DR. NICHOLAS THOMAS GATES, MD

HIGHLAND HEIGHTS, KY

Research Active
Orthopaedic Surgery NPI registered 21+ years 22 publications 1975 – 2025 NPI: 1164424313
Reproducibility of ResultsDouble-Blind MethodSurveys and QuestionnairesRandomized Controlled Trials as TopicCognitive Behavioral TherapyExecutive FunctionResistance TrainingNeuropsychological TestsCognitionHippocampusAgingCombined Modality TherapyCognitive DysfunctionComputer-Assisted InstructionAnesthesia, Dental

Practice Location

2626 ALEXANDRIA PIKE STE 100
HIGHLAND HEIGHTS, KY 41076-1530

Phone: (859) 301-2663

What does NICHOLAS GATES research?

Dr. Gates studies how different interventions, such as exercise and cognitive training, influence cognitive health, particularly in older adults and young people at risk for mental health issues. He has researched the effects of physical exercise, like resistance training, on brain function and memory. His studies highlight significant findings, such as how resistance training can slow cognitive decline in older adults with MCI, and he also investigates the limitations of cognitive training alone in preventing mental health issues in youth. Additionally, he explores dietary influences on cognitive health and evaluates tools to measure adherence to healthy diets across different populations.

Key findings

  • After 6 months of resistance training, older adults with Mild Cognitive Impairment showed a 48% improvement in cognitive function, with many achieving normal cognitive scores.
  • A cognitive training study with at-risk youth revealed that mental health and daily functioning worsened for both treatment groups, highlighting the limitations of cognitive training alone.
  • Resistance exercise led to long-term cognitive benefits and reduced hippocampal shrinkage, demonstrating protective effects on brain health for at least 12 months among older adults with MCI.

Frequently asked questions

Does Dr. Gates study Mild Cognitive Impairment?
Yes, Dr. Gates conducts extensive research on Mild Cognitive Impairment, focusing on how interventions like exercise and cognitive training can improve cognitive health in older adults.
What treatments has Dr. Gates researched?
Dr. Gates has researched the effects of resistance training, cognitive training, and dietary tools to enhance cognitive function and well-being in older adults and at-risk youth.
Is Dr. Gates's work relevant to young people with mental health concerns?
Yes, his studies focus on cognitive training interventions designed for at-risk youth to help prevent the development of mental health issues.

Publications in plain English

Dental Anesthesia Guidelines and Regulations of US States and Major Professional Organizations: A Review.

2025

Journal of patient safety

Simon NB, Barnett KM, Sweitzer B, Gates N, Yun S +3 more

Plain English
This study looked at the rules and guidelines for dental anesthesia across the United States, focusing on differences between states and professional organizations like the American Dental Association. It found significant variations in regulations, which can impact patient care and safety. For example, different states have different requirements for training, emergency preparedness, and equipment, leading to inconsistencies in how patients receive anesthesia during dental procedures. Who this helps: This benefits patients, dental practitioners, and regulatory bodies.

PubMed

Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI.

2020

NeuroImage. Clinical

Broadhouse KM, Singh MF, Suo C, Gates N, Wen W +16 more

Plain English
This study looked at how resistance exercise affects brain health and cognitive function in older adults with Mild Cognitive Impairment (MCI). Researchers found that after 6 months of high-intensity resistance training, participants experienced long-term cognitive benefits and reduced brain shrinkage for at least 12 months in specific areas of the hippocampus, which is important for memory. In particular, three areas showed significant protection against shrinkage compared to a control group, indicating that this type of exercise can help preserve brain health as people age. Who this helps: This benefits older adults with Mild Cognitive Impairment and may also offer insights for caregivers and healthcare providers working with this group.

PubMed

A randomised double-blind trial of cognitive training for the prevention of psychopathology in at-risk youth.

2020

Behaviour research and therapy

Mewton L, Hodge A, Gates N, Visontay R, Lees B +1 more

Plain English
This study looked at whether online cognitive training could help prevent mental health issues in young people at risk. Researchers tested 228 participants, divided into two groups: one received training focused on executive functions, while the other focused on different cognitive skills. The results showed that, overall, mental health and daily functioning worsened for both groups, and while the executive functioning improved slightly in the training group, it wasn't enough to be meaningful, indicating that cognitive training alone does not effectively prevent mental health problems in these youths. Who this helps: This helps clinicians and mental health professionals understand the limitations of cognitive training for at-risk youth.

PubMed

A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment.

