Practice Location

700 OLYMPIC PLAZA CIR
TYLER, TX 75701-1955

Phone: (903) 595-2441

What does PAUL DETWILER research?

Dr. Detwiler studies various phenomena related to materials and biological responses. His research includes how tiny magnetic particles behave under different conditions, which could lead to advancements in material science and potentially influence medical technology. He also investigates how certain proteins affect our ability to see and how brain chemicals, particularly in low-oxygen situations, can impact brain health. These studies are crucial for improving treatments for vision problems and stroke management.

Key findings

  • In his 2017 study, Dr. Detwiler found that paramagnetic colloids formed distinct groupings under a rotating magnetic field, particularly at tilt angles of 50 to 55 degrees.
  • His 2002 research demonstrated that disrupting a specific protein changed light signal processing in retinal cells, which provides insight into vision-related disorders.
  • In the 1991 study, diphenylhydantoin (DPH) significantly reduced the release of glutamate during low-oxygen conditions in rat brain slices, indicating its potential benefit for patients at risk of strokes.

Frequently asked questions

Does Dr. Detwiler study vision problems?
Yes, he studies how specific proteins affect the way our eyes respond to light, which is relevant for understanding vision disorders.
What treatments has Dr. Detwiler researched?
Dr. Detwiler has researched diphenylhydantoin (DPH) and its effects on brain chemical release during low-oxygen conditions, which may help in stroke treatment.
Is Dr. Detwiler's work relevant to stroke patients?
Yes, his research on how DPH can reduce harmful brain chemical release is directly applicable to managing stroke care.

Publications in plain English

Phase diagram and aggregation dynamics of a monolayer of paramagnetic colloids.

2017

Physical review. E

Pham AT, Zhuang Y, Detwiler P, Socolar JES, Charbonneau P +1 more

Plain English
This study looked at how tiny magnetic particles behave when placed under different magnetic conditions. The researchers found that when the particles were influenced by a specific type of rotating magnetic field, they formed different groupings than expected, especially at tilt angles between 50 and 55 degrees. This matters because it helps us understand how complex materials can be created or manipulated using magnetic forces, which could have applications in fields like medicine or materials science. Who this helps: This helps scientists and engineers working on new materials.

PubMed

Open the loop: dissecting feedback regulation of a second messenger transduction cascade.

2002

Neuron

Detwiler P

Plain English
This study looked at how a specific protein affects the way our eyes respond to light. Researchers compared light responses in normal retinal cells and genetically modified ones that lacked this protein. They found that disrupting this protein changed how well the cells processed light signals, helping us understand more about vision. Who this helps: This research benefits patients with vision problems as it sheds light on the mechanisms involved in seeing.

PubMed

Diphenylhydantoin attenuates hypoxia-induced release of [3H]glutamate from rat hippocampal slices.

1991

Brain research

Potter PE, Detwiler P, Thorne B, Moskal JR

Plain English
This study examined how well diphenylhydantoin (DPH) can prevent the release of a brain chemical called glutamate during low-oxygen conditions in rat brain slices. It found that when DPH was present, the release of glutamate decreased significantly, both during and after the low-oxygen period. This matters because excessive glutamate release can harm brain cells, which is a concern during events like a stroke. Who this helps: This benefits patients at risk of stroke and healthcare providers managing stroke treatment.

PubMed

The formation of bilirubin mono- and diglucuronide by rat liver microsomal fractions.

1972

Biochimica et biophysica acta

Halac E, Dipiazza M, Detwiler P

PubMed

Some properties of cholinesterases in intact rat diaphragm in vitro.

1971

Archives internationales de pharmacodynamie et de therapie

Mittag TW, Ehrenpreis S, Detwiler P, Boyle R

PubMed

Frequent Co-Authors

An T Pham Yuan Zhuang Joshua E S Socolar Patrick Charbonneau Benjamin B Yellen P E Potter B Thorne J R Moskal E Halac M Dipiazza

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.