LINDA ELLEN JAFFE, MD

ORLANDO, FL

Research Active
Internal Medicine - Cardiovascular Disease NPI registered 21+ years 46 publications 1968 – 2025 NPI: 1073517439
MiceGene ExpressionRNA, MessengerCalciumCurriculumHistory, 20th CenturyDNAWound HealingAthletic InjuriesSportsOccupational Therapybeta 2-MicroglobulinEmbryo, MammalianPsychoanalysisPsychoanalytic Therapy

Practice Location

1222 S ORANGE AVE
ORLANDO, FL 32806-1215

Phone: (407) 650-1300

What does LINDA JAFFE research?

Dr. Jaffe's primary focus is on ensuring that occupational therapy practitioners are well-equipped to manage medications effectively. She studies how education and training in medication management can prevent errors that may harm patients. Additionally, her work includes examining the effectiveness of occupational therapy interventions for adults with serious mental illnesses, and innovative surgical techniques for patients with severe ankle damage. By investigating these areas, she aims to enhance the standard of care for patients and improve their quality of life.

Key findings

  • In a study with 20 occupational therapy practitioners, it was found that better training on medication management is needed, as 24% do not include this critical aspect in their practice.
  • A report on acute ischemic stroke patients showed that younger patients under 65 had a recovery rate of 64% with catheter-based therapy, compared to 36% for those 65 and older.
  • Occupational therapy interventions significantly improved social skills in adults with serious mental illness, with social skills training proving to be highly effective.

Frequently asked questions

Does Dr. Jaffe study medication management?
Yes, Dr. Jaffe studies how occupational therapy practitioners can improve their training and practices in medication management to ensure safer care for patients.
What treatments has Dr. Jaffe researched?
Dr. Jaffe has researched various treatments, including occupational therapy interventions for serious mental illnesses and a combination of ankle replacement and tendon transfer surgeries for severe foot issues.
Is Dr. Jaffe's work relevant to stroke patients?
Yes, her research on catheter-based therapy for acute stroke provides crucial insights into recovery outcomes for stroke patients.

Publications in plain English

Understanding the Need for Medication Management Education: A Qualitative Analysis.

2025

Occupational therapy in health care

Allen DD, Jaffe L

Plain English
This study looked at how occupational therapy practitioners manage medications and what they need to improve in this area. Researchers interviewed 20 practitioners and found that they need better training and education on medication management, as well as more standard practices to follow. This is important because improving medication management can prevent serious errors that harm patients. Who this helps: This helps patients and their caregivers by ensuring better and safer medication management.

PubMed

A Survey of Medication Management in Occupational Therapy Practice.

2024

Occupational therapy in health care

Allen DD, Jaffe L

Plain English
This study looked at how occupational therapists handle medication management in their practice by surveying professionals. While most therapists agreed that medication management is important, 24% of them actually don't include it in their work. The study highlights the need for more training and awareness about medication management among occupational therapists to ensure better patient care. Who this helps: Patients receiving care from occupational therapists.

PubMed

ψ(2S) Suppression in Pb-Pb Collisions at the LHC.

2024

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1026 more

Plain English
This study looked at the production of the ψ(2S) particle in lead-lead (Pb-Pb) collisions at high energy using the ALICE experiment at the LHC. Researchers found that the ψ(2S) particle is significantly less produced in these collisions compared to the J/ψ particle, being suppressed by about a factor of 2. Additionally, the ψ(2S) was found to be suppressed by up to a factor of 3 when compared to proton-proton (pp) collisions. This information is crucial because it helps scientists understand how certain particles behave in extreme conditions, like those found in the quark-gluon plasma, which is created during heavy ion collisions. Who this helps: This benefits researchers studying nuclear physics and particle interactions.

PubMed

Measurement of the J/ψ Polarization with Respect to the Event Plane in Pb-Pb Collisions at the LHC.

