Graft SurvivalLiving DonorsPreoperative CarePostoperative ComplicationsKidney TransplantationLaparoscopyPancreatic NeoplasmsLength of StayNephrectomyCholecystectomy, LaparoscopicAbdominal MusclesNew South WalesTissue and Organ HarvestingGallstonesAbdominal Wall
Dr. Edye studies various surgical procedures, particularly in the context of weight loss and organ transplantation. He has researched the effectiveness of converting endoscopic sleeve gastroplasty to sleeve gastrectomy for patients who have not achieved desired weight loss, finding that this conversion can lead to successful weight reduction. Additionally, he explores the use of Botulinum toxin A to improve surgeries for complex hernias and looks at the safety measures in kidney donation, making procedures like laparoscopic nephrectomy safer and more efficient. His research also delves into the implications of antibiotic use during surgical procedures and how the immune response to pain can differ between genders.
Key findings
In a study on converting endoscopic sleeve gastroplasty to sleeve gastrectomy, both patients lost weight successfully within one month of surgery.
After implementing electronic health records in a surgical unit, documentation quality improved, and average post-operative hospital stays were reduced from 1.94 days to 1.37 days.
Research on kidney donors showed a 97.1% success rate for kidney function after laparoscopic donor nephrectomy, with an overall complication rate of 9.8% within 30 days.
In a study on pain responses, Dr. Edye found distinct differences in immune responses between men and women after injuries, suggesting personalized treatment approaches may be necessary.
His research on antibiotic stewardship revealed that adherence to prescribing guidelines at two hospitals was alarmingly low, with only 16.5% following appropriate criteria.
Frequently asked questions
Does Dr. Edye study weight loss surgery?
Yes, Dr. Edye studies various aspects of weight loss surgery, including the conversion of endoscopic sleeve gastroplasty to sleeve gastrectomy for patients not achieving desired results.
What is Dr. Edye's work with kidney transplants?
Dr. Edye has researched the safety and effectiveness of laparoscopic donor nephrectomy, finding it significantly increases donor safety and reduces complications.
What kind of surgical techniques does Dr. Edye focus on?
He focuses on minimally invasive surgical techniques, including laparoscopic procedures for hernia repairs and organ donation, as well as improving recovery through better preoperative measures.
Is Dr. Edye's work relevant to pain management?
Absolutely, he investigates how different individuals respond to pain and how treatments can be tailored based on gender differences.
How does Dr. Edye's research affect postoperative care?
His research has led to improved documentation and processes in surgical units, ultimately resulting in shorter recovery times and better patient outcomes.
Publications in plain English
Implementation of electronic health records systems in surgical units and its impact on performance.
2020
ANZ journal of surgery
Liu ZY, Edye M
Plain English This study looked at how electronic health records (EHR) systems affected the quality of patient documentation and clinical performance in a surgical unit at Blacktown Hospital. After implementing the EHR, documentation quality improved significantly, with scores rising by 9 points, and patients experienced shorter post-operative hospital stays, dropping from an average of 1.94 days to 1.37 days. This matters because better documentation and quicker recovery times can lead to more efficient healthcare and improved patient outcomes.
Who this helps: This benefits patients undergoing surgery and the healthcare providers involved in their care.
Reversal of endoscopic sleeve gastroplasty and conversion to sleeve gastrectomy - Two case reports.
2020
International journal of surgery case reports
Cheng Q, Tree K, Edye M, Devadas M
Plain English This study looked at two patients who had previously undergone a procedure called endoscopic sleeve gastroplasty (ESG) for weight loss but were not seeing the results they wanted, so they switched to a different weight loss surgery called sleeve gastrectomy. The doctors found that reversing the ESG and converting to sleeve gastrectomy was mostly straightforward and did not lead to any complications post-surgery. Both patients lost weight successfully one month after the surgery, indicating that this conversion can be a safe and effective option for individuals who do not achieve their weight loss goals with ESG.
