DR. RONNIE KEITH, D.O.

NORMAN, OK

Research Active
Surgery NPI registered 21+ years 50 publications 2005 – 2026 NPI: 1508862145
BiomarkersDisease ProgressionMedicareCardiovascular DiseasesResearch DesignVapingElectronic Nicotine Delivery SystemsLungPrimary Health CareHeart RateVascular StiffnessSpeech PerceptionTreesConservation of Natural ResourcesFlavoring Agents

Practice Location

2405 PALMER CIR
NORMAN, OK 73069-6349

Phone: (405) 360-7100

What does RONNIE KEITH research?

Dr. Ronnie Keith studies how the environment affects our health, particularly in urban areas. He has conducted extensive research on the benefits of adding green spaces, like microforests and trees, which can improve cardiovascular health and reduce stress for city residents. Additionally, he explores the health risks of e-cigarettes and lung diseases like myositis-associated interstitial lung disease, seeking to identify effective treatments and understanding the progression of these conditions. His work is essential for public health officials and communities aiming for better health outcomes.

Key findings

  • In the Green Heart Project, planting over 8,000 trees in low-income neighborhoods led to improved cardiovascular health and reduced pollution exposure for nearly 1,800 residents.
  • In a study of e-cigarettes labeled as 'clear,' users experienced a significant increase in diastolic blood pressure and heart rate compared to non-users, raising safety concerns about these products.
  • 28% of patients with myositis-associated interstitial lung disease showed signs of peridiaphragmatic inflammation, which often persists over time, highlighting the need for early diagnosis.
  • Patients who were in critical care had a 25% progression rate to metastatic disease within five years, compared to 14% in standard hospitalization.
  • The introduction of a new testing method identified 35 harmful chemicals in urine samples, aiding in the understanding of health risks related to environmental and tobacco exposure.

Frequently asked questions

Does Dr. Keith study the health effects of e-cigarettes?
Yes, Dr. Keith researches the health risks associated with e-cigarettes, focusing on their impact on cardiovascular health.
What conditions does Dr. Keith's research address?
Dr. Keith's research addresses various conditions including lung diseases like myositis-associated interstitial lung disease, pollution exposure, and the effects of urban greenery on health.
How is Dr. Keith's work relevant to urban residents?
His studies on urban greenery and its health benefits are crucial for city planners and residents looking to improve community health and reduce environmental stress.
What treatments has Dr. Keith researched for lung disease?
He has explored treatments for progressive pulmonary fibrosis, focusing on new medications that target inflammation to preserve lung function.
Can Dr. Keith's work help improve vaccination rates for older adults?
Yes, his research identifies gaps in influenza vaccination among Medicare-Medicaid beneficiaries, which can inform strategies to improve immunization rates.

Publications in plain English

The Green Heart Project: objectives, design, and methods.

2026

American journal of epidemiology

Bhatnagar A, Keith R, Yeager R, Riggs D, Sears C +9 more

Plain English
The Green Heart Project studied how adding more green spaces, like trees and shrubs, in a community affects people's health. Researchers looked at air pollution levels and conducted health exams on nearly 1,800 residents before and after planting over 8,000 trees in 2022. They found that improving greenery could lead to better cardiovascular health and reduced pollution exposure, which is important for the well-being of residents in urban areas, especially those in lower-income neighborhoods. Who this helps: This benefits residents of low- to middle-income communities seeking better health outcomes.

PubMed

Evaluating Microclimate Modification and Acute Cardiovascular Stress Responses to a Dense Urban Microforest: The Green Oasis (GRO) Protocol.

2026

International journal of environmental research and public health

Keith R, Willis S, Christian N, Khayat F, Gallagher J +10 more

Plain English
The Green Oasis (GRO) Project studied the effects of adding a microforest—a dense area filled with trees and shrubs—on both the environment and people's health in downtown Louisville. The project turned a bare park into a space with 119 trees and over 200 shrubs, and researchers measured changes in heart rate, stress levels, and other health markers while participants walked in both the microforest and a nearby parking lot. Preliminary findings will help urban planners and health officials understand how such green spaces can improve health and comfort in crowded cities, potentially benefiting city residents by making urban areas healthier and more pleasant to live in. Who this helps: Urban residents and city planners.

PubMed

Potential of phosphodiesterase 4B inhibition in the treatment of progressive pulmonary fibrosis.