2023

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1027 more

Plain English
This study looked at the polarization of a particle called J/ψ created during lead-lead collisions in a particle accelerator. Researchers found that the J/ψ has a small degree of transverse polarization, with a notable measurement at a level of 3.9 standard deviations, especially in collisions with moderate intensity. Understanding this polarization is important because it may provide insights into the quark-gluon plasma—a state of matter that exists at extremely high temperatures and densities. Who this helps: This research helps physicists studying the fundamental properties of matter and the universe.

PubMed

Enhanced Deuteron Coalescence Probability in Jets.

2023

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1035 more

Plain English
This study looked at how (anti)deuterons, which are nuclei made up of two protons and one neutron, behave in high-energy proton-proton collisions at the Large Hadron Collider. Researchers found that the likelihood of these particles combining in jet areas (regions where high-energy fragments of particles are produced) was about ten times higher than in other areas of the collisions. This is important because it helps us understand how nuclear particles form in extreme conditions, enhancing our knowledge of fundamental processes in physics. Who this helps: This research benefits physicists studying particle collisions and nuclear interactions.

PubMed

First Measurement of Antideuteron Number Fluctuations at Energies Available at the Large Hadron Collider.

2023

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1027 more

Plain English
This study looked at how the number of antideuterons (a type of antimatter) varies during high-energy collisions between lead atoms at the Large Hadron Collider. Researchers found a notable connection: as the number of antiprotons increased, the number of antideuterons decreased, showing that these particles are related. This research helps improve our understanding of particle interactions and matter-antimatter production in extreme conditions, which can shed light on the early universe's conditions. Who this helps: This helps physicists and researchers studying the fundamental properties of matter and antimatter.

PubMed

Measurement of the Lifetime and Λ Separation Energy of _{Λ}^{3}H.

2023

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1038 more

Plain English
This study measured how long a specific particle called _{Λ}^{3}H lasts before it decays and the energy required to separate it from its atomic structure. The researchers found that the _{Λ}^{3}H particle has a lifetime of about 253 picoseconds and a separation energy of 102 keV, confirming predictions from theoretical models. These findings improve our understanding of subatomic particles, which can help refine particle physics theories. Who this helps: This benefits researchers studying fundamental particles and their interactions.

PubMed

Measurements of Groomed-Jet Substructure of Charm Jets Tagged by D^{0} Mesons in Proton-Proton Collisions at sqrt[s]=13 TeV.

2023

Physical review letters

Acharya S, Adamová D, Adler A, Aglieri Rinella G, Agnello M +1033 more

Plain English
This study looked at how charm quarks, which are heavy particles, behave during collisions of protons at high energy levels. It found that charm quarks split differently than lighter quarks and gluons, with a steeper pattern in their emissions and fewer large-angle emissions, showing they undergo less disturbance in their paths. This information helps scientists better understand the fundamental processes that govern particle behavior in high-energy physics, which is important for future experiments and theories. Who this helps: This benefits particle physicists and researchers studying fundamental particles.

PubMed

Freud and Therapeutic Action Reconsidered: Current Applications.

2021

Journal of the American Psychoanalytic Association

Jaffe L

PubMed

Dressings, Topical Therapy, and Negative Pressure Wound Therapy.

2019

Clinics in podiatric medicine and surgery

Jaffe L, Wu SC

Plain English
This research paper looks at how different types of wound dressings and treatments affect healing, especially for people with diabetic ulcers. It highlights that proper wound care can significantly improve healing conditions, with studies indicating better outcomes when specific topical therapies are used. This matters because effective wound management can reduce complications and improve the quality of life for patients suffering from diabetes-related wounds. Who this helps: Patients with diabetes and their healthcare providers.

PubMed

Interprofessionalism.

2018

Journal of the American Podiatric Medical Association

Joseph R, Robinson R, Fleischer A, Jaffe L, Joseph A +5 more

Plain English
The research paper discusses the history and role of the Dr. William M. Scholl College of Podiatric Medicine, which was established in 1912 and is now part of Rosalind Franklin University. It highlights how alumni from this college have significantly contributed to advancements in the field of podiatric medicine over the years. This matters because strong educational foundations and ongoing contributions from graduates can improve patient care and treatment outcomes in foot health. Who this helps: Patients receiving care for foot-related issues.

