LEVI S. KIRKLAND JR., M.D.

SAINT LOUIS, MO

Research Active
Surgery NPI registered 21+ years 31 publications 1967 – 2026 NPI: 1720082233
Postoperative ComplicationsBeesReproductionGene Expression ProfilingAustraliaCost of IllnessQuality of Health CareRespiration, ArtificialWeight LossCommunity ParticipationPollenCost ControlFlowersPollinationLabor Unions

Practice Location

1034 S BRENTWOOD BLVD
SAINT LOUIS, MO 63117-1223

Phone: (314) 644-1411

What does LEVI KIRKLAND research?

Dr. Kirkland's research primarily centers on conditions related to heart health and cancer, along with the effectiveness of healthcare training methods. He studies how heart cells change after events like heart attacks, aiming to uncover protective factors that can aid recovery. Additionally, he investigates the accuracy of diagnostic tests for ovarian cancer in different ethnic groups to ensure fair treatment options. Dr. Kirkland is also dedicated to improving healthcare training by using novel approaches, such as escape room simulations for ECMO training, enhancing teamwork and decision-making skills among medical teams.

Key findings

  • In a study involving 37 nurses, escape room simulations for ECMO training led to faster completion times, with participants reporting improved knowledge and teamwork skills.
  • Research found that mice without specific heart receptors lost more than 25% of heart muscle cells compared to normal mice after a heart attack, highlighting the role of these receptors in heart protection.
  • Analysis of 1,056 patients showed that those who completed an insurance-mandated weight management program before bariatric surgery had 34.4% weight loss compared to 36.6% without the program at 36 months.
  • A study on CA-125 test accuracy indicated that it predicted a higher chance of ovarian cancer in Asian and Black women, but this difference vanished after considering other health factors.
  • In a study of COVID-19 patients requiring prolonged mechanical ventilation, 44% died within 30 days, with better survival rates linked to fewer pre-existing health issues.

Frequently asked questions

Does Dr. Kirkland study heart disease?
Yes, he focuses on understanding heart cell changes after heart attacks and other aspects of heart health.
What treatments has Dr. Kirkland researched?
He has researched various treatments related to heart health, cancer diagnostics, and weight management prior to bariatric surgery.
Is Dr. Kirkland's work relevant to cancer patients?
Absolutely, his studies on ovarian cancer diagnostics and treatment insights are aimed to improve outcomes for cancer patients.
What training methods does Dr. Kirkland promote?
He promotes innovative training methods like escape room simulations to enhance teamwork and decision-making in critical medical procedures.
How can Dr. Kirkland's research help college students?
His study on mindfulness micro-interventions aims to strengthen resilience and well-being among college students during their studies.

Publications in plain English

Extracorporeal membrane oxygenation escape room simulation teamwork dynamics and effectiveness.

2026

Perfusion

Vidovich C, Tsutsui S, Kirkland L, Corroto C, Palettas M +2 more

Plain English
This study investigated how effective escape room-style simulations are for training medical teams in using extracorporeal membrane oxygenation (ECMO), a complex procedure that requires strong teamwork. Thirty-seven nurses participated, and the results showed that better teamwork led to faster completion times, with observer ratings indicating that stronger communication and decision-making were linked to efficiency. Additionally, all participants reported they improved their knowledge and skills regarding ECMO, highlighting the potential of this engaging training method. Who this helps: This benefits nurses and healthcare teams who handle ECMO procedures.

PubMed

Evaluation of curricular mindfulness micro-interventions to support college student resilience: a pilot study.

2025

Journal of American college health : J of ACH

Lee S, Umeda C, Tucker-Roghi G, Rosenberg BD, Gutierrez K +2 more

Plain English
This study looked at whether short mindfulness activities, called micro-interventions, can be easily added to college classes and how students and teachers feel about them. Researchers found that the micro-interventions were easy to implement, and 267 students reported feeling positively affected by the activities. This is important because it shows that such interventions can help strengthen students' resilience and well-being during their college experience. Who this helps: This benefits college students and their teachers.

PubMed

Novel insights into post-myocardial infarction cardiac remodeling through algorithmic detection of cell-type composition shifts.

2025

PLoS genetics

Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J +9 more

Plain English
This study looked at how heart cells change after a heart attack, focusing on a specific type of receptor in mice. Researchers used advanced computer techniques to analyze cell types in heart tissue and found that mice without these receptors lost more heart muscle cells and gained more other cells compared to normal mice. The findings show that understanding these cell changes is important for better understanding heart injuries and highlights how specific receptors can protect the heart. Who this helps: This benefits patients recovering from heart attacks and their doctors by improving insights into heart repair processes.

