Dr. Durci studies the effectiveness of different radiation therapy techniques for treating cancers, including those that are difficult to operate on. His research primarily targets patients suffering from pancreatic cancer, liver tumors, lung cancer, and rare types of tumors, such as cardiac angiosarcoma. By investigating therapies like proton beam therapy and stereotactic body radiation therapy, he aims to improve patient outcomes, minimize side effects, and preserve quality of life for those undergoing cancer treatment.
Key findings
In a study on pancreatic cancer patients, proton beam therapy resulted in a median overall survival of 14.6 months, with a low recurrence rate of 81.7% at two years.
For patients with inoperable liver tumors, 91.2% of patients with hepatocellular carcinoma (HCC) achieved good tumor control after one year using hypofractionated proton beam radiotherapy.
In research on early-stage non-small cell lung cancer, 93% of patients diagnosed via biopsy and 94% diagnosed through imaging experienced no local cancer progression after three years.
The local control rate for early-stage lung cancer using helical stereotactic body radiotherapy was 93.6%, with a notable 3-year survival rate of 58.4%.
In a study involving subungual squamous cell carcinoma, patients treated with radiation therapy instead of amputation remained cancer-free for up to 52 months, preserving their fingers' functionality.
Frequently asked questions
Does Dr. Durci study pancreatic cancer?
Yes, Dr. Durci focuses on proton beam therapy for patients with unresectable pancreatic cancer, showing promising survival rates and low recurrence.
What types of cancer treatments has Dr. Durci researched?
He has researched various radiation therapies, including proton beam therapy and stereotactic body radiation therapy, for cancers of the pancreas, liver, and lungs.
Is Dr. Durci's work relevant for patients with liver cancer?
Absolutely, his work on hypofractionated proton beam radiotherapy has shown high tumor control rates for patients with inoperable liver tumors.
Can radiation therapy help avoid surgery for skin cancers?
Yes, Dr. Durci's research indicates that radiation therapy can effectively treat subungual squamous cell carcinoma, allowing patients to avoid amputation.
What are the benefits of the therapies studied by Dr. Durci?
The therapies studied, especially proton beam therapy, offer effective disease control with fewer side effects, making treatments more convenient and feasible for patients.
Publications in plain English
A Ten-Year Patterns of Use Analysis for the World's First Commercial Compact Pencil Beam Scanning Proton Therapy System.
2026
International journal of radiation oncology, biology, physics
Walter YA, Wu HT, Durci M, Katz S, Wang CJ +10 more
Plain English This study looked at how the compact proton therapy system has been used over ten years at a cancer center in Louisiana. They found that from September 2014 to September 2024, 1,382 treatments were given, with 188 treatments in the last year, showing consistent use despite challenges like the COVID-19 pandemic. Most of the patients treated had prostate cancer and lived close to the center, and the study noted a trend towards fewer treatment sessions over time, which can reduce the burden on patients.
Who this helps: This benefits cancer patients by providing effective and accessible treatment options.
Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry.
2023
Advances in radiation oncology
Eckstein J, Choi JI, Lozano A, Ohri N, Press R +15 more
Plain English This study looked at how effective proton beam radiation therapy (PBT) is for patients with advanced pancreatic cancer that cannot be operated on. It involved 19 patients, who received a specific dose of radiation and were monitored for side effects and survival rates. The results showed that most patients tolerated the treatment well, with a median overall survival of about 14.6 months and a low recurrence rate of 81.7% at two years, indicating that PBT can control the disease effectively.
Who this helps: This benefits patients with unresectable pancreatic cancer and their doctors by providing a potentially better treatment option.
Hypofractionated proton beam radiotherapy in patients with unresectable liver tumors: multi-institutional prospective results from the Proton Collaborative Group.
Plain English This study looked at a new type of radiation therapy called hypofractionated proton beam radiotherapy (PBT) for patients with liver tumors that could not be surgically removed. Researchers treated 63 patients and found that 91.2% of patients with hepatocellular carcinoma (HCC) and 90.9% of those with intrahepatic cholangiocarcinoma (ICC) had good control of their tumors after one year. The therapy was effective with low side effects, which is important for patients whose tumors are difficult to treat.
Who this helps: This helps patients with inoperable liver tumors and their doctors.
Comparison of stereotactic body radiation therapy for biopsy-proven versus radiographically diagnosed early-stage non-small lung cancer: a single-institution experience.
2015
Tumori
Fischer-Valuck BW, Boggs H, Katz S, Durci M, Acharya S +1 more
Plain English This study examined the effectiveness of a treatment called stereotactic body radiation therapy (SBRT) for patients with early-stage non-small cell lung cancer (NSCLC), comparing those diagnosed through biopsy to those diagnosed based on imaging. The researchers analyzed the records of 88 patients and found that both groups had similar outcomes: after 3 years, about 93% of biopsy patients and 94% of imaging patients did not have local cancer progression, and the overall survival rates were around 60% for both groups. This is important because it shows that patients who cannot have a biopsy and are diagnosed by imaging can still receive effective treatment.
