DR. RALPH SILVERMAN, MD

ST. LOUIS, MO

Research Active
Colon & Rectal Surgery NPI registered 21+ years 50 publications 2019 – 2026 NPI: 1801899141
Analgesics, OpioidCOVID-19PregnancyCarcinoma, Squamous CellEmergency Service, HospitalArtificial IntelligenceSurveys and QuestionnairesIncidenceCardiac Surgical ProceduresAthletic InjuriesPhysiciansGlobal HealthSoccerNegative-Pressure Wound TherapyFinancial Management

Practice Location

12345 WEST BEND DR.
ST. LOUIS, MO 63128

Phone: (314) 849-1811

What does RALPH SILVERMAN research?

Dr. Silverman's work primarily addresses the intersection of mental health and physical health, particularly in perinatal care. He studies the mental health challenges faced by new parents and the effectiveness of current support systems, finding that many do not receive the necessary referrals for depression treatment. Additionally, he investigates how technology can change medical training and improve clinician experiences, with a focus on reducing burnout among healthcare providers. He also explores injury patterns in athletes and the nuances of patient care in emergency settings, highlighting the importance of preoperative care for patients with existing health conditions.

Key findings

  • In a study focused on new parents in Syracuse, 30% reported feeling depressed during pregnancy, but over 44% of those who were very depressed did not receive treatment referrals.
  • 74% of anterior cruciate ligament (ACL) tears in NFL players were identified as mid-substance tears, which are common in both non-contact and contact situations.
  • Using ambient documentation technology reduced burnout among doctors from 50.6% to 29.4%, significantly improving their job satisfaction.
  • In a study of 285 newborns with major congenital heart disease, 34% of those with truncus arteriosus did not survive at the NICU, yet 81.5% of all treated babies were able to go home eventually.
  • Implementation of a non-mydriatic ocular fundus camera in emergency departments resulted in imaging 1,274 patients, improving the detection of eye issues.

Frequently asked questions

Does Dr. Silverman study mental health issues in new parents?
Yes, he examines the mental health challenges, such as depression, faced by new parents and the effectiveness of support systems for them.
What impact does Dr. Silverman's research have on surgical practices?
His research on ACL injuries and other surgical outcomes aims to enhance treatment strategies and improve recovery for patients.
Is Dr. Silverman's work relevant for patients with chronic conditions?
Yes, he investigates how underlying conditions like COPD can complicate surgical outcomes, highlighting the need for preoperative care.
What advancements in medical training has Dr. Silverman contributed to?
He has researched methods to improve the learning environment for medical students, focusing on how to enhance their feeling of value during training.
How does Dr. Silverman’s research address cultural factors in patient care?
He studies the influence of cultural background on conditions like anorexia nervosa, emphasizing the importance of understanding cultural contexts in treatment.

Publications in plain English

Sustainability of the "Name, Ask, Thank" Method to Improve Student Mattering in the Operating Room.

2026

Journal of surgical education

Turner H, Patten C, Silverman R, Higgins RM

Plain English
This study looked at a method called "Name, Ask, Thank" (NAT) designed to help medical students feel more valued during their surgery training. Over two years, the researchers found that 71.4% of educators used NAT in 2021-2022, which increased to 75.8% in 2023, indicating the method was consistently used. Despite the method being utilized, there was no significant change in the students’ feedback about feeling valued after the intervention, suggesting that while the NAT method is being used, it might need more support to be truly effective. Who this helps: This helps medical students by promoting a more supportive learning environment in the operating room.

PubMed

A Gap Analysis in Therapeutic Services for Birthing Individuals with Perinatal Mental Health Disorders.

2026

Social work in public health

Ahmed MK, Keefe RH, Kmush B, Shuman E, Walker K +4 more

Plain English
This study looked at the lack of mental health support for new parents in New York who experience mental health issues around pregnancy. Researchers found that from 2017 to 2019, about 30% of new parents in Syracuse reported feeling depressed during pregnancy, and over 44% of those who were very depressed did not receive any treatment referrals. With only 2 out of 21 social work programs in the state covering perinatal mental health, there is a clear need for better training for social workers to help these families. Who this helps: This helps new parents struggling with mental health issues and the professionals who care for them.

PubMed

Epidemiology of Injury and Illness in North American Professional Men's Soccer: Comparing COVID-19 Lockdown With Previous Seasons.