PubMed

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.

2017

BMC pharmacology & toxicology

Todd Milne G, , Sandner P, Lincoln KA, Harrison PC +475 more

PubMed

Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report.

2017

Journal of medical case reports

Smith-Singares E, Boachie JA, Iglesias IM, Jaffe L, Goldkind A +1 more

Plain English
This report describes a rare case of a severe leg infection caused by a type of bacteria called Fusobacterium necrophorum, which typically affects other parts of the body. A 50-year-old homeless man experienced extreme pain in his leg, leading to emergency surgery to save his limb. This case is the first of its kind reported and highlights that Fusobacterium should now be considered when diagnosing serious leg infections, as it could cause significant harm if untreated. Who this helps: This helps doctors and healthcare providers better identify and treat severe infections in patients.

PubMed

Predictors of outcomes following catheter-based therapy for acute stroke.

2015

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Htyte N, Parto P, Ragbir S, Jaffe L, White CJ

Plain English
This study looked at patients with acute ischemic stroke who received catheter-based therapy (CBT) to restore blood flow when they couldn't get timely treatment with a clot-busting drug. It found that younger patients (under 65) had a better chance of recovery, with 64% reaching a good neurologic outcome, compared to only 36% of older patients (65 and over). The research showed that achieving good blood flow (TICI score of 2 or more) after the procedure was critical, resulting in 57% of patients who achieved this experiencing good outcomes, while only 17% did without it. Who this helps: This benefits stroke patients and the doctors treating them.

PubMed

Process-oriented guided-inquiry learning: a natural fit for occupational therapy education.

2015

Occupational therapy in health care

Jaffe L, Gibson R, D'Amico M

Plain English
This paper examines a teaching method called Process-Oriented Guided-Inquiry Learning (POGIL) for occupational therapy education. The study found that using POGIL improved students' critical thinking, memory of the material, and ability to work in teams. This is important because better-trained occupational therapy students can provide higher-quality care to their future patients. Who this helps: This benefits occupational therapy students and their future patients.

PubMed

Combined total ankle replacement and modified bridle tendon transfer for end-stage ankle joint arthrosis with paralytic dropfoot: report of an unusual case.

2011

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Bibbo C, Baronofsky HJ, Jaffe L

Plain English
This study looked at a unique approach to treat a patient with severe ankle damage and paralysis affecting their foot movement. The researchers combined two procedures: a total ankle replacement and a modified surgery to reposition the tendons, which helped stabilize the foot. This combination can significantly improve mobility in patients who would otherwise not benefit from traditional surgery, enhancing their quality of life. Who this helps: This helps patients with severe ankle joint damage and foot drop due to paralysis.

PubMed

Occupational therapy interventions for recovery in the areas of community integration and normative life roles for adults with serious mental illness: a systematic review.

2011

The American journal of occupational therapy : official publication of the American Occupational Therapy Association

Gibson RW, D'Amico M, Jaffe L, Arbesman M

Plain English
This study looked at how effective occupational therapy is for helping adults with serious mental illnesses improve their social skills, daily living skills, and overall community involvement. The findings showed that social skills training is quite effective, while life skills training and daily living assistance training show moderate effectiveness. Notably, combining cognitive training with skills training can also help with work and social participation. Who this helps: This benefits adults with serious mental illnesses and the therapists working to support their recovery.

PubMed

Mental health evidence in the American Journal of Occupational Therapy.

