MARK R. MIKLES, MD

RALEIGH, NC

Research Active
Orthopaedic Surgery NPI registered 21+ years 2 publications 1997 – 2023 NPI: 1316940133
Orthopaedic Surgery Orthopaedic Surgery - Orthopaedic Surgery of the Spine
RadiographyOrthopedicsBone DiseasesMucopolysaccharidosis IVPrenatal Diagnosis

Practice Location

3001 EDWARDS MILL RD STE 200
RALEIGH, NC 27612-5243

Phone: (919) 781-5600

What does MARK MIKLES research?

Dr. Mikles studies how oral enzymes can alleviate pain and inflammation for patients after surgeries, particularly total hip replacements. His recent research showed that a combination of bromelain, trypsin, and rutoside can lead to a significant decrease in inflammation and improved recovery times. Additionally, he has explored the effects of Morquio syndrome, a rare genetic disorder that leads to abnormal growth and skeletal issues. His findings help inform better management strategies for individuals with this condition.

Key findings

  • Patients taking the enzyme combination after total hip replacement surgery had 32% lower levels of inflammation as measured by C-reactive protein.
  • The same patients reported significantly less pain in the week following surgery compared to those receiving a placebo.
  • Understanding Morquio syndrome is essential for managing the growth and skeletal issues it causes, improving the quality of life for those affected.

Frequently asked questions

Does Dr. Mikles study pain relief after surgery?
Yes, he researches how oral enzyme combinations can reduce pain and inflammation in patients after total hip replacement surgery.
What treatments has Dr. Mikles researched?
He has researched the effectiveness of oral enzymes such as bromelain, trypsin, and rutoside for post-operative recovery.
Is Dr. Mikles's work relevant to Morquio syndrome patients?
Yes, his publications address the challenges of managing Morquio syndrome, which affects growth and skeletal development.

Publications in plain English

Oral enzyme combination with bromelain, trypsin and the flavonoid rutoside reduces systemic inflammation and pain when used pre- and post-operatively in elective total hip replacement: a randomized exploratory placebo-controlled trial.

2023

Therapeutic advances in musculoskeletal disease

Vosáhlo J, Salus A, Smolko M, Němcová B, Nordmeyer V +3 more

Plain English
This study looked at whether a combination of oral enzymes (bromelain, trypsin, and rutoside) could help reduce inflammation and pain for patients undergoing total hip replacement surgery. The researchers found that those taking the enzyme combination had 32% lower levels of a marker for inflammation (C-reactive protein) and reported significantly less pain in the first week after surgery compared to those on a placebo. This is important because it suggests that using these enzymes could lead to quicker recoveries and less need for pain medications after surgery. Who this helps: This benefits patients undergoing total hip replacement surgery.

PubMed

A review of Morquio syndrome.

1997

American journal of orthopedics (Belle Mead, N.J.)

Mikles M, Stanton RP

Plain English
This research paper reviews Morquio syndrome, a genetic condition where certain substances build up in the body, causing problems with growth and development. It specifically highlights how this buildup affects the skeleton, leading to issues like shorter limbs, curved spines, and alignment problems in the legs. Understanding these effects is crucial for properly managing the condition and helping affected individuals improve their quality of life. Who this helps: Patients with Morquio syndrome and their doctors.

PubMed

Frequent Co-Authors

Jiří Vosáhlo Adam Salus Michael Smolko Barbora Němcová Veit Nordmeyer Stefanie M Rau Odd Erik Johansen R P Stanton

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.