of 35 in the renal capsule were viable. The grafts in the omentum also showed better growth and higher enzyme activity than those in the renal capsule, with maltase activity significantly higher at 33.4 compared to only 8.3 in control pups (P less than .005). Who this helps: This research assists doctors and researchers in developing better methods for intestinal transplants, particularly for patients needing small intestine grafts.

PubMed

Frequent Co-Authors

J Grosfeld F Shedd R Harris J Unthank K Abu-Dalu

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.