DR. KEVIN J. SHANNON, M.D.

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This study looked at women living with HIV in heterosexual relationships in Metro Vancouver from 2014 to 2019. It found that women with high relationship power were more likely to be on HIV treatment (antiretroviral therapy or ART) and to use it effectively. Specifically, those with medium to high relationship power had significantly better treatment outcomes, highlighting the importance of empowering women in their relationships to improve health. Who this helps: This helps women living with HIV and their healthcare providers.

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This study looked at how a new pharmacy model was set up in a health system with 10 hospitals to enhance patient care. By placing pharmacists directly in important hospital units and focusing on their training and integration into patient care, the hospitals saw improvements in patient satisfaction scores. Specifically, after implementing these changes, hospitals reported better feedback from patients, indicating that the model worked effectively in addressing their needs. Who this helps: This benefits patients by improving their overall care experience in hospitals.

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This study looked at how lung tissues change in interstitial lung diseases, which lead to serious scarring of the lungs. Researchers found that certain types of lung cells, including pro-fibrotic fibroblasts and abnormal epithelial cells, cluster together in areas with active fibrosis. They discovered that specific molecules (TGF-β, IL-1β, and TNF-α) are needed to trigger these damaging changes in lung cells. Who this helps: This research benefits patients with interstitial lung diseases by improving understanding of disease mechanisms, potentially guiding future treatments.

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This study looked at how to reduce the use of opioids after outpatient surgeries, which can lead to addiction problems. Researchers developed a pain management plan using ibuprofen and acetaminophen instead of opioids, and they studied 223 patients to find out who might still need opioids after surgery. They found that 42% of the patients filled their opioid prescriptions and used an average of 4 doses, while a machine learning model they created had a moderate success rate in predicting which patients might need opioids. Who this helps: This benefits patients undergoing outpatient surgery by reducing their risk of opioid dependence.

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This study examined how often sex workers who use drugs in Vancouver access overdose prevention services in community and clinic settings from 2017 to 2024. It found that 82.1% of the 503 sex workers used these services, with 70.2% using community-based services compared to 60.2% using clinics. Despite high initial use, there was a concerning decline over time, showing that expanding sex worker-specific programs is crucial for improving access to these vital services. Who this helps: This helps sex workers who use drugs by improving their access to overdose prevention resources.

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The study tested a new drug called risvodetinib on 137 people with early-stage Parkinson's disease to see if it was safe and well tolerated. Most participants (95%) completed the 12-week treatment without significant issues, and there were no notable differences in side effects between those taking the drug and those given a placebo. While the study didn't show that the drug improves Parkinson's symptoms, it confirmed that risvodetinib is safe enough for further testing. Who this helps: This helps patients with Parkinson's disease looking for new treatment options.

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This study looked at what encourages and prevents chiropractic faculty and administrators from engaging in research. Among 95 participants, 75.8% said career advancement was a major motivator, while 82.1% reported that lack of time was a significant barrier. Understanding these factors is important because addressing the barriers can help increase research participation, which is essential for advancing the profession. Who this helps: Chiropractic faculty and students benefit from improved research opportunities and outcomes.

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This study looked at how patients' physical abilities change after surgery for ventral hernias, a type of abdominal bulge. Researchers tested 127 patients at various times, finding that while patients showed an initial decline in physical tasks right after surgery, their ability to perform one specific test (the Five Times Sit-to-Stand) improved significantly over the next year, but eventually leveled off. Overall, these results show that even though patients might struggle immediately after surgery, significant recovery is possible, and it’s important to keep exploring rehabilitation methods to help patients recover fully. Who this helps: This benefits patients recovering from ventral hernia surgery.

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Researchers developed new tools, called Ras isoform-specific binders (RIBs), to target different versions of the Ras protein, which is linked to cancer. These RIBs successfully attach to specific Ras types and can stop them from working properly, which could help us learn more about how Ras contributes to diseases and may lead to new treatments. The study shows that the RIBs can selectively bind to Ras proteins in lab tests and living cells, contributing to better understanding and targeting of cancer therapies. Who this helps: This benefits cancer patients and doctors looking for more effective treatments.