2025

Sports health

Hardin S, Silverman R, Brophy R, Putukian M, Silvers-Granelli H

Plain English
This study examined how the COVID-19 lockdown affected injuries and illnesses in U.S. professional men's soccer during the 2020 season. The findings showed that injury rates were significantly higher in 2020, with an injury rate of 10.8 per 1,000 hours compared to 5.4 in 2018 and 5.0 in 2019. Additionally, injuries like lower extremity muscle injuries and concussions saw increases, and more players missed over 90 days due to injuries in 2020 (17.7%) compared to previous seasons (around 10%). Who this helps: This information is useful for coaches, medical staff, and players in professional soccer to better understand injury risks and improve training and recovery strategies.

PubMed

Breaking the barriers: Methodology of implementation of a non-mydriatic ocular fundus camera in an emergency department.

2025

Survey of ophthalmology

Berman G, Pendley AM, Wright DW, Silverman R, Kelley C +6 more

Plain English
This study focused on how to successfully introduce a special camera that takes pictures of the back of the eye in emergency departments. Over the course of the first year, they trained staff and used this camera with 1,274 patients, imaging between 12 and 42 patients each week. This matters because it shows that adding this technology can help detect eye issues quickly in emergency situations, improving patient care. Who this helps: Patients who visit emergency departments with eye-related problems.

PubMed

Effects of the Federal Government's Move to Reschedule Cannabis: A Commentary.

2025

Journal of studies on alcohol and drugs

Collins RL, Thanos PK, Ashare R, Herzberg D, Silverman R

Plain English
Researchers studied the impact of changing cannabis from a highly restricted classification to a less restricted one, which would encourage more research into its effects and potential medical uses. They argue that moving cannabis to a Schedule III status could lead to better understanding of its impact on health and behavior and improve policies for its use, especially for treating conditions like chronic pain. This change is significant because it could open doors for more effective treatments and better regulations surrounding cannabis. Who this helps: This benefits patients seeking alternative treatments and researchers looking to study cannabis.

PubMed

Anti-osteoporotic treatment reduces risk of revision following total shoulder arthroplasty in patients with osteoporosis.

2025

Journal of shoulder and elbow surgery

Parel PM, Kuyl EV, Haft M, Silverman R, Ramesh A +5 more

Plain English
This study looked at how treating osteoporosis affects the outcomes of patients who had total shoulder surgery. Researchers found that of the 40,532 patients studied, those who received osteoporosis treatment before surgery were less likely to need additional surgery within two years, with a 31% greater risk of needing revision found in those who did not get treatment. This is important because it suggests that managing osteoporosis can lead to better results after shoulder surgery, helping to reduce complications and the need for further surgeries. Who this helps: This helps patients with osteoporosis who are undergoing shoulder surgery.

PubMed

Optimizing Patients With Chronic Obstructive Pulmonary Disease Preoperatively May Reduce Complications and Improve Outcomes in Infrainguinal Endovascular Revascularization.

2025

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

Li R, Silverman R, Sidawy A, Nguyen BN

Plain English
This study examined patients with chronic obstructive pulmonary disease (COPD) who underwent a specific type of surgery called infrainguinal endovascular revascularization. It found that patients with COPD had a 3.24% chance of dying within 30 days of the surgery compared to 2.18% for those without COPD, and they also faced higher risks of other serious complications and hospital readmissions. This matters because it shows that COPD increases the risks associated with this surgery, suggesting that better preparation and treatment for COPD patients before surgery could lead to better outcomes. Who this helps: This research benefits COPD patients who need surgery, as well as their doctors, by highlighting the importance of preoperative care.

PubMed

A Complex Presentation of Anorexia Nervosa and Takotsubo Cardiomyopathy in a Patient of East Asian Descent.

2025

Cureus

Rienas WM, Pu J, McMahon B, Sarma V, Silverman R +2 more

Plain English
This study examined a 52-year-old woman of East Asian descent who faced severe anorexia nervosa and a heart condition called takotsubo cardiomyopathy, with a dangerously low body mass index (BMI) of 10. The findings highlight that her unique views on her eating disorder were influenced by her cultural background, which complicated her treatment and decision to leave the hospital against medical advice. This matters because understanding a patient’s cultural context can improve their care and treatment outcomes for eating disorders. Who this helps: This helps doctors and healthcare providers working with patients from diverse cultural backgrounds.

PubMed

Ambient Documentation Technology in Clinician Experience of Documentation Burden and Burnout.

