Practice Location

575 S 70TH ST
LINCOLN, NE 68510-2471

Phone: (402) 441-4760

What does ROBERT MABEN research?

Dr. Maben studies how the chemical compounds found in plants, particularly phenolic compounds in leaves, impact the health and growth of caterpillars. He specifically investigates how these compounds affect different caterpillar species when they consume leaves from red oaks and sugar maples. Additionally, he researches how the cancer treatment dexamethasone influences certain human leukemia cells, focusing on how these cells respond to the treatment and what biological changes occur as a result. This research is essential for developing better strategies in both pest management and leukemia therapy.

Key findings

  • Caterpillars fed on sugar maple leaves had higher levels of harmful radicals in their gut fluids, indicating stronger prooxidant activity compared to red oak leaves.
  • Malacosoma disstria caterpillars exhibited higher radical levels than Orgyia leucostigma, suggesting different responses to plant phenolics.
  • Human T-cell leukemia cells sensitive to glucocorticoids showed a significant increase in dolichol after 24 hours of treatment with dexamethasone, while resistant cells did not.

Frequently asked questions

Does Dr. Maben study caterpillar health?
Yes, he studies how different plants affect caterpillar growth and health, especially through the chemicals found in their leaves.
What treatments has Dr. Maben researched for leukemia?
Dr. Maben has researched the effects of dexamethasone on human T-cell leukemia cells, focusing on how the treatment influences cell biology.
Is Dr. Maben's work relevant to cancer treatment?
Yes, his findings on how certain leukemia cells respond to dexamethasone could help improve treatment strategies for leukemia patients.

Publications in plain English

Phenolic compounds in red oak and sugar maple leaves have prooxidant activities in the midgut fluids of Malacosoma disstria and Orgyia leucostigma caterpillars.

2005

Journal of chemical ecology

Barbehenn R, Cheek S, Gasperut A, Lister E, Maben R

Plain English
This study examined how chemicals called phenolic compounds in red oak and sugar maple leaves affect two types of caterpillars—Malacosoma disstria and Orgyia leucostigma—when they eat these leaves. The researchers found that when the caterpillars consumed sugar maple leaves, their gut fluids had higher levels of harmful radicals, which indicates that sugar maple phenolics are more likely to cause oxidation compared to those in red oak. Specifically, Malacosoma disstria had higher radical levels than Orgyia leucostigma, suggesting that different caterpillar species respond differently to these compounds. Who this helps: This research helps scientists and agricultural professionals understand how different plant species can affect caterpillar growth and health, which is important for managing insect populations.

PubMed

Increased dolichol content in glucocorticoid-sensitive human T-cell leukemia line grown in the presence of dexamethasone.

1989

Biochemical and biophysical research communications

Dutta A, Parikh B, Maben R, Melnykovych G

Plain English
This study looked at two types of human T-cell leukemia cells to see how they reacted to a treatment called dexamethasone. The researchers found that after 24 hours, the glucocorticoid-sensitive cells showed a significant increase in a substance called dolichol, while the resistant cells did not. This is important because it suggests that dolichol might play a role in how these cells are killed by glucocorticoids, advancing our understanding of leukemia treatment. Who this helps: This helps doctors and researchers working on leukemia therapies.

PubMed

Frequent Co-Authors

Raymond Barbehenn Susannah Cheek Adrian Gasperut Emma Lister A Dutta B Parikh G Melnykovych

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.