DR. RICHARD CHARLES AVIOLI, MD

MARTINSBURG, WV

Research Active
Orthopaedic Surgery NPI registered 21+ years 2 publications 1980 – 1989 NPI: 1124022173
Orthopaedic Surgery
Cell LineKineticsDNADNA ReplicationCyclic AMPCell DivisionCell CycleOsteosarcomaAluminumProtein BiosynthesisAluminum ChlorideAluminum CompoundsChloridesOsteomalaciaProcollagen

Practice Location

510 BUTLER AVE
MARTINSBURG, WV 25405-9990

Phone: (304) 263-0811

What does RICHARD AVIOLI research?

Dr. Avioli studies how aluminum exposure and vitamin D affect the body's ability to absorb important minerals like phosphate and how these processes impact bone health. One significant aspect of his research involves how even low levels of aluminum can hinder the growth and DNA production of bone-forming cells, which is crucial for maintaining strong bones. Additionally, he investigates how chick intestinal cells absorb phosphate and the role vitamin D plays in this process, which could have broader implications for patients with mineral absorption disorders.

Key findings

  • Aluminum at micromolar levels can reduce DNA production in osteoblasts by 60%, affecting bone health.
  • The phosphate absorption in chick intestinal cells occurs through two distinct pathways influenced by calcium and acidity.
  • The findings signify that even minimal aluminum exposure could be detrimental to patients on hemodialysis, who are already vulnerable to bone disorders.

Frequently asked questions

Does Dr. Avioli study the effects of aluminum on bone health?
Yes, he studies how aluminum, even in small amounts, negatively impacts bone-forming cells.
What is the significance of vitamin D in Dr. Avioli's research?
He examines how vitamin D influences phosphate absorption in the intestines, which is important for overall mineral health.
Are Dr. Avioli's findings relevant for patients undergoing hemodialysis?
His research is particularly relevant as it addresses how aluminum exposure can complicate bone health in these patients.
What conditions might Dr. Avioli's research impact?
His work could impact conditions related to bone density and mineral absorption, especially in patients with kidney issues.

Publications in plain English

Micromolar aluminum levels reduce 3H-thymidine incorporation by cell line UMR 106-01.

1989

Kidney international

Blair HC, Finch JL, Avioli R, Crouch EC, Slatopolsky E +1 more

Plain English
This study looked at how different levels of aluminum affect the growth of bone-forming cells, known as osteoblasts, in a lab setting. Researchers found that aluminum reduced the ability of these cells to make DNA by 60% at a level of just 20 micrograms per liter, which is much lower than what is often found in contaminated environments. This is important because it highlights that even small amounts of aluminum can negatively impact bone health, especially for patients on hemodialysis who might already be at risk for bone problems. Who this helps: This helps patients on hemodialysis and healthcare providers treating them.

PubMed

Characterization of phosphate uptake in isolated chick intestinal cells.

1980

Advances in experimental medicine and biology

Avioli R, Miller RA, Birge SJ

Plain English
This study looked at how chick intestinal cells absorb phosphate, particularly in the presence of vitamin D. Researchers found that there are two different ways the cells take up phosphate, each with unique characteristics such as responsiveness to calcium and changes in acidity levels. Understanding these processes is important because it can help us learn how vitamin D affects phosphate absorption in the body. Who this helps: This helps researchers studying vitamin D and phosphate metabolism, which can impact patients with conditions related to mineral absorption.

PubMed

Frequent Co-Authors

H C Blair J L Finch E C Crouch E Slatopolsky S L Teitelbaum R A Miller S J Birge

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.