Who this helps: This benefits patients who need further help for weight loss after ESG, especially those who have not seen success with their initial procedure.
A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain.
2019
Anaerobe
Wehrhahn MC, Keighley C, Kurtovic J, Knight DR, Hong S +7 more
Plain English This study looked at three patients in Australia who suffered from a severe infection caused by a specific strain of bacteria called Clostridium difficile, known as ribotype 251. All patients experienced severe diarrhea, with two having repeated infections and one dying after surgery. The study found that this strain can produce harmful toxins and behaves similarly to a more well-known dangerous strain, suggesting it could be a serious health threat.
Who this helps: This information is important for doctors and healthcare providers to better understand and treat severe C. difficile infections.
Preoperative chemical component relaxation using Botulinum toxin A: enabling laparoscopic repair of complex ventral hernia.
2017
Surgical endoscopy
Elstner KE, Read JW, Rodriguez-Acevedo O, Cosman PH, Dardano AN +6 more
Plain English This study looked at the use of Botulinum toxin A (BTA) to relax abdominal muscles before surgery to repair complex hernias. Researchers found that after BTA injections, the length of the abdominal wall muscles increased from an average of 16.4 cm to 20.4 cm, allowing for better closure of the hernia defects, with no complications reported. This matters because it helps surgeons successfully repair large hernias without causing high pressures inside the abdomen, reducing the risk of problems later on.
Who this helps: This benefits patients with complex ventral hernias needing surgery.
Sex differences in peripheral not central immune responses to pain-inducing injury.
2017
Scientific reports
Lopes DM, Malek N, Edye M, Jager SB, McMurray S +2 more
Plain English This study looked at how men and women differ in their body's response to pain after an injury using a mouse model. Researchers found that while there were no significant differences in nerve responses in the spinal cord, they did notice that the immune response in the peripheral nervous system was different between the sexes. This is important because it suggests that treatments for pain might need to take into account these gender differences in immune responses.
Who this helps: This helps doctors and researchers understand how to tailor pain treatments for men and women.
Preoperative abdominal muscle elongation with botulinum toxin A for complex incisional ventral hernia repair.
2016
ANZ journal of surgery
Farooque F, Jacombs AS, Roussos E, Read JW, Dardano AN +2 more
Plain English This study looked at using botulinum toxin A (BTA) to relax the abdominal muscles before surgery for complex hernias. Researchers injected BTA into the side muscles of eight patients two weeks before their hernia repairs. They found that the length of these muscles increased significantly, from an average of 18.5 cm to 21.3 cm, helping to reduce the hernia defects without early complications after surgery.
Who this helps: This helps patients with complex abdominal hernias.
Adherence to Surgical Antibiotic Prophylaxis Guidelines in New South Wales, Australia: Identifying Deficiencies and Regression Analysis of Contributing Factors.
2016
Surgical infections
Knox MC, Edye M
Plain English This study looked at how well hospitals in New South Wales, Australia, followed guidelines for giving antibiotics before surgery to prevent infections. Researchers found that only 16.5% of cases at Blacktown Hospital and 19.5% at Lismore Base Hospital met the guidelines. The most common mistakes were using the wrong antibiotics and giving them too early, especially in emergency surgeries.
Who this helps: This research benefits patients undergoing surgery by highlighting the need for better antibiotic use to prevent infections.
Plain English This study looked at whether an educational program for doctors at Blacktown Hospital could improve the way antibiotics are prescribed to patients undergoing abdominal surgery. The findings showed that before the program, 18% of prescriptions followed the guidelines, and after the program, that number dropped to 15%, so there was no real change. This matters because improper antibiotic use can lead to antibiotic resistance, making infections harder to treat.
Who this helps: This helps patients by aiming to reduce the risk of ineffective antibiotic treatments.