Who this helps: This helps patients who cannot undergo biopsy, allowing them to access effective cancer treatment.
Helical image-guided stereotactic body radiotherapy (SBRT) for the treatment of early-stage lung cancer: a single-institution experience at the Willis-Knighton Cancer Center.
2014
Tumori
Rosen LR, Fischer-Valuck BW, Katz SR, Durci M, Wu HT +3 more
Plain English This study looked at a specific type of radiation therapy called helical SBRT, used to treat early-stage lung cancer in 79 patients. The results showed that the treatment was highly effective, with a local control rate of 93.6% and a 3-year survival rate of 58.4%. Patients receiving a higher dose of radiation (60 Gy) had better survival rates than those who received a lower dose (65.2% compared to 37.5%).
Who this helps: Patients with early-stage non-small cell lung cancer.
Influence of patient characteristics on survival following treatment with helical stereotactic body radiotherapy (SBRT) in stage I non-small-cell lung cancer.
2013
Thoracic cancer
Fischer-Valuck BW, Durci M, Katz SR, Wu HT, Syh J +3 more
Plain English This study looked at how different patient and tumor characteristics affect survival rates in people with early-stage non-small cell lung cancer treated with a specialized radiation therapy called helical stereotactic body radiotherapy (SBRT). It found that overall survival after three years was 53.4% for all patients, but it varied significantly based on tumor stage—64.4% for those with Stage IA and only 32.1% for Stage IB. Additionally, smaller tumors (less than 30 mm) had better survival rates compared to larger ones. Understanding these factors is important because it helps doctors predict outcomes and tailor treatment plans for patients.
Who this helps: This helps patients with non-small cell lung cancer and their doctors.
SU-E-T-136: Comparison of TomoScanner™ 2D Water Phantom versus IBA Helix for Tomotherapy Profile Measurements.
2012
Medical physics
Patel B, Syh J, Durci M, Rosen L, Katz S +1 more
Plain English This study compared two devices used to measure radiation therapy profiles: the TomoScanner™ 2D Water Phantom and the IBA Helix. Researchers found that the IBA Helix provided measurements closely matching those from the TomoScanner, with differences of less than 1% at various depths, but showed up to 3% variance at a shallow depth. Understanding these differences is crucial for ensuring accurate radiation delivery in cancer treatments.
Who this helps: This research benefits doctors and radiologists who ensure precise radiation treatment for cancer patients.
SU-E-T-135: Investigation of Commercial-Grade Flatbed Scanners and a Medical- Grade Scanner for Radiochromic EBT Film Dosimetry.
2012
Medical physics
Syh J, Patel B, Syh J, Wu H, Rosen L +3 more
Plain English This study examined how well different types of scanners—specifically commercial-grade and medical-grade scanners—work for analyzing radiochromic EBT film used in radiation dose measurement. The researchers tested four scanners and found that the Vidar scanner performed the best overall, with a repeatability uncertainty of just 0.1% and the ability to distinguish between 3.38 optical density levels, while the least effective scanner, the ScanMaker 8700, had a maximum distinguishable level of only 1.32 and a 20% uncertainty in dose ranges. These findings are important because they can help improve the accuracy of radiation dose measurements, which is crucial for patient safety in medical treatments.
Who this helps: This helps patients receiving radiation therapy by ensuring more precise treatment dosages.
Cardiac angiosarcoma treated with resection and adjuvant radiation therapy.
2012
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
Slepicka C, Durci M
Plain English This study looked at a rare and aggressive heart tumor called primary cardiac angiosarcoma, focusing on a 35-year-old woman who had surgery to remove the tumor and followed it up with radiation therapy. Although she initially did well and had no symptoms for eight months, the cancer spread to her bones and other areas after that time. This matters because it highlights the challenges of treating this type of tumor and the high likelihood of it spreading even after initial treatment.
Who this helps: This helps patients with cardiac angiosarcoma and their doctors by providing insights into treatment outcomes.
Subungual squamous cell carcinoma: radiation therapy as an alternative to amputation and review of the literature.
2010
American journal of clinical dermatology
Rosen LR, Powell K, Katz SR, Wu HT, Durci M
Plain English This study looked at three patients aged 46 to 83 who had subungual squamous cell carcinoma, a type of skin cancer under the nail, and were treated with radiation therapy instead of having their finger amputated. All three patients remained cancer-free for up to 52 months, and they were able to fully use their fingers afterward. This research is important because it shows that radiation therapy can effectively treat this type of cancer without the need for amputation, potentially preserving patients' quality of life.
Who this helps: Patients with subungual squamous cell carcinoma who want to avoid amputation.