Practice Location

5400 N OAK TRFY
KANSAS CITY, MO 64118-4688

Phone: (816) 454-1658

What does MARK DEWOLFE research?

Dr. DeWolfe studies the interaction between brain regions that regulate fear and anxiety, specifically how the lateral septum and the amygdala communicate. He explores groundbreaking surgical techniques to aid patients who have undergone significant surgeries, particularly in the head and neck area, and works on improving surgical outcomes for transgender men requiring penile implants.

Key findings

  • In his study on the lateral septum and amygdala, stimulation of the lateral septum reduced amygdala activity, indicating a feedback system for managing fear responses.
  • In reconstructive surgery using the split lateral iliac crest chimera flap, all four cancer patients had successful tissue survival, highlighting the technique's effectiveness in complex surgeries.
  • After using a novel anchoring technique for penile prostheses in transgender men, both patients reported excellent sexual health scores of 23 and 25 out of 25 after 8 and 13 months, respectively.

Frequently asked questions

Does Dr. DeWolfe study anxiety or fear responses?
Yes, he studies the brain regions involved in regulating fear and anxiety, particularly their interactions.
What treatments has Dr. DeWolfe researched?
He has researched surgical techniques for head and neck reconstruction and methods for anchoring penile prostheses in transgender men.
Is Dr. DeWolfe's work relevant to transgender patients?
Yes, his research includes improving the surgical options and outcomes for transgender men seeking penile implant surgery.
How can Dr. DeWolfe's research help patients with cancer?
His work on innovative reconstructive techniques can significantly aid patients recovering from major surgeries related to cancer.
What type of patients benefit from Dr. DeWolfe's surgical techniques?
Patients requiring complex head and neck reconstruction and transgender men needing penile prostheses can benefit from his research.

Publications in plain English

Electrophysiological analysis of the interaction between the lateral septum and the central nucleus of the amygdala.

2012

Neuroscience letters

Thomas E, Dewolfe M, Sancar F, Todi N, Yadin E

Plain English
This study looked at how two brain regions, the lateral septum and the central nucleus of the amygdala, influence each other's activity related to fear and anxiety in rats. When the lateral septum was stimulated, it mainly reduced the activity in the amygdala, while stimulating the amygdala increased the activity in the lateral septum. These findings indicate that these brain regions may work together as a feedback system to help balance fear responses. Who this helps: This helps researchers and clinicians understand the brain's regulation of fear and anxiety, which could lead to better treatments for patients with anxiety disorders.

PubMed

Split lateral iliac crest chimera flap: utility of the ascending branch of the lateral femoral circumflex vessels.

2010

Plastic and reconstructive surgery

Dorafshar AH, Seitz IA, DeWolfe M, Agarwal JP, Gottlieb LJ

Plain English
This study focused on a new method for rebuilding complex areas in the head and neck after major surgery or injury, specifically using a technique called the split lateral iliac crest chimera flap. The researchers worked with four patients who had advanced cancer and needed reconstruction, and they found that all the tissue used successfully survived the procedure. This method effectively provides both bone and soft tissue, which is crucial for restoring function and appearance in patients after their surgeries. Who this helps: This benefits patients requiring complex head and neck reconstructions.

PubMed

Novel technique for proximal anchoring of penile prostheses in female-to-male transsexual.

2009

Urology

Large MC, Gottlieb LJ, Wille MA, DeWolfe M, Bales GT

Plain English
Researchers studied a new method to securely attach inflatable penile prostheses in transgender men, as traditional techniques can be difficult due to anatomical differences. They successfully used a bone drill to create a secure attachment point in the pelvic bone for two patients, both of whom reported outstanding sexual health scores of 23 and 25 out of 25 after 8 and 13 months. This method shows promise for improving the effectiveness and safety of penile implants for transgender men. Who this helps: This benefits transgender men seeking penile prosthesis surgery.

PubMed

Frequent Co-Authors

Lawrence J Gottlieb Earl Thomas Feyza Sancar Nisha Todi Elna Yadin Amir H Dorafshar Iris A Seitz Jayant P Agarwal Michael C Large Mark A Wille

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.