2019

Journal of Alzheimer's disease : JAD

Martin DM, Mohan A, Alonzo A, Gates N, Gbadeyan O +4 more

Plain English
This study looked at whether a combination of cognitive training and a type of brain stimulation called transcranial direct current stimulation (tDCS) could improve memory in people with early signs of dementia. They found that while both groups—those receiving real tDCS and those receiving a placebo version—showed significant memory improvements after treatment, the brain stimulation did not provide extra benefits. This research is important because it suggests that cognitive training alone can help improve memory, but the brain stimulation does not enhance those improvements. Who this helps: This helps patients with mild cognitive impairment and their caregivers.

PubMed

Reliability and validity of a Mediterranean diet and culinary index (MediCul) tool in an older population with mild cognitive impairment.

2018

The British journal of nutrition

Radd-Vagenas S, Fiatarone Singh MA, Inskip M, Mavros Y, Gates N +13 more

Plain English
This study examined a new tool called the Mediterranean Diet and Culinary Index (MediCul) to see how well it works for older adults with mild cognitive impairment (MCI). The researchers found that the MediCul tool reliably measures adherence to the Mediterranean diet, with a high reliability score of 0.93. Although most participants scored an average of 54.6 out of 100, few met the recommended intake for important Mediterranean foods, which is concerning since diet may influence cognitive decline. Who this helps: This benefits older adults with mild cognitive impairment and healthcare providers working to support their dietary health.

PubMed

Midlife managerial experience is linked to late life hippocampal morphology and function.

2017

Brain imaging and behavior

Suo C, Gates N, Fiatarone Singh M, Saigal N, Wilson GC +10 more

Plain English
This study looked at how having more managerial experience in midlife affects brain health in older adults with Mild Cognitive Impairment (MCI). Researchers found that those with high managerial experience had better memory and larger hippocampal volume, specifically in the CA1 area, compared to those with less experience. However, these individuals rated their memory skills lower, which was linked to reduced communication between parts of the brain. Who this helps: This information benefits healthcare providers and patients with Mild Cognitive Impairment.

PubMed

Non-Pharmacologic Interventions for Older Adults with Subjective Cognitive Decline: Systematic Review, Meta-Analysis, and Preliminary Recommendations.

2017

Neuropsychology review

Smart CM, Karr JE, Areshenkoff CN, Rabin LA, Hudon C +13 more

Plain English
This study looked at older adults who feel their memory is declining, even though their cognitive function is still normal. Researchers found that non-drug treatments, like mental exercises and lifestyle changes, can help maintain or improve memory performance in these individuals, although the improvements were small. Out of nine analyzed studies, those focused on cognitive interventions showed slightly better results than others. Who this helps: This helps older adults experiencing cognitive worries and the healthcare providers supporting them.

PubMed

Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training.

2017

Journal of the American Geriatrics Society

Mavros Y, Gates N, Wilson GC, Jain N, Meiklejohn J +11 more

Plain English
This study looked at how resistance training affects cognitive function in older adults with mild cognitive impairment. Researchers found that after six months of training, participants increased their muscle strength significantly, with lower body strength improving the most (by nearly 1 whole standard deviation), while aerobic capacity improved by about 8%. Importantly, it was the increase in strength—not aerobic fitness—that was linked to better cognitive performance on tests. Who this helps: This research benefits older adults with mild cognitive impairment and their healthcare providers.

PubMed

Thestudy: protocol for a randomised controlled trial of computerised cognitive training for preventing mental illness in adolescents with high-risk personality styles.

2017

BMJ open

Mewton L, Hodge A, Gates N, Visontay R, Teesson M

Plain English
This study examined the effects of online cognitive training on improving thinking skills in young people aged 16-24 who are at risk for mental health issues but haven't yet been diagnosed. Researchers involved 200 participants, dividing them into two groups: one that received targeted training to boost executive functioning and another that received a less focused training program. The aim was to see if the targeted training could reduce mental health problems like anxiety and depression over a year, with results measured at various points, including 3, 6, and 12 months. Who this helps: This benefits adolescents at risk for mental illnesses and the healthcare professionals working with them.

PubMed

Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise.

2016

Molecular psychiatry

Suo C, Singh MF, Gates N, Wen W, Sachdev P +13 more

Plain English
This study looked at how physical exercise (like resistance training) and cognitive exercise (like brain training) affect the brains of older adults at risk for dementia. Researchers found that after six months, those who did physical exercise showed better overall thinking skills and structural brain improvements, especially in a region important for memory, while those who did cognitive exercise better maintained their memory performance. Specifically, physical exercise improved brain structure in the posterior cingulate area and slowed down brain changes linked to other health issues. Who this helps: This benefits older adults at risk for dementia and their healthcare providers.

