Dr. Still's research primarily tackles how to better diagnose and treat various health conditions. For instance, he has developed a new blood test for colorectal cancer that can accurately identify about 96% of cases, streamlining the process for patients before they undergo more invasive procedures like colonoscopies. Additionally, he examines the effectiveness of different antibody tests for COVID-19, revealing which tests provide reliable results over time. His work also includes using advanced devices to improve surgical safety and exploring new treatment options for COVID-19 patients.
Furthermore, Dr. Still investigates the management of conditions like diabetes through exercise and nutrition, showing how dietary choices can stabilize blood sugar levels in people with type 1 diabetes. His findings bridge the gap between cutting-edge engineering and essential medical applications, ultimately aiming to enhance patient care.
Key findings
In a pilot study of 532 patients, 29 (5%) were diagnosed with colorectal cancer using a new blood test that accurately identified about 96% of cases.
For COVID-19 antibody tests, the Abbott test showed only 50% sensitivity after about 175 days, while Roche and MSD tests maintained over 90% sensitivity up to 200 days.
Using a special tissue graft in heart surgeries reduced complications from 13% to 3.1% for fluid buildup in the lungs and 2.6% to 1.5% for fluid around the heart.
A study on type 1 diabetes showed that consuming isomaltulose led to 21% lower average blood sugar levels after exercise compared to dextrose when managing carbohydrate intake.
Frequently asked questions
Does Dr. Still study colorectal cancer?
Yes, Dr. Still has developed a novel blood test to help identify colorectal cancer, improving the speed and ease of diagnosis.
What is Dr. Still's work related to COVID-19?
He studies the effectiveness of various COVID-19 antibody tests and explores treatment options like the drug probenecid, which prevents virus replication.
How does Dr. Still's research help patients undergoing heart surgery?
His research on using special tissue grafts in heart surgeries has led to significantly fewer complications and lower hospital readmission rates.
What are Dr. Still's contributions to managing diabetes?
He investigates how dietary manipulation can stabilize blood sugar levels in people with type 1 diabetes during and after exercise.
What technology does Dr. Still work with?
He develops devices that enhance safety during surgical procedures by capturing harmful aerosols and improving human-robot interactions.
Publications in plain English
Development of a Force Perturbation Handle for Physical Interaction Research in Humans.
2026
Journal of biomechanical engineering
Tien H, Song YS, Burns D, Mohammadi Beirami M, Ghorbani Zadeh K +1 more
Plain English Researchers created a special tool called a force perturbation handle to study how people physically interact with each other, like during a handshake. They found that when participants were asked to adjust their arm stiffness, the tool accurately measured these changes and confirmed that the stiffness levels matched their instructions. This research is important because it helps improve the design of robots that will work alongside humans, making those interactions smoother and more natural.
Who this helps: This helps robot developers and engineers working on human-robot collaboration.
A novel blood based triage test for colorectal cancer in primary care: a pilot study.
2023
BJGP open
Jenkins C, Woods F, Chandler S, Carter K, Jenkins R +14 more
Plain English This study tested a new blood test called Raman-CRC to help doctors identify colorectal cancer (CRC) in patients before they undergo colonoscopy. Out of 532 patients aged 50 and older, 29 (or 5%) were found to have CRC, with the blood test accurately identifying about 96% of cases. This is important because it provides a simpler and faster way for doctors to prioritize patients who may have cancer, potentially leading to quicker diagnoses and better treatment outcomes.
Who this helps: This benefits patients who need faster access to cancer diagnosis and care.
Computational modelling of an aerosol extraction device for use in COVID-19 surgical tracheotomy.
2022
Journal of aerosol science
Calmet H, Bertomeu PF, McIntyre C, Rennie C, Gouder K +4 more
Plain English This study explored a new device designed to capture and remove potentially harmful aerosols released during surgical procedures like tracheotomies, which have become more frequent due to COVID-19. The researchers used advanced computer models to test how well this device works, finding it can effectively contain and extract aerosol particles. This is important because it helps reduce the risk of spreading infections to healthcare workers and keeps operating rooms safer.
Who this helps: This benefits healthcare workers and patients undergoing surgery.
The Influence of Time on the Sensitivity of SARS-CoV-2 Serological Testing.
