DR. LEE S. PORTNOFF, M.D.

SAINT LOUIS, MO

Research Active
Dermatology - MOHS-Micrographic Surgery NPI registered 21+ years 10 publications 2016 – 2025 NPI: 1043214505
SARS-CoV-2COVID-19Particle SizeAerosolsEquipment DesignMaterials TestingPrinting, Three-DimensionalGloves, SurgicalCoughTextilesMasksLatexProtective ClothingN95 RespiratorsGloves, Protective

Practice Location

3009 N BALLAS RD
SAINT LOUIS, MO 63131-2353

Phone: (314) 993-2909

What does LEE PORTNOFF research?

Dr. Portnoff studies how germs and harmful substances spread, particularly through the air and liquids. He develops and assesses the effectiveness of masks, gloves, and protective clothing used in healthcare settings. His research not only aims to improve protective equipment used during pandemics, like COVID-19, but also ensures that healthcare workers are safeguarded against exposure to infectious fluids while treating patients, especially in high-risk situations like Ebola.

Key findings

  • Developed a cough simulator that helps test respiratory illness spread, improving public health safety.
  • Found that air leaking from face masks varied from 10% to 58%, with three-layer masks being most effective during the COVID-19 pandemic.
  • Discovered that nitrile gloves had a 2.38% failure rate under stress conditions, while latex and vinyl gloves had significantly higher failure rates of 19.4% and 27.1%, respectively.
  • Created a ventilation system that reduced airborne particles by over 98%, improving air quality for retail workers.
  • Identified that viruses penetrate protective fabrics 17 seconds faster than liquids, emphasizing the need for effective fabric testing.

Frequently asked questions

Does Dr. Portnoff study respiratory diseases?
Yes, he studies how respiratory diseases spread and develops tools to test these conditions.
What types of protective equipment has Dr. Portnoff researched?
He has researched face masks, medical gloves, and protective clothing to ensure they effectively block harmful substances.
Is Dr. Portnoff's work relevant to healthcare workers?
Absolutely, his studies improve safety standards for gear used by healthcare workers, particularly during high-risk procedures.
How does Dr. Portnoff's research help the general public?
His work identifies more effective face coverings, which helps the public reduce the risk of virus transmission.
What findings does Dr. Portnoff have about masks during the COVID-19 pandemic?
He found that three-layer disposable masks performed significantly better than single-layer cloth masks, highlighting the need for recommended standards.

Publications in plain English

Total outward leakage of face-worn products used by the general public for source control.

2025

American journal of infection control

Yang W, Myers W, Bergman M, Fisher E, Ryan KJ +3 more

Plain English
This study looked at how well different types of face masks and coverings used by the general public prevent the spread of viruses, especially during the COVID-19 pandemic. Researchers tested nine categories of face coverings and found that the amount of air leaking out, which indicates how effective they are, ranged from 10% to 58%. It showed that single-layer cloth masks were the least effective, while three-layer disposable masks performed better, highlighting the need for standards in mask design to ensure public safety. Who this helps: This helps patients and the general public by identifying more effective face coverings for preventing virus transmission.

PubMed

A cough simulator constructed from off-the-shelf and 3D-printed components.

2025

Journal of occupational and environmental hygiene

Portnoff L, Lee T

Plain English
Researchers created a new cough simulator using affordable materials, making it easier for scientists to study how respiratory diseases spread. This simulator can precisely control how strongly it coughs and the size of particles released, which helps test things like air flow, disinfection methods, and the effectiveness of masks. This is important because it enhances our understanding of respiratory illness and improves public health safety. Who this helps: This helps researchers, healthcare professionals, and public health officials.

PubMed

Development of an experimental technique to determine the barrier performance of medical gloves when stretched.

2024

Annals of work exposures and health

Soo JC, Portnoff L, Bickson J, Fisher EM

Plain English
Researchers developed a new testing method to assess how well medical gloves protect against harmful substances when they are stretched, which mirrors how they are actually used. They tested latex, nitrile, and vinyl gloves under various conditions and found that nitrile gloves performed the best, with only a 2.38% failure rate, while latex and vinyl gloves had higher failure rates of 19.4% and 27.1%, respectively. This matters because ensuring effective barrier protection can help prevent contamination and exposure to harmful agents for healthcare workers and patients. Who this helps: This helps healthcare workers who rely on gloves for protection during medical procedures.

PubMed

Evaluation of a prototype local ventilation system to mitigate retail store worker exposure to airborne particles.

2023

Journal of occupational and environmental hygiene

Lee T, Barone TL, Yantek DS, Portnoff L, Zheng Y

Plain English
This study tested a new ventilation system designed to help retail workers breathe cleaner air by reducing exposure to harmful particles. The system was effective, cutting airborne particle levels by more than 98% directly under it and over 97% in the area where a worker would breathe, even when simulating a cough. However, if the airflow in the store was disrupted, the system's effectiveness dropped significantly. Who this helps: This benefits retail store workers by providing a safer working environment.