2025

Therapeutic advances in respiratory disease

Keith R, Nambiar AM

Plain English
This study explored a new treatment option for progressive pulmonary fibrosis (PPF), particularly focusing on a drug called nerandomilast that targets a specific enzyme (PDE4B) involved in inflammation. Researchers found that in an earlier trial, this drug successfully helped preserve lung function in patients with idiopathic pulmonary fibrosis (IPF) and is currently being tested in larger trials. This is important because existing treatments only slow down lung function decline and can have unwanted side effects, so a better option could significantly improve patients' quality of life and health. Who this helps: This helps patients with idiopathic pulmonary fibrosis and progressive pulmonary fibrosis.

PubMed

High-throughput UPLC-ESI/MSMS method for simultaneous measurement of the urinary metabolites of volatile organic compounds and tobacco alkaloids.

2025

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Srivastava S, Krivokhizhina T, Keith R, Bhatnagar A, Srivastava S +2 more

Plain English
This study developed a new testing method that allows researchers to measure the levels of 35 harmful chemicals from tobacco and the environment in urine samples at once. The new method is faster and more accurate, making it easier to detect individual exposure to these substances. This is important because understanding exposure to these chemicals can help identify links to serious health issues like cancer and heart disease. Who this helps: Patients and public health researchers.

PubMed

Cardiovascular Health Effects and Synthetic Cooling Agents in E-Cigarettes Labeled as "Clear" Marketed in Massachusetts After the Tobacco Product Flavoring Ban.

2025

Journal of the American Heart Association

Minetti ET, Erythropel HC, Keith R, Davis DR, Zimmerman JB +2 more

Plain English
This study looked at the health effects of a new type of e-cigarette labeled "clear" that appeared in Massachusetts after a ban on flavored tobacco products. Researchers found that using these "clear" e-cigarettes led to a significant increase in blood pressure and heart rate compared to those using non-"clear" flavored e-cigarettes and non-users. Specifically, participants experienced more noticeable changes in their cardiovascular function after using the "clear" e-cigarettes, which raises concerns about their safety. Who this helps: Patients concerned about the health risks of e-cigarettes.

PubMed

Peridiaphragmatic inflammation and fibrosis in myositis associated interstitial lung disease; a case series.

2025

Respiratory medicine and research

Pryor JB, Solomon JJ, Swigris JJ, Bang TJ, Fuentealba A +10 more

Plain English
This study looked at a specific type of inflammation and scarring around the diaphragm in patients with a lung disease linked to muscle inflammation, known as myositis-associated interstitial lung disease (M-ILD). Out of 46 patients, about 28% (13 patients) had this inflammation detected on CT scans, and 69% of these patients had this finding present from their first scan, showing it tends to persist over time. Recognizing this condition early can help doctors better diagnose and manage M-ILD, but it does not appear to worsen the disease. Who this helps: Patients with myositis-associated interstitial lung disease and their doctors.

PubMed

Cardiovascular Health Effects and Synthetic Cooling Agents in E-cigarettes Labeled as 'clear' Marketed in Massachusetts After the Tobacco Product Flavoring Ban.

2024

medRxiv : the preprint server for health sciences

Minetti ET, Erythropel HC, Keith R, Davis DR, Zimmerman JB +2 more

Plain English
This study looked at the health effects of a new type of e-cigarette called 'clear' that appeared on the market in Massachusetts after flavored tobacco products were banned in June 2020. Researchers found that using 'clear' e-cigarettes led to a greater increase in blood pressure and heart rate compared to other flavored e-cigarettes and non-users, with users experiencing a significant rise in diastolic blood pressure and heart rate. All tested 'clear' e-liquids contained synthetic cooling agents, which violates Massachusetts' flavor regulations, signaling a need for tighter control of these products. Who this helps: This information benefits public health officials and patients concerned about the risks of e-cigarettes.

PubMed

Rate of non-metastatic solid tumor progression following critical illness: a prospective cohort study of UK Biobank participants.

2024

Critical care science

Puxty K, Keith R, McPeake J, Morrison D, Shaw M

Plain English
This study looked at how patients with early-stage solid tumors fared after being admitted to critical care. Researchers found that 25% of patients who had been in critical care developed metastatic disease within five years, compared to just 14% of those who were hospitalized but not in critical care. This suggests that those who experienced critical care may be at a higher risk for their cancer worsening. Who this helps: Doctors and healthcare providers caring for cancer patients.

PubMed

An organizational assessment of 101 Community-Based Adult Services centers to identify and address gaps in influenza vaccination among Medicare-Medicaid beneficiaries.