2022
Research square
Ortiz AT, Torrente FF, Twigg A, Hatcher J, Saso A +10 more
Plain English This study looked at how well different tests detect antibodies for COVID-19 over time after someone has been infected. Researchers found that one test, the Abbott-N assay, became less effective and failed to show positive results for 50% of people after about 175 days. In contrast, the Roche and MSD tests remained accurate, with 93-97% of results still positive even after 200 days. This matters because choosing the right test can help ensure that patients receive proper care and follow-up after infection.
Who this helps: Patients recovering from COVID-19 and healthcare providers making treatment decisions.
The influence of time on the sensitivity of SARS-CoV-2 serological testing.
2022
Scientific reports
Torres Ortiz A, Fenn Torrente F, Twigg A, Hatcher J, Saso A +10 more
Plain English This research focused on how the effectiveness of different SARS-CoV-2 antibody tests changes over time after infection. The study found that the Abbott test loses sensitivity quickly, with only 50% of it detecting antibodies after about 175 days, while tests from Roche and MSD maintained high sensitivity, detecting antibodies in over 90% of cases even after 200 days. This is important because it helps determine which tests can reliably measure immunity and guide decisions for vaccinations and treatments.
Who this helps: Patients and doctors managing COVID-19 treatments and vaccinations.
Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro.
2021
Scientific reports
Murray J, Hogan RJ, Martin DE, Blahunka K, Sancilio FD +4 more
Plain English This study looked at how well a drug called probenecid can stop the COVID-19 virus from multiplying. Researchers found that probenecid effectively blocked the virus in both lab-grown cells and in hamsters, showing that levels of the drug in the bloodstream can be high enough to be effective for at least 24 hours after taking it. This matters because it suggests probenecid could be a valuable treatment option for COVID-19 patients.
Who this helps: Patients with COVID-19.
Pericardial closure with extracellular matrix scaffold following cardiac surgery associated with a reduction of postoperative complications and 30-day hospital readmissions.
2019
Journal of cardiothoracic surgery
Rego A, Cheung PC, Harris WJ, Brady KM, Newman J +1 more
Plain English This study examined how using a special tissue graft to close the heart's outer layer after surgery affects patients' recovery. Researchers found that patients who had valve surgery using this graft experienced fewer complications, such as fluid buildup in the lungs and around the heart, with rates dropping from 13% to 3.1% and from 2.6% to 1.5%, respectively. Additionally, patients who received coronary artery bypass grafting (CABG) had a lower chance of bleeding and less fluid buildup compared to others, resulting in fewer hospital readmissions within 30 days.
Who this helps: This benefits patients undergoing heart surgeries, as it may lead to smoother recoveries and fewer complications.
Mothers' understanding of the term 'exclusive breastfeeding': a systematic review.
2017
Maternal & child nutrition
Still R, Marais D, Hollis JL
Plain English This study looked at how well mothers understand the term "exclusive breastfeeding," which means feeding an infant only breast milk without any other foods or drinks. Out of 21 studies reviewed, 70.9% of mothers could accurately define exclusive breastfeeding, although understanding varied widely, with some believing they could give water or mixed milk. This is important because misunderstandings about exclusive breastfeeding could lead to unhealthy feeding practices for infants.
Who this helps: This helps mothers and healthcare providers by improving education on breastfeeding practices.
Plain English This study focuses on melanoma, a type of skin cancer that can occur during pregnancy. Researchers found that melanoma during pregnancy is serious and can spread more easily, making early detection crucial to improving outcomes. They emphasize the need for careful checking of any unusual skin spots, especially since pregnancy can cause skin changes. Delaying another pregnancy for two to three years after a melanoma diagnosis is recommended if there’s a high risk of it coming back.
Who this helps: This information benefits pregnant patients and their healthcare providers.
Iron-Catalyzed Stereoselective Cross-Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents.
2016
Angewandte Chemie (International ed. in English)
Rivera AC, Still R, Frantz DE
Plain English This study explored a new chemical reaction using iron to combine special compounds called enol carbamates with Grignard reagents to create specific types of acrylates, which are useful in various applications. The researchers developed a straightforward way to produce these enol carbamates and found that the reaction is highly selective, leading to the desired products efficiently. This is important because it can make it easier and cheaper to create complex materials used in medicines and other areas.
Who this helps: This research benefits chemists and industries that produce pharmaceuticals and other chemical products.
James D, Ames D, Lopez B, Still R, Simpson W +1 more
Plain English This study looked at how different medical labs can improve their quality by participating in external quality assessment (EQA) programs. It found that labs often have varying levels of understanding about EQA, with important factors affecting quality being how samples are handled and how results are used. Clear definitions from EQA providers on what their programs offer can help labs choose the right option for improving their services.
