NIRMAL SAMUEL JAYASEELAN, M.D.

DALLAS, TX

Research Active
Surgery NPI registered 21+ years 1 publication 2025 – 2025 NPI: 1023012069
Surgery
Cell Line, TumorRatsReactive Oxygen SpeciesOxidative StressApoptosisBrain NeoplasmsGliomaMembrane Potential, MitochondrialPyrogallolCell Cycle Checkpoints

Practice Location

11970 N CENTRAL EXPY STE 670
DALLAS, TX 75243-3787

Phone: (972) 331-1111

What does NIRMAL JAYASEELAN research?

Dr. Jayaseelan studies how certain natural compounds can treat aggressive brain tumors known as gliomas. In particular, he focuses on a compound called pyrogallol, which appears to effectively kill glioma cells, leading to cell damage and stopping these cells from dividing further. This research is crucial for patients suffering from gliomas, as it explores alternatives to current treatments and aims to improve patient outcomes.

Key findings

  • Pyrogallol reduced the concentration needed to kill C6 glioma cells from 40 micromolar after 24 hours to 15 micromolar after 72 hours.
  • The study demonstrated that pyrogallol effectively induced cell damage in glioma cells.
  • Cell cycle arrest was observed in glioma cells treated with pyrogallol, indicating its potential to stop tumor growth.

Frequently asked questions

Does Dr. Jayaseelan study brain tumors?
Yes, Dr. Jayaseelan focuses on brain tumors, specifically a type called gliomas.
What treatments has Dr. Jayaseelan researched?
He has researched the effects of pyrogallol, a natural compound, as a potential treatment for gliomas.
Is Dr. Jayaseelan's work relevant to glioma patients?
Absolutely, his research aims to provide new treatment options for patients suffering from gliomas.
What is pyrogallol and why is it important?
Pyrogallol is a natural compound that has shown promise in killing glioma cells and could lead to new therapies for brain tumors.

Publications in plain English

Pyrogallol induces apoptosis, oxidative stress and cell cycle arrest in C6 glioma cells: a potential therapeutic agent.

2025

Medical oncology (Northwood, London, England)

Venkatesan KB, Srinivasan MK, Prasad M, Jayaseelan N, Alamelu S +5 more

Plain English
This study examined how pyrogallol, a natural compound, affects C6 glioma cells, which are a type of aggressive brain tumor. Researchers found that pyrogallol killed these cancer cells effectively, with the concentration needed to do so decreasing from 40 micromolar after 24 hours to 15 micromolar after 72 hours. The compound also caused cell damage and halted the cells in a specific phase of the cell cycle, making it a promising treatment option for gliomas. Who this helps: This benefits patients with glioma and their doctors by offering a potential new treatment option.

PubMed

Frequent Co-Authors

Kamalesh Balakumar Venkatesan Manoj Kumar Srinivasan Monisha Prasad Saravanan Alamelu Chellasamy Panneerselvam Mohammed A Al-Duais Abdulrahman Alasmari Mohammad Rehan Ajmal Hatem A Al-Aoh

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.