2023

Vaccine

Cuddihy MT, Berger WL, Cummings PL, Keith R, Dao B +2 more

Plain English
This study examined 101 adult service centers in Los Angeles County to find out why many Medicare-Medicaid recipients aren't getting vaccinated for influenza. It found that about 58% of these centers do not perform immunization assessments, but 71% believe it would be possible to start if it were included in their care plans. Addressing these gaps is important to increase vaccination rates among vulnerable groups, helping to protect their health during flu season. Who this helps: This helps patients, particularly older adults on Medicare and Medicaid, who are at higher risk for flu-related diseases.

PubMed

Interstitial lung disease progression after genomic usual interstitial pneumonia testing.

2023

The European respiratory journal

Chaudhary S, Weigt SS, Ribeiro Neto ML, Benn BS, Pugashetti JV +9 more

Plain English
This study looked at whether a genetic test for usual interstitial pneumonia (gUIP) could help predict the progression of idiopathic pulmonary fibrosis (IPF) in patients. They analyzed data from 192 patients who were tested, finding that those with a positive gUIP result lost lung function at a rate of about 101.8 mL per year, while those with a negative result lost about 73.2 mL per year. Although there was a trend suggesting that those with a positive test experienced worse outcomes, it wasn't statistically significant, meaning we can’t be certain about the results. Who this helps: This research helps doctors understand how to interpret gUIP test results for their patients.

PubMed

Greenness and equity: Complex connections between intra-neighborhood contexts and residential tree planting implementation.

2023

Environment international

Yeager R, Browning MHEM, Breyer E, Ossola A, Larson LR +9 more

Plain English
This study examined how neighborhood income levels and other factors influence tree planting efforts in the Oakdale neighborhood of Louisville, Kentucky. Researchers found that higher income was linked to greener areas, with stronger connections in front yards compared to back yards. However, offering free trees didn’t lead to significant differences in who participated in planting, indicating that factors other than income and education, like yard size and area greenness, play a key role in these efforts. Who this helps: This research benefits community planners and environmental advocates looking to improve access to green spaces, especially for low-income residents.

PubMed

Enhancing household soybean processing and utilization in the Eastern Province of Zambia, a concurrent triangulation study design.

2023

PloS one

Funduluka P, Hachibamba T, Mukuma M, Bwembya P, Keith R +2 more

Plain English
This study looked at how households in the Eastern Province of Zambia can improve the processing and use of soybeans. Researchers found that only 48% of households were processing soybeans, and access to soybeans for year-round consumption was very low at just 0.29%. The study highlights barriers like high labor demands and limited knowledge, while also pointing out that socio-economic factors, like community membership and male leadership in households, positively affect soybean use. Who this helps: This research helps local farmers, households, and community organizations focused on improving nutrition and agricultural practices.

PubMed

The Green Heart Project: Objectives, Design, and Methods.

2023

medRxiv : the preprint server for health sciences

Bhatnagar A, Keith R, Yeager R, Riggs D, Sears C +9 more

Plain English
The Green Heart Project studied how adding more green spaces in a neighborhood can impact community health and the environment in Louisville, KY. Researchers measured air pollution and collected health data from nearly 1,300 local residents before and after planting over 8,000 trees and shrubs in 2022. They aim to see if these changes lead to better health outcomes and a healthier environment for the community. Who this helps: This helps residents of urban areas, particularly those living in low-to-middle-income neighborhoods.

PubMed

Electronic Cigarette Solvents, JUUL E-Liquids, and Biomarkers of Exposure: In Vivo Evidence for Acrolein and Glycidol in E-Cig-Derived Aerosols.

2022

Chemical research in toxicology

Lorkiewicz P, Keith R, Lynch J, Jin L, Theis W +5 more

Plain English
This study looked at the effects of e-cigarette ingredients on health, focusing on how certain harmful chemicals are formed when e-cigarettes are used. Researchers found that mice exposed to e-cigarette aerosols showed increased levels of two harmful substances—acrolein and glycidol—in their urine. In humans, e-cigarette use raised levels of one of these substances, 23HPMA, indicating that harmful chemicals from e-cigarettes can enter the body and might cause health problems. Who this helps: This helps patients and healthcare providers understand the potential risks of e-cigarette use.

PubMed

Stepped implementation-to-target: a study protocol of an adaptive trial to expand access to addiction medications.

