Dr. Kiene studies different ways to help patients, especially children, take their medications more easily and effectively. He develops novel drug delivery systems, like dissolvable tablets and films, which are crucial for accurate dosing, particularly when treating young patients. Additionally, he researches methods to enhance liver-related treatments using innovative drug delivery mechanisms that target liver cells without causing harm. His work also extends to ensuring safety for critically ill patients during hospital transportation and exploring therapeutic options for skin diseases and gastrointestinal procedures.
Key findings
In a study of a dissolvable tablet formulation, 93% of parents and all participating children reported it was easy to take.
The new buccal film containing microdoses of midazolam effectively measured liver enzyme activity as shown in a study with 12 healthy volunteers.
Polymersomes created for liver targeting were found safe even at high concentrations, which may improve treatment options for liver diseases.
Cimetidine reduced the chances of duodenal ulcer relapse by 75% compared to a placebo group.
In a study on critically ill pediatric patients, 71.7% experienced significant changes during transport, highlighting the need for improved safety protocols.
Frequently asked questions
Does Dr. Kiene study children's medication delivery?
Yes, Dr. Kiene develops new methods like dissolvable tablets to help children take their medications more easily.
What treatments has Dr. Kiene researched for liver diseases?
He has researched innovative drug delivery systems, such as polymersomes that target liver cells safely.
Is Dr. Kiene's work relevant to patients with duodenal ulcers?
Yes, he has studied cimetidine, a drug that significantly helps prevent the recurrence of duodenal ulcers.
How does Dr. Kiene improve safety for critically ill patients?
He has conducted research to understand the risks during transport, which can lead to better safety practices in hospitals.
What is a key focus of Dr. Kiene's work in dermatology?
He has studied the use of botulinum toxin (Botox) for cosmetic procedures to reduce facial wrinkles.
Publications in plain English
High Acceptability of an Orally Dispersible Tablet Formulation by Children.
2021
Children (Basel, Switzerland)
Wagner-Hattler L, Kiene K, Bielicki J, Pfister M, Puchkov M +1 more
Plain English This study looked at how well young children accept a new type of dissolvable tablet designed for easy swallowing. It involved 40 kids aged 2 to 10, and the results showed that 93% of parents and all the kids found the tablets easy to take. This is important because it means that these tablets could make it easier for children to take their medicine, improving their health treatment compliance.
Who this helps: This helps children who need to take medicine and their parents.
Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film.
2019
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Kiene K, Hayasi N, Burhenne J, Uchitomi R, Sünderhauf C +7 more
Plain English This study looked at a new way to use a very small dose of midazolam, a drug that helps measure how well a specific enzyme in the liver (called CYP3A) works. Researchers tested a fast-dissolving film containing 30 micrograms of midazolam in 12 healthy volunteers and found that the film worked similarly to a traditional solution, although they are not exactly the same according to regulatory guidelines. This new film is easier to use and could be especially helpful for specific groups of patients, like children, who need precise dosage assessments.
Who this helps: Patients, especially children needing accurate medication dosing.
PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity.
2017
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Kiene K, Schenk SH, Porta F, Ernst A, Witzigmann D +2 more
Plain English This study focused on creating tiny drug delivery systems called polymersomes to target liver cells effectively. Researchers developed these polymersomes with an average size of 150 nanometers and tested them for safety. They found that the polymersomes did not harm cells even at high concentrations, and they effectively delivered drugs to liver cells without toxicity, making them a promising option for treating liver-related conditions.
Who this helps: This helps patients with liver diseases by improving targeted treatment options.
Plain English This study focuses on botulinum toxin (commonly known as Botox) and its use in dermatology for cosmetic purposes, particularly for reducing wrinkles. Researchers found that Botox effectively relaxes muscles in the face, which leads to a noticeable decrease in lines and wrinkles. This matters because it offers a safe and effective solution for those looking to improve their appearance with relatively simple treatments.
Who this helps: This helps patients seeking cosmetic procedures to reduce facial wrinkles.
Intrahospital transport of critically ill pediatric patients.
1995
Critical care medicine
Wallen E, Venkataraman ST, Grosso MJ, Kiene K, Orr RA
Plain English This study looked at how often critically ill children experience problems during transport within a hospital, like changes in vital signs or equipment issues. Researchers found that during 180 transport events, 71.7% of the transports had at least one significant change in the patient's condition, and 13.9% required major medical interventions. This matters because understanding these issues can help hospitals improve patient safety and care during these critical moves.