PubMed

Improving the spatial and temporal resolution of burden of disease measures with Bayesian models.

2024

Spatial and spatio-temporal epidemiology

Hogg J, Staples K, Davis A, Cramb S, Patterson C +4 more

Plain English
This study looked at ways to improve how health data is analyzed, specifically focusing on the burden of diseases like asthma and coronary heart disease. By using advanced statistical methods called Bayesian models, the researchers found that these methods could provide more accurate and detailed health information for smaller areas across Australia. This matters because better data helps health officials make informed decisions and allocate resources effectively. Who this helps: This helps health departments and policymakers in targeting interventions for diseases.

PubMed

Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts.

2024

bioRxiv : the preprint server for biology

Gural B, Kirkland L, Hockett A, Sandroni P, Zhang J +9 more

Plain English
This research investigated how changes in the types of cells in the heart after a heart attack can affect disease progression. The study found that even a small change in the number of heart cells (10%) could lead to inaccurate results, with over 25% of measured changes being wrong. By using a new algorithm to analyze heart cell composition more accurately, the researchers discovered that when certain genes were adjusted for cell types, it highlighted new important genes linked to heart function and potential heart disease pathways. Who this helps: Patients at risk for heart disease and heart failure, as well as their doctors.

PubMed

The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data.

2024

Journal of ovarian research

Barlow M, Down L, Mounce LTA, Funston G, Merriel SWD +5 more

Plain English
This study looked at how well the CA-125 blood test can detect ovarian cancer in women from different ethnic backgrounds in England. Researchers found that while Asian and Black women had higher CA-125 levels compared to White women at similar cancer risks, using different thresholds for different ethnicities may improve certain test results but could miss some cancer cases. This is important because it highlights the need for standardized testing for all women to ensure they receive the best care possible. Who this helps: This helps patients, particularly women undergoing tests for ovarian cancer, by ensuring they receive equitable and accurate diagnostic care.

PubMed

Insurance-mandated weight management program completion before bariatric surgery provides no long-term clinical benefit.

2023

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Hutcheon DA, Ewing JA, St Ville M, Miller M, Kirkland L +2 more

Plain English
This study looked at whether completing a weight management program required by insurance before bariatric (weight loss) surgery leads to better long-term weight loss results. The researchers examined 1,056 patients who had either gastric bypass or sleeve gastrectomy surgeries and found that those who completed the program did not lose more weight over time compared to those who didn’t. In fact, without the program, patients lost slightly more weight: 34.4% versus 29.8% for gastric bypass and 21.4% versus 18.2% for sleeve gastrectomy at 36 months. Who this helps: This information benefits patients seeking bariatric surgery by highlighting that they can bypass unnecessary weight loss programs and get quicker access to surgery.

PubMed

Value of a national burden-of-disease study: a comparison of estimates between the Australian Burden of Disease Study 2015 and the Global Burden of Disease Study 2017.

2022

International journal of epidemiology

Zhao C, Choi C, Laws P, Gourley M, Dobson A +4 more

Plain English
This study compared two major health assessments: Australia’s Burden of Disease Study from 2015 and the Global Burden of Disease Study from 2017. It found that the Global Study reported higher figures for years of life lost and years lived with disability, mainly due to differences in how deaths were categorized and the data used. Understanding these differences helps inform health policy and improve services, ensuring that health decisions are based on accurate and thorough data. Who this helps: Patients and healthcare policymakers.

PubMed

Prognostic factors and outcomes in COVID-19 patients requiring prolonged mechanical ventilation: a retrospective cohort study.

2022

Therapeutic advances in respiratory disease

Melamed R, Paz F, Jepsen S, Smith C, Saavedra R +6 more

Plain English
This study looked at patients with COVID-19 who needed mechanical ventilation for more than 17 days to understand their health outcomes and factors affecting their survival. Out of 355 patients, 86 (24%) required prolonged mechanical ventilation, and about 44% of these patients died within 30 days after starting treatment. The findings indicate that patients with less severe lung function and fewer pre-existing health issues had better chances of survival, highlighting the challenges and resource needs in treating seriously ill COVID-19 patients. Who this helps: This information is valuable for doctors managing COVID-19 patients who require intensive care.

PubMed

Spirotetramat resistance in Myzus persicae (Sulzer) (Hemiptera: Aphididae) and its association with the presence of the A2666V mutation.

2022

Pest management science

Umina PA, Bass C, van Rooyen A, Chirgwin E, Arthur AL +4 more

Plain English
This study focused on how the aphid pest Myzus persicae has developed resistance to a new chemical pesticide called spirotetramat. Researchers found a specific gene mutation, A2666V, that is linked to this resistance, and noted that resistant aphids also show cross-resistance to other similar insecticides. This matters because understanding this resistance can help improve pest management strategies and ensure that farmers can effectively protect their crops from these damaging pests. Who this helps: Farmers and agricultural specialists who need effective solutions for managing aphid infestations.