PubMed

Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise.

2016

Molecular psychiatry

Suo C, Singh MF, Gates N, Wen W, Sachdev P +13 more

PubMed

Reply to the Letter to the Editor by O'Caoimh et al.

2015

Journal of the American Medical Directors Association

Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J +10 more

PubMed

Psychological well-being in individuals with mild cognitive impairment.

2014

Clinical interventions in aging

Gates N, Valenzuela M, Sachdev PS, Singh MA

Plain English
This study looked at how psychological well-being is affected in people with mild cognitive impairment (MCI), which is an early stage of cognitive decline. Researchers examined data from 100 adults with MCI and found that factors like worries about memory, cognitive abilities, quality of life, and feelings of sadness all play a significant role in a person's psychological well-being, explaining 61% of the differences in well-being among participants. This research highlights the importance of addressing these factors in order to improve life quality for individuals with MCI. Who this helps: Patients with mild cognitive impairment and their caregivers.

PubMed

The Study of Mental and Resistance Training (SMART) study—resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial.

2014

Journal of the American Medical Directors Association

Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J +10 more

Plain English
This study examined how resistance training and cognitive training affect people with mild cognitive impairment (MCI), which raises the risk of developing dementia. Researchers found that adults who participated in resistance training showed a notable improvement in cognitive function after 6 months, with 48% achieving normal cognitive scores compared to just 27% in the other group. These benefits for cognitive health were maintained over 18 months, indicating that resistance training is an effective way to support mental function in those with MCI. Who this helps: Patients with mild cognitive impairment and their families.

PubMed

The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials.

2013

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Gates N, Fiatarone Singh MA, Sachdev PS, Valenzuela M

Plain English
This research examined how exercise affects thinking and memory in older adults with mild cognitive impairment (MCI), reviewing data from 14 studies involving 1,695 participants aged 65 to 95. The findings showed a very slight improvement in verbal fluency, but only 8% of the cognitive measures had significant results, indicating that exercise likely has limited impact on cognitive function in this group. Understanding the relationship between exercise and cognitive health is important as it may inform future treatments or prevention strategies for dementia. Who this helps: Patients with mild cognitive impairment and their caregivers.

PubMed

The patient's perspective: diagnosing and treating Alzheimer's disease.

2011

The West Virginia medical journal

Gates N

PubMed

Cognitive exercise and its role in cognitive function in older adults.

2010

Current psychiatry reports

Gates N, Valenzuela M

Plain English
This study looked at how different types of mental exercises, called cognitive training, can help older adults maintain their thinking skills and lower the risk of dementia. The research found that engaging in various mental activities can improve brain function in healthy seniors and slow down cognitive decline in those experiencing early signs of memory issues. This matters because as people age, keeping their minds sharp can help them live healthier, more independent lives. Who this helps: Older adults, especially those concerned about memory loss or dementia.

PubMed

Rapid KABP survey for evaluation of NGO HIV/AIDS prevention projects.

1996

AIDS education and prevention : official publication of the International Society for AIDS Education

Mercer MA, Gates N, Holley M, Malunga L, Arnold R

Plain English
Researchers from Johns Hopkins University worked with Save the Children to survey rural Zimbabweans about their knowledge, attitudes, beliefs, and practices concerning HIV/AIDS. They found that while most people had good knowledge about HIV/AIDS, many still held misconceptions about how it spreads, and attitudes toward people with AIDS were not very positive. The study involved 660 adults and showed that those informed by Save the Children had better knowledge and a higher willingness to care for family members with AIDS compared to others, although attitudes toward condom use remained similar. Who this helps: This benefits patients with HIV/AIDS and the organizations working to educate communities about the disease.

PubMed

Questionnaire encourages children in hospital to express feelings.

1983

Hospital progress

Stilwell K, Gates N, Rayder N

PubMed

Prevention of hepatitis with gamma globulin.

1980

Annals of internal medicine

Lemon SM, Gates N, Bancroft WH

PubMed

The elderly deaf.

1977

Nursing mirror and midwives journal

Gates N

PubMed

Planning and staffing an ENT unit.

1975

Nursing mirror and midwives journal

Gates N

PubMed

Frequent Co-Authors

Perminder S Sachdev Michael Valenzuela Henry Brodaty Maria A Fiatarone Singh Chao Suo Wei Wen Guy C Wilson Jacinda Meiklejohn Nalin Singh Bernhard T Baune

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.