2022

Implementation science : IS

Ford JH, Cheng H, Gassman M, Fontaine H, Garneau HC +3 more

Plain English
This study focuses on improving how addiction treatment programs in Washington State implement medications for opioid use disorder. Researchers are testing various strategies to see which ones work best for helping 72 addiction programs increase their effectiveness, measuring outcomes and costs along the way. By tailoring approaches to each program's needs, this research aims to provide valuable insights that could lead to better treatment practices for addressing the opioid crisis. Who this helps: This helps addiction treatment programs and their patients by enhancing access to effective medications.

PubMed

Antisynthetase Syndrome Induced by Influenza Vaccine: A Unique Case of ASIA Syndrome.

2021

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Philip C, Kabani N, Keith R, Mehta P, Seidman R +1 more

PubMed

Complement factor serum and plasma levels measured by a MILLIPLEXMagnetic Bead Panel: A reply.

2021

Scandinavian journal of immunology

Keith R, Gilliam B, Pepin D, Xiao Q

PubMed

Cardiorespiratory and Immunologic Effects of Electronic Cigarettes.

2021

Current addiction reports

Keith R, Bhatnagar A

Plain English
This study looked at the health effects of electronic cigarettes (e-cigarettes) on the heart, lungs, and immune system. Researchers found that using e-cigarettes can raise blood pressure and heart rate, cause lung problems, and trigger immune responses, with long-term exposure linked to serious health risks like DNA damage and lung inflammation. While the negative effects of e-cigarettes are less severe than traditional cigarettes, they can still harm health significantly. Who this helps: This information is important for patients, healthcare providers, and policymakers who want to understand the risks of e-cigarettes.

PubMed

Ecological factors influence balancing selection on leaf chemical profiles of a wildflower.

2021

Nature ecology & evolution

Carley LN, Mojica JP, Wang B, Chen CY, Lin YP +15 more

Plain English
This study looked at how different environmental factors, such as herbivory (plant-eating animals) and drought, affect the chemical traits of a wildflower called Boechera stricta. Researchers found that the genes influencing these chemicals have different impacts depending on the environment, helping to maintain a variety of these traits within the plant population. This research matters because it shows how plants adapt to their surroundings, which can help in conservation efforts and understanding plant resilience. Who this helps: This research benefits ecologists and conservationists working to protect plant diversity.

PubMed

Clinical Guideline Highlights for the Hospitalist: The GOLD and NICE Guidelines for the Management of COPD.

2020

Journal of hospital medicine

Neumeier A, Keith R

Plain English
This research focused on guidelines for diagnosing and managing chronic obstructive pulmonary disease (COPD) in adults aged 16 and older. The findings from the GOLD and NICE guidelines offer updated recommendations for care, helping healthcare providers improve treatment plans for COPD patients. This matters because using these guidelines leads to better patient outcomes, potentially enhancing the quality of life for those affected by this condition. Who this helps: Patients with chronic obstructive pulmonary disease and the doctors who treat them.

PubMed

Early Detection and Chemoprevention of Lung Cancer.

2018

F1000Research

New M, Keith R

Plain English
This study looked at how to find and prevent lung cancer early, which is important since many cases are diagnosed late when they are harder to treat. It found that low-dose CT scans can reduce lung cancer deaths, and there are also promising new tests and methods to help in early detection and prevention, especially through encouraging people to quit smoking. These advancements are crucial for saving lives and improving treatment outcomes for lung cancer patients. Who this helps: Patients at risk of lung cancer and healthcare providers.

PubMed

The Impact of a Health Information Technology-Focused Patient-centered Medical Neighborhood Program Among Medicare Beneficiaries in Primary Care Practices: The Effect on Patient Outcomes and Spending.

2018

Medical care

Orzol S, Keith R, Hossain M, Barna M, Peterson GG +7 more

Plain English
This study looked at a program aimed at improving healthcare for Medicare patients by using technology in doctor’s offices. It found that the program reduced hospital admissions by 7.1% and outpatient emergency visits by 5.7%, which means fewer patients were needing to go to the hospital or emergency rooms. However, there was no significant improvement in the quality of care or overall spending from this program. Who this helps: This benefits Medicare patients by potentially reducing the need for hospital visits.

PubMed

Electronic Cigarette Use Prevalence, Associated Factors, and Pattern by Cigarette Smoking Status in the United States From NHANES (National Health and Nutrition Examination Survey) 2013-2014.