2025

JAMA network open

You JG, Dbouk RH, Landman A, Ting DY, Dutta S +21 more

Plain English
This study looked at how a new technology, called ambient documentation technology (ADT), impacts doctors' workloads and feelings of burnout. Using ADT, which creates medical notes automatically from conversations with patients, resulted in a significant drop in burnout among doctors at Mass General Brigham, from 50.6% to 29.4%, and a rise in well-being at Emory Healthcare, where positive feelings about documentation increased from 1.6% to 32.3%. These results show that using this technology can make doctors feel more satisfied and less overwhelmed, ultimately improving their work experience. Who this helps: This helps healthcare providers, particularly doctors, by reducing their administrative burdens and improving their job satisfaction.

PubMed

The Association Between Neighborhood Gunshot Frequency and the Development of Preterm Birth.

2025

Women's health reports (New Rochelle, N.Y.)

James BW, Fisher R, Yin C, Kmush BL, Silverman R +1 more

Plain English
This study looked at whether the number of gunshots in a neighborhood affects the likelihood of women having preterm births (before 37 weeks). Researchers analyzed data from 1,675 births in Syracuse, New York, and found that while different areas had different rates of preterm births—18% in the most affected area compared to 12% in the least—the frequency of gunshots did not appear to be linked to preterm births when the timing of those gunshots was taken into account. This is important because it challenges the assumption that gun violence directly increases the risk of preterm birth, suggesting that other factors may play a more significant role. Who this helps: This helps healthcare providers and policymakers understand the complexities of stress and birth outcomes in high-crime areas.

PubMed

Feasibility of Using the Apple Vision Pro for Diagnostic Radiology: User Experience and Perceived Clinical Utility.

2025

Journal of imaging informatics in medicine

Volin J, Viswanathan V, Krupinski EA, Safdar N, Silverman R +2 more

Plain English
The study explored how well the Apple Vision Pro headset works for training doctors in reading medical images. Of the 25 radiology specialists who tried it, most (84%) found it easy to use and 80% thought it made their work more efficient. They took about 4 minutes to become comfortable with the device, and after using it, many felt it would help in meetings where different medical teams discuss cases. Who this helps: This benefits doctors in training, particularly in radiology.

PubMed

Anterior Cruciate Ligament Tear Location in National Football League Athletes Based on Magnetic Resonance Imaging.

2025

HSS journal : the musculoskeletal journal of Hospital for Special Surgery

Brophy RH, Crain J, Baker J, Silverman R, Wojtys E +3 more

Plain English
This study examined where tears occur in the anterior cruciate ligament (ACL) of NFL players using MRI scans from 191 athletes who suffered acute injuries between 2015 and 2019. Researchers found that 74% of the tears were "type III," which are mid-substance tears, and these types of injuries were more common in both noncontact and contact situations. Understanding the location of these tears is important because it may affect treatment options and the potential for recovery. Who this helps: This helps athletes and their doctors in making informed treatment decisions after an ACL injury.

PubMed

Limited Agreement on ACL Tear Location Between Arthroscopy and MRI: A Prospective Evaluation.

2025

Orthopaedic journal of sports medicine

Silverman R, Knapik DM, Smith MV, Baker JC, Napier K +2 more

Plain English
This study examined how well MRI scans predict the exact location of tears in the anterior cruciate ligament (ACL) during surgery. Researchers looked at 174 patients with ACL tears and found that only 43% of the time did the MRI results match what doctors saw during surgery. Interestingly, they discovered that younger patients more often had midsubstance tears, while older patients had proximal tears. Who this helps: This information is valuable for doctors treating ACL injuries, helping them make better decisions based on accurate tear location.

PubMed

Contemporary prenatal diagnosis of congenital heart disease in a regional perinatal center lacking onsite pediatric cardiac surgery: obstetrical and neonatal outcomes.

2025

Journal of perinatal medicine

Elkafrawi D, Passafiume D, Blomgren M, Parker P, Gross S +3 more

Plain English
This study looked at the outcomes for newborns with serious heart defects, known as congenital heart disease (CHD), who were born at a specialized hospital without immediate heart surgery capabilities. Over 10 years, researchers found that 285 babies with major CHD were admitted, with a high mortality rate of 34% for those with truncus arteriosus and 31.6% for hypoplastic left heart syndrome. Despite these challenges, 81.5% of the babies who had surgery were able to go home, highlighting that newborns with major CHD can still be effectively cared for in facilities without on-site cardiac surgery. Who this helps: This helps doctors and healthcare providers who care for pregnant women and newborns with heart issues.

PubMed

Surgical site infection outcomes of two different closed incision negative pressure therapy systems in cardiac surgery: Systematic review and meta-analysis.