Laparoscopic repair of complex ventral hernia facilitated by pre-operative chemical component relaxation using Botulinum Toxin A.
2016
Hernia : the journal of hernias and abdominal wall surgery
Elstner KE, Jacombs AS, Read JW, Rodriguez O, Edye M +7 more
Plain English This study looked at how using Botox (Botulinum Toxin A) before surgery can help fix complex ventral hernias, which are tough to repair and often come back even after surgery. Researchers treated 27 patients with Botox injections to relax their abdominal muscles, resulting in a significant increase in muscle length—from about 15.7 cm to 19.9 cm—making the surgery easier and more effective, with no hernias returning after the procedure. This matters because it offers a reliable and safe method to improve surgical outcomes for complicated hernia repairs.
Who this helps: This helps patients undergoing surgery for complex ventral hernias.
Plain English This research paper looks at living-donor kidney transplantation, which helps patients with severe kidney disease who need dialysis. It highlights how laparoscopic surgery has made it safer for healthy donors to give a kidney, reducing risks for them while increasing available organs. With the number of patients needing transplants growing faster than available organs, this approach is vital for improving patient care and survival.
Who this helps: This benefits patients with end-stage renal disease who need a kidney transplant.
A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain.
2011
Advances in pharmacological sciences
Nickolls S, Mace H, Fish R, Edye M, Gurrell R +14 more
Plain English This study examined two potential new pain relief compounds, L-838,417 and TPA023, and how they affect pain in experimental models of inflammation and nerve damage. Researchers found that while both compounds can help reduce pain, neither can completely avoid side effects because they need to work at certain receptor sites in the brain. Specifically, higher effectiveness at certain receptor types is necessary to achieve significant pain relief, which means some side effects may still occur.
Who this helps: This research benefits patients suffering from chronic pain conditions.
MRI estimation of total renal volume demonstrates significant association with healthy donor weight.
2009
European journal of radiology
Cohen EI, Kelly SA, Edye M, Mitty HA, Bromberg JS
Plain English This study examined how the total volume of kidneys in healthy donors relates to their body weight and other physical characteristics. Researchers found that kidney volume was strongly linked to body weight, with a correlation score of 0.7, while it was less related to height, age, and body mass index. They also discovered that traditional methods of estimating kidney volume tend to overestimate it by about 17%.
Who this helps: This information benefits doctors by providing a more accurate way to estimate kidney size based on a patient’s weight.
The first decade of a laparoscopic donor nephrectomy program: effect of surgeon and institution experience with 512 cases from 1996 to 2006.
2009
Journal of the American College of Surgeons
Chin EH, Hazzan D, Edye M, Wisnivesky JP, Herron DM +5 more
Plain English This study examined the outcomes of 512 kidney donors who underwent a minimally invasive surgery called laparoscopic donor nephrectomy at Mount Sinai Medical Center from 1996 to 2006. The researchers found that while most donors had excellent results, with a 97.1% success rate for kidney function after surgery, some experienced complications such as chronic pain and high blood pressure. As surgeons and the hospital gained experience, they were able to perform the surgery faster, although the rates of complications remained the same.
Who this helps: This information benefits kidney donors and medical professionals involved in transplant surgeries.
Laparoscopic donor nephrectomy: intraoperative safety, immediate morbidity, and delayed complications with 500 cases.
2007
Surgical endoscopy
Chin EH, Hazzan D, Herron DM, Gaetano JN, Ames SA +2 more
Plain English This study looked at the safety and complications experienced by kidney donors who underwent laparoscopic surgery over 500 cases from 1996 to 2005. The researchers found that while 9.8% of donors experienced complications within 30 days, long-term problems like hypertension were rare, with only 11 cases reported over an average follow-up of 32.8 months. Importantly, the results showed that as surgeons gained experience, the time taken for surgery and the rate of complications decreased significantly.
Who this helps: This benefits kidney donors and surgeons by providing insights that improve donor safety and outcomes.