2018

Journal of the American Heart Association

Jaber RM, Mirbolouk M, DeFilippis AP, Maziak W, Keith R +8 more

Plain English
This study looked at how many adults and teenagers in the U.S. used electronic cigarettes (e-cigarettes) between 2013 and 2014. It found that 2.6% of adults and 1.21% of adolescents had recently used e-cigarettes, mainly current smokers (68.1% of users) and former smokers (23.7%). Understanding these trends is important for shaping health policies and addressing smoking-related issues in society. Who this helps: This helps public health officials and policymakers in addressing smoking habits and protecting youth from tobacco products.

PubMed

The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA).

2017

Atherosclerosis

Al Rifai M, DeFilippis AP, McEvoy JW, Hall ME, Acien AN +9 more

Plain English
This study looked at how smoking affects the body’s early signs of heart and blood vessel damage in 843 current smokers, mostly around age 58. It found that smoking more cigarettes each day raised levels of inflammation markers like hsCRP and fibrinogen, indicating higher cardiovascular injury. Specifically, for every additional cigarette smoked per day, inflammation markers increased significantly, and the strongest changes were seen with hsCRP, which may be the most sensitive indicator of heart damage from smoking. Who this helps: This information benefits patients who smoke and healthcare providers by highlighting the risks and impacts of cigarette consumption on heart health.

PubMed

The INFANT study-a flawed design foreseen.

2017

Lancet (London, England)

Keith R

PubMed

Provider Experiences with Chronic Care Management (CCM) Services and Fees: A Qualitative Research Study.

2017

Journal of general internal medicine

O'Malley AS, Sarwar R, Keith R, Balke P, Ma S +1 more

Plain English
This study looked at how healthcare providers experience Chronic Care Management (CCM) services, which help patients with multiple long-term health issues receive better care outside of regular office visits. Researchers conducted interviews with 71 healthcare professionals and discovered that most patients appreciated CCM services and experienced benefits like better treatment adherence and improved access to care. However, providers faced challenges such as low payments for CCM work and difficulties in sharing patient information. Who this helps: This research benefits patients with chronic conditions and the healthcare providers who care for them.

PubMed

Vape Shop Employees: Public Health Advocates?

2016

Tobacco prevention & cessation

Hart JL, Walker KL, Sears CG, Lee AS, Smith C +3 more

Plain English
This study looked at vape shop employees in Louisville, Kentucky, to see how they share information about e-cigarettes with customers. It found that almost all of the 16 employees were former smokers, with 93.8% now using only e-cigarettes, and 93.8% reported feeling healthier since making the switch. Many employees see themselves as advocates for health, providing vaping advice and supporting efforts to quit traditional smoking, even though more than half believe e-cigarette regulations should differ from those for regular cigarettes. Who this helps: This helps smokers looking to quit and vaping customers.

PubMed

A Dollars and "Sense" Exploration of Vape Shop Spending and E-cigarette Use.

2016

Tobacco prevention & cessation

Sears C, Hart J, Walker K, Lee A, Keith R +1 more

Plain English
This study looked at how much people spend at vape shops and how that spending affects their use of e-cigarettes. Researchers surveyed 78 vape shop customers and found that spending varied widely, with many spending around $50-75 per month. Those who spent more than $50 tended to use e-cigarettes with lower nicotine levels but consumed more e-liquid; additionally, higher spending was linked to using e-cigarettes to quit smoking. Understanding these spending habits is crucial as new regulations on e-cigarette sales are being considered. Who this helps: This helps patients trying to quit smoking and healthcare providers who support them.

PubMed

Training retinal imagers for retinopathy of prematurity (ROP) screening.

2016

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Karp KA, Baumritter A, Pearson DJ, Pistilli M, Nyquist D +6 more

Plain English
This study focused on training non-doctors to take high-quality retinal images for screening retinopathy of prematurity (ROP) in infants. Out of 39,550 images taken, 91.7% were deemed acceptable for evaluation, though factors like insufficient pupil dilation and obstructive equipment lowered image quality. This is important because clear images are crucial for diagnosing ROP early and improving outcomes for premature infants. Who this helps: This benefits infants at risk for ROP and their healthcare providers.

PubMed

Early Experiences Engaging Patients Through Patient and Family Advisory Councils.

2016

The Journal of ambulatory care management

Peikes D, OʼMalley AS, Wilson C, Crosson J, Gaddes R +6 more

Plain English
This study looked at how Patient and Family Advisory Councils (PFACs) are helping primary care practices improve their services by involving patients in discussions about care delivery. Researchers found that PFACs effectively gathered patient feedback, which led to better care. However, they also noted that improvements are needed, such as involving a more diverse group of patients and ensuring open communication about the changes made. Who this helps: This helps patients and healthcare providers by making care more responsive to patient needs.