2024

International wound journal

Loubani M, Cooper M, Silverman R, Bongards C, Griffin L

Plain English
This study compared two types of closed incision negative pressure therapy systems with standard dressing methods to see how they affect the risk of surgical site infections (SSIs) in heart surgery patients. The results showed that one system, ciNPT with foam dressing, significantly reduced the infection rate by 49% compared to standard dressings, particularly in high-risk patients, while the other system, ciNPT with multilayer absorbent dressing, did not show a significant difference. This finding matters because using the effective dressing could save hospitals an estimated $554 per patient and $3,242 for those at higher risk, making it a potentially cost-effective option for managing surgical wounds. Who this helps: This benefits heart surgery patients and hospitals.

PubMed

Filling in the Blank: The Development of a Writing Screener for Elementary School Students Who Speak African American English.

2024

Language, speech, and hearing services in schools

Byrd AS, Oppenheimer K, Silverman R, Edwards J

Plain English
This study focused on creating a new writing assessment tool for young students who speak African American English, to better understand their writing skills. Researchers tested this tool on 151 first and second graders, finding that second graders performed better than first graders. The results showed that students who did well on reading and writing tests were also more likely to use Mainstream American English in their writing. This matters because it helps ensure that students who speak different dialects are evaluated fairly and accurately, reducing the chances of misdiagnoses related to their writing abilities. Who this helps: This benefits students who speak nonmainstream dialects and the educators assessing their writing skills.

PubMed

The 11+ injury prevention programme decreases rate of hamstring strain injuries in male collegiate soccer players.

2024

British journal of sports medicine

Silvers-Granelli H, Silverman R, Bizzini M, Thorborg K, Brophy RH

Plain English
The study looked at whether the 11+ injury prevention program could lower the risk of hamstring injuries in male college soccer players. It found that teams using the 11+ program had a 63% lower risk of hamstring injuries compared to teams using traditional warm-ups. Additionally, those who regularly followed the program (more than twice a week) reduced their injury risk by 78%. Who this helps: This benefits college soccer players by reducing their risk of injury.

PubMed

The Evolution of Commercial Negative Pressure Wound Therapy Systems over the Past Three Decades.

2024

Advances in wound care

Miller-Mikolajczyk C, Beach K, Silverman R, Cooper M

Plain English
This study looked at how negative pressure wound therapy (NPWT) systems have changed over the last 30 years. It found that advancements like new dressing types, power sources, and smart technology have improved the way wounds are treated. Currently, many options exist for NPWT, which makes it easier to care for different types of wounds, but it can also make choosing the right product more complicated. Who this helps: This research benefits doctors and patients with complex wound care needs.

PubMed

Legal Work of Public Health Professionals: The Case for Better Professional Education.

2024

Public health reports (Washington, D.C. : 1974)

Burris S, Berman M, Silverman R, Ashe M

PubMed

Closed Incision Negative Pressure Therapy Versus Standard of Care Over Closed Abdominal Incisions in the Reduction of Surgical Site Complications: A Systematic Review and Meta-Analysis of Comparative Studies.

2024

Eplasty

Mantyh C, Silverman R, Collinsworth A, Bongards C, Griffin L

Plain English
This study looked at how closed incision negative pressure therapy (ciNPT) compares to standard care for preventing complications at surgical sites after open abdominal surgeries. The researchers found that ciNPT significantly reduced the risk of complications by around 43% overall and led to fewer infections and issues like wound dehiscence, as well as cutting hospital stays by an average of 2.6 days. These findings matter because they indicate that ciNPT can improve recovery and lower healthcare costs for patients undergoing abdominal surgery. Who this helps: This helps patients who have had abdominal surgery.

PubMed

Metastatic Tropism in Urothelial Carcinoma With Variant Histology: A Comprehensive NCDB Analysis.

2024

Clinical genitourinary cancer

Drouaud A, Xu V, Velasquez A, Antar R, Boyarsky B +4 more

Plain English
This study looked at how different types of aggressive bladder cancer, specifically those with variant histology (VH), spread to other parts of the body. Out of over 6,000 patients analyzed, certain subtypes showed distinct patterns: for example, patients with small cell cancer were four times more likely to have liver metastasis, while those with squamous cell carcinoma were less likely to have bone metastasis. Understanding these differences is important because it can help doctors tailor treatment plans more effectively. Who this helps: This helps both patients with bladder cancer and their doctors by improving treatment strategies.

PubMed

Meta-Analysis Comparing Outcomes of Two Different Closed Incision Negative Pressure Systems in Breast Surgery and Implications to Cost of Care.