Urologic complications in renal transplant recipients by donor type.
2006
Journal of endourology
Amukele SA, Belletete B, Samadi AA, Edye M, El-Sabrout R +2 more
Plain English This study looked at the urinary system problems that kidney transplant recipients experienced based on how the donor kidney was obtained: from a deceased donor, using an open surgery, or through laparoscopic (minimally invasive) surgery. Out of 276 transplant patients, 48 (17%) had urinary complications, with 14% from deceased donors, 20% from open donors, and 18% from laparoscopic donors. The findings show that kidneys taken using laparoscopic methods had no ureteral complications, making this approach safer for the recipient’s urinary tract.
Who this helps: This research benefits kidney transplant patients by highlighting safer surgical options.
Accuracy of three-dimensional CT angiography for preoperative vascular evaluation of laparoscopic living renal donors.
2005
Journal of endourology
Rajamahanty S, Simon R, Edye M, Butt K, Eshghi M
Plain English This study looked at how well three-dimensional CT scans can help doctors evaluate blood vessels before kidney donation surgery. Out of 54 patients, 51 had these scans, and the results showed that the scans correctly identified kidney arteries in 98% of cases and veins in 96%. This is important because accurate visualization of blood vessels helps ensure safer and more effective surgeries for living kidney donors.
Who this helps: This helps kidney donors and their surgeons.
Intraoperative cholangiography is still indicated after preoperative endoscopic cholangiography for gallstone disease.
2002
Surgical endoscopy
Edye M, Dalvi A, Canin-Endres J, Baskin-Bey E, Salky B
Plain English The study looked at whether a procedure called intraoperative cholangiography (IOC) is still needed after another procedure, called endoscopic retrograde cholangiography (ERC), for patients with gallstone disease. They found that out of 127 patients who had ERC, 31 underwent IOC during surgery, and in those cases, 33% of patients with normal ERC results still had problems found during IOC. This shows that about half of the patients who had their ducts cleared before surgery still had issues during the operation, indicating that IOC should be routinely performed to ensure all stones are removed.
Who this helps: This benefits patients undergoing gallbladder surgery.
Comprehensive MR imaging in the preoperative evaluation of living donor candidates for laparoscopic nephrectomy: initial experience.
2002
Radiology
Israel GM, Lee VS, Edye M, Krinsky GA, Lavelle MT +2 more
Plain English This study examined how effective magnetic resonance (MR) imaging is in preparing living kidney donors for laparoscopic surgery. Researchers found that MR imaging accurately showed the blood vessels and kidney structures in 21 out of 28 patients, leading to 27 successful surgeries based on MR results. This is important because accurate imaging helps surgeons avoid complications during the procedure, making kidney donation safer and more effective.
Who this helps: This helps patients who want to become living kidney donors.
[Laparoscopic nephrectomy in the liver donor: introduction of the method and preliminary results].
2001
Annales d'urologie
Bettschart V, Schneider R, Halabi G, Wauters JP, Edye M +1 more
Plain English This study looked at a new surgical method called laparoscopic nephrectomy, where kidneys are removed from living donors using small incisions. The researchers found that they successfully performed this surgery on ten people, with no complications and an average hospital stay of just 4 to 8 days. All transplanted kidneys were functioning well after about 10 months, helping to solve the shortage of organs for transplantation.
Who this helps: This benefits patients in need of kidney transplants and living donors considering donating an organ.
Are concerns over right laparoscopic donor nephrectomy unwarranted?
2001
Annals of surgery
Buell JF, Edye M, Johnson M, Li C, Koffron A +13 more
Plain English This study looked at how safe and effective it is to remove a kidney from the right side of the body using a minimally invasive technique called laparoscopic donor nephrectomy. The researchers found that, out of 97 patients, the surgery took an average of 235 minutes and had very limited complications, with only two kidney grafts lost due to blood clots. Importantly, the kidney function of these right-sided donors was just as good in the long run as those donated from the left side, which means it's safe to perform this procedure on the right side without high risks.