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This research looked at why older adults living in long-term care facilities, particularly those aged 60 and older, often need to go to the hospital or emergency room. It found that those newly admitted to long-term care are most at risk in their first year, and problems like respiratory and heart issues, along with factors such as frailty, falls, and poor nutrition, are linked to these emergency visits. By addressing these issues early, healthcare providers can help reduce hospital trips, improving the quality of life for these residents and saving money for the healthcare system. Who this helps: This helps older adults in long-term care and their healthcare providers.

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This study focused on the role of specific genetic changes, known as Ras mutations, in pediatric cancers. Researchers found that these mutations are common in certain types of cancer in children and can lead to a higher risk of developing tumors. They are exploring new treatments that can directly target the effects of these mutations, which could improve outcomes for young patients. Who this helps: This helps pediatric cancer patients and their doctors.

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This study looked at how a medication called semaglutide, which is designed to help manage diabetes, can also help patients in psychiatric hospitals who are taking other drugs that might cause weight gain and metabolic issues. Two patients taking semaglutide showed improved blood sugar levels and did not gain weight while on their psychiatric medications. This is important because it shows that semaglutide can help manage the side effects of psychiatric treatments while supporting overall health. Who this helps: Patients in psychiatric care who also have type 2 diabetes.

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This study looked at a Listeria outbreak in 2022 linked to enoki mushrooms imported from China, marking the second investigation of this type since 2016. Six people got sick from the infection, all of whom were hospitalized. The findings prompted urgent actions like recalls of the mushrooms and new regulations to prevent future outbreaks, highlighting the need for improved monitoring and quick responses to food safety issues. Who this helps: This helps patients and public health officials by improving food safety measures.

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This study explored a new model called the Flint Public Health Youth Academy (FPHYA) that involves young people in writing and publishing scientific research. The findings showed that engaging youth in the writing process, along with supportive mentorship, helps them develop important skills and prepares them for careers in science. This matters because it not only empowers young people but also fosters a more inclusive research environment. Who this helps: This model benefits young aspiring scientists and researchers.

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This study looked at how the surgical margins (the edges of the tissue removed during surgery) affect survival in patients with regional metastases of cutaneous squamous cell carcinoma (cSCC) in the head and neck. Among 401 patients, 43.6% had cancerous tissue at the margins, which was linked to lower overall and disease-specific survival rates. Specifically, having involved margins nearly doubled the risk of dying from the disease. Who this helps: This benefits patients with cutaneous squamous cell carcinoma, as well as the doctors treating them.

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This study looked at how sex workers in Vancouver accessed primary healthcare from 2014 to 2021, revealing that while 87.4% had accessed care at some point, only 60-78% used it in the last six months. Many participants had serious health issues, including high rates of sexually transmitted and blood-borne infections—48% were positive for hepatitis C, 11.5% for HIV, and 10.4% for other STIs—along with significant mental health challenges. The findings highlight the need for better healthcare models that consider the unique barriers faced by sex workers, such as violence and language difficulties. Who this helps: This helps sex workers by improving their access to necessary healthcare services.

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This study looked at a group of proteins called Ras isoforms, which are important in different types of cancer. Researchers created specific binders that target each Ras isoform, successfully disrupting their function in lab tests and showing strong ability to distinguish between the types. This is important because understanding how each Ras isoform works could lead to better treatments for various cancers. Who this helps: This helps cancer researchers and patients by providing tools to study and potentially target specific cancer pathways.

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This study looked at how being an immigrant, speaking English poorly, and identifying as Asian affects access to health and community services for sex workers in Canada from 2014 to 2022. The researchers found that 22.8% of the 652 women sex workers studied were immigrants, and those without Canadian citizenship had lower chances of accessing health services, especially if they had limited English fluency—up to 85% of those affected. This matters because it highlights significant barriers that some sex workers face, pointing to the need for services that better support their unique experiences. Who this helps: This helps immigrant sex workers, particularly those with limited English skills and Asian identities.