PubMed

Behavioral Measures of Temporal Processing and Speech Perception in Cochlear Implant Users.

2016

Journal of the American Academy of Audiology

Blankenship C, Zhang F, Keith R

Plain English
This study looked at how well people with cochlear implants (CIs) understand speech and how their ability to detect short gaps in sounds affects their speech perception. It found that while some CI users performed well, many struggled with detecting gaps of more than 20 milliseconds, which linked to poorer speech understanding in tests compared to normal-hearing individuals. The results suggest that using a simple clinical test (the Randomized Gap Detection Test) can help identify CI users who need extra support to improve their speech perception. Who this helps: This helps cochlear implant users who may need additional resources to enhance their speech understanding.

PubMed

Obesity prevention for children with physical disabilities: a scoping review of physical activity and nutrition interventions.

2014

Disability and rehabilitation

McPherson AC, Keith R, Swift JA

Plain English
This study looked at ways to help children with physical disabilities manage their weight through physical activity and healthy eating. Researchers reviewed 34 articles and found that while many programs helped increase activity levels, none provided long-term solutions for obesity. Notably, 18 interventions showed positive short-term effects, mostly by motivating children and encouraging strength training, but there’s still a lack of long-lasting strategies. Who this helps: This helps children with physical disabilities and their families.

PubMed

Neural adaptation and behavioral measures of temporal processing and speech perception in cochlear implant recipients.

2013

PloS one

Zhang F, Benson C, Murphy D, Boian M, Scott M +3 more

Plain English
This study looked at how changes in brain activity, called neural adaptation, affect the ability of people with cochlear implants to process sounds and understand speech. Researchers found that while everyone's brain adapted differently, those who were implanted at a younger age showed more adaptation in their brain responses. Importantly, the level of neural adaptation did not explain differences in how well individuals detected sound gaps or understood speech. Who this helps: This study benefits cochlear implant recipients and audiologists working to improve speech perception in these patients.

PubMed

Associations of passerine birds, rabbits, and ticks with Borrelia miyamotoi and Borrelia andersonii in Michigan, U.S.A.

2012

Parasites & vectors

Hamer SA, Hickling GJ, Keith R, Sidge JL, Walker ED +1 more

Plain English
The research studied how wild birds, rabbits, and ticks in Michigan are related to two specific types of bacteria, Borrelia miyamotoi and Borrelia andersonii, which can affect both animals and humans. Over four years, 12,432 ticks were collected, with 86.5% being a type that mainly feeds on birds and rabbits. It was found that 0.7% of ticks from birds and 5.3% from rabbits carried B. andersonii, while the presence of B. miyamotoi in ticks from birds was also documented for the first time, highlighting the potential for increased human exposure to these bacteria as tick populations grow. Who this helps: This helps patients and doctors by identifying new risks and informing better diagnostic tests for tick-borne diseases.

PubMed

Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion.

2012

Basic research in cardiology

Obal D, Dai S, Keith R, Dimova N, Kingery J +10 more

Plain English
This study explored how increasing a protein called extracellular superoxide dismutase (ecSOD) in heart muscle cells affects heart injury caused by lack of blood flow followed by its restoration. The researchers found that increasing ecSOD levels made these heart cells 27.5 times more active at reducing harmful substances. As a result, hearts with more ecSOD showed smaller injury areas and better recovery after blood flow was restored, indicating this approach could help protect heart tissue during such events. Who this helps: This research benefits patients recovering from heart attacks or surgeries involving blood flow issues.

PubMed

Iron regulator hepcidin exhibits antiviral activity against hepatitis C virus.

2012

PloS one

Liu H, Trinh TL, Dong H, Keith R, Nelson D +1 more

Plain English
This study looked at the relationship between hepcidin, a protein that helps control iron levels in the body, and the hepatitis C virus (HCV) in liver cells. Researchers found that HCV infection reduces hepcidin levels, which might help the virus avoid the body’s natural defenses, and that hepcidin can directly fight against HCV in lab tests. This is important because understanding how HCV interacts with hepcidin could lead to better treatments for the 170 million people infected with hepatitis C. Who this helps: This helps patients with hepatitis C and healthcare providers looking for new treatment options.

PubMed

Natural selection drives clinal life history patterns in the perennial sunflower species, Helianthus maximiliani.

