SpineSpinal FusionDecompression, SurgicalTuberculosisBone TransplantationDisease OutbreaksDebridementFiltrationBone MatrixCenters for Disease Control and Prevention, U.S.Tuberculosis, SpinalDelawareProduct Recalls and WithdrawalsFluoresceinsFluorometry
Dr. Lingenfelter studies the use of cellular bone matrix (CBM) in spine surgeries, which is a type of biological material used to promote healing in the spine after surgery. His research looks into both the benefits and potential complications that can arise from its use, particularly concerning infections such as tuberculosis. Through his work, he aims to better inform patients and surgeons about the risks and rewards involved in using CBM during spinal fusion surgeries.
Key findings
Fusion success rates for lower back surgeries using CBM range from 68% to 98.7%, while neck surgeries have success rates between 87% and 100%.
Two cases of tuberculosis were reported in patients who underwent spinal fusion with contaminated cellular bone matrix, leading to serious complications.
The evidence supporting the use of cellular bone matrix remains weak, indicating a need for further investigation to determine its safety and effectiveness.
Frequently asked questions
Does Dr. Lingenfelter study infections related to spine surgery?
Yes, he has researched infections, including tuberculosis, that can occur after spinal surgeries using cellular bone matrix.
What are the success rates of spine surgery with cellular bone matrix?
Success rates vary, showing 68% to 98.7% for lower back surgeries and 87% to 100% for neck surgeries.
Is Dr. Lingenfelter's work relevant for patients considering spinal fusion?
Absolutely, his research provides important insights into the risks and benefits of using cellular bone matrix in spinal fusion surgeries.
What complications are associated with cellular bone matrix in surgery?
Complications may include severe infections and concerns about contaminated tissue, as highlighted in his studies.
Has Dr. Lingenfelter developed any tools for medical testing?
Yes, he has contributed to research on a new device for accurately measuring drugs in blood samples, which can assist in patient diagnosis and treatment.
Publications in plain English
Cellular Bone Matrix in Spine Surgery - Are They Worth the Risk: A Systematic Review.
2024
Global spine journal
Lambrechts MJ, Issa TZ, Mazmudar A, Lee Y, Toci GR +6 more
Plain English This study looked at the use of cellular bone matrix (CBM) in spine surgery to see if it leads to complications or successful outcomes. Researchers found that fusion success rates ranged from 68% to 98.7% for lower back surgeries and 87% to 100% for neck surgeries, but there were concerns about a severe complication involving contaminated tissue and many studies not being very rigorous. Overall, the evidence around CBM use is weak and needs more thorough investigation to ensure the benefits are worth the potential dangers.
Who this helps: This helps patients considering spine surgery and their doctors.
Cellular Bone Matrix Leading to Disseminated Tuberculosis After Spinal Fusion: A Report of 2 Cases.
2023
JBJS case connector
Issa TZ, Lambrechts MJ, Toci GR, D'Antonio ND, Kanhere AP +3 more
Plain English This research examined two cases of patients who developed tuberculosis after having spinal surgery with a specific type of bone material called cellular bone matrix. Both patients experienced serious complications due to the infection, which was linked to this contaminated bone product. The study emphasizes the critical need for thorough removal of the infected material and proper cleaning during surgery to effectively eliminate the tuberculosis and stabilize the spine.
Who this helps: This information benefits doctors and spinal surgery patients by highlighting the risks associated with certain surgical materials.
Khalil OS, Routh WS, Lingenfelter K, Carr DB, Ladouceur P
Plain English Researchers created a new tool that enhances a device called the Abbott VP bichromatic analyzer, allowing it to measure fluorescence, which is useful for detecting specific substances like drugs in blood samples. They found that this modified device can accurately measure small amounts of fluorescein, a fluorescent dye, down to 192 parts per trillion per liter. The results from their new method closely matched traditional testing methods for theophylline in patients, showing it to be reliable and effective.
Who this helps: This benefits doctors and laboratories testing patients' blood for specific medications and conditions.
Mark J Lambrechts Tariq Z Issa Gregory R Toci Nicholas D D'Antonio Gregory D Schroeder Alexander R Vaccaro Aditya Mazmudar Yunsoo Lee Meghan Schilken Christopher K Kepler
Physician data sourced from the
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Publication data from
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Plain-English summaries generated by AI.
Not medical advice.