2010

The American journal of occupational therapy : official publication of the American Occupational Therapy Association

D'Amico M, Jaffe L, Gibson RW

Plain English
This study looked at mental health articles published in the American Journal of Occupational Therapy between 2008 and 2009 to see how well they supported real-world therapy practice. Out of seven articles reviewed, only two specifically tested the effectiveness of occupational therapy for mental health, with one rated as moderately strong evidence (Level II) and the other as weaker evidence (Level V). This shows that while there is some research in this area, much more is needed to provide solid backing for occupational therapy practices in mental health. Who this helps: Patients with mental health conditions benefiting from occupational therapy.

PubMed

Complications of digital and lesser metatarsal surgery.

2010

Clinics in podiatric medicine and surgery

Bibbo C, Jaffe L, Goldkind A

Plain English
This study looked at the complications that can happen after surgeries on the toes and smaller bones in the foot. It found that these complications can arise from various issues, such as the patient's overall health or the surgery itself. Understanding these risks and how to prevent or manage them is crucial for successful outcomes, helping to improve patient care. Who this helps: This helps patients undergoing foot surgery and the doctors who treat them.

PubMed

The discovery of calcium waves.

2006

Seminars in cell & developmental biology

Jaffe L

PubMed

Cell polarity: don't forget calcium's role.

2005

BioEssays : news and reviews in molecular, cellular and developmental biology

Jaffe L

PubMed

Response to paper by Henry Harris.

2005

BioEssays : news and reviews in molecular, cellular and developmental biology

Jaffe L

PubMed

Analytic training and indirect countertransference.

2003

Journal of the American Psychoanalytic Association

Jaffe L

PubMed

In-patient treatment of substance abuse.

2002

The International journal of psycho-analysis

Greive P, Jaffe L

PubMed

On the conservation of fast calcium wave speeds.

2002

Cell calcium

Jaffe L

Plain English
This study looked at how quickly calcium waves move in different types of cells, from fish eggs to human cells. It found that these fast calcium waves travel at similar speeds across various organisms—about 10 to 30 micrometers per second depending on the activity of the cells. Understanding these speeds is important because it helps scientists learn how cells communicate and respond to each other, which has implications for many biological processes and diseases. Who this helps: This helps researchers studying cell biology and diseases.

PubMed

Countertransference, supervised analysis, and psychoanalytic training requirements.

2001

Journal of the American Psychoanalytic Association

Jaffe L

Plain English
This study looked at how psychoanalysts and their patients influence each other during therapy sessions. It found that trainee psychoanalysts experience more complex emotional responses, known as "countertransference," due to their training environment, which can affect their therapy effectiveness. For example, the author provided four specific cases showing how these indirect responses can arise at different stages of therapy. Understanding these dynamics is important for improving training programs and ultimately the quality of patient care. Who this helps: This helps psychoanalytic trainees, their supervisors, and ultimately the patients they will serve.

PubMed

Supervision as an intersubjective process: hearing from candidates and supervisors.

2000

Journal of the American Psychoanalytic Association

Jaffe L

PubMed

A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.

1997

Genes & development

Jaffe L, Ryoo HD, Mann RS

Plain English
The study investigated how a specific protein called Antennapedia (ANTP) in fruit flies is affected by a process called phosphorylation, which is carried out by an enzyme known as casein kinase II (CKII). Researchers found that a modified version of ANTP that couldn't be phosphorylated caused severe issues in developing body parts, while another version that pretended to be always "on" actually worked much worse. This matters because it helps us understand how ANTP’s activity is controlled during early development, which is crucial for ensuring proper body formation. Who this helps: This helps researchers studying developmental biology and genetic disorders.

PubMed

Perspectives of an orthopaedist team physician.

1994

Bailliere's clinical rheumatology

Jaffe L

PubMed

The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

1994

Cell

Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS

Plain English
This study examined how a protein called Ultrabithorax (Ubx) interacts with another protein, extradenticle (exd), to better bind to specific DNA segments. Researchers found that when Ubx works with exd, it increases Ubx's ability to attach to certain DNA sequences, making it more effective than the related protein Antennapedia (Antp) in this regard. These interactions are important because they help determine how different genes influence the development of specific body patterns in fruit flies, showing that their effects can be shaped by the presence of other proteins. Who this helps: This benefits researchers studying gene regulation and development in various organisms.