2024

Eplasty

Singh DP, Gabriel A, Silverman R, Bongards C, Griffin L

Plain English
This study looked at two different types of closed incision negative pressure therapy systems used after breast surgery to see if they could reduce complications like infections and wound issues. The researchers found that using one type of system (ciNPT-F) significantly lowered the overall complication rates by 50%, and also reduced the number of wounds that opened up again (dehiscence) by over 65%. The other system (ciNPT-MLA) also reduced the risk of wounds reopening, but not as dramatically. Who this helps: This benefits patients recovering from breast surgery by reducing complications.

PubMed

Scleral growth stunting via sub-Tenon injection of cross-linking solutions in live rabbits.

2023

The British journal of ophthalmology

Hoang QV, Wen Q, Paik DC, Chun YY, Silverman R +3 more

Plain English
This study looked at how a special chemical solution (sodium hydroxymethylglycinate, or SMG) can help stop the eye from growing too long in rabbits, which can lead to severe eyesight problems called myopia. The researchers found that after treatment, the rabbits’ eye growth was slowed down by 10% to 20%, and the treated areas were more resilient to heat, which suggests that the treatment is effective and not harmful. This is important because it offers a new way to potentially treat progressive myopia in humans and could help prevent serious eye issues. Who this helps: Patients with progressive myopia.

PubMed

Planned organ preservation for elderly patients with rectal cancer using short course radiotherapy and a contact brachytherapy boost-an International multi-institution analysis.

2023

Clinical and translational radiation oncology

Steinke J, Jordan C, Rossides S, Minnaar H, Yu J +11 more

Plain English
This study looked at how short course radiotherapy (SCRT) combined with a targeted treatment called contact X-Ray brachytherapy (CXB) can help elderly patients with early-stage rectal cancer keep their organs and avoid surgeries that create stomas (external bags for waste). They reviewed data from 258 patients, mostly around 81 years old, and found that 70% of those who received SCRT alone and 97% of those who had it after surgery showed no signs of cancer after treatment. Patients treated with SCRT and CXB generally had good survival rates—40 months for those treated with just radiotherapy and 52 months for those treated after surgery, with a high 94% remaining free of stomas. Who this helps: This benefits elderly patients with rectal cancer by offering them effective treatment options that help preserve their quality of life.

PubMed

A retrospective analysis of gender among patients admitted to a clinical decision unit at risk for acute coronary syndrome.

2023

World journal of emergency medicine

Thoppil J, Kraut L, Montgomery C, Castillo W, Silverman R +2 more

PubMed

Closed Incision Negative Pressure Therapy versus Standard of Care in Reduction of Surgical Site Complications: A Systematic Review and Meta-analysis.

2023

Plastic and reconstructive surgery. Global open

Cooper HJ, Singh DP, Gabriel A, Mantyh C, Silverman R +1 more

Plain English
This study compared two methods for caring for surgical wounds: closed incision negative pressure therapy (ciNPT) and standard dressings. It found that ciNPT significantly reduced issues like infections and complications by 50%, leading to fewer readmissions and shorter hospital stays—patients on ciNPT left the hospital almost a day earlier. This matters because better wound management can improve recovery and lower healthcare costs. Who this helps: Patients undergoing surgery benefit from improved healing and comfort.

PubMed

Proceedings of the 10th Pediatric Dermatology Research Alliance (PeDRA) Annual Conference.

2023

Pediatric dermatology

Dykman M, Coughlin C, Cotton C, Hawryluk E, Kirkorian AY +7 more

Plain English
The 10th Pediatric Dermatology Research Alliance conference brought together over 300 professionals in pediatric dermatology to share knowledge and collaboration after two years of virtual meetings. Attendees participated in various educational sessions, including workshops and discussions about how to improve the understanding and treatment of skin diseases in children, highlighting 108 research projects. This conference is important as it fosters connections that can lead to better care and innovative treatments for young patients with dermatological issues. Who this helps: Patients, doctors, and researchers in pediatric dermatology.

PubMed

Vitiligo induced by dupilumab treatment: A case series.

2023

Journal of the European Academy of Dermatology and Venereology : JEADV

Ren H, Akabane AL, Kelleher K, Halverstam C, Hicks M +6 more

PubMed

Veterans Health Administration: Implementation of pharmacogenomic clinical decision support with statin medications and the SLCO1B1 gene as an exemplar.

