Dr. Cooperman studies several important health issues, including chronic kidney disease related to diabetes and hypertension, the impact of neighborhood environments on recovery in sober living houses, and the dynamics of addiction involving opioid dependency. She integrates community input to ensure that her research is relevant and beneficial to patients’ needs. Additionally, her earlier work explored the safety and efficacy of collagen treatments for skin contour issues, providing insights into immune responses related to injectable treatments.
Key findings
In the Kidney Precision Medicine Project, patient input shaped ethical guidelines, significantly aligning the study with real-world patient concerns.
The sober living house study revealed that 4% of participants experienced another violent injury after intervention, compared to a historical rate of 8%. Women and Black individuals showed even lower rates of reinjury.
Using stem cells, Dr. Cooperman's research found that a genetic variation impacts dopamine dynamics in opioid-dependent individuals, suggesting new directions for addiction treatment.
In her collagen studies, 89% of patients experienced positive results after 5 or fewer collagen implant injections, demonstrating the treatment's effectiveness and safety record.
A retrospective review on the immunogenicity of injectable collagen revealed that reactions were mostly localized, and higher exposure did not increase immune response risks.
Frequently asked questions
Does Dr. Cooperman study kidney disease?
Yes, she researches chronic kidney disease and aims to integrate patient priorities into the study of its causes and treatments.
What treatments has Dr. Cooperman researched related to addiction?
She studies the effects of opioid dependence on dopamine neurons and explores potential new treatments based on her findings.
Is Dr. Cooperman's work relevant to patients in recovery?
Absolutely, her research into sober living environments helps improve recovery experiences for individuals in those settings.
What can patients expect from collagen treatments based on her research?
Patients can expect a high efficacy rate and minimal serious side effects, as demonstrated in her studies on collagen implants.
How does Dr. Cooperman involve patients in her research?
She emphasizes patient engagement to ensure research reflects the real concerns and needs of those affected by health conditions.
Publications in plain English
Integrating Patient Priorities with Science by Community Engagement in the Kidney Precision Medicine Project.
2021
Clinical journal of the American Society of Nephrology : CJASN
Tuttle KR, Knight R, Appelbaum PS, Arora T, Bansal S +19 more
Plain English The Kidney Precision Medicine Project (KPMP) studied chronic kidney disease (CKD) caused by diabetes and hypertension, along with acute kidney injury (AKI), by using kidney tissue samples for in-depth analysis. The project involved patients and doctors working together to shape the research, ensuring it reflects their real-world concerns and needs. As a result, patients significantly influenced key parts of the study, including ethical guidelines and how results are shared.
Who this helps: This helps patients with kidney disease and the doctors treating them.
Recovery in context: Sober living houses and the ecology of recovery.
2020
Journal of community psychology
Mericle AA, Karriker-Jaffe K, Patterson D, Mahoney E, Cooperman L +1 more
Plain English This study looked at sober living houses in Los Angeles County to understand how their locations affect residents' recovery experiences. It found that larger sober living houses were in neighborhoods with more alcohol outlets but also closer to treatment facilities, while houses with higher fees tended to be in better neighborhoods that were further from recovery services. This matters because it highlights how the neighborhood environment can support or challenge recovery efforts for people living in these houses.
Who this helps: This helps patients in recovery and the organizations that support them.
Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.
2016
Brain and behavior
Sheng Y, Filichia E, Shick E, Preston KL, Phillips KA +5 more
Plain English This study focused on understanding how dopamine neurons from people who are dependent on opioids behave differently compared to those from people who are not. Researchers created these neurons using stem cells and discovered that a specific genetic variation affected the levels of a protein that helps dopamine function, which is critical for addiction. They also found that treatment with a drug called valproic acid led to changes in important genes related to dopamine, especially in the neurons from opioid-dependent individuals, suggesting new ways to explore and address addiction.
Who this helps: Patients struggling with addiction and doctors looking for new treatment options.
A decade of hospital-based violence intervention: Benefits and shortcomings.
2016
The journal of trauma and acute care surgery
Juillard C, Cooperman L, Allen I, Pirracchio R, Henderson T +4 more
Plain English This study looked at a program aimed at helping people in hospitals who have been injured by violence to prevent them from getting hurt again. Over ten years, only 4% of participants in this program suffered another violent injury, which is lower than the historical rate of 8% from a previous period. It found that certain groups, like women and Black individuals, had even lower rates of reinjury, while Latino individuals had higher rates, suggesting that the program needs to adjust its services to better support these specific groups.
Who this helps: Patients recovering from violent injuries, particularly those from underserved communities.
Instructional design for online course development.
2007
Journal of veterinary medical education
Cooperman L
Plain English This paper looks at how teaching online is very different from teaching in a physical classroom. It explores the importance of proper instructional design, which helps educators create effective online courses tailored to different subjects. Understanding these differences can lead to better learning experiences for students.
Who this helps: This benefits teachers and educators developing online courses.
Collagen implantation in patients treated previously with silicone.
1985
The Journal of international medical research
Cooperman L, Mackinnon V
Plain English This study looked at the effectiveness and safety of a collagen implant called Zyderm Collagen Implant (ZCI) in 158 patients who had previously received silicone injections for skin issues. Out of those, 121 patients completed the treatment, and 89% experienced positive results after five or fewer injections of ZCI. Importantly, the treatment did not cause any serious side effects or unwanted changes in skin texture or color.
Who this helps: This benefits patients with skin contour issues, especially those who have had prior silicone treatments.
The immunogenicity of injectable collagen. I. A 1-year prospective study.
1984
Journal of the American Academy of Dermatology
Cooperman L, Michaeli D
Plain English This study looked at how the body reacts to a common injectable collagen used for skin treatments. Out of 61 people, only 2 (or 3%) had minor inflammation at the injection site, and their bodies produced antibodies against the collagen, but these did not affect human collagen or lead to any serious health issues. This is important because it shows that the collagen used is generally safe and causes very few immune reactions in patients.
Who this helps: Patients receiving collagen injections for skin treatments.
The immunogenicity of injectable collagen. II. A retrospective review of seventy-two tested and treated patients.
1984
Journal of the American Academy of Dermatology
Cooperman L, Michaeli D
Plain English This study looked at the immune responses of 72 patients who received a common injectable collagen treatment for skin issues. Researchers found that out of these patients, those who experienced reactions at their injection sites had higher levels of antibodies specifically against the collagen implant—31 reported only local site reactions, while 35 had general symptoms not linked to the injection sites. Importantly, increases in exposure to the implant did not raise the chances of developing an immune response, indicating that most reactions are localized and happen soon after the first few treatments.
Who this helps: This information is valuable for patients receiving collagen implants and the doctors who treat them.