PubMed

Predictors of repeat pregnancy outcome among black and Puerto Rican adolescent mothers.

1992

Journal of developmental and behavioral pediatrics : JDBP

Linares LO, Leadbeater BJ, Jaffe L, Kato PM, Diaz A

Plain English
This study looked at the factors that influence whether young mothers from inner-city areas have another baby within a year after their first child. Researchers found that mothers who had therapeutic abortions were more likely to have had earlier pregnancies and more delays in their schooling compared to those who had no repeat pregnancies. Specifically, 41% of those who had therapeutic abortions faced these issues, while only 15% of those with no repeat pregnancy did. This matters because understanding these challenges can help provide better support and resources to young mothers, ultimately improving their educational success and well-being. Who this helps: Patients, specifically young mothers facing similar circumstances.

PubMed

Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.

1992

Proceedings of the National Academy of Sciences of the United States of America

Jaffe L, Robertson EJ, Bikoff EK

Plain English
This study looked at how high levels of a specific protein called H-2Dd affect the development of embryos. Researchers found that when they artificially increased H-2Dd in embryonic stem cells, the embryos developed normally at first but ultimately failed around the halfway point of pregnancy. This matters because it reveals that too much of this protein can harm embryo development, which could help us understand pregnancy complications. Who this helps: This helps scientists and medical professionals understand the factors that affect embryo health during pregnancy.

PubMed

Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development.

1991

Journal of immunology (Baltimore, Md. : 1950)

Jaffe L, Robertson EJ, Bikoff EK

Plain English
This study looked at how certain genes related to immune response develop in mouse embryos. Researchers found that a gene called MHC class I starts being expressed at day 9.5 after conception, while another gene, beta 2-microglobulin, has a different expression pattern. Specifically, MHC class I was only found in certain cells, while beta 2m was not present in some key areas of the developing placenta, showing that these genes are regulated separately. Who this helps: This helps researchers better understand fetal development and immune tolerance, which is important for improving pregnancy outcomes.

PubMed

MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon.

1991

Nature

Bikoff EK, Jaffe L, Ribaudo RK, Otten GR, Germain RN +1 more

Plain English
This study looked at how certain embryonic cells express a protein called MHC class I, which helps the immune system recognize cells. The researchers found that these embryonic cells usually have trouble building this protein on their surface, but can successfully do so when treated with a specific peptide or interferon. Understanding how this works is important because it may help explain why a mother’s immune system does not attack her developing fetus. Who this helps: This benefits researchers studying fetal development and immune tolerance.

PubMed

Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.

1990

Journal of immunology (Baltimore, Md. : 1950)

Jaffe L, Jeannotte L, Bikoff EK, Robertson EJ

Plain English
This study looked at a specific gene, beta 2-microglobulin, in developing mouse embryos and their placentas. Researchers found that this gene starts to be active in tissues related to the placenta and yolk sac early in development, with strong activity observed in the liver around day 9.5. Understanding how this gene works is important because it helps clarify how the mother’s body accepts the embryo as a part of her own and could inform future research on pregnancy and immune responses. Who this helps: This helps researchers studying pregnancy, maternal-fetal interactions, and immune tolerance.

PubMed

Fertilization and ooplasmic movements in the ascidian egg.

1989

Development (Cambridge, England)

Sardet C, Speksnijder J, Inoue S, Jaffe L

Plain English
This study looked at how an ascidian egg moves and changes after being fertilized. Researchers found that right after fertilization, a wave of contraction travels through the egg at a speed of 1.4 microns per second, leading to different parts of the egg moving and dividing. They discovered that some key movements happen shortly before the egg prepares to split, with the last changes taking place around 60-65 minutes after fertilization. Who this helps: This research helps scientists understand the early stages of development in some marine animals, which may benefit developmental biology studies.

PubMed

Preface.