PubMed

Evolution of non-fatal burden estimates for cardiovascular disease in Australia: a comparison of national and state-wide methodology of burden of disease.

2022

Australian health review : a publication of the Australian Hospital Association

Weber C, Hobday M, Sun W, Kirkland L, Nedkoff L +1 more

Plain English
This research studied how different methods for estimating the prevalence of cardiovascular diseases in Australia—such as stroke and heart valve issues—might affect the reported numbers. They found that estimates varied widely depending on the method used: for example, one method reported aortic aneurysms as being eight times more common than another method. These differences can significantly influence healthcare policy and resource allocation. Who this helps: This benefits public health officials and policymakers by providing better data for decision-making.

PubMed

: Evolution of non-fatal burden estimates for cardiovascular disease in Australia: a comparison of national and state-wide methodology of burden of disease.

2022

Australian health review : a publication of the Australian Hospital Association

Weber C, Hobday M, Sun W, Kirkland L, Nedkoff L +1 more

Plain English
This study looked at how different methods of estimating the prevalence of cardiovascular diseases in Australia, like strokes and heart conditions, affect the numbers we get. It found that one method predicted aortic aneurysm cases to be eight times more common than another method, while estimates for stroke were up to one-third higher in some models compared to others. These findings are crucial because accurate disease estimates help inform government health policies and improve patient care. Who this helps: This helps patients and healthcare policymakers by providing better information for planning services and treatments.

PubMed

Using RNA-seq to characterize pollen-stigma interactions for pollination studies.

2021

Scientific reports

Lobaton J, Andrew R, Duitama J, Kirkland L, Macfadyen S +1 more

Plain English
This study focused on understanding how pollen from honey bees affects apple flower pollination by using advanced RNA sequencing techniques. The researchers found that at least 10 visits from honey bees are needed to achieve a 25% chance of producing fruit, and they identified three key indicators that show successful pollination through changes in gene expression. This research matters because it helps improve crop yields and supports the management of pollinator-dependent crops. Who this helps: This helps farmers and agricultural scientists.

PubMed

Pollen tube growth from multiple pollinator visits more accurately quantifies pollinator performance and plant reproduction.

2020

Scientific reports

Stavert JR, Bailey C, Kirkland L, Rader R

Plain English
This research studied how different numbers of visits from pollinators, like bees, affect the ability of apple flowers to produce fruit and seeds. It found that a single visit didn’t lead to successful fertilization or fruit production, while multiple visits often resulted in the growth of pollen tubes that could fertilize the flowers, leading to successful fruit and seed production. This is important because it helps identify which pollinators are most effective for the reproduction of plants, particularly in crops like apples. Who this helps: This helps farmers and agricultural scientists improve crop yields by understanding the importance of multiple pollinator visits.

PubMed

Evaluating the taxa that provide shared pollination services across multiple crops and regions.

2019

Scientific reports

Willcox BK, Howlett BG, Robson AJ, Cutting B, Evans L +6 more

Plain English
This study looked at the different types of pollinators that visit avocado, mango, and macadamia crops and how effective they are in helping these plants grow. Researchers found that out of 13,200 floral visits, two main types of bees and a fly were the most common visitors, with significant differences in their effectiveness across different sites and years. Understanding which pollinators are most helpful can lead to better ways to manage and support these beneficial insects, ultimately improving crop production. Who this helps: This benefits farmers and agricultural workers by enhancing crop yields.

PubMed

Improving patient flow in pre-operative assessment.

2015

BMJ quality improvement reports

Stark C, Gent A, Kirkland L

Plain English
This study looked at how to improve the efficiency of the pre-operative assessment process, where patients are evaluated before surgery. After implementing changes like streamlining the patient flow, reducing the number of referral routes, and improving room usage, the average wait time decreased from 79 minutes to 59 minutes. Additionally, fewer patients had to return for follow-up assessments, dropping from 10% to 0% within the review period, which enhances the overall patient experience. Who this helps: This benefits patients preparing for surgery by reducing wait times and making the process smoother.

PubMed

Isotope ratios of H, C, and O in CO2 and H2O of the martian atmosphere.

2013

Science (New York, N.Y.)