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This study focused on a specific process in cancer cells called palmitoylation, which is important for the growth of certain types of leukemia, particularly acute myeloid leukemia (AML) with specific mutations. The researchers found that a drug named ABD778 can effectively slow the growth of mutant AML cells and works well with another drug called PD901, increasing the survival of mice with this type of cancer. These findings highlight the potential of targeting the palmitoylation process as a new treatment approach for AML and possibly other types of mutant cancers. Who this helps: This research benefits patients with acute myeloid leukemia and their doctors by offering new treatment options.

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This study looked at how sex workers who use drugs in Vancouver respond to drug overdoses using naloxone, a medication that can reverse overdoses. Over 5.5 years, they found that 57.9% of the 427 participants administered naloxone at least once. Those who participated in sex work-specific programs and experienced violence were more likely to use naloxone, suggesting that improving support for sex workers can enhance overdose response and safety measures. Who this helps: This research benefits sex workers, particularly those who use drugs, by highlighting the importance of tailored community programs.

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This study looked at how graduate-entry nursing students develop their identities as nurses and express that identity in their actions and thoughts. Researchers followed 21 students over three years, conducting a total of 57 interviews. They found that students' professional identities grew from aligning their personal values with their nursing roles and feeling a sense of belonging within the nursing community. This understanding is crucial because it helps shape better-prepared nurses who are more connected to their work and care for patients effectively. Who this helps: This helps nursing students and educators improve training and support for new nurses.

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This study focused on acute myeloid leukemia (AML), a challenging cancer to treat. Researchers found that certain mutations in AML cells make them resistant to the treatment drug revumenib. Specifically, they noted that these mutations affected the cells’ ability to respond to the drug, and they identified a different drug, MIK665, that could help make the mutant cells more responsive to revumenib. Who this helps: This finding benefits patients with AML who have specific mutations, as well as doctors looking for more effective treatment combinations.

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This study looked at how the muscle disease known as LGMDR4 affects the ability to move over time. Researchers followed 46 people aged 3 to 55 and found that kids improved in their motor skills until about age 7, after which their abilities leveled off. They discovered that losing the ability to get up from the floor was one of the earliest signs of progression in the disease, especially for those who took more than 7.7 seconds to walk a short distance. Who this helps: This research benefits patients and doctors by providing better insights for managing the disease and designing treatments.

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This study looked at the patterns of nonfatal drug overdoses among marginalized women in Vancouver from 2014 to 2022. It found that nearly 37% of the 650 women experienced a nonfatal overdose at least once, with the rate increasing from 9% in 2014-2015 to 25% in 2021-2022. Overdose clusters were most common in certain neighborhoods, and living near these areas was linked to a higher chance of overdose, particularly for women facing unstable housing and violence. Who this helps: This research benefits marginalized women who use drugs by highlighting the need for targeted support and prevention services.

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This study examined how discrimination affects sex workers' access to healthcare services, including primary care, mental health support, and substance use treatment, in Vancouver, Canada, from 2015 to 2024. The researchers found that sex workers experienced significant discrimination, with a median discrimination score of 19 out of a possible higher range, which led to more barriers in accessing healthcare; for example, each point increase in discrimination made it 3% more likely that a person faced difficulties getting the health services they needed. This matters because it highlights the urgent need for anti-discrimination initiatives and better healthcare strategies to support this vulnerable community. Who this helps: This helps sex workers by advocating for improved access to healthcare and reduced discrimination.

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This study looked at how social and structural issues affect women living with HIV in Metro Vancouver when it comes to accessing mental health services. It found that factors like stigma related to HIV, food insecurity, lack of access to primary healthcare, and experiences of gender-based violence significantly increase the chances that these women will not get the mental health support they need. For example, the risk of unmet mental health needs was nearly doubled for those facing gender-based violence. This research highlights the urgent need for better healthcare support and services for these women to improve their mental well-being. Who this helps: Women living with HIV.