2011

Molecular ecology

Kawakami T, Morgan TJ, Nippert JB, Ocheltree TW, Keith R +2 more

Plain English
Researchers studied how certain traits in Helianthus maximiliani, a type of perennial sunflower, change across different geographic locations in North America. They found significant differences in traits like flowering time and growth rate among sunflower populations, showing that these variations are not just random but are likely the result of local adaptation to different environments. This matters because it highlights how plants can evolve in response to their surroundings, helping us understand biodiversity and ecosystem health. Who this helps: This information benefits ecologists and conservationists who work to preserve plant species and their habitats.

PubMed

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

2011

Canadian journal of surgery. Journal canadien de chirurgie

Chiu JC, Shi X, Karmali S, Birch DW, Apriasz I +642 more

PubMed

Developing and testing a tool to measure nurse/physician communication in the intensive care unit.

2011

Journal of patient safety

Manojlovich M, Saint S, Forman J, Fletcher CE, Keith R +1 more

Plain English
This study focused on how nurses and doctors communicate in three intensive care units (ICUs) at a Veterans Affairs Medical Center. Researchers found significant differences in how communication and safety culture were perceived across the units, with nurses in the unit that reported the weakest safety culture also feeling less satisfied with their communication with doctors. These findings are important because better communication can improve patient care and safety in critical settings. Who this helps: This benefits patients and healthcare workers in ICUs.

PubMed

Using Electronic Health Record Systems in Diabetes Care: Emerging Practices.

2010

IHI ... : proceedings of the ... ACM SIGHIT International Health Informatics Symposium. ACM SIGHIT International Health Informatics Symposium

Veinot TC, Zheng K, Lowery JC, Souden M, Keith R

Plain English
This study looked at how healthcare workers at Veterans' Affairs (VA) Medical Centers use electronic health record (EHR) systems during visits with diabetes patients. Researchers observed 64 consultations and interviewed 39 providers, finding that while EHRs help in tracking patient information, there are gaps between how the systems are designed and the actual needs of diabetes care. This matters because improving EHR design can enhance the quality of care provided to patients with chronic illnesses like diabetes. Who this helps: This helps patients with diabetes and their healthcare providers.

PubMed

Exercise peripheral oxygen saturation (SpO2) accurately reflects arterial oxygen saturation (SaO2) and predicts mortality in systemic sclerosis.

2009

Thorax

Swigris JJ, Zhou X, Wamboldt FS, du Bois R, Keith R +5 more

Plain English
This study looked at how well the oxygen levels measured from the skin (SpO2) matched those measured directly from the blood (SaO2) in patients with a lung disease linked to systemic sclerosis (SSc-ILD). Researchers found that if a patient's SpO2 during exercise dropped below 89%, their risk of dying increased significantly, by about 2.4 times over the following years. This is important because it shows that easy-to-measure SpO2 can effectively indicate a patient's health and survival outlook, making it a useful tool for monitoring these patients. Who this helps: Patients with systemic sclerosis-related lung disease and their doctors.

PubMed

Mini epidemic of isoniazide resistant TB in rural TN: a need for supervised preventive therapy.

2009

Tennessee medicine : journal of the Tennessee Medical Association

Mehta J, Keith R, Al Hasan M, Ryland B, Roy T

Plain English
This study examined the rise of isoniazide-resistant tuberculosis (TB) in Greene County, TN, where researchers found four cases of drug-resistant TB, including a 14-month-old child. Among 65 people who had close contact with these patients, 11 tested positive for latent TB, and two active cases were identified, one due to non-compliance with preventive therapy. These findings highlight the urgent need for better preventive treatments in rural areas, as the infection rates were concerning and could have been reduced with proper supervision of the therapy. Who this helps: This benefits patients, especially those at risk of contracting drug-resistant TB, and healthcare providers in rural communities.

PubMed

Development of the North American Listening in Spatialized Noise-Sentences test (NA LiSN-S): sentence equivalence, normative data, and test-retest reliability studies.

2009

Journal of the American Academy of Audiology

Cameron S, Brown D, Keith R, Martin J, Watson C +1 more

Plain English
This study created a new version of a test called the North American Listening in Spatialized Noise-Sentences test (NA LiSN-S) to help evaluate how children hear and understand speech in noisy environments, particularly for those suspected of having auditory processing issues. Researchers tested 72 children and found that improving the volume of the speech by 1 dB made it 18.7% clearer, and when they retested 36 children later, they saw no significant changes in performance, indicating reliability. This tool is important because it can help track improvements in listening skills over time, especially for children using hearing devices or receiving therapy. Who this helps: This benefits children who may struggle with hearing and understanding speech, along with their doctors and therapists.