Who this helps: Patients needing a kidney transplant can be assured that both left and right kidneys can be harvested safely.
Diagnostic and interventional laparoscopy and intraoperative ultrasonography in the management of pancreatic disease.
2001
The Surgical clinics of North America
Pertsemlidis D, Edye M
Plain English This research looked at how laparoscopic surgery (a less invasive way to operate) and intraoperative ultrasound (a way to see inside the body during surgery) are used to handle diseases of the pancreas. The study found that these methods have improved significantly since they were first introduced, helping doctors stage pancreatic cancer and treat non-cancerous pancreatic issues. These advancements mean that more surgeries can be done safely without large incisions, making recovery easier for patients.
Who this helps: This helps patients with pancreatic diseases by providing safer treatment options.
Laparoscopic pancreatic resection: single-institution experience of 19 patients.
2001
Journal of the American College of Surgeons
Patterson EJ, Gagner M, Salky B, Inabnet WB, Brower S +4 more
Plain English This study looked at how 19 patients underwent laparoscopic surgery to remove parts of the pancreas from November 1993 to March 2000. The results showed that while 26% of patients had complications, such as leaks and infections, there were no deaths, and patients had shorter hospital stays compared to traditional surgery. This is important because it shows that laparoscopic surgery can be a safe option for treating benign pancreatic conditions, potentially leading to quicker recoveries.
Who this helps: This helps patients needing pancreatic surgery and their doctors by offering a less invasive treatment option.
Laparoscopically assisted intestinal resection in 88 patients with Crohn's disease.
1999
Surgical endoscopy
Canin-Endres J, Salky B, Gattorno F, Edye M
Plain English This study looked at 88 patients with Crohn's disease who underwent minimally invasive surgery to remove parts of their intestines. The researchers found that most patients (over 85%) were able to start a liquid diet by the next day after surgery, and the average hospital stay was about 4 days. This is important because using laparoscopic techniques can lead to quicker recoveries and fewer complications, making surgery easier for patients suffering from this chronic condition.
Who this helps: Patients with Crohn's disease who need intestinal surgery.
Sac excision is essential to adequate laparoscopic repair of paraesophageal hernia.
1998
Surgical endoscopy
Edye M, Salky B, Posner A, Fierer A
Plain English This study looked at two groups of patients who had surgery for a type of hernia called paraesophageal hernia. In one group of 25 patients, the surgeons did not remove the hernia sac, while in the second group of 30 patients, the sac was removed. The key finding was that removing the sac helped prevent any early returns of the hernia after surgery, with no recurrences observed in the second group, compared to a higher risk in the first group.
Who this helps: This research benefits patients undergoing surgery for paraesophageal hernia by improving their chances of successful long-term outcomes.
Current laparoscopic approaches to pancreatico-biliary disease.
1997
European journal of gastroenterology & hepatology
Edye M
Plain English This study looks at new laparoscopic (minimally invasive) methods used to treat problems in the bile ducts and pancreas. It found that doctors can now effectively connect the bile duct to the intestines during surgery for serious conditions like gallstones or bile duct cancer, and that some can even perform a full life-extending procedure in one visit. These advancements are important because they can lead to less recovery time and better outcomes for patients facing complex bile duct issues or pancreatic cancer.
Who this helps: This helps patients with bile duct diseases and pancreatic cancer.
Laparoscopic surgery in the management of inflammatory bowel disease.
1996
American journal of surgery
Reissman P, Salky BA, Pfeifer J, Edye M, Jagelman DG +1 more
Plain English This study looked at how laparoscopic surgery, a less invasive surgical method, can be used to treat inflammatory bowel disease (IBD) in 72 patients. The researchers found that while laparoscopic surgery had an overall effective outcome, there were some complications; specifically, 18% of patients experienced issues such as bleeding or infections, and total colectomy procedures had higher complication rates compared to other surgeries. This is important because it can help doctors better choose surgical options for IBD patients, balancing effectiveness with risks.
