Dr. Kleinhans studies the socio-economic factors affecting urban neighborhoods, particularly how ethnic minorities and low-income families struggle with relocation even when they desire better living situations. His work aims to uncover the barriers these groups face, contributing to better policies for urban planning and housing. In addition, he develops cutting-edge sensor technologies to monitor living cells and tissues, which has significant implications for cancer research. His methods allow for real-time, precise measurements of cancer cell responses to treatments, facilitating more personalized chemotherapy options for patients.
Key findings
In a study of urban neighborhoods, Dr. Kleinhans found that ethnic minorities are less likely to relocate despite wanting to, highlighting significant barriers for low-income households.
His automated platform for monitoring breast cancer cells showed an effective tracking of cell reactions over time when exposed to toxic substances, providing data that traditional methods couldn't capture.
In testing breast cancer cells with doxorubicin, Dr. Kleinhans observed a measurable decrease in oxygen consumption, demonstrating the potential for personalized chemotherapy based on real-time cell response.
A miniaturized electronic system developed in his research could monitor 24 cells simultaneously, leading to more precise testing of drug effects on living cells without causing damage.
In a study of 658 forced relocations, it was found that ethnic minorities had greater needs for neighborhood improvements and tended to move into areas with higher concentrations of their own ethnicity, indicating patterns of segregation.
Frequently asked questions
Does Dr. Kleinhans study urban neighborhoods?
Yes, he examines the barriers faced by ethnic minorities and low-income families regarding relocation and neighborhood selection.
What treatments has Dr. Kleinhans researched?
He focuses on personalized cancer treatments, specifically how breast cancer cells respond to chemotherapy drugs.
Is Dr. Kleinhans's work relevant to cancer patients?
Absolutely, his research aims to improve cancer treatment options through innovative monitoring technologies that help personalize chemotherapy.
How does Dr. Kleinhans's work help city planners?
His findings on neighborhood dynamics assist city planners and policymakers in creating more integrated and equitable communities.
What technological advances has Dr. Kleinhans made?
He has developed sensor platforms that allow real-time monitoring of living cells, significantly improving the accuracy and efficiency of drug testing.
Publications in plain English
Ethnic differences in realising desires to leave urban neighbourhoods.
2017
Journal of housing and the built environment : HBE
Boschman S, Kleinhans R, van Ham M
Plain English This study looked at why some people want to leave their neighborhoods but can’t, focusing on ethnic and economic differences. Researchers found that ethnic minorities and low-income households are less likely to move even when they wish to, highlighting a problem in how these groups face barriers to leaving their neighborhoods. Understanding these barriers matters because it can help address issues of segregation and improve living conditions for affected groups.
Who this helps: This helps low-income families and ethnic minorities seeking better living situations.
Automated platform for sensor-based monitoring and controlled assays of living cells and tissues.
2013
Biosensors & bioelectronics
Wolf P, Brischwein M, Kleinhans R, Demmel F, Schwarzenberger T +2 more
Plain English This research focused on developing an automated system for monitoring living cells and tissues in real-time. The new platform uses special sensors to measure important factors like oxygen consumption and cell changes without needing a human to oversee the tests, allowing the process to run for days automatically. In tests with breast cancer cells, the system effectively tracked how these cells reacted over time to a toxic substance, providing valuable data that traditional methods couldn't capture.
Who this helps: This benefits researchers and pharmaceutical companies working on cancer treatments.
Sensor-based cell and tissue screening for personalized cancer chemotherapy.
2012
Medical & biological engineering & computing
Kleinhans R, Brischwein M, Wang P, Becker B, Demmel F +5 more
Plain English This study looked at a new way to test how breast cancer cells respond to chemotherapy drugs by using sensors to measure their activity in real-time. The researchers found that when exposed to drugs like doxorubicin, the oxygen consumption of the cancer cells decreased, showing a measurable response to treatment. This method offers a faster and more detailed analysis compared to traditional testing, helping doctors choose the most effective chemotherapy for individual patients.
Who this helps: This benefits cancer patients by providing personalized treatment options.
Residential outcomes of forced relocation: lifting a corner of the veil on neighbourhood selection.
2011
Urban studies (Edinburgh, Scotland)
Doff W, Kleinhans R
Plain English This study looked at how 658 people who were forced to move due to changes in urban areas in The Hague ended up choosing their new neighborhoods. It found that ethnic minorities reported needing more improvement in their neighborhoods compared to native Dutch people and were more likely to move to areas with high concentrations of their own ethnicity. This matters because it shows that policies meant to reduce segregation may actually lead to new patterns of ethnic concentration instead.
Who this helps: This helps city planners and policymakers aiming to create more integrated communities.
Impedance sensor technology for cell-based assays in the framework of a high-content screening system.
2011
Physiological measurement
Schwarzenberger T, Wolf P, Brischwein M, Kleinhans R, Demmel F +3 more
Plain English This study looks at a new technology that helps scientists monitor living cells more effectively when testing drugs. Researchers developed a miniaturized electronic system that measures how cells react to medications without damaging them, using a setup that tracks 24 cells at once. They found that by improving how sensors work together, they could get better data about cell health, particularly using a breast cancer cell line treated with a common drug called doxorubicin. This is important because it allows for more precise testing of how treatments affect cells, which could lead to better cancer therapies.
Who this helps: Patients undergoing cancer treatment and their doctors.
A fluorescent two-hybrid assay for direct visualization of protein interactions in living cells.
2008
Molecular & cellular proteomics : MCP
Zolghadr K, Mortusewicz O, Rothbauer U, Kleinhans R, Goehler H +3 more
Plain English Researchers developed a new method to see how proteins interact inside living cells by using special fluorescent markers. They successfully tracked these interactions in various parts of the cell and found they change during different phases of the cell cycle. This tool is important because it allows scientists to study protein interactions in real-time, which can lead to better understanding of cell functions and responses to changes in their environment.
Who this helps: This helps researchers and scientists studying cellular processes and diseases.