PubMed

Understanding auditory processing disorders.

2008

The Turkish journal of pediatrics

Yalçinkaya F, Keith R

Plain English
This study focused on auditory processing disorders (APD), which affect children's ability to hear and understand speech even when their hearing is normal. It found that children with APD often struggle to follow instructions, listen in noisy environments, and comprehend fast or unclear speech. Recognizing APD is important because it can be confused with other issues like attention deficit disorders, which could lead to incorrect treatment. Who this helps: This helps children with auditory processing disorders by improving their diagnosis and support.

PubMed

Gender differences in circulating endothelial progenitor cell colony-forming capacity and migratory activity in middle-aged adults.

2007

The American journal of cardiology

Hoetzer GL, MacEneaney OJ, Irmiger HM, Keith R, Van Guilder GP +2 more

Plain English
This study looked at how healthy blood vessel cells, called endothelial progenitor cells (EPCs), behave in middle-aged men and women. Researchers found that middle-aged women had about 150% more EPCs that could grow into colonies compared to men, and women's EPCs also moved about 40% better than those of men. This discovery helps explain why women generally experience fewer heart problems than men, which is important for understanding heart health. Who this helps: This benefits patients, particularly middle-aged women at risk for heart disease.

PubMed

Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer.

2007

American journal of respiratory and critical care medicine

Varella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC +4 more

Plain English
In this study, researchers examined changes in the chromosomes of bronchial cells from different groups: 43 high-risk smokers without lung cancer, 14 patients with lung cancer, and 14 healthy non-smokers. They found that 15.8% of cancer patients' cells had chromosome abnormalities, while 10.1% of high-risk smokers' cells showed similar issues, compared to just 0.7% in non-smokers. This research is important because it highlights that chromosomal damage can occur in lung cells before cancer develops, helping to identify early indicators of lung cancer risk. Who this helps: This helps patients at risk for lung cancer and their doctors in early detection and monitoring.

PubMed

Pulmonary capillary hemangiomatosis: an immunohistochemical analysis of vascular remodeling.

2006

European journal of medical research

Sullivan A, Chmura K, Cool CD, Keith R, Schwartz GG +1 more

Plain English
This study looked at pulmonary capillary hemangiomatosis (PCH), a rare condition that causes severe high blood pressure in the lungs, by examining lung tissue from a patient. Researchers found that PCH shows increased levels of proteins linked to blood vessel growth, like vascular endothelial growth factor, while still showing signs of cell growth suppression. These findings indicate that the cells causing PCH are different from those in another similar condition, which is important for developing targeted treatments. Who this helps: This helps patients with pulmonary capillary hemangiomatosis and their doctors in understanding the disease better.

PubMed

Sound blending in the brain: a functional magnetic resonance imaging investigation.

2005

Neuroreport

Chiu CY, Coen-Cummings M, Schmithorst VJ, Holland SK, Keith R +3 more

Plain English
This study looked at how the brain processes sounds by using a special scanning technique to reduce background noise, allowing researchers to focus on how people blend speech sounds called phonemes. They found that when participants blended sounds, certain areas of the brain were more active compared to when they just counted tones; specifically, the left side of the brain was more involved in this task. This is important because it helps us understand the brain mechanisms behind language processing, which can improve treatments for those with speech or language difficulties. Who this helps: Patients with speech and language disorders.

PubMed

Impact on child mortality of removing user fees: simulation model.

2005

BMJ (Clinical research ed.)

James C, Morris SS, Keith R, Taylor A

Plain English
This study looked at how removing user fees for healthcare in 20 African countries could save the lives of young children. The researchers found that eliminating these fees could prevent around 233,000 child deaths each year, with a possible range of 153,000 to 305,000 lives saved. This is important because making healthcare accessible by removing costs can significantly improve child survival rates and help meet global health goals. Who this helps: This benefits young children and their families in African countries.

PubMed

The expression of prostacyclin synthase is decreased in the small pulmonary arteries from patients with emphysema.

2005

Chest

Lee JD, Taraseviciene-Stewart L, Keith R, Geraci MW, Voelkel NF

PubMed

Frequent Co-Authors

A Okrainec Aruni Bhatnagar R Boushey K Pitzul G Fried L Feldman C Brown P Kaneva S Forbes R McLeod

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.