2023

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Tomcsanyi KM, Tran KA, Bates J, Cunningham FE, Silverman R +3 more

Plain English
This study looked at how the Veterans Health Administration (VHA) implemented tools to improve safety and effectiveness when prescribing statin medications, especially for veterans with specific genetic traits related to the SLCO1B1 gene. The VHA found that of around 500,000 new statin users in 2021, many could benefit from genetic testing to reduce the risk of muscle pain from statins, known as statin-associated muscle symptoms (SAMS). By using the PHASER program, the VHA aimed to alert doctors about these genetic risks and help adjust prescriptions accordingly, which can lead to fewer side effects and better treatment adherence. Who this helps: This helps veterans who are prescribed statins.

PubMed

Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer.

2023

Clinical cancer research : an official journal of the American Association for Cancer Research

Williams CJM, Elliott F, Sapanara N, Aghaei F, Zhang L +49 more

Plain English
This study looked at whether high levels of certain proteins, amphiregulin (AREG) and epiregulin (EREG), in tumors can predict how well patients with metastatic colorectal cancer (mCRC) respond to anti-EGFR therapies like panitumumab and cetuximab. Of 449 patients analyzed, those with high levels of AREG and EREG lived longer without their cancer worsening (8.5 months vs. 4.4 months) and had better overall survival (16.4 months vs. 8.9 months). This finding is important because it suggests that testing for these proteins could help doctors make better treatment decisions for their patients. Who this helps: This helps patients with metastatic colorectal cancer and their doctors in choosing more effective treatments.

PubMed

Outcomes of Two Different Negative Pressure Therapy Systems for Closed Incision Management in Knee and Hip Arthroplasty: A Systematic Review and Meta-Analysis.

2023

Cureus

Cooper HJ, Griffin LP, Bongards C, Silverman R

Plain English
This research reviewed two types of negative pressure therapy systems used after knee and hip surgeries to see which is more effective in preventing infections and complications. The study found that the foam dressing system (ciNPT-F) significantly reduced surgical site infections by 60% and complications by 68% compared to standard care. In contrast, the multilayer absorbent dressing system (ciNPT-MLA) did not show a significant difference in preventing infections or complications compared to standard care. Who this helps: This helps patients undergoing knee and hip surgeries by identifying a more effective treatment option for preventing post-surgical infections and complications.

PubMed

Neonatal serious illness: operational definition.

2023

BMJ supportive & palliative care

Guttmann K, Silverman R, Weintraub AS

Plain English
This study looked at how to define and identify serious illnesses in newborns who died before leaving the hospital's intensive care unit. Researchers found that 88% of these infants met the serious illness criteria within the first 48 hours of life, and just 5.7% received palliative care. Understanding this definition can help healthcare providers better support seriously ill newborns and their families. Who this helps: This benefits patients and their families, as well as doctors and healthcare providers working with newborns.

PubMed

State-level regulations and opioid-related health outcomes.

2022

Drug and alcohol dependence

Jackson JR, Harle CA, Silverman R, Simon K, Menachemi N

Plain English
This study looked at how different regulations for opioid treatment programs (OTPs) in various states affect health outcomes related to opioid use, such as deaths and hospital visits. It found that states with more OTP regulations had worse outcomes—specifically, each additional regulation in the area of physical facilities was linked to more opioid-related deaths, with states having many regulations seeing increased deaths and emergency visits. Improving access to treatment could help reduce these negative health effects. Who this helps: This helps patients struggling with opioid use and healthcare providers working to treat them.

PubMed

Pulmonary metastases from mucinous colorectal cancers and their appearance on CT: a case series.

2022

BJR case reports

Jackson JIF, Au-Yong ITH, Higashi Y, Silverman R, Clarke CGD

Plain English
This study looked at a rare type of colorectal cancer known as mucinous colorectal adenocarcinoma and how its lung metastases appear on CT scans. Researchers found that these lung metastases had low density on CT, which can lead doctors to mistake them for benign growths. Recognizing this can help radiologists better diagnose and monitor these patients since the appearance of the cancer in the lungs can mimic harmless conditions. Who this helps: This helps doctors and radiologists in diagnosing and managing patients with mucinous colorectal cancer.

PubMed

Absence of QT prolongation after administration of a 24-mg bimodal-release ondansetron pill (RHB-102).

2021

The American journal of emergency medicine

Miller J, House S, Lovato L, Meltzer A, Hahn B +5 more

Plain English
This study looked at the effects of a 24-mg ondansetron pill (RHB-102) on heart function in patients with acute gastroenteritis, specifically focusing on whether it causes an increase in the QTc interval, which is a measure related to heart rhythm. Researchers found that there was no significant difference in QTc changes between those taking RHB-102 and those receiving a placebo, with changes of +4 milliseconds for RHB-102 and +5 milliseconds for placebo after four hours. This is important because it shows that RHB-102 is safe for the heart in this patient group and does not significantly alter heart rhythm. Who this helps: This helps patients suffering from acute gastroenteritis.