Who this helps: This benefits laboratory staff and healthcare providers who rely on accurate lab results for patient care.
Plain English Researchers studied how water droplets behave on incredibly hot surfaces, particularly focusing on their ability to move around using a special surface design that looks like a series of saw-teeth. They found that by using this design and a technique called transition boiling, droplets could be made to climb steeper surfaces and change directions based on the temperature of the surface. This is important because it can improve how we control small droplets in various applications, like cooling systems and drug delivery.
Who this helps: This helps engineers and scientists developing new technologies for cooling and precision fluid delivery.
Isomaltulose Improves Postexercise Glycemia by Reducing CHO Oxidation in T1DM.
2011
Medicine and science in sports and exercise
West DJ, Morton RD, Stephens JW, Bain SC, Kilduff LP +3 more
Plain English This study looked at how two different types of carbohydrates (CHO)—isomaltulose and dextrose—affect blood sugar levels in people with type 1 diabetes during and after exercise. The results showed that those who consumed isomaltulose had a smaller increase in blood sugar before exercising and lower blood sugar levels throughout the post-exercise period compared to those who took dextrose. Specifically, isomaltulose led to a 21% lower average blood sugar than dextrose after exercise, which is significant for managing diabetes.
Who this helps: This benefits patients with type 1 diabetes, especially those engaging in regular exercise.
A combined insulin reduction and carbohydrate feeding strategy 30 min before running best preserves blood glucose concentration after exercise through improved fuel oxidation in type 1 diabetes mellitus.
2011
Journal of sports sciences
West DJ, Stephens JW, Bain SC, Kilduff LP, Luzio S +2 more
Plain English This study looked at how changing the timing of a low-sugar meal and lowering insulin before running affects blood sugar levels in people with type 1 diabetes. It found that taking these measures 30 minutes before exercise resulted in lower blood sugar drops during running and better recovery afterwards, with average blood sugar levels at 3.7 mmol/l compared to 6.4 mmol/l when done 120 minutes before. It also showed fewer cases of dangerous low blood sugar (hypoglycemia) in the 30-minute preparation group compared to longer waits.
Who this helps: This helps people with type 1 diabetes who exercise.
Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates.
2011
The Journal of organic chemistry
Babinski DJ, Aguilar HR, Still R, Frantz DE
Plain English Researchers developed a new method to create a type of chemical compound called pyrazoles, which are important in medicine. They successfully produced 3,4,5-trisubstituted pyrazoles using a combination of two techniques, allowing for a variety of chemical structures, including both straight and ring-shaped forms. The results show that this method produces complex compounds efficiently, which could lead to the discovery of new drugs.
Who this helps: This helps pharmaceutical companies and researchers looking to develop new medications.
Evaluation of plasma glutamate levels in normal tension glaucoma.
2010
Ophthalmic research
Bunting H, Still R, Williams DR, Gravenor M, Austin MW
Plain English This study looked at whether people with normal-tension glaucoma (NTG) have higher levels of a chemical called glutamate in their blood compared to healthy individuals. Researchers tested 27 people, finding that those with NTG did not have significantly different glutamate levels than the control group (p = 0.67). This is important because while migraines are linked to both glutamate levels and NTG, high glutamate levels are not a factor in NTG.
Who this helps: This information helps doctors better understand the relationship between glaucoma and migraine in patients.
Assault by burning--a retrospective review with focus on legal outcomes.
2001
The Journal of burn care & rehabilitation
Dorn TW, Still JM, Law E, Still R
Plain English This study looked at cases where people were intentionally burned, finding 85 incidents at a burn center. Out of these, 15 people died from their injuries. This matters because it highlights the serious consequences of these assaults, not just for the victims but also for society, which has to deal with both the victims' care and the legal actions against the attackers.
Who this helps: This helps patients who are burn victims and society by raising awareness of the impact of violent assaults.
Fine needle aspiration of the prostate gland in the community hospital. A predictive value analysis.
1988
Acta cytologica
Bentley EM, Mallery WR, Mueller JJ, Anderson MC, Schott AW +2 more
Plain English This study looked at a technique called fine needle aspiration, which is used to take samples from the prostate gland, to see how accurate and useful it is. Researchers analyzed samples from 50 patients, evaluating the results from four pathologists. They found that this method can provide important information for diagnosing prostate issues, helping clinicians understand patient conditions better.
Who this helps: This benefits patients experiencing prostate problems and the doctors treating them.