Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial.
2023JAMA
Raison CL, Sanacora G, Woolley J, Heinzerling K, Dunlop BW +29 more
Plain English
This study looked at the effects of a single dose of psilocybin, a compound found in certain mushrooms, on adults with major depressive disorder. Researchers found that those who received psilocybin reported a significant reduction in depression symptoms, with scores dropping by an average of 12.3 points on a depression scale by day 43, compared to those given a placebo. This finding is important because it suggests that psilocybin, when combined with psychological support, could be a new and effective treatment for people suffering from depression.
Who this helps: This helps patients with major depressive disorder looking for new treatment options.