Webster CR, Mahaffy PR, Flesch GJ, Niles PB, Jones JH +442 more

Plain English
This study looked at the chemical composition of Mars' atmosphere, specifically the ratios of different types of hydrogen, carbon, and oxygen found in carbon dioxide and water. Researchers found that the Martian atmosphere has not changed much since the planet was young, around 4 billion years ago, but there is still evidence suggesting the atmosphere is losing gas or interacting with the surface today. Understanding these processes is important because it informs us about Mars' history and its potential to support life. Who this helps: This benefits scientists studying Mars and those interested in planetary science and potential future explorations.

PubMed

The attitudes and knowledge of medical students towards surrogacy.

2009

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Bruce-Hickman K, Kirkland L, Ba-Obeid T

Plain English
This study looked at how medical students in the UK feel about and understand surrogacy, a method of assisted reproduction. Out of 185 students surveyed, 72.2% supported surrogacy, but only 28.7% correctly identified the surrogate as the legal mother. This matters because it highlights gaps in medical knowledge about surrogacy laws, which could affect how future doctors advise patients on these matters. Who this helps: This helps future doctors and their patients considering surrogacy.

PubMed

Pay for performance in critical care: an executive summary of the position paper by the Society of Critical Care Medicine.

2009

Critical care medicine

Egol A, Shander A, Kirkland L, Wall MH, Dorman T +10 more

PubMed

A simulated airway management curriculum.

2004

Medical education

Ashton R, Kennedy C, Kirkland L

PubMed

Pulmonary embolism: even your patient is at risk.

2001

Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses

Mendez-Eastman S, Shields M, Kirkland L

Plain English
This research examined the risks of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing plastic surgery, particularly facelifts. The study found that DVT occurs in about 0.39% and PE in about 0.16% of these patients. Despite being rare in this context, PE is a serious condition and is the third leading cause of death in the U.S., highlighting the need for healthcare professionals to be aware of these risks. Who this helps: Patients undergoing plastic surgery and their healthcare providers.

PubMed

Effects of ventilator resetting on indirect calorimetry measurement--the importance of patience.

1999

Critical care medicine

Kirkland L

PubMed

Neuromuscular paralysis and withdrawal of mechanical ventilation.

1994

The Journal of clinical ethics

Kirkland L

PubMed

Achieving healthy weights.

1993

Canadian family physician Medecin de famille canadien

Kirkland L, Anderson R

Plain English
This study looked at the effectiveness of traditional dieting for weight loss. It found that only 5% of people who try to diet successfully achieve permanent weight loss, leading to various health issues. Instead, the research highlights the need for better methods that encourage enjoyable and small changes towards healthier eating and living. Who this helps: This benefits patients who struggle with dieting and seek healthier lifestyle changes.

PubMed

Taxing health benefits: snake oil ... or smart health policy?

1993

The Journal of American health policy

Kirkland L, Havighurst CC

Plain English
This study looked at the impact of taxing employer-paid health benefits on workers' wages. It found that while some experts believe taxing these benefits could improve health policies, labor groups worry it would unfairly hurt workers who are already struggling with low wages. Understanding the effects of this tax policy is crucial because it influences the financial health of many employees and their access to affordable healthcare. Who this helps: This helps workers and their families who rely on employer health benefits.

PubMed

A labor leader's view of insurance reform.

1991

Health affairs (Project Hope)

Kirkland L

PubMed

Coronary artery bypass grafting in a predominately black group of patients.

1987

Journal of the National Medical Association

Peniston RL, Miles N, Lowery RC, Kirkland L, Landes FS +5 more

Plain English
This study looked at 163 patients, mostly black, who underwent heart surgery called coronary artery bypass grafting between 1983 and 1986. It found that a high 74% of these patients had high blood pressure, 35% had diabetes, and many were obese or had a history of smoking. The results showed that while these patients had common risk factors for heart disease, their surgery had a relatively low immediate death rate of 4%, highlighting the importance of understanding different health profiles in different racial groups. Who this helps: This helps patients and healthcare providers by improving awareness of how to manage heart disease in diverse populations.

PubMed

Health physics aspects of the EMI computerized tomography brain scanner.

1978

Health physics

Villafana T, Scouras J, Kirkland L, McElroy N, Paras P

PubMed

Health care's enduring crisis.

1978

The AFL-CIO American federationist. AFL-CIO

Kirkland L

PubMed

Labor's point of view on HMOs.

1975

Public health reports (Washington, D.C. : 1974)

Kirkland L

PubMed

Chronic primary chylopericardium. Report of a case and review of the literature.

1967

Circulation

Fawal IA, Kirkland L, Dykes R, Foster GL

PubMed

Frequent Co-Authors

Wendy Sun Romina Rader Brian Gural Peyton Sandroni Jiandong Zhang Manuel Rosa-Garrido Samantha K Swift Michael A Flinn Caitlin C O'Meara Thomas M Vondriska

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.