PubMed

Effects of volume, velocity, and composition on the resistance to synthetic blood penetration of N95 filtering facepiece respirators and other head/facial personal protective equipment.

2021

Journal of occupational and environmental hygiene

Portnoff L, Rengasamy S, Niezgoda G, Sbarra D, Pissano A +1 more

Plain English
This study looked at how various factors, like the amount of liquid, the speed it sprays, and the type of liquid, affect how well different masks and protective equipment block liquid from getting through. Researchers tested 20 different models of N95 masks, surgical masks, and other protective gear. They found that faster spray speeds led to more liquid getting through in 9 out of 20 models, while diluted synthetic blood penetrated better than expected in another 8 models, suggesting the type of fluid is very important to consider alongside speed. Who this helps: This information benefits healthcare workers who rely on these protective devices in clinical settings.

PubMed

A new approach to measure the resistance of fabric to liquid and viral penetration.

2019

PloS one

Li M, Furlong JL, Yorio PL, Portnoff L

Plain English
This study explored a new way to test how well protective fabrics stop liquids and viruses from getting through. The researchers found that, on average, viruses penetrated the fabric 17 seconds sooner than liquids, indicating that liquid penetration can predict viral penetration. This is important because it means that testing for liquid resistance could help identify fabrics that are also good at blocking viruses. Who this helps: This benefits manufacturers of protective clothing and healthcare providers who rely on effective protective gear.

PubMed

Evaluation of Apparatus Used to Test Liquid through Protective Materials: Comparison of a Modified Dot-Blot Apparatus to the ASTM Penetration Cell.

2019

Journal of testing and evaluation

Schwerin MR, Portnoff L, Furlong JL, Das SS, Gordon EA +3 more

Plain English
This study compared two methods for testing how well protective clothing, like gowns used during Ebola outbreaks, keeps out liquids such as blood and vomit. The researchers found that the new dot-blot method required much less liquid—over six times less—and didn’t have issues with leaks, making it easier and more reliable. This matters because determining the effectiveness of protective gear can help prevent disease spread in healthcare settings. Who this helps: This benefits healthcare workers and patients by ensuring better protective gear is used during outbreaks.

PubMed

The Surface Tension of Synthetic Blood used for ASTM F1670 Penetration Tests.

2018

Journal of testing and evaluation

Portnoff L, Jaques PA, Furlong JL

Plain English
This study looked at how the surface tension of synthetic blood, which is used to test how well fabrics resist penetrating fluids, changes during testing. The researchers found that the initial surface tension of the synthetic blood was over 50 dynes/cm, much higher than the 40-44 dynes/cm that was expected, but it dropped below 40 dynes/cm after 60 minutes. These findings are important because they can help improve safety standards for materials used in situations where exposure to bloodborne pathogens is possible. Who this helps: This helps patients and healthcare workers who rely on effective protective clothing.

PubMed

Evaluation of a passive method for determining particle penetration through protective clothing materials.

2017

Journal of occupational and environmental hygiene

Jaques PA, Portnoff L

Plain English
This study developed a new way to test how well different types of protective clothing keep out tiny particles, especially those from engineered materials. The new method showed that using a passive technique, which simulates real-world conditions like wind, resulted in better accuracy, revealing that some fabrics let in particles up to 5.5 times more than previously thought using older methods. This is important because it helps improve the safety of workers who rely on protective clothing from harmful exposures. Who this helps: This helps workers in industries dealing with engineered nanomaterials by ensuring they have more effective protective clothing.

PubMed

Evaluation of gowns and coveralls used by medical personnel working with Ebola patients against simulated bodily fluids using an Elbow Lean Test.

2016

Journal of occupational and environmental hygiene

Jaques PA, Gao P, Kilinc-Balci S, Portnoff L, Weible R +3 more

Plain English
This study looked at how well different gowns and coveralls protect medical workers from bodily fluids when treating Ebola patients. Out of nine garments tested, one gown and two coveralls effectively blocked fluids without any leakage, while the others showed increased leakage when pressure was applied or when fluids had lower surface tension. This is important because it helps identify which protective clothing is most effective in preventing exposure to infectious fluids, ensuring the safety of healthcare workers. Who this helps: This helps medical personnel treating Ebola patients.

PubMed

Frequent Co-Authors

Jennifer L Furlong Peter A Jaques Taekhee Lee Weihua Yang Warren Myers Mike Bergman Edward Fisher Kenneth J Ryan Brooke Vollmer Ziqing Zhuang

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.