Does Dr. Maliner study brain tumors?

Yes, Dr. Maliner's research is specifically focused on brain tumors and how photodynamic therapy affects both tumors and healthy brain tissue.

What are the risks associated with photodynamic therapy in the brain?

His research indicates that certain dosages, like 4 mg of Photofrin per kilogram, can cause significant and harmful effects to healthy brain structures, emphasizing the importance of determining safe dosage levels.

LLOYD IAN MALINER, M.D.

PLANTATION, FL

Research Active

Neurological Surgery NPI registered 21+ years 2 publications 1994 – 2000 NPI: 1255336863

Neurological Surgery

RatsRats, Sprague-DawleyPhotochemotherapyMagnetic Resonance ImagingBrainCatheterization, Central VenousIatrogenic DiseaseBlood-Brain BarrierPneumocephalusDihematoporphyrin EtherLasers

Practice Location

301 NW 84TH AVE
PLANTATION, FL 33324-1807

Phone: (954) 862-7099

What does LLOYD MALINER research?

Dr. Maliner studies photodynamic therapy, a treatment that uses light-activated drugs to destroy cancer cells, particularly focusing on how it affects healthy brain tissue. By examining the reactions of normal rat brains to this therapy, he aims to establish the safe limits of drug dosages when treating brain tumor patients. His work helps identify risks and protects surrounding healthy tissue, which is crucial for effective and safe cancer treatment.

Key findings

A dose of 2 mg of Photofrin per kilogram of body weight resulted in temporary damage to normal rat brains.
A higher dose of 4 mg/kg caused significant and lasting damage, indicating it is unsafe for use in healthy brain tissue.
The study provides critical insights into safe treatment options for patients undergoing PDT for brain tumors.

Frequently asked questions

Does Dr. Maliner study brain tumors?: Yes, Dr. Maliner's research is specifically focused on brain tumors and how photodynamic therapy affects both tumors and healthy brain tissue.
What is photodynamic therapy?: Photodynamic therapy is a treatment method that uses light-activated drugs to destroy cancer cells, and Dr. Maliner studies its effects on brain tissue.
What are the risks associated with photodynamic therapy in the brain?: His research indicates that certain dosages, like 4 mg of Photofrin per kilogram, can cause significant and harmful effects to healthy brain structures, emphasizing the importance of determining safe dosage levels.

Publications in plain English

Iatrogenic pneumocephalus.

2000

Journal of neurosurgery

Maliner L

PubMed

Toxicity of photodynamic therapy with photofrin in the normal rat brain.

1994

Lasers in surgery and medicine

Ji Y, Powers SK, Brown JT, Walstad D, Maliner L

Plain English
This study explored the effects of a treatment called photodynamic therapy (PDT) on healthy rat brains to see how much damage it can cause. Researchers found that a dose of 2 mg of a drug called Photofrin per kilogram of body weight led to temporary harm, while a higher dose of 4 mg/kg caused significant and lasting damage, making it unsuitable for safe use in normal brain tissue. Understanding the toxicity levels of PDT is crucial because it helps determine safe treatment options for brain tumor patients. Who this helps: Patients undergoing brain tumor treatment.

PubMed

Frequent Co-Authors

Y Ji S K Powers J T Brown D Walstad

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.