1989

The Biological bulletin

Jaffe L

PubMed

The selected response procedure: a variation on Appelbaum's altered atmosphere procedure for the Rorschach.

1988

Journal of personality assessment

Jaffe L

Plain English
This study introduces a new method called the Selected Response Procedure, which adds an extra step to the Rorschach test, a psychological assessment using inkblots. After taking the test, patients choose an additional response from any card, which helps to reveal deeper insights into their thoughts and feelings. The researchers argue that this approach can give more information about patients’ inner worlds compared to standard testing methods, making it easier for psychologists to understand their emotional states. Who this helps: This benefits psychologists and mental health professionals working with patients.

PubMed

Martial arts: a perspective on their evolution, injuries, and training formats.

1988

Orthopaedic review

Jaffe L, Minkoff J

Plain English
This study looked at martial arts to understand how they have changed over time, the injuries people get while practicing them, and how training is organized. It found that many injuries happen during tournaments, especially among children, but most of these injuries could be avoided with the right protective gear and by reducing the level of contact during matches. This is important because it highlights how better safety practices can help keep young martial artists healthier and prevent unnecessary injuries. Who this helps: This helps children who practice martial arts, their parents, and coaches.

PubMed

Computed tomography (CT) arthrography of shoulder instabilities in athletes.

1988

The American journal of sports medicine

Rafii M, Minkoff J, Bonamo J, Firooznia H, Jaffe L +2 more

Plain English
This study looked at 60 athletes who had ongoing shoulder pain that affected their sports performance and didn't improve with standard treatments. The researchers used a special imaging technique called CT arthrography to find out what was wrong with their shoulders. They discovered that 17 athletes had significant shoulder instability linked to specific types of tears in their joint, and the CT scans accurately identified these issues in 95% of cases. This is important because it helps doctors effectively diagnose shoulder problems, allowing for better treatment options. Who this helps: This helps athletes and doctors by providing a clear understanding of shoulder injuries.

PubMed

Limited posterolateral surgical approach to the knee for excision of osteoid osteoma.

1987

Clinical orthopaedics and related research

Minkoff J, Jaffe L, Menendez L

Plain English
This study looked at an 18-year-old man's long-standing knee pain caused by a small tumor called an osteoid osteoma, which was difficult to detect and access. Using advanced imaging and careful surgical techniques, doctors were able to remove the tumor by taking out a small piece of bone measuring just 15 mm³. This is important because it highlights the challenges in diagnosing this tumor and the need for proper imaging, as earlier misdiagnoses included common knee issues like a torn meniscus. Who this helps: This benefits patients with unexplained knee pain and their doctors.

PubMed

Simple technique for removing impacted guide pin.

1986

Orthopaedic review

Jaffe L

PubMed

On electrical currents in development.

1986

BioEssays : news and reviews in molecular, cellular and developmental biology

Nuccitelli R, Robinson K, Jaffe L

PubMed

The importance of drug use histories in a series of alcoholics.

1981

The Journal of clinical psychiatry

Jaffe L, Schuckit MA

Plain English
This study looked at the drug use histories of 163 male alcoholics to see how substance misuse and antisocial behavior relate to alcoholism. It found that 71% were primarily alcoholics with no major drug issues except for marijuana use, 18% misused multiple drugs, and 11% had antisocial personality traits. Those with both antisocial behavior and alcoholism faced the most severe issues related to drugs and alcohol, while multi-drug users had challenges that were more serious than primary alcoholics but less severe than those with antisocial traits. Who this helps: This research benefits doctors and treatment providers who work with alcoholics to better understand and address their patients’ needs.

PubMed

Terminal candor and the coda syndrome.

1976

The American journal of nursing

Jaffe L, Jaffe A

PubMed

Continuing education.

1968

Archives of dermatology

Jaffe L

PubMed

Frequent Co-Authors

R Singh J Kim S Chattopadhyay P Das B Singh M Ivanov S Sharma Andreas Friebe S Acharya

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.