Who this helps: Patients with inflammatory bowel disease.
Plain English This study examined the safety and effectiveness of using laparoscopic surgery to remove part of the pancreas. The researchers found that this method is safe and workable, particularly for non-cancerous conditions, though it requires a deep understanding of pancreatic anatomy and two-handed surgical techniques. Laparoscopic surgery is beneficial because it can lead to less pain and shorter recovery times for patients compared to traditional surgery methods.
Who this helps: This helps patients with non-cancerous pancreatic diseases.
Plain English This study looked at laparoscopic assisted colectomy (LAC), a minimally invasive surgery for treating colon issues. Out of 104 surgery attempts, 102 were successful, with a 5.9-day hospital stay compared to 11 days for traditional surgery, and a low complication rate of 4.8%. These findings suggest that LAC is a practical option for patients, offering shorter recovery times.
Who this helps: This benefits patients undergoing colon surgery.
Laparoscopic surgery in Crohn's disease. Indications and results.
1996
Surgical endoscopy
Reissman P, Salky BA, Edye M, Wexner SD
Plain English This study looked at laparoscopic surgery for patients with Crohn's disease, focusing on its safety and effectiveness. Out of 51 patients, the average surgery took about 2.4 hours, with most staying in the hospital for about 5 days. While 14% experienced complications, no one died, showing that laparoscopic surgery is a safe and effective option for treating Crohn's disease.
Who this helps: This benefits patients with Crohn's disease who may need surgery.
Conversions and complications of laparoscopic cholecystectomy. Results of a survey conducted by the French Society of Endoscopic Surgery and Interventional Radiology.
1993
Surgical endoscopy
Collet D, Edye M, Périssat J
Plain English This study examined the experiences of 41 French surgeons who performed 3,673 gallbladder removals in 1991, focusing on complications and the need to switch from a minimally invasive method to open surgery. They found that 4.8% of patients (142 people) had to switch to open surgery, mostly due to issues in the abdomen, while 3.4% experienced complications after surgery, including 18 bile duct injuries and 6 deaths. These findings highlight the risks and benefits of laparoscopic gallbladder removal and suggest that switching to open surgery can be a safe option when facing difficulties.
Who this helps: This information benefits surgeons and their patients by improving understanding of potential risks in surgery.
Laparoscopic cholecystectomy in the obese patient.
1992
Surgical endoscopy
Collet D, Edye M, Magne E, Perissat J
Plain English This study looked at the safety and effectiveness of a surgery called laparoscopic cholecystectomy, which is used to remove the gallbladder, specifically in obese patients. Out of 310 patients, 28 were classified as obese and showed similar surgery outcomes to normal or overweight patients; none died, and the surgery conversion rate to a more invasive procedure was only 2.9%. This research matters because it shows that obese patients can undergo this type of surgery with comparable risks and results as others, making it a viable option for treating gallbladder issues.
Who this helps: Patients, especially those who are obese and need gallbladder surgery.
Laparoscopic cholecystectomy: an analysis of 777 cases.
1992
Bailliere's clinical gastroenterology
Perissat J, Collet D, Edye M, Magne E, Belliard R +1 more
Plain English This study looked at 777 patients who had laparoscopic cholecystectomy, a minimally invasive surgery to remove the gallbladder, and found that it has very low risks, with a death rate of only 0.1% and complications occurring in just 3.3% of cases, including a 0.4% chance of injury to the bile duct. Patients experienced less pain, shorter hospital stays, and were able to return to their normal activities within 10 days. This surgery is becoming the preferred method for treating gallstones because of its clear benefits over traditional surgery.
Who this helps: This helps patients with gallstones by providing a safer and quicker recovery option.