PubMed

Analysis of lesional color to differentiate infantile hemangiomas from port-wine birthmarks in infants less than 3 months old: A pilot study.

2021

Pediatric dermatology

O'Brien KF, Frieden IJ, Zeymo A, Vasic J, Silverman R +2 more

Plain English
This study looked at how color measurements can help tell apart two types of skin marks in babies under three months: infantile hemangiomas (IH) and port-wine birthmarks (PWB). The researchers used color analysis on images of 119 IH and 59 PWB and found that PWBs had significantly higher levels of red, green, and blue colors compared to IH. This is important because it can lead to better and quicker diagnosis of these two conditions, improving care for affected infants. Who this helps: This helps doctors and healthcare providers make clearer diagnoses for babies with skin marks.

PubMed

How Should the World Pay for a Coronavirus Disease (COVID-19) Vaccine?

2021

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Towse A, Chalkidou K, Firth I, Kettler H, Silverman R

Plain English
This study explores how the world can effectively pay for future COVID-19 vaccines, especially as new versions are needed beyond the initial vaccines. It suggests a plan called the Benefit-Based Advance Market Commitment (BBAMC), which would set fair prices based on the vaccine's value and ensure that poorer countries can access vaccines at low costs, funded mainly by global donors. It's important because it aims to make vaccines more available and affordable for everyone, which can help prevent future outbreaks and save lives. Who this helps: This helps patients in low-income countries and healthcare systems worldwide.

PubMed

Assessing Variation in State Opioid Tapering Laws: Comparing State Laws with the CDC Guideline.

2021

Pain medicine (Malden, Mass.)

Danielson EC, Harle CA, Silverman R, Blackburn J, Menachemi N

Plain English
This study looked at how different states in the U.S. handle laws about tapering opioids, which is the slow reduction of opioid medication, in light of federal guidelines designed to prevent misuse. The researchers found that 27 states and one federal district had laws mentioning tapering, but only about half of the key recommendations from federal guidelines were included in these state laws. This is important because it means many patients could face sudden changes in their medication without proper support or guidance, increasing the risk of negative health outcomes. Who this helps: This helps patients relying on opioids for pain management.

PubMed

New Study Shows 3M™ V.A.C.® Therapy is More Cost Effective Compared to Competitors.

2021

Advances in skin & wound care

Silverman R

PubMed

The GAP-ED Project: Improving Care for Elderly Patients Presenting to the Emergency Department.

2020

The Journal of emergency medicine

Liberman T, Roofeh R, Sohn N, Brave M, Smith A +3 more

Plain English
The study looked at how a program called GAP-ED, which includes a specialist to help older patients in the emergency department, influences their care and hospital visits. The results showed that while there weren't fewer visits to the emergency department in 30 days, there was a significant drop in hospital admissions due to these visits—meaning some patients could go home without needing to be hospitalized. Patient and family satisfaction with the care provided was very high, indicating that the program is helping improve the experience for older adults. Who this helps: This helps elderly patients and their families.

PubMed

Market-driven, value-based, advance commitment (MVAC): accelerating the development of a pathbreaking universal drug regimen to end TB.

2020

BMJ global health

Chalkidou K, Towse A, Silverman R, Garau M, Ramakrishnan G

PubMed

Optical Coherence Tomography-Angiography of a large retinal microaneurysm.

2020

American journal of ophthalmology case reports

Diaz JD, Oellers P, Silverman R, Miller JB

Plain English
This study looked at a 63-year-old woman with a large retinal microaneurysm, which is a small bulge in a blood vessel in the eye that can lead to vision problems. The researchers used a new imaging technique called optical coherence tomography angiography (OCT-A), which effectively showed the details of the aneurysm, suggesting it might be better for diagnosing and monitoring such conditions than the traditional method, fluorescein angiography. This is important because it could lead to more accurate and safer eye examinations for people with similar issues. Who this helps: Patients with retinal vascular conditions.

PubMed

Value-based tiered pricing for universal health coverage: an idea worth revisiting.

2020

Gates open research

Chalkidou K, Claxton K, Silverman R, Yadav P

Plain English
This study looked at how pricing for medicines affects healthcare, especially in low- and middle-income countries, where high medicine prices make it hard for everyone to get the care they need. The researchers suggest using a system called value-based tiered pricing, where each country pays a price for medications based on how valuable those medications are to them. This could improve access to medicines and help countries negotiate better deals, making universal healthcare more achievable. Who this helps: This helps patients in low- and middle-income countries.