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This research reviewed how "entropy," a concept from information theory, can help doctors understand uncertainty in medical decisions. Over the past 15 years, 20 studies showed that entropy is mainly used to measure uncertainty, especially in fields like cancer diagnosis and radiology, which improves accuracy; however, it hasn't yet been turned into practical tools for everyday use. This matters because better understanding and handling uncertainty can lead to more informed and effective patient care. Who this helps: Patients and doctors in high-stakes medical fields.

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This study looked at how sex workers in Vancouver use mutual aid networks, both online and in-person, to support their well-being between 2020 and 2024. The researchers found that 37.2% of 367 sex workers engaged in digital mutual aid, while 58% participated in in-person mutual aid. The study highlights that those facing violence were more likely to seek in-person help, and those with a history of incarceration had less access to online support, emphasizing the need for better resources and full decriminalization of sex work. Who this helps: This helps sex workers and organizations that support them.

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This study looked at whether the size of a ventral hernia affects patients' physical function, measured through two specific exercises: the Five Times Sit-to-Stand and the Timed Up & Go tests. Out of 112 patients, with an average hernia size of 7 cm, the results showed no significant connection between hernia size and performance in these tests. This matters because it suggests that hernia size might not impact physical ability in the same way that other health factors do. Who this helps: This helps patients preparing for ventral hernia repair by providing insight into how hernia size may not influence their physical function.

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This study looked at how certain treatments, specifically the drug PLX51107 combined with another drug PD0325901, affected adult and pediatric patients with acute myeloid leukemia (AML). Researchers found that while PLX51107 effectively slowed down the growth of specific AML cells, some leukemias that came back after treatment developed a resistance to the drugs, changing their behavior and characteristics. This finding is important because it highlights how these leukemias adapt and change, suggesting that new treatment strategies should be considered for these patients. Who this helps: This helps patients with acute myeloid leukemia and their doctors by providing insights for better treatment options after relapse.

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This study examined how immigration status and race affect the ability of sex workers in Vancouver to access non-barrier contraceptives, like birth control pills. Among 803 participants over 12.8 years, it was found that 25% had trouble getting these contraceptives at least once, and those who were both immigrants and from racialized groups faced 50% higher odds of difficulty compared to others. This matters because it highlights the urgent need for better sexual health services that are safe, accessible, and considerate of cultural and linguistic differences to help reduce health disparities. Who this helps: This helps immigrant and racialized sex workers facing barriers in accessing contraceptives.

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This study looked at survival factors in patients with a rare type of cancer called adenoid cystic carcinoma (AdCC) that affects the head and neck. Researchers reviewed information from 89 patients treated between 1990 and 2020 and found that 35% of them had a recurrence of the disease, especially at distant sites. Patients with cancer spread to the lymph nodes or with higher tumor grades had lower chances of survival. Who this helps: This information benefits patients and doctors by identifying key factors that affect treatment outcomes, helping in better management of the disease.

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This study looked at how quickly graduate nursing students develop their professional identity as they adjust to their new roles. It found that out of 871 research articles, 20 were relevant, showing that students experienced a rapid shift in their sense of belonging and identity while adjusting to nursing, aided by strong relationships in clinical settings. This is important because it highlights how educational programs can effectively support these students in becoming confident and competent nurses quickly. Who this helps: This benefits nursing students and educators in graduate programs.

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This study looked at the experiences of women living with HIV in Metro Vancouver, focusing on pain and its effects on their quality of life. Out of 335 women surveyed, 77.3% reported experiencing pain at least once, with 46.3% having pain that had not been diagnosed. The research found that factors like age, food and housing insecurity, and depression increased the chances of experiencing pain, while access to health services reduced it. Addressing these issues is crucial because living with pain can significantly impact women’s health and daily activities. Who this helps: This helps women living with HIV and healthcare providers working to improve their care.

