Dr. McMillin studies emulsions, which are mixtures of liquids that normally don’t combine well, like oil and water. He examines how these mixtures behave in different environments, including the microgravity of space, to make advancements in food, cosmetics, and pharmaceuticals. Additionally, he is involved in research related to diabetes medication delivery methods and the impact of environmental pollutants on aquatic life, which helps guide water safety and conservation efforts. His work also delves into specific medical conditions such as autism and heart cell injuries.
Key findings
In a study on microgravity effects, droplets in emulsions were found to quickly clump together initially but evolved to involve both small and large droplets over time, showing significant changes in behavior critical for product development.
By improving 3D printing techniques, Dr. McMillin increased the metformin drug loading in tablets from 0.08% to 1.40%, enhancing delivery for diabetic patients.
His research identified novel contaminants causing fish kills—specifically a porphyrin contaminant confirmed in the Red River, vital for understanding pollution sources affecting aquatic ecosystems.
In a study on heart cells, it was discovered that oxygen deprivation leads to a significant release of enzymes, indicating higher injury levels, which is crucial for improving heart attack treatment strategies.
A study on autism revealed that individuals with traits of autism perceive motion differently than non-autistic individuals, showing the need for tailored support in understanding sensory processing.
Frequently asked questions
Does Dr. McMillin study diabetes?
Yes, he researches improved delivery methods for diabetes medications, including the use of 3D printing for metformin tablets.
What environmental issues has Dr. McMillin researched?
He has identified harmful contaminants in aquatic environments, specifically linked to fish kills and water quality.
Is Dr. McMillin's work relevant to patients with autism?
Yes, his research into motion perception differences helps inform care strategies for individuals with autistic traits.
Has Dr. McMillin conducted research on heart health?
Yes, he studied how heart cells respond to oxygen deprivation, which is important for understanding heart attack impacts.
What are emulsions and why are they important?
Emulsions are mixtures of liquids that don't normally mix, like oil and water. They are crucial for the food, cosmetics, and pharmaceutical industries as they impact product development and stability.
Publications in plain English
Intrinsic dynamics of emulsions: Experiments in microgravity on the International Space Station.
2025
Journal of colloid and interface science
Lorusso V, Orsi D, Vaccari M, Ravera F, Santini E +8 more
Plain English This study looked at how tiny droplets in oil and water mixtures behave in microgravity on the International Space Station. Researchers found that right after the droplets are mixed, they tend to clump together quickly, but as time goes on, the process changes to involve both small and large droplets interacting. Understanding these behaviors is important for improving products that rely on emulsions, like food and cosmetics, and can also lead to innovations for space missions.
Who this helps: This helps food and cosmetic manufacturers, as well as researchers in space exploration.
Recent developments in emulsion characterization: Diffusing Wave Spectroscopy beyond average values.
2021
Advances in colloid and interface science
Lorusso V, Orsi D, Salerni F, Liggieri L, Ravera F +3 more
Plain English This study looked at a method called Diffusing Wave Spectroscopy (DWS) to better understand emulsions, which are mixtures of liquids that normally don’t mix well, like oil and water. The researchers developed a new way to analyze DWS data, allowing them to measure not just average drop sizes but also how much those sizes vary. They found that in unstable emulsions, the variation in drop velocity affects how often drops collide and combine, which is important for understanding how these mixtures behave, especially in situations like weightlessness on the International Space Station.
Who this helps: This research benefits scientists and engineers working with emulsions, especially in food, cosmetics, and pharmaceuticals.
3D Printing of Metformin HCl PVA Tablets by Fused Deposition Modeling: Drug Loading, Tablet Design, and Dissolution Studies.
2019
AAPS PharmSciTech
Ibrahim M, Barnes M, McMillin R, Cook DW, Smith S +3 more
Plain English This study focused on using 3D printing to create tablets containing metformin, a common diabetes medication, mixed with a substance called PVA. They found that by soaking PVA filaments in a special solution, they could significantly increase the amount of metformin loaded into the tablets—from just 0.08% to 1.40%. The design of the tablets, which included channels to increase surface area, also improved how quickly the medication dissolves, greatly affecting how the body can absorb it.
Who this helps: This research benefits patients with diabetes by potentially improving how their medication is delivered.
Novel contaminants identified in fish kills in the Red River watershed, 2011-2013.
2018
Environmental toxicology and chemistry
Jones-Lepp TL, Taguchi V, Sovocool W, Betowski D, DeArmond P +4 more
Plain English Researchers studied the causes of fish deaths in the Red River area by looking for unknown pollutants in water and sediment samples collected between 2011 and 2013. They discovered two significant contaminants: one was a type of porphyrin called chlorin-e6-trimethyl ester, which was confirmed to be present, and the other was an amide porphyrin created during the testing process. Identifying these chemicals is crucial because it helps understand pollution sources and their impact on aquatic life.
Who this helps: This research benefits environmental scientists and regulators working to protect water quality and fish populations.
Plain English This study looked at how people perceive motion, particularly in the context of eye movement and low light. Researchers found that the way individuals with autism perceive motion differs from non-autistic individuals; specifically, those with autistic traits can have a less clear sense of prior knowledge, which affects their perception of speed. These results highlight that understanding these differences in perception is important for tailoring support and interventions for individuals with autistic traits.
Who this helps: This helps patients with autism and their caregivers.
Trace level haloacetic acids in drinking water by direct injection ion chromatography and single quadrupole mass spectrometry.
2009
Journal of chromatographic science
Mathew J, McMillin R, Gandhi J, Mohsin S, Czyborra S
Plain English This study looked at trace levels of haloacetic acids (HAAs), which are harmful by-products that can form when chlorine disinfects drinking water. Researchers introduced a new, simpler method using direct injection ion chromatography combined with mass spectrometry to quickly and accurately analyze these chemicals. They found this new method offers a more efficient way to detect HAAs than previous techniques, which is important for ensuring safe drinking water.
Who this helps: This benefits water quality managers and health officials monitoring the safety of drinking water.
Complications of acquired diverticula of the ileum.
1983
The American surgeon
Jones D, McMillin R, Greene F
Plain English This study looked at rare pouches called acquired diverticula that can form in the ileum, a part of the small intestine. These diverticula affect less than one percent of people, and complications happen in under ten percent of cases, but when they do, the risk of death can be very high—between 25 and 50 percent. The researchers shared three cases where patients presented with severe abdominal pain; two required surgical removal of the affected area due to perforation, and one patient had diverticulitis without perforation, highlighting the serious risks and the need for prompt diagnosis and treatment.
Who this helps: This research helps doctors better understand and treat patients with ileal diverticula.
Ischemic myocardial injury in cultured heart cells: leakage of cytoplasmic enzymes from injured cells.
1978
In vitro
Acosta D, Puckett M, McMillin R
Plain English Researchers studied how heart cells respond to a lack of oxygen and glucose, simulating a heart attack in lab conditions. They found that when heart cells were deprived of both oxygen and glucose, they released significantly more crucial enzymes (lactate dehydrogenase and creatine phosphokinase) into the surrounding medium, indicating more damage. In contrast, just cutting off glucose led to only slight enzyme leakage, suggesting that oxygen deprivation plays a major role in heart cell injury. The cells recovered well when given normal conditions afterwards.
Who this helps: This research helps doctors understand how to better protect heart cells during a heart attack.