Dr. Fraiman studies conditions primarily related to the urinary and reproductive systems, with a strong emphasis on prostate health and cancer. He examines the effectiveness of advanced treatment methods, such as the Rezūm water vaporization therapy for urinary retention in men and minimally invasive techniques for treating urological cancers. His research also delves into the genetic and molecular aspects of prostate cancer, identifying critical proteins that may influence cancer development. By understanding these conditions and treatments, he aims to improve patient outcomes and in some cases, reduce anxiety related to unusual growths or symptoms.
Key findings
In a study involving 49 men, Rezūm treatment significantly reduced urinary symptom scores from 17 to 4 and decreased residual bladder urine from 900 ml to 78 ml after six months.
BTG2 protein levels were found in about 50% of normal prostate cells but decreased significantly in prostate cancer cases, indicating its role in cancer progression.
In a study on upper urinary tract cancers, 55% of patients had low-grade tumors that were effectively treated without disease progression, highlighting the effectiveness of minimally invasive approaches.
The case of a 75-year-old woman revealed a rare type of liver cancer during a liver transplant, enhancing understanding of cancer risks among patients with autoimmune liver diseases.
Frequently asked questions
Does Dr. Fraiman study prostate cancer?
Yes, he conducts research on the molecular mechanisms behind prostate cancer and its treatment options.
What treatments has Dr. Fraiman researched for urinary conditions?
He has studied the effectiveness of Rezūm water vaporization therapy for urinary retention in men with benign prostatic hyperplasia.
Can Dr. Fraiman's work help patients with kidney or bladder cancer?
Yes, his research into minimally invasive techniques for treating upper urinary tract cancers can help patients with those conditions.
Is Dr. Fraiman involved in research related to liver diseases?
Yes, he has studied the relationship between autoimmune liver diseases and the risk of developing liver cancer.
What impact does Dr. Fraiman's research have on transplant patients?
His studies on immune responses to pig organs aim to improve the success rates of future organ transplants.
Publications in plain English
Rezūm for retention-retrospective review of water vaporization therapy in the management of urinary retention in men with benign prostatic hyperplasia.
2021
The Prostate
Bassily D, Wong V, Phillips JL, Fraiman M, Bauer R +2 more
Plain English This study looked at how well the Rezūm treatment works for men with urinary retention caused by benign prostatic hyperplasia (BPH). Out of 49 men who were initially reliant on catheters, the treatment significantly improved their urinary symptoms, reducing scores on the International Prostate Symptom Score from 17 to 4 and lowering the amount of urine left in the bladder after going to the bathroom from 900 ml to 78 ml after six months. This is important because it shows that Rezūm can be a safe and effective option for men suffering from urinary retention, especially for those who may not be able to undergo more invasive procedures.
Who this helps: This helps men with BPH and urinary retention, especially those who prefer less invasive treatment options.
McNall S, Holmes D, Anderson LA, Fraiman M, Dixon CM
Plain English Researchers studied a case involving a 57-year-old man who developed a large cyst on his penis that grew rapidly to about 7 cm long. Medical imaging indicated it was a cyst, and after surgery to remove it, tests confirmed it was a median raphe cyst, a harmless condition. This matters because it highlights the importance of timely evaluation and treatment for unusual growths, ensuring patients do not suffer from unnecessary anxiety or complications.
Who this helps: This helps patients experiencing similar symptoms.
Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis.
2001
Carcinogenesis
Ficazzola MA, Fraiman M, Gitlin J, Woo K, Melamed J +2 more
Plain English This study focused on a protein called BTG2, which helps control cell growth and can prevent cancer development in prostate cells. Researchers found that BTG2 was present in about 50% of normal prostate cells but was much less common in cancerous cells, with levels decreasing significantly in high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer. This matters because the low levels of BTG2 may contribute to the initiation and progression of prostate cancer, indicating a possible target for therapy.
Who this helps: This helps patients with prostate cancer and those at risk of developing it.
Hepatocellular carcinoma with fibrolamellar pattern in a patient with autoimmune cholangitis.
1999
The Mount Sinai journal of medicine, New York
Singson RC, Fraiman M, Geller SA
Plain English This study looked at a 75-year-old woman with autoimmune cholangitis who needed a liver transplant due to severe liver problems. During the procedure, doctors discovered she had liver cancer, specifically a rare type called fibrolamellar hepatocellular carcinoma, which is uncommon in her condition. Understanding this link is important because it helps improve knowledge about cancer risks in patients with autoimmune liver diseases.
Who this helps: This benefits patients with autoimmune liver diseases and their doctors by highlighting potential cancer risks.
Ureteropyeloscopic diagnosis and treatment of upper urinary tract urothelial malignancies.
1999
Urology
Grasso M, Fraiman M, Levine M
Plain English This study looked at how endoscopic techniques can be used to diagnose and treat cancer in the upper urinary tract, focusing on 20 patients with a specific type of bladder cancer. Researchers found that 55% of the patients had low-grade tumors, which they were able to successfully treat using minimally invasive methods without any progression of the disease. In contrast, patients with high-grade tumors faced a higher risk of disease progression, indicating that more aggressive surgical treatment was necessary for them.
Who this helps: This research benefits patients with upper urinary tract cancers by guiding treatment options based on the severity of their tumors.
Xenoantibodies to pig endothelium are expressed in germline configuration and share a conserved immunoglobulin VH gene structure with antibodies to common infectious agents.
1998
Transplantation
Kearns-Jonker M, Fraiman M, Chu W, Gochi E, Michel J +2 more
Plain English This study looked at how the human immune system reacts to pig organs and tissues, focusing on specific antibodies that are naturally present in the body and may lead to rejection of pig transplants. Researchers found that the genes for these antibodies, which target pig cells, share similar structures with antibodies that attack bacteria and viruses, indicating a common immune response mechanism. This matters because understanding this reaction could improve the chances of successfully using pig organs for human transplants.
Who this helps: This helps patients needing organ transplants.
Dietary calcium and lead interact to modify maternal blood pressure, erythropoiesis, and fetal and neonatal growth in rats during pregnancy and lactation.
1995
The Journal of nutrition
Bogden JD, Kemp FW, Han S, Murphy M, Fraiman M +5 more
Plain English This study looked at how calcium in the diet and exposure to lead affects pregnant rats' blood pressure and the growth of their babies. It found that rats on a low-calcium diet had the highest levels of lead in their blood and organs, which led to reduced blood cell levels and lower growth rates in their pups. Mothers with low calcium who were exposed to lead also had higher blood pressure during pregnancy compared to those without lead or those on a high-calcium diet.
Who this helps: This research helps pregnant women and their unborn children by highlighting the importance of proper calcium intake to reduce lead toxicity.