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This study examined ageism against older nurses in their workplaces and found that negative attitudes about their abilities are common, which harms their health and job longevity. Specifically, researchers noted that fostering positive relationships and a supportive work environment can help older nurses continue their careers, yet many healthcare organizations lack strategies to combat ageism. This is important because addressing these issues is crucial for retaining experienced nurses and ensuring a diverse workforce. Who this helps: This helps older nurses and healthcare organizations aiming to create more inclusive work environments.

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Researchers studied a specific genetic change on chromosome 7 that is often found in blood cancers, particularly myelodysplastic syndromes and acute myeloid leukemia. They created a mouse model with a deletion on a chromosome section (5G2) corresponding to the human 7q22 segment, which affects blood cell production but does not lead to blood cancer on its own. The findings revealed that while the mice seemed to have disrupted blood cell formation, exposure to certain chemicals slightly sped up tumor development, but the deletion didn’t work with other common cancer-related gene mutations to cause leukemia. Who this helps: This research helps doctors and scientists understand better ways to study and potentially treat blood cancers.

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The study focused on the knowledge of danger signs during pregnancy among mothers in The Gambia, where maternal deaths are alarmingly high due to avoidable issues. Although 75% of the women believed they knew enough about these danger signs, most could only recall a few specific signs, revealing that 77% actually had low awareness. This lack of knowledge is concerning, but the study suggests that educating women through smartphone apps could significantly improve their understanding of these critical signs. Who this helps: This helps pregnant women in The Gambia and their families.

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This study looked at how the COVID-19 pandemic affected sex workers in Vancouver, focusing on their ability to access food and healthcare. It found that 41% of the 170 participants faced challenges getting food, and 26% had difficulty accessing healthcare. Importantly, those who struggled to get food were nearly twice as likely to also face healthcare access issues. This matters because it highlights the need for specific support for marginalized groups during crises to ensure they can get food and healthcare. Who this helps: This helps sex workers and similar marginalized groups who need stable access to basic needs during emergencies.

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This study looked at how well trametinib, a medication that blocks certain cancer signals, works for children with a hard-to-treat form of leukemia called juvenile myelomonocytic leukemia (JMML). Out of 10 children treated, 50% had a positive response, with many either being able to continue treatment or going on to a stem cell transplant. This is important because JMML has very low survival rates, and trametinib offers a potential new option for improving outcomes. Who this helps: This helps young patients with relapsed or treatment-resistant juvenile myelomonocytic leukemia and their families.

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Researchers studied the gut bacteria of thousands of people with inflammatory bowel disease (IBD) and healthy individuals to understand which specific strains are linked to the disease. They found over 140,000 different bacterial types, with hundreds more common in people with IBD. Notably, certain strains that thrive in inflammatory conditions could signal the severity of the disease, making it easier to monitor patient health. Who this helps: This research benefits patients with inflammatory bowel disease by improving diagnosis and treatment options.

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This study looked at how a new living arrangement for older people in care facilities in New Zealand can help them live better, similar to a village in the Netherlands. It found that shifting from traditional settings to a more home-like environment not only made residents feel more engaged in meaningful activities but also supported their personal identities. The key finding is that when the environment is tailored to encourage social interaction and participation, and when staff are knowledgeable about residents' needs, it significantly improves the quality of life for the elderly. Who this helps: This benefits elderly residents in care facilities, particularly those with dementia.

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This study examined how stricter housing rules and surveillance due to COVID-19 affected non-fatal overdoses and the use of naloxone (a medication that reverses overdoses) among women sex workers using drugs in Vancouver. Out of 166 participants, 10.8% had experienced a recent non-fatal overdose, while 31.3% had recently used naloxone. Women who faced increased housing rules and surveillance had higher rates of non-fatal overdoses (83.3% vs. 52.1%) and naloxone use (75.0% vs. 48.2%) compared to those who did not experience these measures. Who this helps: This research benefits women sex workers who use drugs by highlighting the need for supportive housing policies that prioritize their health and safety.