PubMed

Multiple Bilateral Incidental Lung Nodules in a Patient with Human Immunodeficiency Virus.

2020

Cureus

Khan MUH, Abdul Rauf MU, Mustafa A, Silverman R

Plain English
This study looked at a patient with HIV who was found to have multiple lung nodules during imaging, which can either indicate a serious infection or a tumor. In this case, these nodules were identified as a rare type of lung tumor known as a bronchial carcinoid. This finding is important because it highlights the need for careful monitoring and evaluation of lung nodules in patients with HIV, even if they show no symptoms. Who this helps: This benefits patients with HIV and their doctors by improving detection and treatment strategies for lung issues.

PubMed

Comparison of Negative Pressure Wound Therapy With and Without Instillation of Saline in the Management of Infected Wounds.

2020

Cureus

Kim PJ, Silverman R, Attinger CE, Griffin L

Plain English
This study looked at two methods of treating infected wounds: one that uses negative pressure alone and another that adds a saline solution during treatment. The researchers found that the group treated with saline had better results, including fewer surgeries (8.5 vs. 12 on average), shorter hospital stays (12 days vs. 16 days), and a higher rate of wounds that closed completely (72% vs. 48%). This matters because it shows that using saline with negative pressure therapy can lead to quicker healing and fewer complications for patients. Who this helps: This helps patients with infected wounds, leading to better recovery outcomes.

PubMed

Supporting Inclusive Learning Environments and Professional Development in Medical Education Through an Identity and Inclusion Initiative.

2020

Academic medicine : journal of the Association of American Medical Colleges

Woodruff JN, Vela MB, Zayyad Z, Johnson TA, Kyalwazi B +8 more

Plain English
The study focused on creating a more inclusive learning environment at the Pritzker School of Medicine, in response to students' growing interest in social issues affecting identity and patients. Over four years, the school implemented various initiatives through a steering committee designed to improve students' feelings of inclusion and respect for different perspectives, resulting in significant improvements in these areas—though specific numbers weren't provided. This work is important because it helps medical students learn to communicate better with a diverse range of patients, ultimately improving health care delivery. Who this helps: This helps medical students and their future patients, particularly those from diverse backgrounds.

PubMed

On results reporting and evidentiary standards: spotlight on the Global Fund.

2019

Lancet (London, England)

Friebel R, Silverman R, Glassman A, Chalkidou K

PubMed

Multiple Cutaneous Squamous Cell Carcinoma in Immunosuppressed vs Immunocompetent Patients.

2019

JAMA dermatology

Gonzalez JL, Reddy ND, Cunningham K, Silverman R, Madan E +1 more

Plain English
This study looked at how multiple skin cancers, called squamous cell carcinomas, affect patients with weakened immune systems compared to those with normal immune systems. Researchers found that patients with weakened immune systems had worse outcomes, with 60% facing serious complications, compared to only 20% of those with healthy immune systems. This matters because it highlights the need for closer monitoring and better treatment for immunosuppressed patients to improve their health outcomes. Who this helps: This helps patients with weakened immune systems and their doctors.

PubMed

Case-Control Study of Tumor Stage-Dependent Outcomes for Cutaneous Squamous Cell Carcinoma in Immunosuppressed and Immunocompetent Patients.

2019

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Gonzalez JL, Cunningham K, Silverman R, Madan E, Nguyen BM

Plain English
This study looked at how immunosuppressed patients (those with weakened immune systems) fare with cutaneous squamous cell carcinoma (cSCC), a type of skin cancer, compared to patients with healthy immune systems. The researchers found that immunosuppressed patients are four to three times more likely to have poor outcomes, such as recurrence of the cancer or related deaths, even when their tumors are in the early stages. This is important because it highlights that early-stage cancers can be more dangerous for immunosuppressed individuals, and it underscores the need for effective treatment strategies for these patients. Who this helps: This helps immunosuppressed patients and their doctors in managing skin cancer risks.

PubMed

The Global Fund impact - Authors' reply.

2019

Lancet (London, England)

Friebel R, Silverman R, Glassman A, Chalkidou K

PubMed

Frequent Co-Authors

Leah Griffin Kalipso Chalkidou Christine Bongards Robert H Brophy Dimitrios Mastrogiannis Holly Silvers-Granelli Devinder P Singh Allen Gabriel Christopher Mantyh Matthew Cooper

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.