Dr. Boothby's research primarily addresses conditions affecting women's health, including rare ovarian tumors, cervical cancer, and congenital issues such as cleft palates. He employs innovative techniques like laparoscopic venous sampling, which helps identify hormone-related tumors in teenage girls. Additionally, he evaluates new treatment regimens, such as the combination of topotecan and cisplatin for cervical cancer, to enhance patient outcomes. His work also emphasizes the critical need for early intervention in treating conditions like cleft palates, showcasing the importance of timely medical support.
Key findings
In a study of 14-year-old girl with a Sertoli-Leydig tumor, laparoscopic venous sampling successfully diagnosed the tumor, which constitutes about 0.5% of ovarian tumors.
In a trial for treating persistent cervical cancer, 28% of 32 patients experienced tumor shrinkage, with responses lasting up to 15 months.
Out of 768 children with cleft palates studied over 22 years, only one required additional surgery thanks to timely interventions and support.
Two methods of preventing infections after cesarean sections showed similar effectiveness, with endometritis rates of 3.8% for irrigation and 4% for IV treatment.
Regular monitoring for women exposed to the drug DES, as highlighted in a study, is crucial since they can develop cancers despite initial normal check-ups.
Frequently asked questions
Does Dr. Boothby study ovarian tumors?
Yes, he focuses on diagnosing rare ovarian tumors like Sertoli-Leydig tumors, particularly in teenage girls.
What treatments has Dr. Boothby researched for cervical cancer?
He has researched the effectiveness of combining topotecan and cisplatin for treating persistent or recurrent cervical cancer.
Is Dr. Boothby's work relevant to children with cleft palates?
Absolutely, his research emphasizes early intervention and support for children with cleft palates, benefiting their communication and development.
How does Dr. Boothby’s research impact new mothers?
His studies on cesarean sections help inform best practices for preventing infections related to the procedure.
What can women with a history of DES exposure learn from Dr. Boothby’s research?
Women exposed to DES during pregnancy should continue regular medical check-ups, as they may still be at risk for developing cancer.
Publications in plain English
Direct laparoscopic venous sampling to diagnose a small Sertoli-Leydig tumor.
2003
Gynecologic oncology
White LC, Buchanan KD, O'Leary TD, Carlan SJ, Boothby R
Plain English This study looked at a rare type of ovarian tumor called Sertoli-Leydig cell tumors (SLCT), which make up 0.5% of ovarian tumors. Researchers used a special method called laparoscopic venous sampling to diagnose a 14-year-old girl who had high testosterone levels, indicating she had an SLCT. After treating her successfully, she developed another SLCT three years later but is now disease-free.
Who this helps: This research benefits teenage girls with similar hormonal issues by improving diagnostic methods for rare ovarian tumors.
Phase II trial of topotecan and cisplatin in persistent or recurrent squamous and nonsquamous carcinomas of the cervix.
2002
Gynecologic oncology
Fiorica J, Holloway R, Ndubisi B, Orr J, Grendys E +5 more
Plain English This study explored the effectiveness of combining two drugs, topotecan and cisplatin, to treat patients with persistent or recurrent cervical cancer. Out of 32 patients who were evaluated, 28% saw their tumors shrink, with some patients having responses lasting up to 15 months. The treatment was generally safe, with most patients experiencing manageable side effects, and the average survival time for patients was 10 months.
Who this helps: This helps patients with persistent or recurrent cervical cancer seeking new treatment options.
LCD versus CRT displays: a comparison of visual search performance for colored symbols.
2002
Human factors
Hollands JG, Parker HA, McFadden S, Boothby R
Plain English This study compared how well people can find colored symbols on two different types of screens: liquid-crystal displays (LCDs) and cathode-ray tube displays (CRTs). Twenty-four adults participated, and the results showed that when looking at symbols at an angle on LCD screens, people took longer to respond and had a harder time finding them compared to CRTs. This is important because it suggests that LCDs may not be the best choice for tasks that involve color-coded symbols viewed from the side.
Who this helps: This helps military personnel and others who rely on tactical displays for quick visual searches.
Cleft palate: modern technology and neuroscience merge.
2000
The Journal of craniofacial surgery
Scheuerle J, Guilford AM, Habal MB, Abdoney M, Boothby R +3 more
Plain English This study looked at the treatment of 768 kids with cleft palates over 22 years, focusing on how to help them communicate better and prevent related issues. The team used strategies like early hearing checks, parent training, and timely surgeries that minimized scarring, leading to just one child needing additional surgery later. Overall, this approach helped most children adapt well, highlighting the importance of early intervention and support for their development.
Who this helps: This benefits children with cleft palates and their families.
Stage II papillary clear cell adenocarcinoma of the vagina during observation in a diethylstilbestrol-exposed daughter.
1989
Gynecologic oncology
Carlson JA, Morgan M, Boothby R, Rubin M
Plain English This study looked at a 32-year-old woman who developed a type of vaginal cancer known as stage II clear cell adenocarcinoma after being monitored for eight years with normal check-ups. Despite her regular evaluations showing no cancer, she still ended up with this serious condition linked to her mother's past use of a drug called Diethylstilbestrol (DES) during pregnancy. The findings highlight the importance of ongoing medical check-ups for women exposed to DES, as they can still be at risk for developing cancer even if initial tests appear normal.
Who this helps: This helps women exposed to DES in utero and their doctors.
Vernix caseosa granuloma: a rare complication of cesarean section.
1985
Southern medical journal
Boothby R, Lammert N, Benrubi GI, Weiss B
Plain English The researchers studied a rare condition called vernix caseosa granuloma that occurred in a young woman after her cesarean section. This condition required a second surgery where part of her bowel was removed. It is important because it highlights a potential complication that has not been previously reported in other cases related to cesarean sections.
Who this helps: This information is valuable for doctors and healthcare providers who manage cesarean deliveries.
Comparison of intravenous cefoxitin prophylaxis with intraoperative cefoxitin irrigation for the prevention of post-cesarean-section endometritis.
1984
The Journal of reproductive medicine
Boothby R, Benrubi G, Ferrell E
Plain English This study looked at two methods for preventing endometritis, an infection after cesarean sections. One group of 103 patients received a direct irrigation of cefoxitin during surgery, while the other group received a short IV dose of cefoxitin along with saline irrigation. The rates of endometritis were very similar in both groups, with 3.8% for irrigation and 4% for the IV treatment, showing no significant difference in effectiveness.
Who this helps: This helps new mothers undergoing cesarean deliveries.