Who this helps: This helps patients and healthcare providers ensure safer transport for critically ill children.
Hepatitis, HIV, and the dermatologist: a risk review.
1994
Journal of the American Academy of Dermatology
Kiene K, Hsu B, Rowe D, Carruthers A
Plain English This study looked at the risks dermatologists face when treating patients with HIV and hepatitis B or C. It found that hepatitis B is a significant threat, causing around 200 healthcare worker deaths each year, while HIV has affected only 327 healthcare workers since 1990 without any reported deaths. The study emphasizes the importance of safety measures, like vaccinations and immediate treatment after potential exposure, to protect both doctors and patients from these infections.
Who this helps: This research helps doctors and healthcare workers providing care to patients with these infections.
CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires.
1993
Journal of immunology (Baltimore, Md. : 1950)
Uyemura K, Pirmez C, Sieling PA, Kiene K, Paes-Oliveira M +1 more
Plain English This study looked at specific types of immune cells called T cells in patients with a skin disease known as American cutaneous leishmaniasis, which can heal on its own. Researchers found that the T cells in the lesions had different characteristics compared to those in the patients' blood, with the most noticeable differences in certain T cell gene families. They discovered that the CD4+ T cells were linked to a protective response, while CD8+ T cells were associated with another type of immune response, suggesting that both play unique roles in fighting the disease.
Who this helps: This research benefits patients with leishmaniasis and their doctors by improving understanding of immune responses to the disease.
[Prograde colonic irrigation without disturbance of the water-electrolyte balance].
1983
Deutsche medizinische Wochenschrift (1946)
Peerenboom H, Mann K, Knieknecht A, Kiene K, Wienbeck M
Plain English This study examined how different solutions used for cleansing the colon before a colonoscopy affected patients. Among 64 patients, the isotonic saline mannitol solution was the most well-tolerated, resulting in only a slight weight gain of 0.5 kg and balanced sodium levels. In contrast, other solutions caused issues like vomiting and significant weight gain, highlighting the importance of using a comfortable and effective preparation method for colonoscopy.
Who this helps: This research helps patients undergoing colonoscopy preparation.
[Prevention of duodenal ulcer recurrence with cimetidine (author's transl)].
1979
Deutsche medizinische Wochenschrift (1946)
Sonnenberg A, Kiene K, Weber KB, Pelloni S, Peter P +3 more
Plain English The study looked at how effective the drug cimetidine is in preventing duodenal ulcers from coming back. The results showed that patients taking cimetidine had their chances of relapse reduced by 75%, with only 10% of those patients experiencing a return of ulcers, compared to 40% of those on a placebo. However, if patients did not receive long-term cimetidine treatment after their ulcers healed slowly, their chances of recurrence increased significantly.
Who this helps: This helps patients with duodenal ulcers by providing a preventive treatment option.
[Whole gut irrigation for cleansing the bowel (author's transl)].
1979
Zeitschrift fur Gastroenterologie
Kiene K, Knieknecht A, Peerenboom H, Wienbeck M
Plain English This study looked at a method called whole gut irrigation, which uses a saline solution to clean the bowel before colonoscopy. It involved 35 patients, who gained an average of 1.8 kilograms from the fluid and experienced a quick drop in the time food moves through their intestines, reducing it by about 50%. These changes were mostly gone within a day, indicating that while this method is effective and easy, doctors should be careful when treating patients with issues related to sodium and water balance.
Who this helps: This benefits patients preparing for colonoscopy.
[Cimetidine in the treatment of duodenal ulcer (author's transl)].
1978
Deutsche medizinische Wochenschrift (1946)
Peter P, Kiene K, Gonvers JJ, Pelloni S, Weber K +6 more
Plain English This study looked at the effectiveness of cimetidine, a medication, in treating duodenal ulcers. After four weeks of treatment with 1 gram of cimetidine daily, 79% of patients healed, compared to only 58% of those taking placebo pills. While cimetidine helped with healing, it didn’t significantly relieve pain or reduce the need for other antacids, and long-term use may help prevent relapses, although stopping the medication could lead to a greater chance of relapse.
Who this helps: Patients with duodenal ulcers.