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This study looked at how stigma related to sex work affects women's use of condoms during sexual encounters in Vancouver from 2014 to 2022. Researchers found that nearly one-third (32.1%) of women sex workers reported not using condoms consistently, and those experiencing sex work-specific stigma were nearly twice as likely (1.93 times) to use condoms inconsistently. This research highlights the need for better support and services for these women to reduce health risks related to HIV and STIs. Who this helps: This helps women sex workers and public health officials working to improve sexual health services.

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This study looked at how sex workers in Vancouver accessed primary healthcare over a seven-year period and found that 87.4% had used primary care at some point, but usage in the past six months ranged from 60% to 78%. The researchers identified that experiencing intimate partner violence made it less likely for these individuals to access care, while limited English skills also contributed to challenges. Addressing these barriers matters because sex workers face significant health issues, including high rates of infections and mental health disorders, which can worsen without proper access to healthcare. Who this helps: This helps sex workers by highlighting the need for better healthcare access tailored to their unique challenges.

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This study looked at the challenges faced by women living with HIV in Metro Vancouver who have experienced violence, particularly in getting access to mental health counselling. The researchers found that those who faced barriers to counselling were more likely to have thoughts of suicide, lack health care coverage, and experience different forms of HIV stigma. For example, having any barriers increased the odds of suicidal thoughts by about 64%. This is important because it highlights the need for better mental health services and efforts to reduce stigma around HIV, which can significantly improve the lives of these women. Who this helps: This helps women living with HIV, particularly those who have experienced violence.

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This study focused on a rare condition called Superior Mesenteric Artery syndrome, which affects how food moves through the digestive system. The case involved an 84-year-old man who experienced severe stomach pain, nausea, and significant weight loss of 30 pounds over two years. After diagnosis through a CT scan, he successfully underwent a robotic-assisted surgery that helped alleviate his symptoms. Who this helps: This research helps patients suffering from Superior Mesenteric Artery syndrome and their healthcare providers by highlighting treatment options.

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This study looked at health insurance coverage among sex workers in Vancouver, focusing on those who are racialized immigrants. It found that a significant 63.8% of the 644 sex workers surveyed did not have health insurance. Factors like precarious immigration status and being a racialized Asian immigrant greatly increased the chances of lacking coverage, with some groups facing up to four times the risk. Who this helps: This research benefits sex workers, particularly those who are racialized immigrants, by highlighting their need for better access to health care.

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This study examined the challenges faced by African, Caribbean, and Black women living with HIV in Canada, focusing on issues like stigma and the impact of their migration experiences on accessing care. Researchers found that these women were more likely to be outed as HIV positive without their consent (2.34 times more likely) and faced higher rates of verbal or physical abuse related to their status (2.11 times more likely). The findings highlight the importance of protecting patients' privacy and creating supportive health environments, which can help improve care for this vulnerable group. Who this helps: This helps African, Caribbean, and Black women living with HIV, as well as healthcare providers who work with them.

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This study looked at how the sense of community—measured by resource sharing, trust, and support—affects the experiences of violence and access to support for women sex workers in Metro Vancouver from 2010 to 2022. The findings showed that those with stronger community ties were less likely to experience physical or sexual violence, with a small but significant decrease in risk (a 2% reduction in risk for each point increase in the community support score). This matters because improving social connections among sex workers can lead to safer work environments and better access to necessary services. Who this helps: This research benefits women sex workers and advocates pushing for safer working conditions.

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Researchers studied why heart attack patients—especially men—develop dangerous irregular heartbeats, focusing on the vagus nerve, which normally protects the heart. They found that after a heart attack, men's vagus nerves lose the ability to send protective signals to the heart because of chemical and energy problems in nerve cells, while women's nerves stay relatively protected, likely because of natural estrogen. When they gave estrogen to male mice after a heart attack, it restored the nerve's protective signaling and prevented the dangerous heart rhythms.